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1. 发明授权

US5181914A Medicating device for nails and adjacent tissue 失效
标题翻译：用于指甲和相邻组织的药物装置
公开(公告)号：US5181914A
公开(公告)日：1993-01-26
申请号：US879792
申请日：1992-05-06
申请人： Gerald P. Zook
发明人： Gerald P. Zook
IPC分类号： A61F13/00 , A61F13/02 , A61K9/70
CPC分类号： A61F13/105 , A61K9/703 , A61K9/7084 , A61F2013/00506 , A61F2013/00846 , A61F2013/00893 , A61F2013/00906
摘要： A medicating device for human nails and adjacent tissue which, in the preferred embodiment, includes a transparent viscoelastic gel pad having one or more pharmacologically-active substances incorporated therein; a sheet of transparent, impermeable, and elastic material providing an occlusive layer adjacent to the upper surface of the viscoelastic gel pad; an elastic retaining ring perimetrically surrounding the viscoelastic gel pad to prevent migration due to shoe pressure; and a porous meshwork attached to the elastic retaining ring so as to additionally anchor the gel pad from migration. The porous meshwork member may be located at the surface of the viscoelastic gel pad opposite the occlusive covering sheet, or may run through the viscoelastic gel pad in its anchoring function. The viscoelastic gel pad, occlusive covering sheet, and elastic retaining ring with porous meshwork may be secured to the digit of the wearer by a transparent digit-engaging elastic tubular sheath, or by an adhesive tape bandage with a visual access opening.
摘要翻译：一种用于人指甲和相邻组织的药物装置，在优选实施方案中包括其中掺入一种或多种药理活性物质的透明粘弹性凝胶垫; 一片透明，不渗透和弹性材料，提供邻近粘弹性凝胶垫的上表面的闭塞层; 环绕着粘弹性凝胶垫的弹性保持环以防止由于鞋的压力而迁移; 以及连接到弹性保持环的多孔网，以便另外锚定凝胶垫以免迁移。多孔网状构件可以位于与封闭覆盖片相对的粘弹性凝胶垫的表面处，或者可以在其锚定功能中穿过粘弹性凝胶垫。粘弹性凝胶垫，封闭覆盖片和具有多孔网的弹性保持环可以通过透明的数字接合弹性管状护套或通过具有视觉进入口的胶带绷带固定到佩戴者的数字上。

2. 发明授权

US5497789A Foot protector incorporating a viscoelastic gel 失效
标题翻译：装有粘弹性凝胶的脚部保护器
公开(公告)号：US5497789A
公开(公告)日：1996-03-12
申请号：US969530
申请日：1992-10-30
申请人： Gerald P. Zook
发明人： Gerald P. Zook
IPC分类号： A61F13/06
CPC分类号： A61F13/068 , A61F13/063
摘要： A padding and medicating device for corns, hammertoes, bunions, blisters, and the like comprising a noncompressible, thermoplastic, oleaginous, viscoelastic gel directly impregnated onto a carrier structure of elastic fabric. The ultrasoft gel is retained on and compressed against the body part being treated by the elastic tension of the fabric which causes the noncompressible gel to expand radially outward, flow over the lesion, and conform to the shape of the lesion in a manner which dissipates externally-applied pressure equally throughout the fabric-gel-tissue system. The invention also internally absorbs frictional or horizontal shearing forces, delivers a therapeutically significant dose of a lubricating, soothing, and emolifying oil such as Mineral Oil U.S.P., and is further capable of delivering a pharmacologically active substance to the foot lesion.
摘要翻译：包含直接浸渍在弹性织物的载体结构上的不可压缩，热塑性，含油粘弹性凝胶的用于玉米，榔头，圆形，水疱等的填充和治疗装置。超软凝胶被保持在身体部分上并被压在被织物的弹性张力处理的身体部位上，导致不可压缩的凝胶径向向外扩张，流过病变，并以外部消散的方式与病变的形状一致在整个织物 - 凝胶组织系统中均匀地施加压力。本发明还内部吸收摩擦或水平剪切力，递送治疗显着剂量的润滑，舒缓和润肤油如矿物油U.S.P.，并且还能够将药理活性物质递送至足部损伤。

