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1. 发明申请

WO2017017124A1 HIV KINASE VARIANTS 审中-公开
标题翻译：艾滋病毒激素变种
公开(公告)号：WO2017017124A1
公开(公告)日：2017-02-02
申请号：PCT/EP2016/067865
申请日：2016-07-27
申请人： GLOBAL BIOENERGIES , SCIENTIST OF FORTUNE S.A.
发明人： MAZALEYRAT, Sabine , BARBAROUX, Jean-Baptiste , DELCOURT, Marc , STRICHER, Francois , MARLIERE, Philippe
IPC分类号： C12P5/02
CPC分类号： C12N9/12 , C12N9/88 , C12P5/02 , C12Y401/01033
摘要： Described are HIV kinase variants showing an improved activity in converting 3- hydroxyisovalerate (HIV) into 3-phosphonoxyisovalerate (PIV), methods for the production of PIV using such enzyme variants as well as methods for the production isobutene in a subsequent reaction.
摘要翻译：描述了显示出将3-羟基异戊酸酯（HIV）转化为3-膦酸异戊酸酯（PIV）的改善的活性的HIV激酶变体，使用这种酶变体生产PIV的方法以及在后续反应中生产异丁烯的方法。

2. 发明申请

WO2015144447A1 ENZYMATIC PRODUCTION OF ACETYL PHOSPHATE FROM FORMALDEHYDE 审中-公开
标题翻译：从甲醛生产乙酸磷酸酯
公开(公告)号：WO2015144447A1
公开(公告)日：2015-10-01
申请号：PCT/EP2015/055254
申请日：2015-03-13
申请人： SCIENTIST OF FORTUNE S.A.
发明人： MARLIERE, Philippe
IPC分类号： C12P9/00
CPC分类号： C12P9/00 , C12Y203/03015 , C12Y401/02009 , C12Y401/02022
摘要： Described is a method for the enzymatic production of acetyl phosphate from formaldehyde using a phosphoketolase or a sulfoacetaldehyde acetyltransferase.
摘要翻译：描述了使用磷酸酮糖苷酶或磺乙醛乙酰转移酶从甲醛酶促生产乙酰基磷酸的方法。

3. 发明申请

WO2014001517A1 PROCESS FOR PRODUCING A C2-C10 MONOALKENE EMPLOYING A TERPENE SYNTHASE OR A PRENYL TRANSFERASE 审中-公开
标题翻译：生产使用酪蛋白合成酶或丙烯转移酶的C2-C10单烷醇的方法
公开(公告)号：WO2014001517A1
公开(公告)日：2014-01-03
申请号：PCT/EP2013/063657
申请日：2013-06-28
申请人： SCIENTIST OF FORTUNE S.A. , GLOBAL BIOENERGIES
发明人： MARLIÈRE, Philippe , ANISSIMOVA, Maria , ALLARD, Mathieu
IPC分类号： C12P5/02 , C12N9/88 , C12N9/10
CPC分类号： C12P5/026 , C12N9/1085 , C12N9/88 , C12Y402/03 , Y02P20/52
摘要： The present invention relates to a method for producing a monoalkene comprising the step of enzymatically converting an alkyl monoester. The conversion preferably makes use of an enzyme which belongs to the group of terpene synthases or to the family of prenyltransferases. Moreover, the present invention relates to the use of a terpene synthase or of a prenyltransferase for enzymatically converting an alkyl monoester into a monoalkene.
摘要翻译：本发明涉及一种生产单链烯烃的方法，包括将烷基单酯酶转化的步骤。该转化优选利用属于萜烯合成酶或异戊烯基转移酶家族的酶。此外，本发明涉及萜烯合酶或异戊烯基转移酶用于将烷基单酯酶化转化成单烯烃的用途。

