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    • 3. 发明申请
    • COMPOSITIONS AND METHODS FOR DRUG DELIVERY
    • 用于药物递送的组合物和方法
    • WO2014060601A1
    • 2014-04-24
    • PCT/EP2013/071898
    • 2013-10-18
    • VECT-HORUSCENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEUNIVERSITE D'AIX-MARSEILLE
    • JACQUOT, GuillaumeLECORCHE, PascalineMALCOR, JDPAYROT, NadineDAVID, MarionMOLINO, YvesKHRESTCHATISKY, Michel
    • A61K38/00C07K7/00C07K14/00
    • C07K7/06A61K38/00
    • The invention relates to compositions and methods suitable for delivering molecules to a mammal. The invention particularly relates to peptide derivatives (peptides and pseudo- peptides), dimers or multimers thereof, and to their use as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention or a dimer or multimer thereof bound to a molecule of interest. The peptides of the invention can be used, in particular, to vectorize via specific receptors (receptor-mediated transport, RMT), generally in the form of prodrug conjugates, molecules of pharmaceutical or diagnostic interest such as, for example, therapeutic molecules, imaging or diagnostic agents, or molecular probes, across cell membranes of different tissues or organs (such as liver, adrenal gland and intestine), healthy or pathologic (cancer cells), and in particular to enable their transport across physiological barriers of the nervous system such as the Blood brain barrier (BBB), Blood-spinal cord barrier (BSCB), or Blood-retinal barrier (BRB).
    • 本发明涉及适合于向哺乳动物递送分子的组合物和方法。 本发明特别涉及肽衍生物(肽和假肽),二聚体或多聚体,以及它们作为感兴趣分子载体的用途。 本发明还涉及含有本发明的肽衍生物或与感兴趣的分子结合的二聚体或多聚体的缀合物。 本发明的肽可以特别用于通过特异性受体(受体介导的转运,RMT)进行载体,通常以前药缀合物的形式,药物或诊断感兴趣的分子,例如治疗分子,成像 或诊断剂或分子探针,穿过不同组织或器官(例如肝,肾上腺和肠)的细胞膜,健康或病理(癌细胞),并且特别是使其能够跨越神经系统的生理屏障运输,例如 作为血脑屏障(BBB),血脊髓屏障(BSCB)或血液视网膜屏障(BRB)。