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1. 发明申请

WO2008150780A1 APPARATUS AND METHODS FOR PHOTO-DEGRADATION ANALYSIS 审中-公开
标题翻译：照相分析的装置和方法
公开(公告)号：WO2008150780A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/064941
申请日：2008-05-28
申请人： WATERS INVESTMENTS LIMITED , SWARTZ, Michael
发明人： SWARTZ, Michael
IPC分类号： C07C1/00
CPC分类号： G01N30/72 , G01N17/00 , G01N30/04 , G01N2030/201 , G01N2030/202
摘要： Embodiments of the present invention are directed to apparatus and methods for photo- degradation analysis. In one embodiment, the present invention is an apparatus for the analysis of compounds in a solution comprising a photon source, a sample carrier means and a separator. The photon source may emit photons of a selected wavelength or wavelengths. The sample carrier means has an inlet aperture and an outlet aperture. The inlet aperture is for receiving a solution having one or more compounds and the outlet aperture is for discharging the solution and the one or more compounds. The sample carrier means has at least one section translucent to photons of a selected wavelength or wavelengths. This section is in optical communication with the photon source to subject the one or more compounds in the solution to the photons and potentially form one or more photoreaction products. The separator is in fluid communication with the outlet aperture and is for receiving the solution, the one or more compounds and the one or more photoreaction products. The separator resolves or separates the compounds and photoreaction products for detection.
摘要翻译：本发明的实施例涉及光降解分析的装置和方法。在一个实施方案中，本发明是用于分析包含光子源，样品载体装置和分离器的溶液中化合物的装置。光子源可以发射所选波长或波长的光子。样品载体装置具有入口孔和出口孔。入口孔用于接收具有一种或多种化合物的溶液，并且出口孔用于排出溶液和一种或多种化合物。样品载体装置具有至少一个对所选波长或波长的光子半透明的部分。该部分与光子源光学通信，以将溶液中的一种或多种化合物照射到光子上，并潜在地形成一种或多种光反应产物。分离器与出口孔流体连通，用于接收溶液，一种或多种化合物和一种或多种光反应产物。分离器分离或分离化合物和光反应产物进行检测。

2. 发明申请

WO2008144301A1 APPARATUS AND METHODS FOR THE DETECTION OF PLASMA METANEPHRINES 审中-公开
标题翻译：用于检测等离子体代谢物的装置和方法
公开(公告)号：WO2008144301A1
公开(公告)日：2008-11-27
申请号：PCT/US2008/063510
申请日：2008-05-13
申请人： WATERS INVESTMENTS LIMITED , GRAHAM, Kendon, Stuart , KEMA, Ido, P. , COOPER, Donald, P.
发明人： GRAHAM, Kendon, Stuart , KEMA, Ido, P. , COOPER, Donald, P.
IPC分类号： G01N33/536
CPC分类号： G01N33/57488 , G01N33/74 , G01N2333/575
摘要： Embodiments of the present invention feature the determination of normetanephrine, metanephrine and 3-methoxytyraminein raw human plasma with minimal sample pretreatment using a weak cationic extraction media to provide a selective sample clean-up and HILIC chemistries as indicators of pheochromoacytoma.
摘要翻译：本发明的实施方案的特征在于使用弱阳离子萃取介质，以最小化样品预处理提供选择性样品清除和HILIC化学成分作为全血细胞计数的指标来测定正丙肾上腺素，偏肾上腺素和3-甲氧基酪氨酸原始人血浆。