3. 发明授权

US5167649A Drug delivery system for the removal of dermal lesions 失效
标题翻译：用于去除真皮病变的药物递送系统
公开(公告)号：US5167649A
公开(公告)日：1992-12-01
申请号：US870544
申请日：1992-04-17
申请人： Gerald P. Zook
发明人： Gerald P. Zook
IPC分类号： A61F13/00 , A61F13/02 , A61K9/70
CPC分类号： A61K9/703 , A61F13/0203 , A61K9/7084 , A61F2013/00506 , A61F2013/00846 , A61F2013/00893 , A61F2013/00906
摘要： A drug delivery system for the removal of dermal lesions which includes a pad of viscoelastic rubber and oil gel, perfused with a pharmacologically active substance, which is partially encapsulated between a first layer of oil and water impermeable material and a second layer of oil and water impermeable material. The second layer includes an aperture, corresponding to the dimension of the dermal lesion, which is smaller than, and located within, the periphery of the adjacent medicated viscoelastic rubber and oil gel pad. The two layers of oil and water impermeable material are bonded together to form a seal about the periphery of the viscoelastic rubber and oil gel pad. The surface of the patch which is affixed to a wearer's skin is provided with a pressure sensitive adhesive. The viscoelastic rubber and oil pad and the encapsulating layers preferably are transparent.
摘要翻译：一种用于去除真皮损伤的药物递送系统，其包括用药理活性物质灌注的粘弹性橡胶和油凝胶垫，其部分地封装在第一层油和不透水材料之间，以及第二层油和水不渗透材料。第二层包括对应于皮肤损伤的尺寸的孔，其小于并位于邻近的药物粘弹性橡胶和油凝胶垫的周边内。两层不透水和不透水的材料结合在一起，形成围绕粘弹性橡胶和油凝胶垫的周边的密封。粘贴在使用者皮肤上的贴剂的表面设有压敏粘合剂。粘弹性橡胶和油垫以及封装层优选是透明的。

4. 发明授权

US5330452A Topical medicating device 失效
标题翻译：局部用药
公开(公告)号：US5330452A
公开(公告)日：1994-07-19
申请号：US69411
申请日：1993-06-01
申请人： Gerald P. Zook
发明人： Gerald P. Zook
IPC分类号： A61F13/00 , A61F13/02 , A61K9/70
CPC分类号： A61K9/703 , A61F13/0213 , A61F13/0226 , A61F13/025 , A61K9/7084 , A61F2013/00608 , A61F2013/00748 , A61F2013/00825 , A61F2013/00851 , A61F2013/00885 , A61F2013/00893 , A61F2013/00906 , A61F2013/0091
摘要： A topical medicating device includes a transparent viscoelastic gel pad having one or more pharmacologically-active substances incorporated therein; a sheet of transparent, impermeable, and elastic material providing an occlusive layer adjacent to the upper surface of the viscoelastic gel pad; an elastic retaining ring perimetrically surrounding the viscoelastic gel pad to prevent migration due to external pressure; and a porous meshwork attached to the elastic retaining ring so as to additionally anchor the gel pad from migration. The porous meshwork member may be located at the surface of the viscoelastic gel pad opposite the aforementioned occlusive covering sheet, or may run through the viscoelastic gel pad in its anchoring function. The viscoelastic gel pad, occlusive covering sheet, and retaining ring with porous meshwork may be affixed to a target skin surface of the patient by an adhesive tape bandage with a visual access opening. The adhesive bandage may be formed to integrally include the impermeable occlusive layer adjacent to the surface of the viscoelastic gel pad. As a topical anesthetic device, the liquid fraction of the viscoelastic gel pad may be a solution of alcohol and water, preferably, but not limited to, 70% ethyl alcohol, wherein is dissolved 10% to 40%, by weight, of Lidocaine, U.S.P./N.F.
摘要翻译：一种局部用药装置，包括其中掺入一种或多种药理活性物质的透明粘弹性凝胶垫; 一片透明，不渗透和弹性材料，提供邻近粘弹性凝胶垫的上表面的闭塞层; 围绕粘弹性凝胶垫的弹性保持环，以防止由于外部压力而迁移; 以及连接到弹性保持环的多孔网，以便另外锚定凝胶垫以免迁移。多孔网状构件可以位于与上述闭塞性覆盖片相对的粘弹性凝胶垫的表面处，或者可以在其锚定功能中穿过粘弹性凝胶垫。粘弹性凝胶垫，封闭性覆盖片和具有多孔网状物的保持环可以通过具有视觉进入口的胶带绷带附着到患者的目标皮肤表面。粘合绷带可以形成为一体地包括邻近粘弹性凝胶垫表面的不可渗透闭塞层。作为局部麻醉装置，粘弹性凝胶垫的液体部分可以是醇和水的溶液，优选但不限于70％乙醇，其中以重量比为10％至40％的利多卡因， USP / NF

