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1. 发明专利

JP2014221065A ２つの遺伝子の発現の観察による乳癌患者の予後診断审中-公开
标题翻译：通过观察两种基因的表达预测乳腺癌患者
公开(公告)号：JP2014221065A
公开(公告)日：2014-11-27
申请号：JP2014139681
申请日：2014-07-07
申请人：ユニヴァーシタデグリステューディディパドヴァ , Universita' Degli Studi Di Padova , ユニヴァーシタデグリステューディディパドヴァ
发明人： STEFANO PICCOLO , MICHELANGELO CORDENONSI , MADDALENA ADORNO , SILVIO BICCIATO
IPC分类号： C12Q1/68 , C12N15/09 , G01N33/574 , G01N37/00
摘要：【課題】乳癌原発腫瘍の除去後における高再発リスク又は低再発リスクに層別化する方法の提供。【解決手段】乳癌細胞の試料中のサイクリンG2(遺伝子ID=901)の遺伝子発現レベルを検出するステップと、検出された前記サイクリンG2の遺伝子発現レベルを、乳癌を再発した患者及び/又は乳癌を再発しなかった患者からの多数の参照乳癌細胞試料におけるサイクリンG2の平均遺伝子発現レベルと比較するステップと、前記乳癌細胞におけるサイクリンG2の遺伝子発現レベルが、乳癌を再発した患者からの参照乳癌細胞試料におけるサイクリンG2の遺伝子発現レベルよりも高くない場合、及び/又は、前記乳癌細胞におけるサイクリンG2の遺伝子発現レベルが、乳癌を再発しなかった患者からの参照乳癌細胞試料におけるサイクリンG2の遺伝子発現レベルよりも低い場合、前記乳癌細胞が癌再発のリスクが高い患者に由来すると決定するステップと、を含む、方法。【選択図】なし
摘要翻译：要解决的问题：提供在去除乳腺癌原发性肿瘤后分类为高复发风险或低复发风险的方法。解决方案：一种方法包括：检测细胞周期蛋白G2的基因表达水平的步骤（基因ID = 901）在乳腺癌细胞样品中; 将检测到的细胞周期蛋白G2的基因表达水平与来自乳腺癌复发患者和/或没有乳腺癌复发的患者的大量参照乳腺癌细胞样品中的细胞周期蛋白G2的平均基因表达水平进行比较的步骤 ; 在乳腺癌细胞中检测到的细胞周期蛋白G2的基因表达水平不高于细胞周期蛋白G2的基因表达水平的情况下，判定乳腺癌细胞来源于癌复发风险高的患者的步骤在乳腺癌复发患者的参考乳腺癌细胞样品中和/或乳腺癌细胞中细胞周期蛋白G2的基因表达水平低于参考乳腺癌细胞周期蛋白G2的基因表达水平的情况下来自不具有乳腺癌复发的患者的细胞样品。

2. 发明公开

US20230193212A1 TREATMENT FOR NEURODEGENERATIVE DISEASES 审中-公开
公开(公告)号：US20230193212A1
公开(公告)日：2023-06-22
申请号：US17923482
申请日：2021-05-06
申请人： ORCHARD THERAPEUTICS (EUROPE) LIMITED , UNIVERSITA DEGLI STUDI DI PADOVA
发明人： Alessandra Biffi , Yuri Ciervo
IPC分类号： C12N5/10 , C07K14/52 , C12N15/86 , A61P25/28 , A61K35/28
CPC分类号： C12N5/10 , C07K14/52 , C12N15/86 , A61P25/28 , A61K35/28 , C12N2740/16043
摘要： The invention relates to the field of gene therapy and more specifically to hematopoietic stem and progenitor cells that have been genetically modified to express functional progranulin. Suitably, HSPCs that have gene edited using CRISPR/Cas technology, or have been transduced with lentiviral gene delivery vehicles. The invention also relates to the use of such modified HSPCs in therapy. In particular, the invention relates to use of the modified progranulin expressing HSPCs in the prevention or treatment of a neurodegenerative disease mediated by dysfunctional progranulin expression, such as frontotemporal dementia (FTD).