4. 发明申请

WO2013150100A1 METHOD FOR THE ENZYMATIC PRODUCTION OF ISOPRENOL USING MEVALONATE AS A SUBSTRATE 审中-公开
标题翻译：使用甲基丙烯酸酯作为底物生产异丙苯的方法
公开(公告)号：WO2013150100A1
公开(公告)日：2013-10-10
申请号：PCT/EP2013/057108
申请日：2013-04-04
申请人： GLOBAL BIOENERGIES , SCIENTIST OF FORTUNE S.A.
发明人： DELCOURT, Marc , ANISSIMOVA, Maria , MARLIERE, Philippe
IPC分类号： C12P7/04 , C12P5/00 , C12N1/00 , C12N9/88
CPC分类号： C12P7/04 , C12N9/88 , C12P5/007 , C12Y401/01033
摘要： Described is a method for generating isoprenol through a biological process. More specifically, described is a method for producing isoprenol from mevalonate.
摘要翻译：描述了通过生物过程产生异戊二烯醇的方法。更具体地，描述了从甲羟戊酸生产异戊二烯醇的方法。

5. 发明申请

WO2017085167A2 METHODS FOR PRODUCING ISOBUTENE FROM 3-METHYLCROTONIC ACID 审中-公开
标题翻译：从3-甲基丙酮酸生产异丁烯的方法
公开(公告)号：WO2017085167A2
公开(公告)日：2017-05-26
申请号：PCT/EP2016/077956
申请日：2016-11-17
申请人： GLOBAL BIOENERGIES , SCIENTIST OF FORTUNE S.A.
发明人： ALLARD, Mathieu , ANISSIMOVA, Maria , MARLIERE, Philippe
IPC分类号： C12P5/02 , C12P7/40 , C12N15/52 , C12N9/00 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/88
CPC分类号： C12P5/026 , C12N9/1029 , C12N9/1085 , C12N9/1217 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/40 , C12Y205/01 , C12Y207/02007 , C12Y207/02014 , C12Y207/02015 , C12Y208/03001 , C12Y208/03008 , C12Y301/02001 , C12Y301/02018 , C12Y301/0202 , C12Y401/01006 , C12Y401/01063 , C12Y604/01004 , C12Y604/01005
摘要： Described are methods for the production of isobutene comprising the enzymatic conversion of 3-methylcrotonic acid into isobutene wherein said 3-methylcrotonic acid is obtained by the enzymatic conversion of 3-methylcrotonyl-CoA into 3- methylcrotonic acid or wherein said 3-methylcrotonic acid is obtained by the enzymatic conversion of 3-hydroxyisovalerate (HIV) into 3-methylcrotonic acid. It is described that the enzymatic conversion of 3-methylcrotonic acid into isobutene can, e.g., be achieved by making use of a 3-methylcrotonic acid decarboxylase, preferably an FMN-dependent decarboxylase associated with an FMN prenyl transferase, an aconitate decarboxylase (EC 4.1.1.6), a methylcrotonyl-CoA carboxylase (EC 6.4.1.4), or a geranoyl-CoA carboxylase (EC 6.4.1.5).
摘要翻译：描述了用于生产异丁烯的方法，其包括将3-甲基巴豆酸酶促转化为异丁烯，其中所述3-甲基巴豆酸通过将3-甲基巴豆基辅酶A酶促转化为3-甲基巴豆酸或其中所述3-甲基巴豆酸是通过将3-羟基异戊酸（HIV）酶促转化为3-甲基巴豆酸而获得的。据描述，3-甲基巴豆酸到异丁烯的酶促转化可以例如通过利用3-甲基巴豆酸脱羧酶，优选与FMN异戊烯转移酶，乌头酸脱羧酶（EC 4.1）相关的FMN依赖性脱羧酶 1.6），甲基巴豆酰辅酶A羧化酶（EC 6.4.1.4）或ge烯酰辅酶A羧化酶（EC 6.4.1.5）。

