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1. 发明专利

TW200801190A 蛋白質摺疊錯誤及聚集之調節劑與其使用方法 REGULATORS OF PROTEIN MISFOLDING AND AGGREGATION AND METHODS OF USING THE SAME 审中-公开
简体标题：蛋白质折叠错误及聚集之调节剂与其使用方法 REGULATORS OF PROTEIN MISFOLDING AND AGGREGATION AND METHODS OF USING THE SAME
公开(公告)号：TW200801190A
公开(公告)日：2008-01-01
申请号：TW095131221
申请日：2006-08-24
申请人：美國阿拉巴馬大學理事會 THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA FOR AND ON BEHALF OF THE UNIVERSITY O
发明人：蓋A 凱德威 CALDWELL, GUY A. , 金A 凱德威 CALDWELL, KIM A.
IPC分类号： C12N , A61K , G01N
摘要：本發明提供用於由蛋白質聚集來表徵之神經病症之聚核酸分子及由該等分子編碼之蛋白質、診斷及治療方法。本文中所述之基因影響諸如��-突觸核蛋白之易聚集蛋白質之摺疊錯誤及其因此之聚集,且牽制到諸如帕金森式病(Parkinson'sdisease)之與蛋白質聚集相關之神經疾病的診斷及治療。使用RNAi敲除本文中所述之基因的表現導致蛋白質聚集之秀麗隱桿線蟲(C.elegans)模型中��-突觸核蛋白聚集。暴露於神經毒素6-OHDA或��-突觸核蛋白過度表現後的多巴胺能神經保護亦可由蛋白質的過度表現來提供。對與蛋白質摺疊錯誤及聚集相關之基因的認知提供開發診斷性篩檢方法、突變分析及藥物設計資訊之有效方法,用於開發治療諸如帕金森氏病之神經退化性疾病之新穎治療性及神經保護性化合物。
简体摘要：本发明提供用于由蛋白质聚集来表征之神经病症之聚核酸分子及由该等分子编码之蛋白质、诊断及治疗方法。本文中所述之基因影响诸如��-突触核蛋白之易聚集蛋白质之折叠错误及其因此之聚集,且牵制到诸如帕金森式病(Parkinson'sdisease)之与蛋白质聚集相关之神经疾病的诊断及治疗。使用RNAi敲除本文中所述之基因的表现导致蛋白质聚集之秀丽隐杆线虫(C.elegans)模型中��-突触核蛋白聚集。暴露于神经毒素6-OHDA或��-突触核蛋白过度表现后的多巴胺能神经保护亦可由蛋白质的过度表现来提供。对与蛋白质折叠错误及聚集相关之基因的认知提供开发诊断性筛检方法、突变分析及药物设计信息之有效方法,用于开发治疗诸如帕金森氏病之神经退化性疾病之新颖治疗性及神经保护性化合物。

2. 发明专利

TW200526587A 含二級羥基之離子性液體及彼等之製備方法 IONIC LIQUIDS CONTAINING SECONDARY HYDROXYL-GROUPS AND A METHOD FOR THEIR PREPARATION 审中-公开
简体标题：含二级羟基之离子性液体及彼等之制备方法 IONIC LIQUIDS CONTAINING SECONDARY HYDROXYL-GROUPS AND A METHOD FOR THEIR PREPARATION
公开(公告)号：TW200526587A
公开(公告)日：2005-08-16
申请号：TW093126880
申请日：2004-09-06
申请人：美國阿拉巴馬大學理事會 THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA
发明人：約翰D 荷伯瑞 HOLBREY, JOHN D. , 梅根B 透納 TURNER, MEGAN B. , 羅賓D 羅傑 ROGERS, ROBIN D.
IPC分类号： C07D , B01J
CPC分类号： B01J31/0284
摘要：本發明提供含有二級羥基之離子性液體，以及一種製備此等離子性液體之原子有效的方法，其係在一有助於離子性液體形成之陰離子存在下，藉由質子化含氮有機鹼(其視情況可於原位製備)之環氧化作用製得。093126880-p01.bmp
简体摘要：本发明提供含有二级羟基之离子性液体，以及一种制备此等离子性液体之原子有效的方法，其系在一有助于离子性液体形成之阴离子存在下，借由质子化含氮有机碱(其视情况可于原位制备)之环氧化作用制得。093126880-p01.bmp

