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1. 发明专利

TW200716085A 輸送系統 DELIVERY SYSTEM 审中-公开
简体标题：输送系统 DELIVERY SYSTEM
公开(公告)号：TW200716085A
公开(公告)日：2007-05-01
申请号：TW095103811
申请日：2006-02-03
申请人：史塔法瑪PTY有限公司 STARPHARMA PTY LIMITED
发明人：歐文提摩西葛瑞更 GROGAN, OWEN TIMOTHY , 湯瑪斯大衛麥凱西 MCCARTHY, THOMAS DAVID
IPC分类号： A61K , A61F , A61P
CPC分类号： A61K9/0034 , A01N41/04
摘要：一種包括一殺微生物組合物及一避孕器件之殺微生物輸送系統。該組合物包括:一包含一或多個式IV之表面基團之樹枝狀聚合物的殺微生物化合物
095103811-p01.bmp
其一具有殺微生物活性之衍生物,或其醫藥上可接受之鹽或溶劑合物;及其載劑、賦形劑或稀釋劑。該殺微生物組合物係裝載於該避孕器件之一表面上並能與其相容。
095103811-p01.bmp
简体摘要：一种包括一杀微生物组合物及一避孕器件之杀微生物输送系统。该组合物包括:一包含一或多个式IV之表面基团之树枝状聚合物的杀微生物化合物 095103811-p01.bmp 其一具有杀微生物活性之衍生物,或其医药上可接受之盐或溶剂合物;及其载剂、赋形剂或稀释剂。该杀微生物组合物系装载于该避孕器件之一表面上并能与其兼容。 095103811-p01.bmp

2. 发明专利

TWI429427B 輸送系統有权
简体标题：输送系统
公开(公告)号：TWI429427B
公开(公告)日：2014-03-11
申请号：TW095103811
申请日：2006-02-03
申请人：史塔法瑪PTY有限公司 , STARPHARMA PTY LIMITED
发明人：歐文提摩西葛瑞更 , GROGAN, OWEN TIMOTHY , 湯瑪斯大衛麥凱西 , MCCARTHY, THOMAS DAVID
IPC分类号： A61K31/18 , A61K31/785 , A61P31/02
CPC分类号： A61K9/0034 , A01N41/04

3. 发明申请

WO2009103123A1 DENDRIMERIC ENZYME INHIBITORS 审中-公开
标题翻译： DENDRIMERIC ENZYME抑制剂
公开(公告)号：WO2009103123A1
公开(公告)日：2009-08-27
申请号：PCT/AU2009/000196
申请日：2009-02-20
申请人： STARPHARMA PTY LIMITED , FAIRLEY, Jacinth, Kincaid
发明人： FAIRLEY, Jacinth, Kincaid
IPC分类号： A61K31/785 , A61K31/795 , C08L5/08 , C08L79/02 , C08L79/04 , A61K31/728 , A61P9/10 , A61P19/02 , A61P17/02
CPC分类号： A61K31/728 , A61K31/785 , A61K31/795 , C08G69/08 , C08G69/10 , C08G73/0206 , C08G83/003 , C08L5/08 , C08L77/02 , C08L77/04 , C08L79/02 , C08L2666/20 , C08L2666/26
摘要： The present invention relates generally to the use of dendrimer compounds bearing anionic surface groups as inhibitors of hyaluronidase and their use in the treatment of diseases and conditions in which excessive, abnormal or unwanted levels of hyaluronidase are involved or implicated, or in the treatment of diseases or conditions in which the presence or administration of hyaluronic acid is therapeutically effective. The present invention also relates to pharmaceutical compositions and methods for the treatment of such diseases and conditions.
摘要翻译：本发明一般涉及带有阴离子表面基团的树枝状大分子化合物作为透明质酸酶的抑制剂及其用于治疗涉及或牵连过度，异常或不需要的透明质酸酶水平或用于治疗疾病的疾病和病症的用途或其中透明质酸的存在或给药在治疗上有效的条件。本发明还涉及用于治疗这些疾病和病症的药物组合物和方法。

