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1. 发明申请

US20210052399A1 A DEVICE FOR ENHANCING A SUBJECT'S GRASPING CAPABILITY 有权
公开(公告)号：US20210052399A1
公开(公告)日：2021-02-25
申请号：US16076064
申请日：2017-02-09
申请人： UNIVERSITA' DEGLI STUDI DI SIENA
发明人： David CIONCOLONI , Irfan HUSSAIN , Domenico PRATTICHIZZO , Simone ROSSI , Gionata SALVIETTI , Giovanni SPAGNOLETTI
IPC分类号： A61F2/58 , A61F2/70 , A61F2/78
摘要： A device for enhancing a user's grasping capability comprises a belt-like support configured to be tightly fitted about a user's part of the body; an articulated gripping element having a plurality of phalanxes: proximal, fixed to the support, intermediate and distal, which are articulated to each other by articular joints; a motor unit fixed to the support; a winding drum; a tendon partially wound on the drum and extending along the phalanxes and the joints, arranged so that, by pulling it from the drum, the phalanxes rotate about respective articular joints and move the articulated gripping element from an extended position to a gripping bow-shaped position, causing a flexion/extension movement of the articulated gripping element, the joints configured so that by releasing the tendon from the drum, the phalanxes rotate about the respective joints and move the articulated gripping element between gripping bow-shaped position and extended position.

2. 发明授权

US08685953B2 Linear and cyclic guanidine derivatives, method of preparation and uses thereof 有权
标题翻译：线性和环状胍衍生物，其制备方法及其用途
公开(公告)号：US08685953B2
公开(公告)日：2014-04-01
申请号：US12922232
申请日：2009-03-12
申请人： Maurizio Botta , Francesco Raffi , Paolo Visca
发明人： Maurizio Botta , Francesco Raffi , Paolo Visca
IPC分类号： C07D255/02 , C07D259/00 , A61K31/395 , A61P31/10
CPC分类号： C07D255/02 , C07C279/12 , C07C2601/02 , C07D259/00
摘要： The present invention relates to linear and cyclic guanidine derivatives, method of preparation and uses thereof, pharmaceutical compositions to be used as antifungal agents, in particular against Candida species.
摘要翻译：本发明涉及线性和环状胍衍生物，其制备方法及其用途，用作抗真菌剂的药物组合物，特别是针对假丝酵母属物种。

3. 发明授权

US08440794B2 Peptide sequences, their branched form and use thereof for antimicrobial applications 有权
标题翻译：肽序列，其分支形式及其用于抗微生物应用
公开(公告)号：US08440794B2
公开(公告)日：2013-05-14
申请号：US13122426
申请日：2009-10-05
申请人： Luisa Bracci , Chiara Falciani , Alessandro Pini
发明人： Luisa Bracci , Chiara Falciani , Alessandro Pini
IPC分类号： A61K38/08 , C07K7/06 , A61P31/04
CPC分类号： C07K7/06 , A61K38/00
摘要： The present invention relates to an antibacterial peptide having from the amino to the carboxylic terminal an amino acid sequences selected from the group of: KKIRVRLSA, SEQ ID NO. 1, RRIRVRLSA, SEQ ID NO. 2, KRIRVRLSA, SEQ ID NO. 3, RKIRVRLSA, SEQ ID NO. 4 or a derivative thereof and uses thereof.
摘要翻译：本发明涉及一种抗菌肽，其具有从氨基至羧基末端的氨基酸序列，所述氨基酸序列选自：KKIRVRLSA，SEQ ID NO： 1，RRIRVRLSA，SEQ ID NO： 2，KRIRVRLSA，SEQ ID NO： 3，RKIRVRLSA，SEQ ID NO： 4或其衍生物及其用途。