3. 发明申请

WO2020028397A1 STEAM CABINET 审中-公开
公开(公告)号：WO2020028397A1
公开(公告)日：2020-02-06
申请号：PCT/US2019/044190
申请日：2019-07-30
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA , NOVTECH LLC
发明人： WELLER, Stanley , STARKS, Lloyd L. , MACPHEE, David William , KINCAID, Kellis Christian , PITTS, Steven Ryley , LARSEN, Nicholas Corey , CAPPOLA, Jonathan George , HASKEW, Tim A.
IPC分类号： D06F37/02 , D06F58/10 , D06F73/02
摘要： Various implementations include a steam cabinet. The steam cabinet includes at least one chamber wall, a door, at least one heating element, at least one steam generator, a supply fan, and an exhaust fan. The at least one chamber wall defines a processing chamber. The door is for allowing access to the processing chamber. The at least one heating element is configured to provide heat to the processing chamber. The at least one steam generator is configured to provide steam to the processing chamber. The supply fan has a supply fan inlet and a supply fan outlet. The supply fan outlet is in fluid communication with the at least one heating element and the processing chamber. The exhaust fan has an exhaust fan inlet and an exhaust fan outlet. The exhaust fan inlet is in fluid communication with the processing chamber.

4. 发明申请

WO2019195357A1 APPARATUS AND METHOD FOR EMBEDDING CURRENT MEASUREMENT AND RINGING SUPPRESSION IN MULTICHIP MODULES 审中-公开
公开(公告)号：WO2019195357A1
公开(公告)日：2019-10-10
申请号：PCT/US2019/025482
申请日：2019-04-03
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA
发明人： LEMMON, Andrew, N. , SHAHABI, Ali
IPC分类号： G01R15/18 , H02M1/34
摘要： The current disclosure relates to the design of an apparatus for enhancing the operation and reliability of high-power multi-chip modules, which are used in the design and implementation of power electronics converters. This apparatus is especially useful for modules containing recentlycommercialized, high-performance wide band-gap semiconductors such as Silicon Carbide (SiC), which commonly emit undesirable high-frequency ringing and oscillation in the "Near-RF" spectral band between 1-30 MHz. The disclosed apparatus provides near-complete elimination of this high frequency spectral content, while leaving the desired frequency range (1-100 kHz) of the module unaffected. In addition to the suppression of this undesirable high-frequency content, the disclosed apparatus also provides for accurate, galvanically-isolated, high-bandwidth, real-time current measurement, which is essential for some types of power electronics converters. The apparatus disclosed here provides ringing suppression and current measurement in simple circuit topology that can be implemented compactly inside the geometry of a multi-chip power module.

5. 发明申请

WO2018236445A3 METAL PARTICLE-CHITIN COMPOSITE MATERIALS AND METHODS OF MAKING THEREOF 审中-公开
公开(公告)号：WO2018236445A3
公开(公告)日：2018-12-27
申请号：PCT/US2018/023964
申请日：2018-03-23
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA , 525 SOLUTIONS, INC.
发明人： ROGERS, Robin D. , ZAVGORODNYA, Oleksandra , SHAMSHINA, Julia L.
IPC分类号： C08J5/12 , C08K3/10 , C08K5/3445 , C08L5/08
摘要： Methods for making metal particle-chitin composite materials are described. The methods can comprise contacting an ionic liquid with chitin, thereby forming a mixture; contacting the mixture with a non-solvent, thereby forming a chitin substrate in the non-solvent; collecting the chitin substrate from the non-solvent; deacetylating the collected chitin substrate, thereby forming a deacetylated chitin substrate; contacting the deacetylated chitin substrate with a metal salt, thereby forming an impregnated precursor composite material; and contacting the impregnated precursor composite material with a reducing agent, thereby reducing the metal salt to form a plurality of metal particles dispersed on the chitin substrate and forming the metal particle-chitin composite material.

6. 发明申请

WO2016077290A1 DOUBLE SALT IONIC LIQUIDS OF HERBICIDES 审中-公开
标题翻译：双酚盐离子液体
公开(公告)号：WO2016077290A1
公开(公告)日：2016-05-19
申请号：PCT/US2015/059861
申请日：2015-11-10
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA
发明人： ROGERS, Robin Don , COJOCARU, Oana Andreea , GURAU, Gabriela , SHAMSHINA, Julia , PERNAK, Juliusz
IPC分类号： A01N57/18
CPC分类号： A01N37/40 , A01N33/12 , A01N39/04 , A01N57/20 , A01N47/28
摘要： Disclosed are compositions and methods of preparing compositions of active herbicidal ingredients comprising two or more active herbicidal ingredients. Also disclosed are methods of using the compositions described herein to reduce herbicide resistance and minimize off-target movement. The present disclosure relates to compositions of herbicidal ionic liquids comprising one or more active herbicide ingredients and methods of making and using such ionic liquids. In some aspects, the herbicidal ionic liquids with multiple active herbicide ingredients can be prepared as separate ionic liquids, each with a single active, and later combined.
摘要翻译：公开了制备包含两种或更多种活性除草成分的活性除草成分的组合物的组合物和方法。还公开了使用本文所述的组合物来降低除草剂抗性并使离靶移动最小化的方法。本公开涉及包含一种或多种活性除草剂成分的除草离子液体的组合物以及制备和使用这种离子液体的方法。在一些方面，具有多种活性除草剂成分的除草离子液体可以制备为单独的离子液体，每种离子液体具有单一活性物质，然后组合。

