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1. 发明申请

WO2014049520A3 NOVEL EPITOPE AND MECHANISM OF ANTIGEN-ANTIBODY INTERACTION IN AN INFLUENZA VIRUS 审中-公开
标题翻译：流感病毒抗原抗体相互作用的新形象和机制
公开(公告)号：WO2014049520A3
公开(公告)日：2014-11-06
申请号：PCT/IB2013058810
申请日：2013-09-24
申请人： UNIV FUJITA HEALTH , UNIV OSAKA , UNIV OSAKA RES FOUND
发明人： KUROSAWA YOSHIKAZU , IBA YOSHITAKA , OHSHIMA NOBUKO , YOKOYAMA SHIGEYUKI , SHIROUZU MIKAKO , FUJII YOSHIFUMI , SUMIDA TOMOMI , IKUTA KAZUYOSHI , NAKAMURA SHOTA , KAWASHITA NORIHITO , NISHIMURA MITSUHIRO , YAMASHITA AKIFUMI , OKUNO YOSHINOBU , KUBOTA-KOKETSU RITSUKO , OKUBO MASAHIRO
IPC分类号： C07K16/10 , A61P31/16
CPC分类号： C07K16/1018 , C07K2299/00 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/76 , G01N2333/11 , G01N2500/04
摘要： Antibodies (Abs) play roles in protection against influenza. Neutralizing Abs either inhibit the binding of hemagglutinin (HA) to cellular receptors or prevent the conformational change of HA induced by lowpH. The former Ab binds to the regions near the sialic acid-binding pocket on the globular head formed by HAl and generally shows narrow strain specificity. The latter Ab binds to the stem region formed mainly by HA2 and shows broad strain specificity. We isolated a broadly neutralizing Ab against H3N2 viruses. X-ray analysis of the HA/Ab complex indicated that the Ab binds to the valley formed by two neighboring HA monomers at the side of the globular head. The Ab shows neutralizing activity by preventing the conformational change of HA induced at low pH.
摘要翻译：抗体（Abs）在防止流行性感冒方面发挥作用。中和抗体可抑制血细胞凝集素（HA）与细胞受体的结合，或阻止低pH诱导的HA的构象变化。前者Ab与HA1形成的球形头上唾液酸结合口附近的区域结合，通常表现出窄的应变特异性。后者Ab结合主要由HA2形成的茎区，并显示出广泛的应变特异性。我们分离出一种广泛中和的Ab针对H3N2病毒。 HA / Ab复合物的X射线分析表明，Ab与球状头部侧面的两个相邻的HA单体形成的谷结合。 Ab通过防止在低pH下诱导的HA的构象变化来显示中和活性。

2. 发明申请

WO2013035345A3 DENGUE-VIRUS SEROTYPE NEUTRALIZING ANTIBODIES 审中-公开
标题翻译：登革热丝氨酸中和抗体
公开(公告)号：WO2013035345A3
公开(公告)日：2013-09-06
申请号：PCT/JP2012005699
申请日：2012-09-07
申请人： UNIV OSAKA , UNIV OSAKA RES FOUND , MEDICAL & BIOL LAB CO LTD , UNIV MAHIDOL , DEPT OF MEDICAL SCIENCES DMSC , SETTHAPRAMOTE CHAYANEE , SASAKI TADAHIRO , KUHARA MOTOKI , RAMASOOTA PONGRAMA , THATTIYAPHONG AREE , ANANTAPREECHA SURAPEE , SAWANPANYALERT PATHOM , OKUNO YOSHINOBU , IKUTA KAZUYOSHI , A-NUEGOONPIPAT ATCHAREEYA , DHEPAKSON PANADDA , PRACHASUPHAP APICHAI
发明人： SETTHAPRAMOTE CHAYANEE , SASAKI TADAHIRO , KUHARA MOTOKI , RAMASOOTA PONGRAMA , THATTIYAPHONG AREE , ANANTAPREECHA SURAPEE , SAWANPANYALERT PATHOM , OKUNO YOSHINOBU , IKUTA KAZUYOSHI , A-NUEGOONPIPAT ATCHAREEYA , DHEPAKSON PANADDA , PRACHASUPHAP APICHAI
IPC分类号： C07K16/10
CPC分类号： C07K16/1081 , C07K2317/10 , C07K2317/21 , C07K2317/33 , C07K2317/76
摘要： Materials and methods are provided for treating dengue infections. Human monoclonal antibodies against all serotypes of dengue virus are also provided. Methods of using human monoclonal antibodies to neutralize all dengue-virus serotypes are provided using patients' peripheral blood lymphocytes.
摘要翻译：提供了治疗登革热感染的材料和方法。还提供了针对登革热病毒所有血清型的人单克隆抗体。使用患者外周血淋巴细胞提供使用人单克隆抗体中和所有登革热病毒血清型的方法。