3. 发明申请

WO2008136854A2 MONOLITHIC ELECTROKINETIC PUMP FABRICATION 审中-公开
标题翻译：单相电动泵制造
公开(公告)号：WO2008136854A2
公开(公告)日：2008-11-13
申请号：PCT/US2007/083803
申请日：2007-11-06
申请人： WATERS INVESTMENTS LIMITED , JUNG, Moon, Chul , BOUVIER, Edouard, S., P. , COHEN, Steven, A. , YANG, Hua
发明人： JUNG, Moon, Chul , BOUVIER, Edouard, S., P. , COHEN, Steven, A. , YANG, Hua
IPC分类号： B01D71/72
CPC分类号： F04B19/006 , C08G77/16 , C08G77/26 , C08G77/388 , C08K5/09 , C08K5/544 , C08L83/04 , G01N2030/326 , G01N2030/528
摘要： High-pressure electrokinetic ("EK") pumps comprising a hybrid monolith provide a high surface charge density and a continuous stable skeleton morphology with micrometer- sized through-pores. The hybrid monolith of the subject invention has superior mechanical strength and better stability in comparison to prior art monoliths with equivalent mechanical stability. The surface charge of the hybrid monolith can be modified and/or made stable by the use of different chemical reagents. The chemical reagents and resulting modification to the monolith serves to expand the usefulness of the hybrid monolith to a variety of pumping applications including chip-based systems and other applications where the ability to pump an acidic solution is required.
摘要翻译：包括混合整料的高压电动（“EK”）泵提供高表面电荷密度和具有微米尺寸通孔的连续稳定的骨架形态。与具有等效机械稳定性的现有技术的整料相比，本发明的混合整料具有优异的机械强度和更好的稳定性。可以通过使用不同的化学试剂来改变和/或制备稳定的混合整料的表面电荷。化学试剂和对整料的所得改性用于将混合整料的有用性扩展到各种泵送应用，包括基于芯片的系统和需要泵送酸性溶液的能力的其它应用。

4. 发明申请

WO2008024455A9 DIFFERENTIAL SCANNING CALORIMETER SENSOR AND METHOD 审中-公开
公开(公告)号：WO2008024455A9
公开(公告)日：2008-02-28
申请号：PCT/US2007/018685
申请日：2007-08-24
申请人： WATERS INVESTMENTS LIMITED
发明人： DANLEY, Robert, L.
IPC分类号： G01K17/00 , G01N25/00
摘要： A sensor for a heat flux differential scanning calorimeter in which the differential temperatures are measured between locations external to the regions of heat exchange between the sensor and sample containers. The measured differential temperatures respond to the magnitude of the heat flow rate between the sensor and the sample and reference containers and are rendered insensitive to variations in the magnitude and distribution of thermal contact resistance between the sensor and the containers.

5. 发明申请

WO2008014306A2 COMPLIANT-SEAL CHECK VALVE 审中-公开
标题翻译：合格密封检查阀
公开(公告)号：WO2008014306A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/074294
申请日：2007-07-25
申请人： WATERS INVESTMENTS LIMITED , CHARLTON, Christopher, B. , GERHARDT, Geoff, C. , DOURDEVILLE, Theodore
发明人： CHARLTON, Christopher, B. , GERHARDT, Geoff, C. , DOURDEVILLE, Theodore
IPC分类号： F04C14/24
CPC分类号： F16K15/021 , F04B53/1032 , Y10T137/7837 , Y10T137/7876 , Y10T137/7922 , Y10T137/7925
摘要： A check valve includes a valve seat and a compliant member that moves to seal the check valve by contacting the valve seat. A method for priming a chromatography solvent pump includes providing the check valve in fluid communication with an outlet of the pump, drawing fluid into the pump from a fluid source, and expelling the fluid from the pump through the valve, thus wetting the check valve. Another method for priming a chromatography solvent pump includes providing the check valve in fluid communication with an inlet of the pump, drawing fluid through the valve into the pump, and expelling the fluid from the pump.
摘要翻译：止回阀包括阀座和柔性构件，其通过接触阀座而移动以密封止回阀。用于启动色谱溶剂泵的方法包括提供止回阀与泵的出口流体连通，从流体源将流体引入泵中，并且将流体从泵排出通过阀，从而润湿止回阀。用于引发色谱溶剂泵的另一种方法包括提供止回阀与泵的入口流体连通，将流体通过阀吸入泵中，并从泵排出流体。

6. 发明申请

WO2007149488A3 RHEOMETER TORQUE CALIBRATION FIXTURE 审中-公开
公开(公告)号：WO2007149488A3
公开(公告)日：2007-12-27
申请号：PCT/US2007/014385
申请日：2007-06-20
申请人： WATERS INVESTMENTS LIMITED
发明人： DOE, Nigel
IPC分类号： G01N11/14
摘要： A method of calibrating the torque outputs of a rheometer by using a calibrating object with a certified moment of inertia, measuring the moment of inertia of the calibrating object using the rheometer, and calculating the torque adjustment factor by dividing the certified moment of inertia value by the measured moment of inertia value The torque adjustment factor is applied to correct subsequent measurements of rheological properties conducted using the rheometer The torque adjustment factor may be double-checked for reproducibility by measuring the moment of inertia of the calibrating object, correcting it with the torque adjustment factor, and comparing it with its certified moment of inertia value.

