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1. 发明申请

WO2012167254A1 METHOD AND SYSTEM FOR REDUCING INTERFERENCES IN THE SPECTROMETRIC ANALYSIS OF STEROIDS 审中-公开
标题翻译：用于降低STEROIDS光谱分析中干扰物的方法和系统
公开(公告)号：WO2012167254A1
公开(公告)日：2012-12-06
申请号：PCT/US2012/040748
申请日：2012-06-04
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD. , CARAIMAN, Doina , LE BLANC, Yves , LIU, Hua-Fen
发明人： CARAIMAN, Doina , LE BLANC, Yves , LIU, Hua-Fen
IPC分类号： G01N31/00
CPC分类号： G01N27/624 , G01N33/49
摘要： A system and method for reducing interferences in the spectrometric analysis of a sample from a blood collection tube comprising an ion source for ionizing a sample extracted from the blood collection tube, the sample containing one or more steroids. The system comprises a differential mobility spectrometer for receiving the ions from the ion source, a boundary member defining a curtain gas chamber containing the differential mobility spectrometer; and a curtain gas supply for providing a curtain gas into an inlet of the differential mobility spectrometer for providing a gas flow through the differential mobility spectrometer and a curtain gas outflow out of a curtain gas chamber inlet. A system and method is disclosed for providing a modifier supply for supplying an actual volumetric flow rate of an organic acid modifier to a drift gas supply for reducing interferences.
摘要翻译：一种用于减少来自采血管的样品的光谱分析中的干扰的系统和方法，所述采血管包括离子源，用于离子化从采血管提取的样品，所述样品含有一种或多种类固醇。该系统包括用于从离子源接收离子的差分迁移率光谱仪，限定包含差示迁移率光谱仪的帘式气室的边界构件; 以及幕帘气体供应装置，用于向差动迁移谱仪的入口提供帘式气体，用于提供通过差速移动式光谱仪的气流和帘式气体室入口外的帘式气体流出。公开了一种系统和方法，用于提供用于将有机酸改性剂的实际体积流量提供给漂移气体供应源以用于减少干扰的修饰剂供应。

2. 发明申请

WO2008073392A3 COMPOSITIONS AND METHODS FOR CARDIAC TISSUE PROTECTION AND REGENERATION 审中-公开
公开(公告)号：WO2008073392A3
公开(公告)日：2008-06-19
申请号：PCT/US2007/025267
申请日：2007-12-11
申请人： 3D MATRIX, INC. , SPIRIO, Lisa , CHU, Zen
发明人： SPIRIO, Lisa , CHU, Zen
IPC分类号： A61K38/10 , A61P9/00
摘要： In various aspects the present inventions provide compositions and methods for treatment of cardiac conditions. In various embodiments, the present inventions provide methods for treating a cardiac condition comprising the step of administering in a therapeutically effective amount the substantially cell free solution of an amphiphilic self-assembling peptide to a site of cardiac tissue that has been injured due to one or more of atrial fibrillation, acute myocardial infarction; valve disease, pericardial disease, congenital heart disease, congestive heart failure, and embolism.

3. 发明申请

WO2007140291A2 EXPRESSION QUANTIFICATION USING MASS SPECTROMETRY 审中-公开
标题翻译：使用质谱分析的表达量
公开(公告)号：WO2007140291A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/069724
申请日：2007-05-25
申请人： APPLERA CORPORATION , HUNTER, Christie, L.
发明人： HUNTER, Christie, L.
CPC分类号： G01N33/68 , G01N33/6848 , G01N33/6851 , G01N2333/90209
摘要： In various aspects, the present teachings provide systems, methods, assays and kits for the absolute quantitation of protein expression. In various aspects, the present teachings provide methods of determining the concentration of one or more proteins of interest in one or more samples of interest. In various aspects, the present teachings provide methods of determining the absolute concentration of one or more iso forms of a protein using standard samples of signature protein fragments and parent-daughter ion transition monitoring (PDITM). In various embodiments, the absolute concentration of multiple isoforms of a biomolecule in a sample, multiple proteins in a biological process, a combination of multiple samples, or combinations thereof, can be determined in a multiplex fashion using the present teachings. In various aspects, provided are methods of assessing the response of a biological system to a chemical agent.
摘要翻译：在各个方面，本教导提供用于蛋白质表达的绝对定量的系统，方法，测定和试剂盒。在各个方面，本教导提供了确定感兴趣的一种或多种感兴趣的一种或多种感兴趣的蛋白质的浓度的方法。在各个方面，本教导提供使用标记蛋白片段和亲 - 子离子跃迁监测（PDITM）的标准样品来确定蛋白质的一种或多种异构体的绝对浓度的方法。在各种实施方案中，可以使用本教导以多种方式确定样品中生物分子的多种同种型，生物过程中的多种蛋白，多种样品的组合或其组合的绝对浓度。在各个方面，提供了评估生物系统对化学试剂的响应的方法。