4. 发明申请

WO2007048190A1 MACROMOLECULAR COMPOUNDS HAVING CONTROLLED STOICHIOMETRY 审中-公开
标题翻译：具有控制性分析的大分子化合物
公开(公告)号：WO2007048190A1
公开(公告)日：2007-05-03
申请号：PCT/AU2006/001591
申请日：2006-10-25
申请人： STARPHARMA PTY LIMITED , KRIPPNER, Guy, Yeoman , LICHTI, Gottfried , RAZZINO, Pasquale , KELLY, Brian, Devlin , PALLICH, Susanne , HENDERSON, Scott, Andrew , SCHEPPOKAT, Angela, Michelle , WILLIAMS, Charlotte, Claire , PORTER, Christopher, John, Hamilton , BOYD, Benjamin, James , KAMINSKAS, Lisa, Michelle , RENDLE, Phillip, Martin , GREATREX, Ben William
发明人： KRIPPNER, Guy, Yeoman , LICHTI, Gottfried , RAZZINO, Pasquale , KELLY, Brian, Devlin , PALLICH, Susanne , HENDERSON, Scott, Andrew , SCHEPPOKAT, Angela, Michelle , WILLIAMS, Charlotte, Claire , PORTER, Christopher, John, Hamilton , BOYD, Benjamin, James , KAMINSKAS, Lisa, Michelle , RENDLE, Phillip, Martin , GREATREX, Ben William
IPC分类号： C08G69/10 , A61K31/785 , C08G69/42 , C08G73/10 , C08G83/00
CPC分类号： C08G83/003 , A61K31/785
摘要： The following invention is directed to macromolecules having controlled stoichiometry and topology, processes for their production, and applications for their use. The macromolecules have a controlled functional moiety stoichiometry and include at least one dendritic motif having a surface layer formed from at least one surface building unit and at least one subsurface layer formed from at least one building unit, the surface building unit and building units having a hydrocarbon backbone bearing a carbonyl group and at least one amine group; and at least two different functional moieties on the building unit and/or surface building unit; where functional moiety stoichiometry refers to the number and type of functional moieties.
摘要翻译：以下发明涉及具有受控化学计量和拓扑结构的大分子，其生产方法及其应用。大分子具有受控的功能部分化学计量学，并且包括至少一个树突状基序，其具有由至少一个表面构建单元形成的表面层和由至少一个建筑单元形成的至少一个地下层，所述表面建筑单元和建筑单元具有具有羰基和至少一个胺基的烃主链; 和建筑物单元和/或表面建筑单元上的至少两个不同的功能部分; 功能部分化学计量指功能部分的数量和类型。

5. 发明申请

WO2007045009A1 MICROBICIDAL DENDRIMER COMPOSITION DELIVERY SYSTEM 审中-公开
标题翻译： MICROBICIDAL DENDRIMER组合物输送系统
公开(公告)号：WO2007045009A1
公开(公告)日：2007-04-26
申请号：PCT/AU2006/000120
申请日：2006-02-01
申请人： STARPHARMA PTY LIMITED , GROGAN, Owen, Timothy , MCCARTHY, Thomas, David
发明人： GROGAN, Owen, Timothy , MCCARTHY, Thomas, David
IPC分类号： A61K31/785 , A61F6/04 , A61F6/08 , A61F6/10 , A61P31/12 , A61P31/18
CPC分类号： A61K9/0034 , A01N41/04
摘要： A microbicidal delivery system including: a microbicidal composition including a microbicidal compound including a dendrimer including one or more surface groups of formula (IV); a microbicidally active derivative thereof, or pharmaceutically acceptable salt or solvate thereof; and a carrier, excipient or diluent therefor; and a prophylactic device; the microbicidal composition being carried on a surface of the prophylactic device and being compatible therewith.
摘要翻译：一种杀菌剂输送系统，包括：杀菌组合物，其包含包含一种或多种式（IV）表面基团的树枝状大分子的杀菌化合物; 其杀微生物活性衍生物或其药学上可接受的盐或溶剂合物; 及其载体，赋形剂或稀释剂; 和预防装置; 所述杀微生物组合物携带在所述预防装置的表面上并与之相容。