6. 发明申请

WO2016097293A1 PROCESS FOR THE ENZYMATIC PRODUCTION OF 1-BUTENE FROM 2-PENTENOYL-COA 审中-公开
标题翻译： 2-PENTENOYL-COA生产1-丁烯的方法
公开(公告)号：WO2016097293A1
公开(公告)日：2016-06-23
申请号：PCT/EP2015/080491
申请日：2015-12-18
申请人： GLOBAL BIOENERGIES , SCIENTIST OF FORTUNE S.A.
发明人： ALLARD, Mathieu , MARLIERE, Philippe
IPC分类号： C12P5/02 , C12P7/24 , C12P7/64 , C12P11/00 , C12N9/10 , C12N9/12 , C12N9/16
CPC分类号： C12P5/026 , C12N9/88 , C12P7/24 , C12P7/6409 , C12P7/6436 , C12P11/00
摘要： Described is a method for the production of 2-pentenoic acid comprising the enzymatic conversion of 2-pentenoyl-CoA into 2-pentenoic acid comprising two enzymatic steps comprising (i) first enzymatically converting 2-pentenoyl-CoA into 2-pentenoyl phosphate; and (ii) then enzymatically converting the thus obtained 2-pentenoyl phosphate into said 2-pentenoic acid; or a single enzymatic reaction in which 2-pentenoyl-CoA is directly converted into 2-pentenoic acid by making use of a CoA transferase (EC 2.8.3.-), preferably a butyryl-CoA:acetate-CoA transferase (EC 2.8.3.8).
摘要翻译：描述了一种生产2-戊烯酸的方法，其包括将2-戊烯酰辅酶A酶促转化成2-戊烯酸，其包括两个酶步骤，包括（i）首先将2-戊烯酰辅酶A酶促转化为2-戊烯酰磷酸酯; 和（ii）然后将由此获得的2-戊烯酰磷酸酯酶促转化成所述2-戊烯酸; 或通过使用CoA转移酶（EC 2.8.3.-），优选丁酰辅酶A：乙酸酯-CoA转移酶（EC 2.8）直接将2-戊烯酰辅酶A直接转化为2-戊烯酸的单一酶促反应。 3.8）。

7. 发明申请

WO2016075244A1 ALKENOL DEHYDRATASE VARIANTS 审中-公开
公开(公告)号：WO2016075244A1
公开(公告)日：2016-05-19
申请号：PCT/EP2015/076450
申请日：2015-11-12
申请人： GLOBAL BIOENERGIES , SCIENTIST OF FORTUNE S.A.
发明人： MAZALEYRAT, Sabine , DELCOURT, Marc , MARLIERE, Philippe
IPC分类号： C12N9/88
CPC分类号： C12P5/026 , C12N9/88 , C12Y402/01127
摘要： Described are alkenol dehydratase variants having improved activity in catalyzing the conversion of prenol into isoprene, methods for the production of isoprene using such enzyme variants and their uses in the production of isoprene from prenol.
摘要翻译：描述了具有改善的活性来催化前醇醇转化成异戊二烯的烯醇脱水酶变体，使用这种酶变体生产异戊二烯的方法及其在从异戊二烯生产异戊二烯的用途。

8. 发明申请

WO2015000981A2 METHOD FOR THE ENZYMATIC PRODUCTION OF 3-BUTEN-2-ONE 审中-公开
标题翻译： 3-BUTEN-2-ONE生产酶的方法
公开(公告)号：WO2015000981A2
公开(公告)日：2015-01-08
申请号：PCT/EP2014/064102
申请日：2014-07-02
申请人： SCIENTIST OF FORTUNE S.A. , GLOBAL BIOENERGIES
发明人： MARLIERE, Philippe , ANISSIMOVA, Maria , ALLARD, Mathieu
IPC分类号： C12P5/02 , C12P7/26 , C12P7/16 , C12N1/00
CPC分类号： C12P7/16 , C12N1/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/88 , C12N15/52 , C12N15/70 , C12P5/026 , C12P7/04 , C12P7/26 , C12P19/32 , C12Y101/01001 , C12Y101/0103 , C12Y101/01034 , C12Y101/01184 , C12Y102/0105 , C12Y103/08001 , C12Y402/01017 , C12Y402/01018 , C12Y402/01055 , C12Y402/01059 , C12Y402/01074 , C12Y402/01116 , C12Y402/01127 , Y02E50/10
摘要： Described is a method for the production of 3-buten-2-one comprising the enzymatic conversion of 4-hydroxy-2-butanone into 3-buten-2-one by making use of an enzyme catalyzing 4-hydroxy-2-butanone dehydration, wherein said enzyme catalyzing 4-hydroxy-2-butanone dehydration is (a) a 3-hydroxypropiony-CoA dehydratase (EC 4.2.1.116), (b) a 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55), (c) an enoyl-CoA hydratase (EC 4.2.1.17), (d) a 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59), (e) a crotonyl-[acyl-carrier-protein] hydratase (EC 4.2.1.58), (f) a 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.60), (g) a 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61 ), (h) a long-chain-enoyl-CoA hydratase (EC 4.2.1.74), or (i) a 3-methylglutaconyl-CoA hydratase (EC 4.2.1.18). The produced 3-buten-2-one can be further converted into 3-buten-2-ol and finally into 1,3-butadiene.
摘要翻译：描述了用于生产3-丁烯-2-酮的方法，其包括通过利用酶催化将4-羟基-2-丁酮转化为3-丁烯-2-酮其中所述催化4-羟基-2-丁酮脱水的酶是（a）3-羟基丙酸-CoA脱水酶（EC 4.2.1.116），（b）3-羟基丁酰-CoA脱水酶（4-羟基-2-丁酮脱水酶 EC 4.2.1.55），（c）烯酰-CoA水合酶（EC 4.2.1.17），（d）3-羟基辛酰基 - [酰基 - 载体 - 蛋白]脱水酶（EC 4.2.1.59），（e）巴豆酰 - （EC 4.2.1.58），（f）3-羟基癸酰基 - [酰基 - 载体 - 蛋白]脱水酶（EC 4.2.1.60），（g）3-羟基棕榈酰基 - [酰基 - 载体（EC 4.2.1.61），（h）长链烯酰-CoA水合酶（EC 4.2.1.74）或（i）3-甲基戊烯酰-CoA水合酶（EC 4.2.1.18）。生成的3-丁烯-2-酮可以进一步转化成3-丁烯-2-醇，最后转化为1,3-丁二烯。