5. 发明授权

US5098421A Viscoelastic gel foot padding and medicating device 失效
标题翻译：粘弹性脚垫和药物装置
公开(公告)号：US5098421A
公开(公告)日：1992-03-24
申请号：US421644
申请日：1989-10-16
申请人： Gerald P. Zook
发明人： Gerald P. Zook
IPC分类号： A61F13/00 , A61F13/06
CPC分类号： A61F13/063 , A61F2013/00395 , A61F2013/00404 , A61F2013/0091
摘要： A padding and medicating device for the human foot comprising a sheet structure, preferably of an elastic fabric material and partially coated on one surface with a pressure sensitive adhesive, in combination with a pad of viscoelastic gelatinous material impregnated onto a portion of the same surface of the sheet structure as the pressure sensitive adhesive. The pad of viscoelastic gelatinous material is preferably made with an oleaginous plasticizer such as Mineral Oil USP, and may contain one or more pharmacologically active agents. The sheet structure is oil impervious or a separating layer of material impervious to the oleaginous plasticizer is incorporated on either surface of the sheet structure adjacent to the area of the sheet structure to be impregnated with the viscoelastic gelatinous material to prevent the oleaginous plasticizer from bleeding onto the sock or shoe of the wearer. Ideally the viscoelastic gelatinous material is thermoplastic, ultrasoft, able to stretch to many times its relaxed dimensions without tearing, and capable of bleeding a significant amount of a liquid hydrocarbon plasticizer such as Mineral Oil USP onto the skin of the wearer. The present invention can also function as a blister dressing which is able to internally absorb horizontal shearing forces when the gel is employed in thin layers. An alternative embodiment comprising only the viscoelastic gel molded into the shape of a toe spacer, crest pad, corn or bunion pad and the like is also contemplated.
摘要翻译：一种用于人脚的衬垫和治疗装置，包括片状结构，优选为弹性织物材料，并在一个表面上用压敏粘合剂部分地涂覆在粘合剂的一部分上的粘弹性凝胶状材料垫作为压敏粘合剂的片材结构。粘弹性胶状材料垫优选用含油增塑剂如矿物油USP制成，并且可以含有一种或多种药理学活性剂。片状结构是不透油的，或者不透油性增塑剂的材料的分离层被结合到片状结构的邻近片状结构区域的任何一个表面上，以浸渍粘弹性凝胶状材料，以防止油性增塑剂渗透到穿着者的袜子或鞋子。理想地，粘弹性胶状材料是热塑性的，超柔软的，能够拉伸多次其松弛尺寸而不会撕裂，并且能够将大量的液体烃增塑剂例如矿物油USP渗透到穿着者的皮肤上。本发明还可用作泡罩敷料，当凝胶用于薄层时，其能够内部吸收水平剪切力。仅考虑模制成脚趾间隔件，波峰垫，玉米或圆筒垫等形状的粘弹性凝胶的替代实施例。

