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1. 发明申请

WO1993023360A1 NOVEL QUATERNARY AMMONIUM SALTS AND USE THEREOF AS MEDICINE 审中-公开
标题翻译：新的季铵盐和其作为医药使用
公开(公告)号：WO1993023360A1
公开(公告)日：1993-11-25
申请号：PCT/JP1993000607
申请日：1993-05-10
申请人： ZERIA PHARMACEUTICAL CO., LTD. , KITAGAWA, Osamu; , ISHII, Katsuyuki; , NIWA, Seiichi; , UEKI, Sigeru; , SEIKI, Masao;
发明人： ZERIA PHARMACEUTICAL CO., LTD.
IPC分类号： C07C211/63
CPC分类号： C07C323/29 , C07D277/28 , C07D307/52 , C07D333/20
摘要： Quaternary ammonium salts represented by general formula (I) and use thereof as medicines, wherein R and R represent lower alkyl groups which may be the same or different from each other; R represents hydrogen, lower alkyl, etc.; A represents lower alkyl, etc.; Q represents an anion; X represents (a), (b), etc.; Y represents methylene, oxygen or sulfur; Z represents (c), etc.; l and m represent each an integer of 1 or 2; and n represents an integer of 1 to 3.
摘要翻译：由通式（I）表示的季铵盐及其作为药物的用途，其中R 1和R 2表示彼此相同或不同的低级烷基; R 3表示氢，低级烷基等; A代表低级烷基等。 Q < - >表示阴离子; X表示（a），（b）等; Y表示亚甲基，氧或硫; Z代表（c）等; l和m表示1或2的整数; n表示1〜3的整数。

2. 发明申请

WO1993013068A1 TRICYCLIC COMPOUND AND MEDICINE CONTAINING THE SAME 审中-公开
标题翻译：三氯化合物和含有它们的药物
公开(公告)号：WO1993013068A1
公开(公告)日：1993-07-08
申请号：PCT/JP1992001640
申请日：1992-12-16
申请人： ZERIA PHARMACEUTICAL CO., LTD. , KUMAGAI, Kazuhiro; , NAGASAWA, Masaaki; , TAKAHASHI, Hidenori; , ABE, Tooru; , OMATA, Takeshi; , SEGAWA, Yoshihide;
发明人： ZERIA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D211/70
CPC分类号： C07D401/04 , A61K31/445 , C07D211/70 , C07D401/12 , C07D409/04 , C07D409/14
摘要： A tricyclic compound represented by general (I), a salt thereof, and an antihistaminic and an antiallergic containing the same as the active ingredient wherein R represents hydrogen or halogen; X represents -CH2CH2-, -CH=CH- or -CH2-CO-; A represents benzene, thiophene or pyridine; B represents hydroxy, lower alkoxy or ( alpha ); and m represents an integer of 2 to 5. The compound has a potent antihistaminic activity and a high safety, and is hence useful for treating various allergic diseases including inflammation, nephritis, hepatitis, pancreatitis, etc., for preventing and/or treating respiratory system diseases, and as an antiasthmatic.
摘要翻译：由通式（I）表示的三环化合物，其盐，含有与活性成分相同的抗组胺剂和抗过敏剂，其中R表示氢或卤素; X表示-CH 2 CH 2 - ， - CH = CH-或-CH 2 -CO-; A代表苯，噻吩或吡啶; B代表羟基，低级烷氧基或（α）; m表示2〜5的整数。化合物具有有效的抗组胺活性和高安全性，因此可用于治疗各种过敏性疾病，包括炎症，肾炎，肝炎，胰腺炎等，用于预防和/或治疗呼吸系统疾病，以及作为抗哮喘药。

3. 发明申请

WO1991004737A1 OSTEOGENESIS PROMOTER 审中-公开
标题翻译： OSTEOGENESIS推广者
公开(公告)号：WO1991004737A1
公开(公告)日：1991-04-18
申请号：PCT/JP1990001255
申请日：1990-09-28
申请人： ZERIA PHARMACEUTICAL CO., LTD. , HAMARI CHEMICALS CO., LTD. , YAMAGUCHI, Masayoshi
发明人： ZERIA PHARMACEUTICAL CO., LTD. , HAMARI CHEMICALS CO., LTD.
IPC分类号： A61K31/415
CPC分类号： A61K33/30 , A61K31/415
摘要： An osteogenesis promoter containing zinc salt or a complex of L-carnosine as an active ingredient, which has an excellent activity of promoting osteogenesis and remarkably reduced toxicity and adverse effects and can be orally administered.