7. 发明申请

WO2007121230A2 ACTIVE VALVE AND METHODS OF OPERATION THEREOF 审中-公开
标题翻译：主动阀及其操作方法
公开(公告)号：WO2007121230A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/066412
申请日：2007-04-11
申请人： WATERS INVESTMENTS LIMITED , DOURDEVILLE, Theodore , RUBINO, Frank, A. , JOUDREY, Kurt, D. , LUONGO, Joseph, A. , ANGELOSANTO, John
发明人： DOURDEVILLE, Theodore , RUBINO, Frank, A. , JOUDREY, Kurt, D. , LUONGO, Joseph, A. , ANGELOSANTO, John
IPC分类号： F16K21/04
CPC分类号： F16K15/183 , F04B7/0076 , F16K31/047 , F16K37/0041 , Y10T137/0318
摘要： A valve including a linear positioning component operatively connected to a valve body and an actuating element.
摘要翻译：一种阀，包括可操作地连接到阀体和致动元件的线性定位部件。

8. 发明申请

WO2007112224A2 CERAMIC-BASED CHROMATOGRAPHY APPARATUS AND METHODS FOR MAKING SAME 审中-公开
标题翻译：基于陶瓷的色谱装置及其制造方法
公开(公告)号：WO2007112224A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/064267
申请日：2007-03-19
申请人： WATERS INVESTMENTS LIMITED , GERHARDT, Geoff, C. , MICHIENZI, Joseph , BENEVIDES, Christopher, C.
发明人： GERHARDT, Geoff, C. , MICHIENZI, Joseph , BENEVIDES, Christopher, C.
IPC分类号： B01D24/02
CPC分类号： G01N30/606 , G01N30/6026 , G01N30/6095
摘要： A high-performance liquid-chromatography apparatus includes a substrate that defines a separation column in fluidic communication with an inlet port of the processing unit. The processing unit is formed of sintered inorganic particles. The apparatus also includes a pump that delivers a solvent to the inlet port at a pressure sufficient for high-performance liquid-chromatography.
摘要翻译：高效液相色谱装置包括限定与处理单元的入口流体连通的分离塔的基板。处理单元由烧结无机颗粒形成。该设备还包括泵，其以足以用于高效液相色谱的压力将溶剂输送到入口。

9. 发明申请

WO2007094945A3 MOBIL BEAD CONFIGURATION IMMUNOAFFINITY COLUMN AND METHODS OF USE 审中-公开
公开(公告)号：WO2007094945A3
公开(公告)日：2007-08-23
申请号：PCT/US2007/002303
申请日：2007-01-25
申请人： WATERS INVESTMENTS LIMITED , LIU, Jianmin
发明人： LIU, Jianmin
IPC分类号： B01D15/08 , C02F1/28 , C12M1/36
摘要： It has been discovered that a column configuration which allows for suspension of the beads, such as a mobile bead, during washing results in significantly lower levels of background and hence more sensitive levels of quantitation. The present invention provides columns, kits, and methods for more sensitive detection of a toxin or other analyte.

10. 发明申请

WO2006132994A3 SYSTEM AND METHOD FOR ABSOLUTE QUANTITATION OF PROTEINS USING LC/MS 审中-公开
公开(公告)号：WO2006132994A3
公开(公告)日：2006-12-14
申请号：PCT/US2006/021517
申请日：2006-06-02
申请人： WATERS INVESTMENTS LIMITED , GEROMANOS, Scott , SILVA, Jeffrey, Cruz , VISSERS, Hans , LI, Guo-zhong
发明人： GEROMANOS, Scott , SILVA, Jeffrey, Cruz , VISSERS, Hans , LI, Guo-zhong
IPC分类号： G06F19/00
摘要： Absolute quantitation of protein in a saηiple is provided by comparing a sum or average of the N highest ionization intensities observed for peptides of a particular protein along with a calibration standard. The calibration standard can be in the form of a table generated by prior protein peptide analysis performed using one or more pre-determined proteins. The comparison is used to determine a corresponding absolute quantity of protein based on the observed sum or average of ionization intensities. A simple conversion factor can be applied to the calibration standard value to determine the absolute quantity of protein in the sample.

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