6. 发明授权

US4842931A Affixable padding material using gelatinous viscoelastic polymer 失效
标题翻译：使用凝胶状粘弹性聚合物的粘合垫料
公开(公告)号：US4842931A
公开(公告)日：1989-06-27
申请号：US221213
申请日：1988-07-19
申请人： Gerald P. Zook
发明人： Gerald P. Zook
IPC分类号： C09J7/04
CPC分类号： C09J7/04 , C09J2400/263 , Y10T428/28 , Y10T428/2848 , Y10T442/2754
摘要： An affixable pad for corns, calluses, bunions, and the like, made from a soft viscoelastic gel material. Preferably, the gel contains a high percentage of plasticizing oil such as Mineral Oil U.S.P. The gel is impregnated onto an elastic fabric, such as Spandex, which allows the gel to flow around a lesion and equalize pressure in a superior manner.
摘要翻译：由柔软的粘弹性凝胶材料制成的用于玉米，愈伤组织，扁豆等的可贴装垫。优选地，凝胶含有高百分比的增塑油，例如矿物油U.S.P. 将凝胶浸渍在诸如氨纶的弹性织物上，其使得凝胶能够以损伤的方式流动并以优异的方式均衡压力。

7. 发明授权

US5415866A Topical drug delivery system 失效
标题翻译：局部药物输送系统
公开(公告)号：US5415866A
公开(公告)日：1995-05-16
申请号：US89192
申请日：1993-07-12
申请人： Gerald P. Zook
发明人： Gerald P. Zook
IPC分类号： A61K9/70 , A61F13/02
CPC分类号： A61K9/7084 , Y10S514/817
摘要： A drug delivery system for the topical administration of medication which utilizes a viscoelastic gel pad having a liquid fraction, wherein the medication is incorporated within the liquid fraction, the viscoelastic gel pad being partially encapsulated between two layers of liquid fraction impermeable material which are joined together to form a seal about the periphery of the gel pad so as to control migration of the pad, and the medicating skin contact of the pad is limited to a drug delivery aperture formed in the skin-contacting layer of liquid fraction impermeable material. The aperture-containing layer, which contacts a wearer's skin, may be provided with a pressure sensitive adhesive. The invention is exemplified in a topical anesthetic delivery system wherein a viscoelastic gel pad, partially encapsulated by transparent alcohol and water impermeable layers, has an alcohol and water liquid fraction in which is dissolved lidocaine base. The alcohol and liquid fraction of the anesthetic viscoelastic gel pad may be from 20% to 90% alcohol, preferably 70% ethyl alcohol, wherein is dissolved 10% to 40%, by weight, of Lidocaine U.S.P./N.F. Such topical anesthetic drug delivery system can be preliminarily applied with accuracy to a target skin surface by a patient, leaving, upon subsequent removal, a target skin surface anesthetized and ready for immediate dermal surgery or other treatment.
摘要翻译：用于局部施用药物的药物递送系统，其利用具有液体部分的粘弹性凝胶垫，其中药物结合在液体部分内，粘弹性凝胶垫部分包封在两层液体部分不可渗透材料之间，所述两层液体部分不可渗透材料连接在一起以形成围绕凝胶垫的周边的密封，以便控制垫的迁移，并且垫的药物皮肤接触限于形成在液体不可渗透材料的皮肤接触层中的药物递送孔。与穿戴者的皮肤接触的含孔层可以设置有压敏粘合剂。本发明在局部麻醉剂递送系统中举例说明，其中部分由透明醇和不透水层包封的粘弹性凝胶垫具有溶解利多卡因碱的醇和水液体部分。麻醉粘弹性凝胶垫的醇和液体馏分可以是20％至90％的醇，优选70％的乙醇，其中溶解的重量比为利多卡因的10％至40％的美制肽/NF。这种局部麻醉药物递送系统可以由患者准确地准确地施用于目标皮肤表面，随后移除时，将麻醉的目标皮肤表面留下并准备立即进行真皮手术或其他治疗。

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