4. 发明申请

WO1988000048A1 DRUG FOR PROPHYLAXIS AND TREATMENT OF HEPATOPATHY 审中-公开
标题翻译：用于预防和治疗胃肠病的药物
公开(公告)号：WO1988000048A1
公开(公告)日：1988-01-14
申请号：PCT/JP1987000460
申请日：1987-07-02
申请人： ZERIA PHARMACEUTICAL CO., LTD. , HAMARI CHEMICALS, LTD. , INAGAKI, Tetsuya , TAGASHIRA, Eijiro , TAKAYA, Masahiro , NISHIMURA, Yasuhiro
发明人： ZERIA PHARMACEUTICAL CO., LTD. , HAMARI CHEMICALS, LTD.
IPC分类号： A61K31/415
CPC分类号： A61K38/04
摘要： A novel drug for prophylaxis and treatment of alcoholic hepatopathy, viral hepatitis, or other hepatopathies caused by drugs, poisons, radiation, etc., which contains carnosine as effective ingredient and which is administered orally to exhibit significant effects.

5. 发明申请

WO1998001146A1 PREVENTIVES/REMEDIES FOR STOMATITIS 审中-公开
标题翻译： STOMATITIS的预防/补救措施
公开(公告)号：WO1998001146A1
公开(公告)日：1998-01-15
申请号：PCT/JP1997002192
申请日：1997-06-25
申请人： ZERIA PHARMACEUTICAL CO., LTD. , HAMARI CHEMICALS CO., LTD. , HIRANO, Masaaki , KATAYAMA, Shiro
发明人： ZERIA PHARMACEUTICAL CO., LTD. , HAMARI CHEMICALS CO., LTD.
IPC分类号： A61K38/05
CPC分类号： A61Q11/00 , A61K8/27 , A61K8/44 , A61K8/64 , A61K9/006 , A61K31/4172 , A61K31/555 , A61K33/30 , A61K38/05 , A61K47/36 , A61K2800/58 , A61K2300/00
摘要： Preventives/remedies for stomatitis containing L-zinc carnosinate salt or L-carnosin/zinc complex optionally together with sodium alginate. These drugs are excellent in the effects of treating and preventing stomatitis, in particular, one caused by chemotherapy or radiation therapy for cancer.
摘要翻译：含有L-锌肌氨酸盐或L-肌动蛋白/锌复合物的口腔炎的任选与藻酸钠一起预防/治疗。这些药物在治疗和预防口腔炎的作用方面表现出色，特别是由癌症化疗或放射治疗引起的口腔炎。

