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1. 发明申请

US20090075360A1 APPARATUS AND METHODS FOR MANIPULATION AND OPTIMIZATION OF BIOLOGICAL SYSTEMS 有权
标题翻译：用于操纵和优化生物系统的装置和方法
公开(公告)号：US20090075360A1
公开(公告)日：2009-03-19
申请号：US11719749
申请日：2005-11-18
申请人： Chih-Ming Ho , Pak Kin Wong , Ren Sun , Fuqu Yu
发明人： Chih-Ming Ho , Pak Kin Wong , Ren Sun , Fuqu Yu
IPC分类号： C12M3/00 , C12M1/36 , G05B13/02
CPC分类号： C12Q1/02 , C12M41/48 , C12Q3/00 , G01N35/0092 , G01N2035/0094 , Y02A90/26
摘要： The invention provides systems and methods for manipulating, e.g., optimizing and controlling, biological systems, e.g., for eliciting a more desired biological response of biological sample, such as a tissue, organ, and/or a cell. In one aspect, systems and methods of the invention operate by efficiently searching through a large parametric space of stimuli and system parameters to manipulate, control, and optimize the response of biological samples sustained in the system, e.g., a bioreactor. In alternative aspects, systems include a device for sustaining cells or tissue samples, one or more actuators for stimulating the samples via biochemical, electromagnetic, thermal, mechanical, and/or optical stimulation, one or more sensors for measuring a biological response signal of the samples resulting from the stimulation of the sample. In one aspect, the systems and methods of the invention use at least one optimization algorithm to modify the actuator's control inputs for stimulation, responsive to the sensor's output of response signals. The compositions and methods of the invention can be used, e.g., to for systems optimization of any biological manufacturing or experimental system, e.g., bioreactors for proteins, e.g., therapeutic proteins, polypeptides or peptides for vaccines, and the like, small molecules (e.g., antibiotics), polysaccharides, lipids, and the like. Another use of the apparatus and methods includes combination drug therapy, e.g. optimal drug cocktail, directed cell proliferations and differentiations, e.g. in tissue engineering, e.g. neural progenitor cells differentiation, and discovery of key parameters in complex biological systems.
摘要翻译：本发明提供了用于操纵，例如优化和控制生物系统的系统和方法，例如用于引发生物样品例如组织，器官和/或细胞的更期望的生物反应。在一个方面，本发明的系统和方法通过有效地搜索刺激和系统参数的大参数空间来操作，控制和优化在系统例如生物反应器中维持的生物样品的响应。在替代方面，系统包括用于维持细胞或组织样本的装置，用于通过生物化学，电磁，热，机械和/或光刺激刺激样品的一个或多个致动器，用于测量生物反应信号的一个或多个传感器样品刺激产生的样品。在一个方面，本发明的系统和方法使用至少一种优化算法，以响应于传感器的响应信号的输出来修改致动器的用于刺激的控制输入。本发明的组合物和方法可用于例如任何生物制备或实验系统的系统优化，例如用于蛋白质的生物反应器，例如用于疫苗的治疗性蛋白质，多肽或肽等，小分子（例如，，抗生素），多糖，脂质等。该装置和方法的另一用途包括组合药物治疗，例如，最佳药物混合物，定向细胞增殖和分化，例如。在组织工程中。神经祖细胞分化，以及复杂生物系统中关键参数的发现。

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