6. 发明申请

WO2014043576A1 METHOD OF TREATMENT OR PROPHYLAXIS OF INFECTIONS OF THE EYE 审中-公开
标题翻译：治疗或预防眼睛感染的方法
公开(公告)号：WO2014043576A1
公开(公告)日：2014-03-20
申请号：PCT/US2013/059810
申请日：2013-09-13
申请人： STARPHARMA PTY LIMITED , ALTMAN, Daniel, E.
发明人： FAIRLEY, Jacinth, Kincaid , BARRETT, Colin, Paul , PAULL, Jeremy, Robert Arthur
IPC分类号： A61K31/198 , A61K31/255 , A61P27/02
CPC分类号： A61K38/08 , A61K9/0048 , A61K31/795 , A61K47/59
摘要： A microbial infection in an eye of a subject is treated or prevented by topically administering to the eye an effective amount of a macromolecule or a pharmaceutically acceptable salt thereof that includes a dendrimer of 1 to 8 generations with one or more sulfonic acid- or sulfonate-containing moieties attached to one or more surface groups of the outermost generation of the dendrimer. Compositions containing the macromolecule or salt are useful in these methods.
摘要翻译：通过向眼睛局部施用有效量的大分子或其药学上可接受的盐，其包括1至8代的树枝状大分子与一种或多种磺酸或磺酸盐形式，治疗或预防受试者眼睛中的微生物感染，含有部分连接到树枝状聚合物的最外层的一个或多个表面基团。含有大分子或盐的组合物在这些方法中是有用的。

7. 发明申请

WO2007045010A1 INHIBITORY COMPOUNDS 审中-公开
标题翻译：禁忌化合物
公开(公告)号：WO2007045010A1
公开(公告)日：2007-04-26
申请号：PCT/AU2006/000636
申请日：2006-05-15
申请人： STARPHARMA PTY LIMITED , HENDERSON, Scott, Andrew , HOLAN, George , KRIPPNER, Guy, Yeoman , McCARTHY, Thomas, David
发明人： HENDERSON, Scott, Andrew , HOLAN, George , KRIPPNER, Guy, Yeoman , McCARTHY, Thomas, David
IPC分类号： A61K47/48 , A61K31/166 , A61K31/74 , A61K31/785 , C08G69/08 , C08G69/10 , C08G83/00 , C08L77/10
CPC分类号： A61K31/795 , A61K31/166 , A61K31/74 , A61K31/785 , A61K47/59 , A61K47/645 , C08L101/005
摘要： The present invention provides an anionic dendrimer polymer of at least two generations. The present invention also provides for the production of these polymers and to their use in the inhibition of angiogenesis.
摘要翻译：本发明提供了至少两代的阴离子树枝状聚合物聚合物。本发明还提供这些聚合物的制备及其在抑制血管发生中的用途。

8. 发明申请

WO2012142659A1 SITE-SELECTIVE MODIFICATION OF PROTEINS 审中-公开
标题翻译：蛋白质的选择性修饰
公开(公告)号：WO2012142659A1
公开(公告)日：2012-10-26
申请号：PCT/AU2012/000400
申请日：2012-04-19
申请人： BAKER IDI HEART AND DIABETES INSTITUTE HOLDINGS LIMITED , THE UNIVERSITY OF MELBOURNE , STARPHARMA PTY LIMITED , HAGEMEYER, Christoph , PETER, Karlheinz , JOHNSTON, Angus Philip Rayner , OWEN, David
发明人： HAGEMEYER, Christoph , PETER, Karlheinz , JOHNSTON, Angus Philip Rayner , OWEN, David
IPC分类号： C07K1/107 , C07K1/113 , C07K1/13 , C07K5/00 , C07K5/062 , C07K5/083 , C07K5/103 , C07K7/06 , C07K7/08 , C07K9/00 , C07K17/06 , C07K17/08 , C07K17/10 , C07K17/14 , C07K19/00 , C12N9/52 , A61K38/04 , A61K38/08 , A61K38/10 , A61K38/14 , A61K51/08 , C12P21/00 , C12P21/02 , C07K14/00 , C07K14/54 , C07K16/00 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/16 , A61K38/20 , A61K51/10
CPC分类号： C12N9/50 , A61K47/60 , A61K47/64 , A61K47/645 , A61K47/6923 , A61K47/6927 , C07K1/026 , C07K1/13 , C07K5/06026 , C07K5/0806 , C07K5/1008 , C07K14/00 , C07K2319/00 , C12P21/02
摘要： The present invention relates to methods and reagents for use in site-selective modification of proteins and other entities with functionalized peptides using a chemoenzymatic sortase mediated reaction. The functionalized entities may be further reacted to conjugate two large entities together. Functionalized peptides including a glycine motif recognised by Sortase enzymes are also described.
摘要翻译：本发明涉及用于使用化学酶分解酶介导的反应用功能化肽对蛋白质和其他实体进行位点选择性修饰的方法和试剂。功能化实体可以进一步反应以将两个大实体结合在一起。还描述了包括分类酶识别的甘氨酸基序的官能化肽。