6. 发明申请

WO1997034610A1 PROCESS FOR PRODUCING EFONIDIPINE HYDROCHLORIDE PREPARATIONS 审中-公开
标题翻译：生产氟尼泊替氯化氢制剂的方法
公开(公告)号：WO1997034610A1
公开(公告)日：1997-09-25
申请号：PCT/JP1997000842
申请日：1997-03-17
申请人： NISSAN CHEMICAL INDUSTRIES, LTD. , ZERIA PHARMACEUTICAL CO., LTD. , MIYAMOTO, Misao , ODA, Toshihisa , BUNRIN, Toyohiko , OKABE, Toshio , NISHIYAMA, Tetsuyuki
发明人： NISSAN CHEMICAL INDUSTRIES, LTD. , ZERIA PHARMACEUTICAL CO., LTD.
IPC分类号： A61K31/675
CPC分类号： A61K9/146 , A61K9/145 , A61K9/1617 , A61K9/1652 , A61K31/66 , A61K31/675
摘要： The present invention can form an amorphous solid dispersion of efonidipine hydrochloride having a high intestinal absorbability which can be formed by subjecting a mixture containing efonidipine hydrochloride of formula (I), hydroxypropylmethylcellulose acetate succinate and optionally a thermostabilizer to a step A of heat treatment at from 85 to 140 DEG C or mechanochemical treatment at from 0 to 140 DEG C, and then to a step B of dipping treatment into a water-containing solution, impregnation treatment with a water-containing solution or contacting treatment with a water vapor-containing gas; or treating the above-mentioned mixture with a hot steam at from 100 to 140 DEG C and a high pressure. Further, in the above-mentioned step A, the mixture is subjected to high frequency heating, making it possible to give a solid dispersion of efonidipine hydrochloride having a high intestinal absorbability without using the step B. This process is quite advantageous in the production in that the use of an organic solvent is not required.
摘要翻译：本发明可以形成具有高肠吸收能力的盐酸依替地平盐酸盐的无定形固体分散体，其可以通过使式（I）的依地尼地平盐酸盐，乙酸琥珀酸羟丙基甲基纤维素和任选的热稳定剂的混合物进行热处理步骤A 85〜140℃，0〜140℃下进行机械化学处理，然后进行浸渍处理至含水溶液的工序B，用含水溶液进行浸渍处理或与含有水蒸汽的气体进行接触处理 ; 或用100〜140℃的热蒸汽和高压处理上述混合物。此外，在上述步骤A中，将混合物进行高频加热，使得可以在不使用步骤B的情况下得到具有高肠吸收能力的盐酸依替地平的固体分散体。该方法在生产中是非常有利的不需要使用有机溶剂。

7. 发明申请

WO1996005820A1 HYPERLIPEMIA REMEDY 审中-公开
标题翻译： HYPERLIPEMIA补救
公开(公告)号：WO1996005820A1
公开(公告)日：1996-02-29
申请号：PCT/JP1995001486
申请日：1995-07-26
申请人： ZERIA PHARMACEUTICAL CO., LTD. , MERA, Yukinori , NISHI, Naoki , KURIMOTO, Tadashi , SATO, Hiroki
发明人： ZERIA PHARMACEUTICAL CO., LTD.
IPC分类号： A61K31/195
CPC分类号： C07D333/34 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/381 , A61K31/4152 , A61K31/50 , C07D231/20 , C07D237/04 , Y10S514/824
摘要： A hyperlipemia remedy containing an indan derivative represented by general formula (1) or a pharmaceutically acceptable salt thereof as the active ingredient; the use of the above compound for the preparation of a hyperlipemia remedy; and a therapeutic method for hyperlipemia using this compound, wherein R represents C1-C12 alkyl, benzyl, styryl, naphthyl, optionally substitued phenyl or optionally substituted thienyl; R represents carboxy, C1-C4 alkoxycarbonyl or a group represented by formula (a) or (b), Y represents -(CH2)p- (wherein p represents an integer of 0 to 5), -CO-(CH2)q SIMILAR , -CH(OH)-(CH2)q SIMILAR (wherein q represents an integer of 1 to 4, and the symbol SIMILAR represents a bond to R ), oxymethylene or vinylene; and n represents an integer of 1 to 4.
摘要翻译：含有由通式（1）表示的茚满衍生物或其药学上可接受的盐作为活性成分的高脂血症药物; 使用上述化合物制备高脂血症药物; 和使用该化合物的高脂血症的治疗方法，其中R 1表示C 1 -C 12烷基，苄基，苯乙烯基，萘基，任选取代的苯基或任选取代的噻吩基; R 2表示羧基，C 1 -C 4烷氧基羰基或由式（a）或（b）表示的基团，Y表示 - （CH 2）p - （其中p表示0〜5的整数），-CO-（CH 2 ）类似的，-CH（OH） - （CH 2）q类似（其中q表示1至4的整数，符号“SIMILAR表示与R 2的键”），甲醛或亚乙烯基; n表示1〜4的整数。