7. 发明申请

WO2014172703A1 CHITIN AND ALGINATE COMPOSITE FIBERS 审中-公开
标题翻译： CHITIN和ALGINATE复合纤维
公开(公告)号：WO2014172703A1
公开(公告)日：2014-10-23
申请号：PCT/US2014/034793
申请日：2014-04-21
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA
发明人： ROGERS, Robin D. , GURAU, Gabriella , SHAMSHINA, Julia L. , DALY, Daniel T.
IPC分类号： A61L15/28 , A61F13/531 , D01D5/06
CPC分类号： A61L15/44 , A61F2013/00229 , A61F2013/00931 , A61L15/225 , A61L17/005 , A61L17/10 , A61L2300/428 , C08L5/04 , C08L5/08 , D01D1/02 , D01D5/04 , D01F1/10 , D01F9/00 , D01F9/04
摘要： Disclosed herein are composite fibers that comprises chitin and alginate. The formation of the chitinous-alginate composite fiber involves the use of ionic liquids and high molecular weight pure chitin obtained directly from chitin biomass. Optional additive such as vitamin E is successfully incorporated in to the composite fiber. The chitinousalginate fiber formed has a continuous and homogenous morphology, even with the addition of additive. Methods of making and using the chitinous-alginate composite fiber as wound dressing is also disclosed.
摘要翻译：本文公开了包含壳多糖和藻酸盐的复合纤维。几丁质藻酸盐复合纤维的形成涉及使用离子液体和直接由几丁质生物质获得的高分子量纯甲壳素。任选的添加剂如维生素E成功地并入到复合纤维中。形成的几丁质海藻酸纤维具有连续和均匀的形态，即使加入添加剂。还公开了制备和使用壳多糖 - 藻酸盐复合纤维作为伤口敷料的方法。

8. 发明申请

WO2014125438A1 COAGULATION OF BIOPOLYMERS FROM IONIC LIQUID SOLUTIONS USING CO2 审中-公开
标题翻译：使用二氧化碳从离子液体溶液中凝聚生物聚合物
公开(公告)号：WO2014125438A1
公开(公告)日：2014-08-21
申请号：PCT/IB2014/058981
申请日：2014-02-13
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA
发明人： ROGERS, Robin D. , BARBER, Patrick S. , GRIGGS, Chris S. , GURAU, Gabriela , LU, Xingmei , ZHANG, Suojiang
IPC分类号： C08B37/08 , C08L5/08 , C08L67/04 , C08J5/18
CPC分类号： C08B37/003 , C08B15/08 , C08B37/0003 , C08J3/14 , C08J5/08 , C08J2300/16 , C08L5/08 , C08L97/02 , Y02P20/544
摘要： Disclosed herein are processes for providing a biopolymer from a biomass or source of chitin using ionic liquids. The processes involve contacting a biomass or source of chitin with an ionic liquid to produce a biopolymer comprising solution and precipitating the biopolymer from the solution with supercritical CO 2 , gaseous CO 2 , or combinations thereof.
摘要翻译：本文公开了使用离子液体从生物质或几丁质源提供生物聚合物的方法。该方法包括将生物质或几丁质源与离子液体接触，以产生包含溶液的生物聚合物，并用超临界CO 2，气态CO 2或其组合从溶液沉淀生物聚合物。