4. 发明申请

US20110105365A1 PRO-EPIL EXPRESSION LEVEL IN A BIOLOGICAL SAMPLE AS TESTICULAR CANCER BIOMARKER, PARTICULARLY IN COMBINATION WITH THE HCBETA AND AFP BIOMARKERS 审中-公开
标题翻译：作为特定癌症生物标志物的生物样品中的PRO-EPIL表达水平，特别是与HCBETA和AFP生物标志物组合
公开(公告)号：US20110105365A1
公开(公告)日：2011-05-05
申请号：US12989999
申请日：2009-04-28
申请人： Dominique Bellet , Alain Pecking , Sophie Richon , Felice Petraglia
发明人： Dominique Bellet , Alain Pecking , Sophie Richon , Felice Petraglia
IPC分类号： C12Q1/68 , G01N33/68 , C40B40/06 , C40B40/10
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5088 , G01N2800/52
摘要： The present invention is directed to the use of the expression level of the pro-EPIL gene as a biomarker for the diagnosing of testicular cancer, particularly a testicular germ cell tumor. The invention also relates to an in vitro method for detecting and/or classifying a testicular cancer in a subject comprising a step of determining the expression level of the gene encoding the pro-EPIL peptide in a biological, particularly in combination with the determination of the beta subunit HCGβ and the human alpha-fetoprotein AFP. The invention is also directed to a kit or solid support comprising nucleic acids or antibodies capable of determining the presence or the expression level of these three biological markers.
摘要翻译：本发明涉及使用pro-EPIL基因的表达水平作为诊断睾丸癌，特别是睾丸生殖细胞肿瘤的生物标志物。本发明还涉及用于检测和/或分类受试者的睾丸癌的体外方法，其包括确定生物学中编码前EPIL肽的基因的表达水平的步骤，特别是与 β亚基HCG＆bgr; 和人甲胎蛋白AFP。本发明还涉及包含能够测定这三种生物标志物的存在或表达水平的核酸或抗体的试剂盒或固体支持物。

5. 发明申请

US20080235030A1 Automatic Method For Measuring a Baby's, Particularly a Newborn's, Cry, and Related Apparatus 审中-公开
标题翻译：自动测量婴儿的方法，特别是新生儿，哭泣和相关设备
公开(公告)号：US20080235030A1
公开(公告)日：2008-09-25
申请号：US11817927
申请日：2006-03-10
申请人： Renata Sisto , Carlo Valerio Bellieni , Giuseppe Buonocore
发明人： Renata Sisto , Carlo Valerio Bellieni , Giuseppe Buonocore
IPC分类号： G10L17/00 , G10L21/06
CPC分类号： G10L17/26
摘要： The present invention concerns an automatic method for measuring a baby's cry, comprising the following step: A. having N samples ρ(i), for i=O, 1, . . . , (N−1), of an acoustic signal p(t) representing the cry, sampled at a sampling frequencŷ for a period of duration P; the method being characterised in that it assigns a score PainScore to the acoustic signal p(t) by means of a function AF of one or more acoustic parameters selected from the group comprising: —a root-mean-square or rms value prms of the acoustic signal p(t) in the period P; —a fundamental or pitch frequency F0 of the acoustic signal p(t), i.e. the minimum frequency at which a peak in the spectrum of the acoustic signal p(t) occurs in the period P; and—a configuration of amplitude and frequency modulation of the acoustic signal p(t) in the period P. The invention further concerns the apparatus performing the method.
摘要翻译：本发明涉及一种用于测量婴儿哭泣的自动方法，包括以下步骤：A.具有N个样本rho（i），对于i = 0,1，...。。。，（N-1）表示在采样频率下持续时间段P的采样的表示哭泣的声信号p（t）; 该方法的特征在于，其通过从包括以下的组中选择的一个或多个声学参数的函数AF将音分信号p（t）分配给声信号p（t）： - 均方根或均方根值prms P期间的声信号p（t） - 声学信号p（t）的基音或音调频率F 0，即在时间段P中发生声学信号p（t）的频谱中的峰值的最小频率; 以及在周期P中的声学信号p（t）的幅度和频率调制的配置。本发明还涉及执行该方法的装置。

6. 发明授权

US11814366B2 Antiviral compounds and use thereof 有权
公开(公告)号：US11814366B2
公开(公告)日：2023-11-14
申请号：US16981346
申请日：2019-03-18
申请人： UNIVERSITA DEGLI STUDI DI SIENA
发明人： Maurizio Botta , Filippo Canducci , Valeria Cagno , David Lembo , Cristina Tintori , Annalaura Brai , Nastasja Palombi
IPC分类号： C07D403/06 , A61K31/427 , A61P31/14 , A61P31/22 , A61P31/18 , A61P31/16 , A61K31/513 , A61K45/06 , C07D417/06
CPC分类号： C07D403/06 , A61K31/427 , A61K31/513 , A61K45/06 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/22 , C07D417/06
摘要： The present invention relates to compounds of formula (I), their use as medicaments, in particular as broad spectrum antiviral agents, their combination with a further antiviral agent and relative pharmaceutical compositions. In particular, the compounds of the invention are useful in the treatment of a disease caused by an enveloped virus.