3. 发明授权

US3921028A Device for observing waveform of microwave signal 失效
标题翻译：用于观察微波信号波形的装置
公开(公告)号：US3921028A
公开(公告)日：1975-11-18
申请号：US45103174
申请日：1974-03-14
申请人： UNIV OSAKA
发明人： FUJISAWA KAZUO
IPC分类号： G01R13/34 , H01J25/78 , H01J29/98 , H01J23/16 , H01J29/70
CPC分类号： G01R13/342 , H01J25/78
摘要： Apparatus for displaying the waveform of a microwave signal which embodies means for producing an electron beam, deflecting said beam in synchronism with the microwave signal and permitting transmission of the beam only when it is subjected to a predetermined deflection to form a pulsed beam. Deflecting the pulsed beam by a second deflecting signal synchronized with the microwave signal while varying the phase difference by a third signal and then displaying the effect of deflection by the second signal on one axis of the display means and controlling the sweep of the other axis of the display means by said third signal.
摘要翻译：用于显示微波信号的波形的装置，其包括用于产生电子束的装置，与所述微波信号同步地偏转所述光束，并且仅当所述光束经受预定偏转以形成脉冲光束时才能传输光束。通过与微波信号同步的第二偏转信号偏转脉冲光束，同时将相位差改变第三信号，然后通过第二信号在显示装置的一个轴上显示偏转的影响，并且控制另一个轴的扫描所述显示装置通过所述第三信号。

4. 发明授权

US3900759A Device for observing waveform repeated at high frequency 失效
标题翻译：用于观察高频重复波形的装置
公开(公告)号：US3900759A
公开(公告)日：1975-08-19
申请号：US45097274
申请日：1974-03-14
申请人： UNIV OSAKA
发明人： FUJISAWA KAZUO
IPC分类号： G01R13/20 , G01B15/00 , G01R13/34 , G01R13/40 , H01J29/52 , H01J31/26
CPC分类号： H01J29/52 , G01R13/342
摘要： Apparatus for observing waveforms of extremely short duration and repeated at high frequencies wherein an electron beam is produced having a density variation corresponding to the waveform to be observed. The electron beam is deflected by a microwave voltage synchronized with the repetition rate of the waveform. A phase shifter under control of a saw-tooth generator sweeps the phase angle between the electron beam and the microwave voltage and the density of the electron beam is detected only at a predetermined deflection and displayed with the density corresponding to intensity and time corresponding to phase difference.

