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2. 发明申请

US20060246096A1 Nanoparticles from biopolymers 审中-公开
标题翻译：来自生物聚合物的纳米颗粒
公开(公告)号：US20060246096A1
公开(公告)日：2006-11-02
申请号：US11406208
申请日：2004-12-29
申请人： Levente Novak , Eva Fleischer , Janos Borbely
发明人： Levente Novak , Eva Fleischer , Janos Borbely
IPC分类号： A61K38/43 , A61K9/00
CPC分类号： A61K9/5146 , A61K9/19 , A61K47/34
摘要： Methods are disclosed for preparing core-shell polymers of poly-γ-glutamic acid. The final products of the present invention are useful as drug delivery systems, for gene therapy, magnetic resonance imaging as well as in encapsulation technology. A method of forming a poly-γ-glutamic acid (PGA) useful in the formation of core shell polymers is disclosed. According to the method a PGA is prepared by fermentation with a suitable microorganism, capable of producing PGA in a suitable fermentation medium, under conditions and time appropriate for the microorganism used. The resulting culture medium is treated with centrifugation, to separate the cells from the PGA. Acetone is used to treat the resulting cell-free liquid to obtain the PGA from the fermentation medium. The obtained PGA is purified by dialysis and freeze drying the PGA. A method of forming a core shell polymer of a poly-γ-glutamic acid (PGA) is also disclosed. The core is formed by partially amidating a poly-γ-glutamic acid (PGA) by reaction with a diamino compound to at least partially cross-link the PGA. The outer shell of the core shell polymer is formed from a hydrophilic or a hydrophobic polymer.
摘要翻译：公开了制备聚-γ-谷氨酸的核 - 壳聚合物的方法。本发明的最终产品可用作药物递送系统，用于基因治疗，磁共振成像以及封装技术。公开了一种形成用于形成核壳聚合物的聚-γ-谷氨酸（PGA）的方法。根据该方法，通过在合适的微生物发酵能够在合适的发酵培养基中生产PGA，在适合所用微生物的条件和时间下制备PGA。通过离心处理所得培养基，将细胞与PGA分离。丙酮用于处理所得到的无细胞液体，从发酵培养基中获得PGA。所得到的PGA通过透析纯化并冷冻干燥PGA。还公开了形成聚-γ-谷氨酸（PGA）的核壳聚合物的方法。通过与二氨基化合物反应部分酰化聚-γ-谷氨酸（PGA）以至少部分地交联PGA而形成核心。芯壳聚合物的外壳由亲水或疏水聚合物形成。

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