3. 发明授权

US12061158B2 Device and method for measuring the water content of the ground, vegetation and snow 有权
公开(公告)号：US12061158B2
公开(公告)日：2024-08-13
申请号：US17420264
申请日：2019-12-23
申请人： Universita' degli Studi di Padova
发明人： Luca Stevanato , Marcello Lunardon , Sandra Moretto , Cristiano Lino Fontana
IPC分类号： G01N23/09 , G01N33/00 , G01N33/24 , G01T3/06 , G01N33/18
CPC分类号： G01N23/09 , G01N33/0098 , G01N33/246 , G01T3/06 , G01N33/1873 , G01N33/245 , G01N2223/5055
摘要： A device (12) for measuring the water content of the ground, vegetation and snow, comprises: at least one first module (20) adapted to measure a flow of cosmic rays incident to the ground; at least one second module (40) adapted to measure an ambient neutron flow; and a control unit (60) connected to said at least one first module (20) and said at least one second module (40). The control unit (60) is adapted to process the measurements of said at least one first module (20) and said at least one second module (40) to determine the measurement of the water content.

4. 发明申请

US20220387975A9 AMMONIA DEPOSITION PRECIPITATION PROCESS FOR PRODUCING A COPPER-NICKEL/GAMMA-ALUMINA CATALYST, SAID CATALYST AND ITS USE IN THE CONVERSION OF EXHAUST GASES 有权
公开(公告)号：US20220387975A9
公开(公告)日：2022-12-08
申请号：US17288564
申请日：2019-10-21
申请人： Universiteit Antwerpen , Lurederra Centro Tecnológico , Universita' Degli Studi di Padova
发明人： Tamara OROZ MATEO , Cristina SALAZAR CASTRO , Jessica FABRO , Paolo CANU , Qi XIN , Pegie COOL , Vera MEYNEN , Claudio FERNÁNDEZ ACEVEDO , Luis MARTINEZ DE MORENTIN OSABA
IPC分类号： B01J23/755 , B01J21/04 , B01J6/00 , B01J23/72 , B01J37/04 , B01J37/03
摘要： A process for the production of a catalyst comprising the steps of: dissolving the requisite quantities of copper nitrate and nickel nitrate in de-ionised water to provide a sub-0.30 molar aqueous solution of copper nitrate and nickel nitrate together in the ratio required; providing an ammoniacal solution by adding concentrated aqueous solution of ammonia in a quantity equal to between six and ten times the quantity required to realise both a 1:6 molar ratio for Cu2+ to ammonia and a 1:6 molar ratio for Ni2+ to ammonia; loading gamma alumina with 1 to 30% w/w of copper and nickel in a weight ratio of nickel to copper of 1:5 to 2:1 by suspending the requisite quantity of gamma alumina in said ammoniacal solution to achieve the required loading of copper and nickel; stirring the resulting gamma alumina suspension for at least 4 h at room temperature; then the volatile components evaporate under ambient conditions leaving dry loaded gamma alumina, which is calcined at a temperature of at least 260° C. for at least 30 min with a constant heating up rate; a catalyst or catalyst mixture, the catalyst or each catalyst in the catalyst mixture being obtainable by the above-mentioned process; and the use of the catalyst or catalyst mixture for the conversion of exhaust gases from an internal combustion engine into carbon dioxide, water and nitrogen.

5. 发明申请

US20220111016A1 PEPTIDES WITH ANTI-TUMOR ACTIVITY 有权
公开(公告)号：US20220111016A1
公开(公告)日：2022-04-14
申请号：US17431194
申请日：2020-02-18
申请人： UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： Andrea RASOLA , Francesco CISCATO , Paolo BERNARDI
IPC分类号： A61K38/45 , A61P35/00
摘要： The invention concerns an isolated peptide and variants thereof, and therapeutic uses thereof. In particular, such peptides have anti-tumor activity with high selectivity, efficacy and low toxicity. Pharmaceutical compositions comprising the peptides of the invention are also described.

6. 发明授权

US11298348B2 Combination treatment of sarcoglycanopathies 有权
公开(公告)号：US11298348B2
公开(公告)日：2022-04-12
申请号：US16960503
申请日：2019-01-10
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE D'EVRY-VAL-D'ESSONNE , GENETHON , UNIVERSITA 'DEGLI STUDI DI PADOVA
发明人： Isabelle Richard , Dorianna Sandona
IPC分类号： A61K31/47 , A61P21/00 , A61K31/427
摘要： Sarcoglycanopathies are autosomal recessive diseases caused by mutations in the one of the genes coding for any sarcoglycans (SG). The inventors previously showed that the application of small molecules developed to rescue ΔF508-CFTR trafficking, and known as CFTR correctors, improved the maturation of several α-sarcoglycan mutants that were consequently rescued at the plasma membrane (WO 014086687). Now, the inventors show that some specific CFTR correctors provide additive and even synergic effect when administered in combination.