5. 发明授权

US3867269A Process for producing peptides 失效
标题翻译：生产肽的方法
公开(公告)号：US3867269A
公开(公告)日：1975-02-18
申请号：US44823774
申请日：1974-03-05
申请人： UNIV OSAKA
发明人： SHIMONISHI YASUTSUGU , TAKAHASHI SATOMI
IPC分类号： B01J19/00 , B01J19/10 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07K1/04 , C07K14/575 , C40B40/10 , C40B60/14 , B01J1/12
CPC分类号： B01J19/10 , B01J19/0046 , B01J2219/00486 , B01J2219/00596 , B01J2219/00725 , C07K1/045 , C40B40/10 , C40B60/14
摘要： In producing a peptide by coupling an amino acid or oligomer thereof with an amino acid or its oligomer bound to a resin to form a peptide on the resin, cleaving the peptide from the resin and thereafter extracting the peptide, a process which is characterized in that said peptide forming reaction is conducted under the irradiation of ultrasonic waves.
摘要翻译：通过将氨基酸或其低聚物与与树脂结合的氨基酸或其低聚物偶联制备肽，以在树脂上形成肽，从树脂中切割肽，然后提取肽，其特征在于，所述肽形成反应在超声波的照射下进行。

6. 发明授权

US3809699A Process for producing 6-amino-penicillanic acid 失效
标题翻译：生产6-氨基 - 丙酸的方法
公开(公告)号：US3809699A
公开(公告)日：1974-05-07
申请号：US9890770
申请日：1970-12-16
申请人： UNIV OSAKA
发明人： ISHIMARU T
IPC分类号： C07D499/00 , C07D499/42 , C07D91/14 , C07D99/16
CPC分类号： C07D499/00
摘要： 6-AMINOPENCILLANIC ACID IS PREPARED, WITH ADVANTAGE IN INDUSTRIAL VIEWPOINT, BY (A) REACTING 6-ACYLAMINOPENICILLANIC ACID OR A SALT THEREOF WITH A HALOGENATED COMPOUND SUCH AS TRIHALIDE OF PHOSPHORUS, TETRAHALIDE OF SILICON, PHOSPHOROUS PENTAHALIDE, PHOSGENE OR THIOPHOSGENE, IN THE PRESENCE OF AN ACID-BINDING REAGENT FOR THE PURPOSE OF TO PROTECT THE CARBOXYL GROUP OF THE 6-ACYLAMIDOPENICILLANIC ACID BY FORMING A MIXED ACID ANHYDRIDE, (B) CONVERTING THE RESULTANT MIXED ACID ANHYDRIDE INTO THE CORRESPONDING IMINO HALIDE BY REACTING IT WITH AN AMINO HALIDEFORMING REAGENT SUCH AS PHOSPHOROUS OXYCHLORIDE, PHOSPHORUS PENTACHLORIDE, PHOSPHORUS TRIBROMIDE, PHOSGENE, OXALYL CHLORIDE OR PROTOCATECHYL PHOSPHOROUS TRICHLORIDE TO FORM THE CORRESPONDING IMINO HALIDE, (C) CONVERTING THE RESULTANT IMINO HALIDE INTO THE CORRESPONDING IMINOETHER BY REACTING IT WITH AN ALCOHOL AND FINALLY (D) HYDROLYZING THE IMINO ETHER AND REMOVING THE PROTECTED GROUP OF THE CARBOXYL GROUP TO FORM 6-AMINOPENCILLANIC ACID.

7. 发明公开

KR20180041224A X선 현미경 审中-公开
公开(公告)号：KR20180041224A
公开(公告)日：2018-04-23
申请号：KR20187007977
申请日：2016-09-23
申请人： UNIV OSAKA
发明人： MATSUYAMA SATOSHI , YAMADA JUMPEI
IPC分类号： G21K7/00
CPC分类号： G21K1/06 , G21K7/00
摘要： 경로길이를단축하여, 실내반입사이즈의 X선현미경을제공하기위해, X선원(1)과, 시료보유지지부(3)와, 오목면 KB 미러(4)와, 볼록면 KB 미러(5)와, 시료보유지지부(3)의위치와결상관계의위치에있는수광부(8)를, 광축을따라차례로, 적어도하나씩갖는 X선현미경을제작한다.