4. 发明申请

WO2007131146A3 POWER SUPPLY REGULATION USING A FEEDBACK CIRCUIT COMPRISING AN AC AND DC COMPONENT 审中-公开
公开(公告)号：WO2007131146A3
公开(公告)日：2007-11-15
申请号：PCT/US2007/068200
申请日：2007-05-04
申请人： APPLERA CORPORATION , MDS SCIEX, INC. , GABELER, Stephen, C.
发明人： GABELER, Stephen, C.
IPC分类号： H01J49/40 , H01J49/02
摘要： In various aspects, ion sources, mass spectrometer systems, and a power supply circuit coupled to a feedback circuit are provided. A power supply is provided that includes at least the power supply circuit and is operable to transfer charge to a load. The feedback circuit is responsive to a DC component of an output voltage supplied by the power supply in a first feedback loop and an AC component of the output voltage in a second feedback loop to produce a feedback signal representative of at least one of: a value of the output voltage before a charge transfer from a capacitor of the power supply to a load; the value of the output voltage during the charge transfer from the capacitor of the power supply to the load; or the value of the output voltage after the charge transfer from the capacitor of the power supply to the load.

5. 发明申请

WO2007092873A2 CHEMICAL NOISE REDUCTION FOR MASS SPECTROMETRY 审中-公开
标题翻译：化学噪音减少大量光谱
公开(公告)号：WO2007092873A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/061745
申请日：2007-02-07
申请人： APPLERA CORPORATION , MDS SCIEX, INC. , GUO, Xinghua , BRUINS, Andries, P. , COVEY, Tom
发明人： GUO, Xinghua , BRUINS, Andries, P. , COVEY, Tom
IPC分类号： H01J49/00 , G01N27/64 , G01N33/68
CPC分类号： H01J49/0077 , G01N33/6848 , H01J49/421
摘要： In various aspects, the present teachings provide systems and methods for reducing chemical noise in a mass spectrometry instrument that use a neutral chemical reagent and one or more mass filters to reduce interfering chemical background ion signals that are generated by ionization sources of mass spectrometers. In various embodiments, the neutral chemical reagent belongs to the class of organic chemical species containing a disulfide functionality.
摘要翻译：在各个方面，本教导提供了使用中性化学试剂和一个或多个质量过滤器来减少由质谱仪的电离源产生的干扰化学背景离子信号的质谱仪器中减少化学噪声的系统和方法。在各种实施方案中，中性化学试剂属于含有二硫化物官能团的有机化学物质类别。

6. 发明申请

WO2007082305A3 BIODEGRADABLE ELASTOMERS 审中-公开
公开(公告)号：WO2007082305A3
公开(公告)日：2007-07-19
申请号：PCT/US2007/060532
申请日：2007-01-12
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BETTINGER, Christopher, J. , KARP, Jeffrey , KIM, Sonia, J. , LANGER, Robert, S. , ZUMBUEHL, Andreas , BRUGGEMAN, Joost, P. , DA SILVA-FERREIRA, Lino , NIJST, Christiaan , BURDICK, Jason
发明人： BETTINGER, Christopher, J. , KARP, Jeffrey , KIM, Sonia, J. , LANGER, Robert, S. , ZUMBUEHL, Andreas , BRUGGEMAN, Joost, P. , DA SILVA-FERREIRA, Lino , NIJST, Christiaan , BURDICK, Jason
IPC分类号： A61F2/00
摘要： The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.