7. 发明申请

US20210241924A1 METHOD FOR SUICIDE IDENTIFICATION 有权
公开(公告)号：US20210241924A1
公开(公告)日：2021-08-05
申请号：US16776561
申请日：2020-01-30
申请人： UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： Massimo Montisci
IPC分类号： G16H70/60 , G06F16/28 , G16H10/60 , H04W84/04 , G06Q50/26
摘要： A method for contacting a predetermined entity based on a death event classification includes: assigning a numeric value to a first partial score based on the method which caused the subject's death; assigning a numeric value to a second partial score based on the subject's history of mental illness; assigning a numeric value to a third partial score based on consistency of the death scene evidence with suicidal dynamics; assigning a numeric value to a fourth partial score based on the number of means that caused the subject's death; assigning a numeric value to a fifth partial score based on the compatibility of means and injuries with suicidal dynamics; summing the partial scores to obtain a total score; adding a correction factor if at least one suicide indicator is present; and classifying the death event. If the death event is classified as incompatible with suicide, the predetermined entity is notified.

8. 发明申请

US20210128292A1 A FENESTRATED ENDOPROSTHESIS FOR THE CORRECTION OF AORTIC ANEURYSMS 有权
公开(公告)号：US20210128292A1
公开(公告)日：2021-05-06
申请号：US17057159
申请日：2019-05-20
申请人： UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： Franco Grego
IPC分类号： A61F2/07
摘要： A fenestrated endoprosthesis for the correction of aortic arch aneurysms comprising: a stent (20) having a first oblong lateral hole (23) having an area equal to the total area occupied by the innominate artery (11) and by the carotid artery (12); said stent (20) comprises a metal skeleton (21) covered with a fabric (22); characterized by comprising a flexible sac (30) that covers said stent (20) covered with fabric (22); said sac (30) comprises a second lateral hole (32) having an area larger than said first hole (23), so that the edges (26) of said stent (20) covered with fabric (22) that delimit said first hole (23) are visible; the edges (33) of said sac (30) that delimit the hole (32) are welded to said stent (20) covered with fabric (22); a volume (31) is created between said stent (20) covered with fabric (22) and said sac (30); said volume (31) is filled with a polymer.

9. 发明申请

US20200283601A1 BIODEGRADABLE HYDROGEL 审中-公开
公开(公告)号：US20200283601A1
公开(公告)日：2020-09-10
申请号：US16648930
申请日：2018-09-21
申请人： Giacomo GUERRINI , UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： Giacomo GUERRINI , Michele MAGGINI , Silvia GROSS , Valerio CAUSIN
IPC分类号： C08L1/28 , C08J3/075 , C08J3/24
摘要： A hydrogel comprises one or more hydrosoluble polysaccharides which are cross-linked by cross-linking agents, wherein the cross-linking agents form covalent bonds with the polysaccharides, and wherein the cross-linking agents comprises humic and/or fulvic acids.

10. 发明申请

US20190292219A1 METHOD OF SOLID-STATE PEPTIDE SYNTHESIS USING A NOVEL POLYMERIC SUPPORT 审中-公开
公开(公告)号：US20190292219A1
公开(公告)日：2019-09-26
申请号：US16289157
申请日：2019-02-28
申请人： Institute of Chemical Process Fundamentals of the CAS, v.v.i. , Universita degli Studi di Padova
发明人： Karel Jerabek , Libuse Hankova , Ladislav Holub , Marco Zecca , Paolo Centomo , Daniele Trovo , Riccardo Leder , Barbara Biondi
IPC分类号： C07K1/04 , C08F112/36
摘要： A method of solid-state synthesis of peptides that provides a polymeric solid-state synthesis support, attaches a first amino acid to said support to form the first amino acid molecule of the desired peptide chain, attaches additional amino acids to form the desired peptide chain, characterized in that the polymeric solid-state synthesis support is a styrenic polymer containing at least 50 mol % divinylbenzene monomer units, the styrenic polymer being functionalized with chloromethyl and/or benzyloxybenzyl alcohol and/or amino moieties, and having porosity 60-90% and medium pore diameter ranging from 10 to 80 nm. A functionalized styrenic polymer is claimed.

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