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1. 发明申请

WO2010029552A9 TRANSDERMAL DELIVERY OF OLIGOSACCHARIDES 审中-公开
公开(公告)号：WO2010029552A9
公开(公告)日：2010-03-18
申请号：PCT/IL2009/000889
申请日：2009-09-10
申请人： TRANSPHARMA MEDICAL LTD. , LEVIN, Galit , SACKS, Hagit , STERN, Meir , MAZOOZ, Galit
发明人： LEVIN, Galit , SACKS, Hagit , STERN, Meir , MAZOOZ, Galit
IPC分类号： A61F13/70
摘要： The present invention relates to a system for facilitating transdermal delivery of oligosaccharides comprising an apparatus that generates micro-channels in the skin of a subject and a skin patch comprising a pharmaceutical composition comprising as an active agent an oligosaccharide. Particularly, the composition comprises an oligosaccharide of 5-20 monosaccharide units, such as a pentasaccharide, which exerts anticoagulant activity. The system is capable of delivering the oligosaccharides into the blood circulation for treating thromboembolic diseases.

2. 发明申请

WO2009057112A2 VERTICAL PATCH DRYING 审中-公开
标题翻译：垂直皮带干燥
公开(公告)号：WO2009057112A2
公开(公告)日：2009-05-07
申请号：PCT/IL2008/001427
申请日：2008-10-29
申请人： TRANSPHARMA MEDICAL, LTD. , BAR-EL, Yossi , ARBEL, Giora , STERN, Meir
发明人： BAR-EL, Yossi , ARBEL, Giora , STERN, Meir
IPC分类号： F26B3/06
CPC分类号： F26B21/12 , F26B21/004 , F26B21/08 , F26B21/14
摘要： Apparatus is provided, including one or more drug patches (20) and a surface (22) configured to hold the one or more drug patches. A housing (24) is shaped to define one or more gas inflow openings (30) that are configured to facilitate drying of the patches by directing a flow of a gas toward the patches, a midline of the flow being at an angle of less than 20 degrees from a normal to the surface. Other embodiments are also described.
摘要翻译：提供了包括一个或多个药物贴片（20）和被配置为保持一个或多个药物贴片的表面（22）的装置。壳体（24）被成形为限定一个或多个气体流入开口（30），其被构造成便于通过将气流朝着贴片引导来促进贴片的干燥，流体的中线处于小于从正常到表面20度。还描述了其它实施例。

3. 发明申请

WO2007056105A3 HUMAN GROWTH HORMONE PATCH FORMULATIONS 审中-公开
标题翻译：人类生长激素补丁制剂
公开(公告)号：WO2007056105A3
公开(公告)日：2007-07-05
申请号：PCT/US2006042894
申请日：2006-11-02
申请人： TEVA PHARMA , TEVA PHARMA , TRANSPHARMA MEDICAL LTD , SACKS HAGIT , STERN MEIR
发明人： SACKS HAGIT , STERN MEIR
IPC分类号： A61K38/27 , A61K9/70
CPC分类号： A61K9/0009 , A61K9/7023 , A61K38/27 , A61N1/0428
摘要： The invention encompasses a transdermal patch formulation comprising hGH, at least one sugar, one amino acid or polyol, and a buffer, wherein the buffer maintains the pH of the formulation in the range of about 5 to about 9 and the formulation does not contain both glycine and mannitol.
摘要翻译：本发明包括含有hGH，至少一种糖，一种氨基酸或多元醇和缓冲剂的透皮贴剂制剂，其中缓冲剂将制剂的pH保持在约5至约9的范围内，并且制剂不含甘氨酸和甘露醇。

4. 发明申请

WO2006054299A2 COMBINED MICRO-CHANNEL GENERATION AND IONTOPHORESIS FOR TRANSDERMAL DELIVERY OF PHARMACEUTICAL AGENTS 审中-公开
标题翻译：用于药物代谢物转运的组合式微通道生成和异构体
公开(公告)号：WO2006054299A2
公开(公告)日：2006-05-26
申请号：PCT/IL2005/001219
申请日：2005-11-17
申请人： TRANSPHARMA MEDICAL LTD. , LEVIN, Galit , GERSHONOWITZ, Amikam , STERN, Meir , SHERMAN, Amir
发明人： LEVIN, Galit , GERSHONOWITZ, Amikam , STERN, Meir , SHERMAN, Amir
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： The present invention relates to methods of transdermal delivery of pharmaceutical agents. In particular, the present invention relates to a method for transdermal delivery comprising generating micro-channels on the skin of a subject and delivering iontophoretically a pharmaceutical agent through the micro-channels. The method provides synergistic transdermal delivery of pharmaceutical agents. .
摘要翻译：本发明涉及药剂的透皮递送方法。特别地，本发明涉及一种透皮递送方法，其包括在受试者的皮肤上产生微通道并通过微通道离子电渗地输送药剂。该方法提供药剂的协同透皮递送。。