8. 发明申请

WO1990015616A1 REMEDY FOR PANCREATITIS 审中-公开
标题翻译：补救措施
公开(公告)号：WO1990015616A1
公开(公告)日：1990-12-27
申请号：PCT/JP1990000750
申请日：1990-06-08
申请人： ZERIA PHARMACEUTICAL CO., LTD. , HAMARI CHEMICALS CO., LTD. , YOSHIKAWA, Toshikazu , YONETA, Tomoyuki , NISHIMURA, Yasuhiro
发明人： ZERIA PHARMACEUTICAL CO., LTD. , HAMARI CHEMICALS CO., LTD.
IPC分类号： A61K37/02
CPC分类号： A61K38/04
摘要： An oral remedy having a profound effect of curing pancreatitis with an extremely reduced side effect, which contains zinc L-carnosinate as an active ingredient.
摘要翻译：具有治疗胰腺炎的副作用极大降低的深刻效果的口服补救剂，其含有L-肉桂酸锌作为活性成分。

9. 发明申请

WO1998017654A1 SUBSTITUTED BENZOYLAMINOTHIAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME 审中-公开
标题翻译：取代的苯甲酰胺唑衍生物和含有它们的药物
公开(公告)号：WO1998017654A1
公开(公告)日：1998-04-30
申请号：PCT/JP1997003774
申请日：1997-10-20
申请人： ZERIA PHARMACEUTICAL CO., LTD. , NAGASAWA, Masaaki , SATO, Kenji , KURIMOTO, Tadashi , UEKI, Shigeru
发明人： ZERIA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D277/46
CPC分类号： C07D417/12 , C07D277/46 , C07D277/56
摘要： Substituted benzoylaminothiazole derivatives represented by general formula (I) or salts thereof and drugs containing the same as the active ingredient. In said formula, X represents imino optionally substituted by lower alkyl, or oxygen; R represents cyano, lower alkoxycarbonyl, lower alkoxycarbonyloxy, lower alkylsulfonylamino, optionally halogenated lower alkanoyl or lower alkylsulfonyl, 1-ureido, halogenated lower alkyl, or 2-pyrrolylimino; R and R are the same or different and each represents hydrogen or lower alkyl; and m is an integer of 2 to 4. Because of having an excellent effect of improving digestive motions, these compounds are useful as preventives and remedies for unidentified epigastric complaints, vomiturition, vomiting, heartburn, anorexia, abdominal pain, abdominal swelling feel, chronic gastritis, etc.
摘要翻译：由通式（I）表示的取代苯甲酰氨基噻唑衍生物或其盐和含有与活性成分相同的药物。在所述式中，X表示任选被低级烷基或氧取代的亚氨基; R 1表示氰基，低级烷氧基羰基，低级烷氧基羰基氧基，低级烷基磺酰基氨基，任选卤代低级烷酰基或低级烷基磺酰基，1-脲基，卤代低级烷基或2-吡咯基咪唑。 R 2和R 3相同或不同，各自表示氢或低级烷基; m是2〜4的整数。由于具有改善消化运动的优异效果，这些化合物可用作未知的上腹部投诉，呕吐，呕吐，胃灼热，厌食，腹痛，腹部肿胀感，慢性胃炎等

10. 发明申请

WO1998002177A1 WOUND HEALING ACCELERATORS 审中-公开
标题翻译：创伤加速器
公开(公告)号：WO1998002177A1
公开(公告)日：1998-01-22
申请号：PCT/JP1997002193
申请日：1997-06-25
申请人： ZERIA PHARMACEUTICAL CO., LTD. , HAMARI CHEMICALS CO., LTD. , YONETA, Tomoyuki , YOSHIDA, Akihiko , TAKAMI, Tokiro , NISHIMURA, Yasuhiro
发明人： ZERIA PHARMACEUTICAL CO., LTD. , HAMARI CHEMICALS CO., LTD.
IPC分类号： A61K38/05
CPC分类号： A61K33/30 , A61K31/4172 , A61K2300/00
摘要： Accelerators for healing wounds accompanied by skin defects which contain as the active ingredient zinc L-carnosinate or L-carnosin/zinc complex. These drugs are excellent in the effects of accelerating the healing of wounds such as defective wounds, burns, frostbites and bedsores.
摘要翻译：用于治疗伤口伴随皮肤缺陷的促进剂，其包含作为活性成分的L-肉豆蔻酸锌或L-肌动蛋白/锌络合物。这些药物在加速伤口愈合，如伤口不良，烧伤，冻伤和褥疮等方面具有优异的效果。

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