9. 发明申请

WO2007106944A1 CONTRACEPTIVE COMPOSITION 审中-公开
标题翻译：承包组合物
公开(公告)号：WO2007106944A1
公开(公告)日：2007-09-27
申请号：PCT/AU2007/000352
申请日：2007-03-21
申请人： STARPHARMA PTY LIMITED , MCCARTHY, Thomas, David
发明人： MCCARTHY, Thomas, David
IPC分类号： A61K31/785 , A61P15/18 , A61P31/12
CPC分类号： A61K31/785 , Y10S977/754
摘要： The present invention relates to a contraceptive composition including an effective amount of a dendrimer compound including one or more naphthyl disulphonic acid surface groups, or a pharmaceutically acceptable salt or solvate of the dendrimer compound; and a pharmaceutically acceptable carrier, excipient and/or diluent therefor. The contraceptive composition may also exhibit antimicrobial activity. The invention also relates to a method of selectively reducing or preventing conception in a female animal, including a human, which method includes administering to the animal an effective amount of a contraceptive composition which composition includes an effective amount of a dendrimer compound including one or more naphthyl disulphonic acid surface groups, or a pharmaceutically acceptable salt or solvate of the dendrimer compound; and a pharmaceutically acceptable carrier, excipient and/or diluent therefor.
摘要翻译：本发明涉及一种避孕组合物，其包含有效量的包含一个或多个萘基二磺酸表面基团的树枝状大分子化合物，或其树枝状大分子化合物的药学上可接受的盐或溶剂合物; 和其药学上可接受的载体，赋形剂和/或稀释剂。避孕组合物还可以表现出抗微生物活性。本发明还涉及一种在女性动物（包括人）中选择性地减少或预防受孕的方法，该方法包括向动物施用有效量的避孕组合物，该组合物包含有效量的包括一种或多种的树突状化合物萘基二磺酸表面基团，或其树枝状大分子化合物的药学上可接受的盐或溶剂合物; 和其药学上可接受的载体，赋形剂和/或稀释剂。

10. 发明申请

WO2007082331A1 MODIFIED MACROMOLECULE 审中-公开
标题翻译：改性大分子
公开(公告)号：WO2007082331A1
公开(公告)日：2007-07-26
申请号：PCT/AU2006/000637
申请日：2006-05-15
申请人： STARPHARMA PTY LIMITED , BOYD, Benjamin, James , KAMINSKAS, Lisa, Michelle , PORTER, Christopher, John, Hamilton , KARELLAS, Peter , KRIPPNER, Guy, Yeoman , KELLY, Brian, Devlin , WU, Zemin , RAZZINO, Pasquale , PALLICH, Sue
发明人： BOYD, Benjamin, James , KAMINSKAS, Lisa, Michelle , PORTER, Christopher, John, Hamilton , KARELLAS, Peter , KRIPPNER, Guy, Yeoman , KELLY, Brian, Devlin , WU, Zemin , RAZZINO, Pasquale , PALLICH, Sue
IPC分类号： A61K31/74 , A61K31/785 , A61K47/48 , C08G69/08 , C08G69/10 , C08G81/00
CPC分类号： C08G65/33396 , A61K31/74 , A61K31/785 , A61K47/59 , A61K47/595 , A61K47/60 , A61K47/645 , C08G69/10 , C08G83/003
摘要： The present invention relates to a macromolecule having a controlled terminal group stoichiometry, the macromolecule including a surface layer, at least one subsurface layer and at least two terminal groups including: a first terminal group which is a residue of a pharmaceutically active agent, a derivative thereof or precursor therefor; and a second terminal group selected to modify the pharmacokinetics of the pharmaceutically active agent and/or macromolecule, wherein terminal group stoichiometry refers to the number and type of terminal groups.
摘要翻译：本发明涉及具有受控终端基团化学计量的大分子，所述高分子包括表面层，至少一个地下层和至少两个末端基团，所述末端基团包括：第一末端基团，其为药物活性剂的残基，衍生物或其前体; 和选择用于修饰药物活性剂和/或大分子的药代动力学的第二末端基团，其中末端基团化学计量指的是末端基团的数量和类型。

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