5. 发明申请

WO2005069736A2 TRANSDERMAL DELIVERY SYSTEM FOR POLYNUCLEOTIDES 审中-公开
标题翻译：用于聚合物的超导体输送系统
公开(公告)号：WO2005069736A2
公开(公告)日：2005-08-04
申请号：PCT/IL2005000089
申请日：2005-01-25
申请人： TRANSPHARMA MEDICAL LTD , BIRCHALL JAMES , LEVIN GALIT , GERSHONOWITZ AMIKAM
发明人： BIRCHALL JAMES , LEVIN GALIT , GERSHONOWITZ AMIKAM
IPC分类号： A61N1/32 , C07H20060101
CPC分类号： A61N1/327
摘要： The present invention relates to a system for intradermal or transdermal delivery of oligonucleotides or polynucleotides and to methods of use thereof. Particularly, the present invention relates to a system comprising an apparatus that generates micro-channels in the skin of a subject in conjunction with a pharmaceutical composition comprising an oligonucleotide or polynucleotide, wherein the oligonucleotide or polynucleotide can be delivered into the organism through the micro-channels. The system and methods of the present invention achieve expression of target proteins encoded by the polynucleotides, and hence are useful in immunization and gene therapy.
摘要翻译：本发明涉及用于寡核苷酸或多核苷酸的皮内或透皮递送的系统及其使用方法。特别地，本发明涉及一种系统，其包括与包含寡核苷酸或多核苷酸的药物组合物结合的受试者皮肤中产生微通道的装置，其中所述寡核苷酸或多核苷酸可以通过微量载体递送至生物体，通道。本发明的系统和方法实现由多核苷酸编码的靶蛋白的表达，因此可用于免疫和基因治疗。

6. 发明申请

WO2004039428A2 TRANSDERMAL DELIVERY SYSTEM FOR DRIED PARTICULATE OR LYOPHILIZED MEDICATIONS 审中-公开
标题翻译：用于干燥颗粒或冻干药物的透皮递送系统
公开(公告)号：WO2004039428A2
公开(公告)日：2004-05-13
申请号：PCT/IL2003/000903
申请日：2003-10-30
申请人： TRANSPHARMA MEDICAL LTD. , STERN, Meir , LEVIN, Galit
发明人： STERN, Meir , LEVIN, Galit
IPC分类号： A61M
CPC分类号： A61L15/44 , A61K9/0021 , A61K9/703 , A61L2300/252 , A61L2300/414 , A61L2300/43 , A61L2300/602 , A61M37/00 , A61N1/0416 , A61N1/0476 , A61N1/327
摘要： The present invention provides a system for transdermal delivery of dried or lyophilized pharmaceutical compositions and methods using thereof. The system comprises an apparatus for facilitating transdermal delivery of an agent that generates hydrophilic micro-channels, and a patch comprising a therapeutically active agent. The present invention is useful for transdermal delivery of hydrophilic agents, particularly of high molecular weight proteins.
摘要翻译：本发明提供用于透皮递送干燥或冻干的药物组合物的系统和使用它的方法。该系统包括用于促进产生亲水性微通道的试剂的透皮递送的装置和包含治疗活性剂的贴剂。本发明可用于亲水剂，特别是高分子量蛋白质的透皮递送。

7. 发明申请

WO2011128902A3 STIFFENER FOR USE WITH A DRUG PATCH 审中-公开
公开(公告)号：WO2011128902A3
公开(公告)日：2011-10-20
申请号：PCT/IL2011/000315
申请日：2011-04-14
申请人： TRANSPHARMA MEDICAL, LTD. , ARBEL, Giora , BAR-EL, Yossi
发明人： ARBEL, Giora , BAR-EL, Yossi
IPC分类号： A61F13/00
摘要： Apparatus and methods are provided including a patch assembly (20) configured to deliver a substance through a subject's skin. A frame (26) surrounds at least in part an open portion of the patch assembly, such that a region of the skin is exposed through the open portion when the frame is placed on the skin. A substance support area (28) is foldably coupled to the frame at a foldable joint (27). A substance delivery area (23) is adapted to be placed in contact with at least a portion of the region of skin, by the substance support area being folded with respect to the frame. A stiffener (29), disposed on the substance support area between the foldable joint and the substance delivery area, is configured to facilitate the placement of the substance delivery area on the portion of the region of skin. Other applications are also described.