7. 发明申请

WO2007044935A2 METHODS FOR THE DEVELOPMENT OF A BIOMOLECULE ASSAY 审中-公开
标题翻译：开发生物分子测定的方法
公开(公告)号：WO2007044935A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/040263
申请日：2006-10-12
申请人： APPLERA CORPORATION , MDS INC. , HUNTER, Christie, L.
发明人： HUNTER, Christie, L.
IPC分类号： G01N33/68
CPC分类号： G01N33/6848 , G01N30/7233 , Y10T436/105831 , Y10T436/24
摘要： The present teachings provide methods for the development of a mass spectrometric based assay for a protein in a sample using parent-daughter ion transition monitoring (PDITM). In various aspects, the present teachings provide methods for developing a mass spectrometric based assay for a protein in a sample without the use of a standard for the protein. In various embodiments, the sample comprises proteolytic fragments of a protein which is present in low abundance in the physiological fluid from which it is derived.
摘要翻译：本教导提供了使用亲本 - 子代离子转变监测（PDITM）开发样品中蛋白质的基于质谱分析法的方法。在各个方面，本教导提供了用于开发基于质谱的测定样品中蛋白质而不使用蛋白质标准物的方法。在多个实施方案中，样品包含蛋白质的蛋白水解片段，其在其衍生的生理学流体中以低丰度存在。

8. 发明申请

WO2006124098A3 METHODS OF OPERATING ION OPTICS FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2006124098A3
公开(公告)日：2006-11-23
申请号：PCT/US2006/008190
申请日：2006-03-07
申请人： APPLERA CORPORATION , MDS INC. , HAYDEN, Kevin, M. , VESTAL, Marvin, L.
发明人： HAYDEN, Kevin, M. , VESTAL, Marvin, L.
IPC分类号： H01J19/00 , H01J49/06 , B01D59/44
摘要： In various embodiments, provided are methods for focusing ions for an ion fragmentor, and methods for operating an ion optics assembly. In various embodiments, the present teachings provide methods that substantially maintain the position of the focal point of the an incoming ion beam over a wide range of collision energies, and thereby provide a collimated ion beam for a collision cell over a wide range of energies. In various embodiments, the present teachings provide methods that facilitate decreasing' ion transmission losses over a wide range of collision energies.

9. 发明申请

WO2008073395A3 COMPOSITIONS AND METHODS FOR CARDIAC TISSUE PROTECTION AND REGENERATION 审中-公开
公开(公告)号：WO2008073395A3
公开(公告)日：2008-06-19
申请号：PCT/US2007/025271
申请日：2007-12-11
申请人： 3D MATRIX, INC. , SPIRIO, Lisa , CHU, Zen
发明人： SPIRIO, Lisa , CHU, Zen
IPC分类号： A61K38/10 , A61P9/00 , A61P19/02 , A61P25/28 , A61P7/00 , A61P35/00
摘要： In various aspects the present inventions provide compositions and methods for treatment of cardiac conditions. In various embodiments, the present inventions provide methods for treating a cardiac condition comprising the step of administering in a therapeutically effective amount the substantially cell free solution of an amphiphilic self-assembling peptide to a site of cardiac tissue that has been injured due to one or more of atrial fibrillation, acute myocardial infarction; valve disease, pericardial disease, congenital heart disease, congestive heart failure, and embolism.

10. 发明申请

WO2006124095A2 SAMPLE HANDLING MECHANISMS AND METHODS FOR MASS SPECTROMETRY 审中-公开
标题翻译：样品处理机理和质谱方法
公开(公告)号：WO2006124095A2
公开(公告)日：2006-11-23
申请号：PCT/US2006/007889
申请日：2006-03-07
申请人： APPLERA CORPORATION , MDS, INC. , CYGAN, Thomas, R. , TSANG, Vincent , BURKE, Raymond, P. , GILL, Richard , MARTIN, Roy , HUTCHINS, Timothy, E.
发明人： CYGAN, Thomas, R. , TSANG, Vincent , BURKE, Raymond, P. , GILL, Richard , MARTIN, Roy , HUTCHINS, Timothy, E.
IPC分类号： H01J49/04
CPC分类号： H01J49/0495
摘要： In various aspects, the present teaching provide systems for providing sample ions, methods for providing sample ions, and sample support handling mechanisms. The sample support handling mechanisms of the present teachings comprising a sample support transfer mechanism portion and a sample support changing mechanism portion, where the sample support changing mechanism portion is disposed in a vacuum lock chamber. In various embodiments, the sample support handling mechanism facilitates providing consistent positioning of a sample support for subsequent ion generation by MALDI.
摘要翻译：在各个方面，本教导提供用于提供样品离子的系统，用于提供样品离子的方法和样品支持处理机构。本发明的样品支持处理机构包括样品支承转移机构部分和样品支撑体改变机构部分，其中样品支撑体改变机构部分设置在真空锁定室中。在各种实施方案中，样品支持处理机制有助于提供样品载体的一致的定位，以便随后通过MALDI产生离子。

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