8. 发明公开

KR20180039098A 전기회로에 있어서의 전위, 전류, 및 주변 전자계의 계산 방법, 및 프로그램 审中-公开
公开(公告)号：KR20180039098A
公开(公告)日：2018-04-17
申请号：KR20187006414
申请日：2016-06-15
申请人： UNIV OSAKA
发明人： ABE MASAYUKI , TOKI HIROSHI
IPC分类号： G06F17/50 , G01R29/08 , G06F17/10
CPC分类号： G01R29/08 , G06F17/10 , G06F17/50
摘要： (과제) 전기회로에있어서의전송선로의전위·전류, 소자의전위·전류, 및상기전기회로로부터발생하는노이즈를포함한전자계를포괄적으로계산가능하게한다. (해결수단) 컴퓨터가, 분포정수회로및 집중정수회로의회로구성, 및각 변수의초기값을입력하는회로구성입력스텝과, 회로구성및 초기값의하에서전송이론의기초방정식을분포정수회로와집중정수회로의경계인 x=0 및 w에있어서경계조건식을이용하여풂으로써다도체전송선로에있어서의스칼라포텐셜과전류, 소자에있어서의스칼라포텐셜과전압및 전자방사량을얻는계산스텝을실행한다.

9. 发明公开

KR20180032614A 은입자 제조방법, 은입자, 및 은페이스트 审中-公开
标题翻译：银粒子生产方法，银粒子和银浆
公开(公告)号：KR20180032614A
公开(公告)日：2018-03-30
申请号：KR20187004988
申请日：2016-07-22
申请人： UNIV OSAKA
发明人： SUGANUMA KATSUAKI , JIU JINTING
IPC分类号： B22F9/24 , B22F1/00 , H01B1/22 , H01B5/00 , H01B13/00
CPC分类号： B22F1/00 , B22F9/24 , B82Y30/00 , B82Y40/00 , H01B1/00 , H01B1/22 , H01B5/00 , H01B13/00
摘要： 먼저, 적어도은화합물, 환원제, 및분산제를혼합한혼합액을얻는다(S1). 이어서, 혼합액을가열하여은화합물과환원제를반응시키고, 시트형또는판형상의제 1 은입자, 및, 제 1 은입자에비해구형상에가까운형상또는구형상의형상을가지며또한제 1 은입자의한 변의길이의최대값에비해입자지름이작은제 2 은입자를생성한다(S2).
摘要翻译：首先，获得通过混合至少一种化合物，还原剂和分散剂获得的混合溶液（S1）。然后，由hayeoeun化合物反应并且将还原剂加热该混合物，片状或第一板状具有粒子，并且所述第一接近的形状或在除另外粒子的球形的矩形形状，第一是粒子的一个边的长度第二银粒子的粒径小于粒径的最大值（S2）。

10. 发明申请

WO2018088403A8 FRAGMENT ANTIBODY AND METHOD FOR CRYSTALLIZING PROTEIN USING FRAGMENT ANTIBODY 审中-公开
公开(公告)号：WO2018088403A8
公开(公告)日：2018-07-12
申请号：PCT/JP2017040138
申请日：2017-11-07
申请人： FUJIFILM WAKO PURE CHEMICAL CORP , UNIV OSAKA
发明人： TAKAGI JUNICHI
IPC分类号： C07K19/00 , C07K16/46
CPC分类号： C07K16/46 , C07K19/00
摘要： The present invention addresses the problem of providing a fragment antibody which can be easily produced as one having antigen-binding activity, and which has a greater ability to crystallize alone or as a complex with an antigen molecule than that of Fv-clasp (v1) even when the fragment antibody is obtained in an E. coli expression system. The present invention pertains to a fragment antibody comprising a complex of: a peptide (VH(112C)-SARAH) in which the N-terminus of the SARAH domain is linked to the C-terminus of the heavy-chain domain (VH domain) of an antibody, and in the VH region, the amino acid residue of Antibody Residue No. 112 is mutated to cysteine by the Chothia method; and a peptide (VL-SARAH(37C)) in which the N-terminus of the SARAH domain is linked to the C-terminus of the light-chain domain (VL domain) of an antibody, and in the SARAH domain, the thirteenth amino acid residue from the C-terminus is mutated to cysteine.

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