8. 发明申请

WO2010010555A8 TRANSDERMAL SYSTEM FOR EXTENDED DELIVERY OF INCRETINS AND INCRETIN MIMETIC PEPTIDES 审中-公开
标题翻译：用于延长递送和增加纤维蛋白质的变态系统
公开(公告)号：WO2010010555A8
公开(公告)日：2011-03-24
申请号：PCT/IL2009000713
申请日：2009-07-21
申请人： TRANSPHARMA MEDICAL LTD , MEVORAT-KAPLAN KEREN , LEVIN GALIT , SACKS HAGIT , STERN MEIR
发明人： MEVORAT-KAPLAN KEREN , LEVIN GALIT , SACKS HAGIT , STERN MEIR
IPC分类号： A61K9/70
CPC分类号： A61K9/7084 , A61K38/2278
摘要： A transdermal system (or extended delivery of incretins and incretin mimetic peptides, and methods of use thereof are disclosed The transdermal system comprises an apparatus that generates micro-channels in the skin of a subject in conjunction with a patch that comprises a drug reservoir layer comprising a formulation which comprises an incretin or incretin mimetic peptide, such as exendin-4 The system is useful for treating diabetes mellitus and obesity.
摘要翻译：披露了一种透皮系统（或肠溶素肽和肠降血糖素模拟肽的延长递送及其使用方法）。透皮系统包括与包含药物储存层的贴剂一起在受试者皮肤中产生微通道的装置，该药片包含包含肠降血糖素或降解素模拟肽的制剂，如毒蜥外泌肽-4该系统可用于治疗糖尿病和肥胖症。

9. 发明申请

WO2010097790A1 ELECTRICAL SKIN REJUVENATION 审中-公开
标题翻译：电动皮肤护理
公开(公告)号：WO2010097790A1
公开(公告)日：2010-09-02
申请号：PCT/IL2010/000149
申请日：2010-02-22
申请人： TRANSPHARMA MEDICAL LTD. , LEVIN, Galit , SOHN, Zev
发明人： LEVIN, Galit , SOHN, Zev
IPC分类号： A61N1/00
CPC分类号： A61N1/40 , A61B18/14 , A61B2018/00452 , A61B2018/0047 , A61B2018/143 , A61N1/328
摘要： A method is provided for reducing a wrinkle on a skin surface (42). The method includes identifying a person having a skin surface (42) with a wrinkle and in response to identifying the person, positioning at respective sites on the skin surface (42) an array (44) of electrodes (60) coupled to an energy source (46). While the electrodes (60) are at the respective sites: during a first time period, applying energy from the energy source (46) to drive the electrodes (60) to apply radio frequency (RF) current at a first voltage, capable of ablating an epidermal layer of the skin; and during a second time period, applying energy from the energy source (46) to drive the electrodes (60) to apply current at a second voltage, lower than the first voltage. Other embodiments are also described.
摘要翻译：提供了一种用于减少皮肤表面（42）上的皱纹的方法。该方法包括识别具有皱纹的皮肤表面（42）的人，并且响应于识别人，在皮肤表面（42）上的相应位置处定位耦合到能量源的电极阵列（44）（46）。当电极（60）处于相应位置时：在第一时间段期间，从能量源（46）施加能量以驱动电极（60）以施加能够消融的第一电压的射频（RF）电流表皮层皮肤; 并且在第二时间段期间，从能量源（46）施加能量以驱动电极（60）以比第一电压低的第二电压施加电流。还描述了其它实施例。

10. 发明申请

WO2007077487A2 METHOD AND DEVICE FOR TRANSDERMAL IMMUNIZATION 审中-公开
标题翻译：用于转导性免疫的方法和装置
公开(公告)号：WO2007077487A2
公开(公告)日：2007-07-12
申请号：PCT/IB2006/003832
申请日：2006-12-22
申请人： TRANSPHARMA MEDICAL, LTD. , LEVIN, Galit , GERSHONOWITZ, Amikam , GADASI, Hana
发明人： LEVIN, Galit , GERSHONOWITZ, Amikam , GADASI, Hana
IPC分类号： A61N1/30 , A61K39/00
CPC分类号： A61N1/327 , A61K9/0021 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/54 , A61K2039/55544 , A61K2039/70 , A61N1/042 , C12N2760/16134 , C12N2760/16234
摘要： The present invention relates to methods and device for transdermal immunization. More particularly, the invention relates to a device for effective topical administration of antigens comprising an apparatus that generates micro-channels in the skin of a subject. The delivery system is useful for immunization against bacterial, viral, and fungal antigens and for treating tumors and allergies.
摘要翻译：本发明涉及经皮免疫的方法和装置。更具体地，本发明涉及用于有效局部施用抗原的装置，其包括在受试者的皮肤中产生微通道的装置。递送系统可用于免疫细菌，病毒和真菌抗原以及治疗肿瘤和过敏。

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