9. 发明申请

WO2013126897A1 SYSTEMS AND METHODS FOR DETERMINING CONTAINER CONTENTS, LOCATIONS, AND SURROUNDINGS 审中-公开
标题翻译：用于确定集装箱内容，位置和环境的系统和方法
公开(公告)号：WO2013126897A1
公开(公告)日：2013-08-29
申请号：PCT/US2013/027664
申请日：2013-02-25
申请人： ADHERETECH INC. , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA, FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA IN HUNTSVILLE
发明人： STEIN, Joshua , LANGHAUSER, John , MORENA, Michael , JOVANOV, Emil
IPC分类号： A61J1/03 , A61J7/04
CPC分类号： A61J7/0409 , A61J7/0418 , A61J7/0481 , A61J2200/30 , A61J2200/70 , A61J2200/74 , A61J2200/76 , F04C2270/0421 , G06F19/00 , G06F19/3462 , G06Q10/10
摘要： Systems and methods are provided for determining whether and/or when a patient is taking his or her medication and, when appropriate, providing reminders and/or alerts to the patient to improve adherence to a medication regimen. In some embodiments, a medication container is provided that includes a capacitance sensor for sensing the contents of the medication container (e.g., pill count or quantity of liquid medication). The capacitance sensor may include interleaved or interdigitated electrodes oriented vertically, horizontally, or angularly (e.g., diagonally) relative to an axis of the medication container. Reminders and/or alerts to the patient may be triggered based at least in part on the contents of the medication container, when a cap of the container was last opened and/or closed, the location of the medication container, and/or the container's surroundings.
摘要翻译：提供了系统和方法，用于确定患者是否和/或何时服用他或她的药物，并且在适当时向患者提供提醒和/或警报以改善对药物治疗方案的依从性。在一些实施例中，提供了一种药物容器，其包括用于感测药物容器的内容物的电容传感器（例如，药片计数或液体药物的量）。电容传感器可以包括相对于药物容器的轴线垂直，水平或成角度地（例如，对角线）定向的交错或交叉指向的电极。至少部分地基于药物容器的内容触发对患者的提醒和/或警报，当容器的帽最后打开和/或关闭时，药物容器的位置和/或容器的位置环境。

10. 发明申请

WO2012050810A2 SHAPE-CONTROLLED MAGNETIC NANOPARTICLES AS T1 CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：形状控制的磁性纳米粒子作为T1对比剂用于磁共振成像
公开(公告)号：WO2012050810A2
公开(公告)日：2012-04-19
申请号：PCT/US2011/053268
申请日：2011-09-26
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA , BAO, Yuping, Y.
发明人： BAO, Yuping, Y.
IPC分类号： A61K49/18 , A61K49/06 , A61K9/16 , A61K47/48
CPC分类号： A61K49/1839 , A61K49/1833 , A61K49/1854 , A61K49/1857 , Y10T428/2982
摘要： Methods are provided for the generation of nanostructures suitable for use in magnetic resonance imaging where the nanostructures have at least one dimension of about 2 nm or less. In particular, the methods comprise the selective use of incubation temperatures that result in the controlled removal of ligands from metallic cores to which they are attached, allowing the metallic cores or the precursor moieties to unite to form nanostructures of defined and predictable shapes, but having at least one dimension significantly less that at least one other dimension. Accordingly, the nanostructures of the disclosure may be ultrathin sheets, rods, whiskers and the like, or even structures that are thin and porous resembling rice grains. The temperatures useful in the methods of the disclosure are less than 300 °C and allow for progressive elevation of the incubation temperature. The methods are especially advantageous for synthesizing nanoparticles that may be administered to an animal or human subject for imaging with magnetic resonance. Accordingly, the nanostructures of the disclosure comprise a metallic core, most typically, but not necessarily limited to, a ferrite moiety that can be a ferrous or ferric ion alone or in combination with other metallic elements. However, the methods of the disclosure are also suitable for generating nanostructures with non-ferrous cores such as magnesium or manganese cores.
摘要翻译：提供了用于产生适合用于磁共振成像的纳米结构的方法，其中纳米结构具有至少一个约2nm或更小的尺寸。具体而言，所述方法包括选择性使用孵育温度，所述温育温度导致配体从它们所连接的金属核心受控移除，使金属核心或前体部分团聚以形成具有确定和可预测形状的纳米结构，但具有至少一个维度明显小于至少一个其他维度。因此，本公开的纳米结构可以是超薄片，棒，晶须等，或者甚至是类似于米粒的薄且多孔的结构。在本公开的方法中有用的温度低于300℃并且允许孵育温度的逐渐升高。该方法对于合成纳米颗粒是特别有利的，所述纳米颗粒可以施用于动物或人类受试者以用磁共振进行成像。因此，本公开的纳米结构包含金属核，最典型地但不一定限于铁氧体部分，其可以是单独的亚铁或三价铁离子或与其他金属元素组合。然而，本公开的方法也适用于产生具有诸如镁或锰核之类的非铁芯的纳米结构。

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