7. 发明授权

US11444386B2 Reconfigurable antenna assembly having a metasurface of metasurfaces 有权
公开(公告)号：US11444386B2
公开(公告)日：2022-09-13
申请号：US17055315
申请日：2019-05-14
申请人： Paris Sciences et Lettres , Centre National de la Recherche Scientifique (CNRS) , UNIVERSITA DEGLI STUDI DI SIENA , Politecnico Di Torino , Ecole Supérieure De Physique Et De Chimie Industrielles De La Ville De Paris , Sorbonne Universite
发明人： Charlotte Tripon-Canseliet , Stefano Maci , Cristian Della Giovampaola , Giuseppe Vecchi
IPC分类号： H01Q15/00
摘要： An antenna assembly, comprising: a single substrate having a lower surface and an upper surface; an isotropic source of spherical electromagnetic waves configured for emitting surface waves on the upper surface; a ground plane formed on the lower surface comprising a metallic deposit on the entire lower surface; an antenna element formed on the upper surface comprising a periodic patterns metasurface formed on the substrate by a texture of subwavelength patches, the antenna element comprising: a first-scale metasurface defined by a two-dimensional alternation of metal or metamaterial patches having closely spaced vertices in each contiguous element to form small gaps; a plurality of switches disposed in the gap between the vertexes of the patches, each switch permitting to connect several patches through the vertexes for defining a second-scale metasurface having a pattern thus forming the antenna element; wherein each patch has dimensions which do not depend on the frequency of the waves to be radiated, the antenna element configured for transform the emitting surface waves on leaky waves.

8. 发明申请

US20210203077A1 Reconfigurable Antenna Assembly Having A Metasurface Of Metasurfaces 有权
公开(公告)号：US20210203077A1
公开(公告)日：2021-07-01
申请号：US17055315
申请日：2019-05-14
申请人： Paris Sciences Et Lettres - Quartier Latin , Centre National de la Recherche Scientifique (CNRS) , UNIVERSITA DEGLI STUDI DI SIENA , Torino Politecnico , Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris , Sorbonne Universite
发明人： Charlotte Tripon-Canseliet , Stefano Maci , Cristian Della Giovampaola , Giuseppe Vecchi
IPC分类号： H01Q15/00
摘要： An antenna assembly, comprising: a single substrate having a lower surface and an upper surface; an isotropic source of spherical electromagnetic waves configured for emitting surfaces waves on the upper surface; a ground plane formed on the lower surface comprising a metallic deposit on the entire lower surface; an antenna element formed on the upper surface comprising a periodic patterns metasurface formed on the substrate by a texture of subwavelength patches, the antenna element comprising: a first-scale metasurface defined by a two-dimensional alternation of metal or metamaterial patches having closely spaced vertices in each contiguous element to form small gaps; a plurality of switches disposed in the gap between the vertexes of the patches, each switch permitting to connect several patches through the vertexes for defining a second-scale metasurface having a pattern thus forming the antenna element; wherein each patch has dimensions which do not depend on the frequency of the waves to be radiated, the antenna element configured for transforming the emitting surface waves on leaky waves.

9. 发明授权

US10093642B2 Multitarget hedgehog pathway inhibitors and uses thereof 有权
公开(公告)号：US10093642B2
公开(公告)日：2018-10-09
申请号：US14898955
申请日：2014-06-25
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , UNIVERSITA' DEGLI STUDI DI ROMA “LA SAPIENZA”
发明人： Bruno Botta , Alberto Gulino , Maurizio Botta , Mattia Mori , Lucia Di Marcotullio , Paola Infante , Francesca Ghirga , Sara Toscano , Cinzia Ingallina , Romina Alfonsi
IPC分类号： C07D311/34 , A61K9/00 , A61K9/127 , A61K45/06 , A61K31/352 , A61K31/121 , A61K31/343 , A61K31/35
摘要： The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).

10. 发明申请

US20160368886A1 MULTITARGET HEDGEHOG PATHWAY INHIBITORS AND USES THEREOF 审中-公开
标题翻译：多功能HEDGEHOG PATHWAY抑制剂及其用途
公开(公告)号：US20160368886A1
公开(公告)日：2016-12-22
申请号：US14898955
申请日：2014-06-25
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA"
发明人： Bruno BOTTA , Alberto GULINO , Maurizio BOTTA , Mattia MORI , Lucia DI MARCOTULLIO , Paola INFANTE , Francesca GHIRGA , Sara TOSCANO , Cinzia INGALLINA , Romina ALFONSI
IPC分类号： C07D311/34 , A61K9/00 , A61K45/06 , A61K31/352 , A61K9/127
CPC分类号： C07D311/34 , A61K9/0019 , A61K9/127 , A61K31/121 , A61K31/343 , A61K31/35 , A61K31/352 , A61K45/06
摘要： The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).
摘要翻译：本发明涉及选择性抑制Hedgehog（Hh）途径的活性及其制备和用途的化合物。本发明的化合物可用于治疗Hh依赖性肿瘤，例如成神经管细胞瘤（MB）。

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