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1. 发明授权

US12110282B2 Thiobenzopyrans and their use in preparation of drugs for treatment of rheumatoid arthritis 有权
公开(公告)号：US12110282B2
公开(公告)日：2024-10-08
申请号：US18013069
申请日：2021-07-22
申请人： HC SYNTHETIC PHARMACEUTICAL CO., LTD.
发明人： Cheng Yang , Dongxing Li , Sumin Qi , Qiyuan Zhang , Xiaodan Zhao
IPC分类号： C07D335/06 , A61P19/02
CPC分类号： C07D335/06 , A61P19/02
摘要： Provided is a thiobenzopyran-based compound of Formula I and its pharmaceutically acceptable salt, and its use in the preparation of drugs for the treatment of rheumatoid arthritis, wherein X is selected from oxygen, sulfur, —SO—, and —SO2—; Y is a sulfur atom and Z is H, Na, or K. Through preliminary tests of anti-inflammatory activity, compounds of formula I have anti-rheumatoid arthritis effects.

2. 发明授权

US11974765B2 Device and method for treating nosebleeds 有权
公开(公告)号：US11974765B2
公开(公告)日：2024-05-07
申请号：US17158323
申请日：2021-01-26
申请人： Matthew James Ibarra , Christopher Chang
发明人： Matthew James Ibarra , Christopher Chang
IPC分类号： A61B17/24
CPC分类号： A61B17/24
摘要： A mouth insert for treating nosebleeds includes a main body and a bite tab. The bite tab removably engages the main body and is configured to move up and/or down vertically in order to adjust the height of the device. The main body includes a horizontally extending elongated portion, a center portion extending downward from a bottom surface of the elongated portion, and the center portion has a narrower width than the horizontally extending elongated portion. The elongated portion of the main body is shaped and dimensioned to be inserted into a buccal cavity of a user's mouth and to fit behind the user's upper lip and in front of the user's upper gums, and the center portion is shaped and dimensioned to be positioned only in front of the user's upper front teeth. The bite tab includes a horizontally extending portion and a vertically extending portion and the vertically extending portion is configured to removably engage the center portion of the main body and the horizontally extending portion includes a push-surface used for pushing the device upward in order to provide pressure to the user's nose.

3. 发明授权

US11734469B2 System and method for generating a landscape design 有权
公开(公告)号：US11734469B2
公开(公告)日：2023-08-22
申请号：US17079435
申请日：2020-10-24
申请人： HOME OUTSIDE, INC
发明人： Julie Moir Messervy , David Rose , Kyle Scharpf
IPC分类号： G06G7/48 , G06F30/13 , H04L67/02 , G06F30/12
CPC分类号： G06F30/13 , G06F30/12 , H04L67/02
摘要： A method for generating an online landscape design for a property includes first entering an address for a property and then importing satellite view data of the property and a street where the property is located from global mapping databases. Next, calculating property size, topography and house size from the satellite view data using a calculator engine. Next, performing scene segmentations and analyzing existing conditions via a landscape design engine, then applying custom vision classifiers for specific landscape elements via the landscape design engine, and then analyzing foliage conditions from the satellite view data. Next, determining property landscape improvements via a scoring engine and then determining materials lists, and calculating quantities, and costs for fulfilling the property landscape improvements via the calculator engine. Next, entering user preferences for the property landscape improvements via a user interface (UI) and then generating an improved landscape design for the property based on the user's preferences and the results of the scoring engine using the landscape design engine.

4. 发明授权

US11129655B2 System and method for bone fusing implants 有权
公开(公告)号：US11129655B2
公开(公告)日：2021-09-28
申请号：US16515477
申请日：2019-07-18
申请人： SPINEFRONTIER, INC
发明人： Jeremy Crossgrove , Oscar Herrera , Michael Emery , Joshua Finkel , Kyle Woodard , Kingsley R. Chin
IPC分类号： A61B17/86 , A61F2/30
摘要： A bone fusing implant device includes an elongated body extending along a longitudinal direction. The elongated body includes a first segment having an outer surface with cortical threads, a second segment having an outer surface with cancellous threads, a top segment and a bottom segment. The first segment is adjacent to the second segment along the longitudinal direction and is configured to engage a cortical bone with the cortical threads and the second segment is configured to engage a cancellous bone with the cancellous threads. The elongated body has one or more elongated fusing gutters extending along the longitudinal direction on an outer surface of the elongated body covering the first and second segments, a central opening extending along the longitudinal direction through the elongated body's center and one or more through-openings that extend horizontally and intersect with the one or more fusing gutters.

5. 发明授权

US10983058B1 Device and method for visualization of fluorophores 有权
公开(公告)号：US10983058B1
公开(公告)日：2021-04-20
申请号：US16355152
申请日：2019-03-15
申请人： Amplyus LLC
发明人： Ezequiel Alvarez Saavedra , Sebastian Kraves
IPC分类号： G01N21/64
摘要： A device and method are described for the naked eye visualization of fluorophores. The device has a light source capable of exciting fluorophores, a rack to receive one or more fluorophores and a window through which test tubes can be observed. The method provides a means for inferring the conformational state of molecules from the amount of fluorescence emitted by the fluorophores.

6. 发明授权

US10772830B1 Preservative free pharmaceutical compositions for ophthalmic administration 有权
公开(公告)号：US10772830B1
公开(公告)日：2020-09-15
申请号：US16830883
申请日：2020-03-26
申请人： Evangelos Karavas , Efthimios Koutris , Vasiliki Samara , Ioanna Koutri , Anastasia Kalaskani , Andreas Kakouris , George Gotzamanis
发明人： Evangelos Karavas , Efthimios Koutris , Vasiliki Samara , Ioanna Koutri , Anastasia Kalaskani , Andreas Kakouris , George Gotzamanis
IPC分类号： A61K31/5575 , A61K47/00 , A61K47/12 , A61K9/00 , A61K47/26 , A61K47/10 , A61K47/38 , A61K9/08 , A61K31/165 , A61K31/5377 , A61K31/382 , A61K47/02
摘要： The present invention relates to a preservative-free, aqueous solution in the form of eye drops packed in a container that ensures stability of the product, ideal eye drop volume and reduced drop volume variability and provides efficient dispensing.

7. 发明授权

US10677919B2 Self-positioning system and self-positioning identification method of deepwater underwater robot of irregular dam surface of reservoir 有权
公开(公告)号：US10677919B2
公开(公告)日：2020-06-09
申请号：US15938363
申请日：2018-03-28
申请人： NANJING HYDRAULIC RESEARCH INSTITUTE
发明人： Yan Xiang , Zhuo Li , Jinbao Sheng , Yunqing Tang , Chengdong Liu , Guangya Fan , Haifei Sha , Xiaolei Zhan , Kai Zhang , Guangze Shen
IPC分类号： G01S15/08 , B63G8/00 , B63G8/24 , E02B7/00 , G05D1/02 , E02B7/04 , G01S15/88 , G01S15/46 , G01C21/20 , G05D1/04 , E02B17/00
摘要： The present invention provides a self-positioning system of a deepwater underwater robot of an irregular dam surface of a reservoir, including cross reflection metal plates arranged on the irregular dam surface, and an underwater robot provided with a control motherboard, a water level indicator and a sonar system, wherein the water level indicator and the sonar system are respectively connected with the control motherboard, and the control motherboard is connected with a computer via a cable. The cross reflection metal plate has known coordinates and has four quadrants. A sonar signal emitted by the sonar system is reflected by the cross reflection metal plate to generate sonar reflection signals of four quadrants, and the sonar signals in the effective quadrants correspond to known coordinate parameters of the cross reflection metal plate so as to obtain the horizontal distance between the underwater robot and the irregular dam surface. The water level indicator is used for calculating the vertical position of the underwater robot. The computer calculates accurate positioning of the underwater robot according to the horizontal position and the vertical position. The present invention has the beneficial effects of being able to accurately obtain the positioning coordinates of the underwater robot in the deepwater of the irregular dam surface of the reservoir.

8. 发明授权

US10672594B2 System and method for plasma head thermal control 审中-公开
公开(公告)号：US10672594B2
公开(公告)日：2020-06-02
申请号：US15797017
申请日：2017-10-30
申请人： Ontos Equipment Systems, Inc.
发明人： Robert Emmett Hughlett , Matthew Sheldon Phillips , Eric Frank Schulte , Michael Dow Stead
IPC分类号： B32B41/00 , H01J37/32
摘要： An atmospheric pressure plasma system includes an atmospheric pressure plasma source that generates a glow discharge-type plasma. The atmospheric pressure plasma source comprises a plasma head, a heating element and an active cooling element and the heating element and active cooling element control the plasma head temperature to a set-point temperature independent of variations in plasma generating power or plasma power ON/OFF status.

9. 发明授权

US10258994B2 Method and apparatus for processing a used mattress 有权
公开(公告)号：US10258994B2
公开(公告)日：2019-04-16
申请号：US14422030
申请日：2013-08-16
申请人： MADDISON MORGAN & BAILEY LIMITED
发明人： Philip Andrew Cooke
IPC分类号： B02C19/00 , B29B17/02 , B26F3/00 , B29B17/04 , B09B5/00 , B29L31/58 , B29L31/00
摘要： Method and apparatus for deconstructing, cutting, shredding or disintegrating a mattress, sofa, car seat or similar items with steel or metal sub frames by the use of high pressure water jets whereby the mattress, sofa, car seat or the like is compressed and then deconstructed while compressed by the use of high pressure water jets.

10. 发明授权

US09943484B2 Preparation of polylactide-polyglycolide microparticles having a sigmoidal release profile 有权
公开(公告)号：US09943484B2
公开(公告)日：2018-04-17
申请号：US14898415
申请日：2014-06-18
申请人： PHARMATHEN S.A.
发明人： Evangelos Karavas , Efthymios Koutris , Sotiria Haitidou , Theofanis Mantourlias , Georgia Papanikolaou
IPC分类号： A61K9/14 , A61K9/16 , C08J3/12 , C08J3/14 , A61K31/519
CPC分类号： A61K9/1682 , A61K9/1647 , A61K9/1694 , A61K31/519 , C08J3/12 , C08J3/14 , C08J2300/16 , C08J2367/04
摘要： The present invention relates to preparation of biodegradable microparticles formed from polylactide-polyglycolide copolymers (PLGA) polymer and how to achieve sigmoidal release of active pharmaceutical compound from the microparticles. In particular, the present invention relates to emulsification of an inner/oil phase to an outer/water phase followed by quenching and a single drying step for the preparation of microparticles having a preferred release profile of preferably basic/nucleophilic compounds such as risperidone. Alternatively the present invention is also suitable for hydrophobic compounds that have poor water-solubility and a high drug loading of >20% w/w is required. The release profile can be controlled by adjusting the degree of saturation of the outer/water phase with the organic solvent used in the inner/oil phase, the polymer concentration of the inner/oil phase and the temperature at the quenching step. In particular, an initial lag phase and a substantially sigmoidal release profile are achieved by using an outer aqueous phase over saturated with the solvent used in the inner phase at emulsification step, in combination with a low temperature during quenching.

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