9. 发明申请

WO2013007786A1 RECOMBINANT MICROORGANISM FOR THE PRODUCTION OF USEFUL METABOLITES 审中-公开
标题翻译：用于生产有用代谢物的重组微生物
公开(公告)号：WO2013007786A1
公开(公告)日：2013-01-17
申请号：PCT/EP2012/063685
申请日：2012-07-12
申请人： SCIENTIST OF FORTUNE S.A. , MARLIERE, Philippe
发明人： MARLIERE, Philippe
IPC分类号： C12N9/04 , C12N9/12 , C12N9/88 , C12P7/28 , C12N9/00
CPC分类号： C12P7/28 , C12N9/16 , C12N9/88 , C12N15/63 , C12P5/026 , C12P17/182 , C12P19/32 , C12Y301/03011 , C12Y401/02009 , C12Y401/02022 , Y02P20/52
摘要： Described are recombinant microorganisms characterized by having phosphoketolase activity, having a diminished or inactivated Embden-Meyerhof-Parnas pathway (EMPP) by inactivation of the gene(s) encoding phosphofructokinase or by reducing phosphofructokinase activity as compared to a non-modified microorganism and having a diminished or inactivated oxidative branch of the pentose phosphate pathway (PPP) by inactivation of the gene(s) encoding glucose-6-phosphate dehydrogenase or by reducing glucose-6-phosphate dehydrogenase activity as compared to a non-modified microorganism. These microorganisms can be used for the production of useful metabolites such as acetone, isobutene or propene.
摘要翻译：描述的是具有磷酸酮醇酯酶活性的重组微生物，与未修饰的微生物相比，通过灭活编码磷酸果糖激酶的基因或通过减少磷酸果糖激酶活性而具有减少或失活的Embden-Meyerhof-Parnas途径（EMPP）通过灭活编码葡萄糖-6-磷酸脱氢酶的基因或通过降低葡萄糖-6-磷酸脱氢酶活性与未修饰的微生物相比，戊糖磷酸途径（PPP）的减少或失活的氧化分支。这些微生物可用于生产有用的代谢物如丙酮，异丁烯或丙烯。

10. 发明申请

WO2017162738A1 METHOD FOR PRODUCING ISOBUTENE FROM 3-METHYLCROTONYL-COA 审中-公开
标题翻译：由3-甲基烟酰基-CoA制备异丁烯的方法
公开(公告)号：WO2017162738A1
公开(公告)日：2017-09-28
申请号：PCT/EP2017/056822
申请日：2017-03-22
申请人： GLOBAL BIOENERGIES , SCIENTIST OF FORTUNE S.A.
发明人： ALLARD, Mathieu , MARLIERE, Philippe
IPC分类号： C12P5/02
摘要： Described is a method for the production of isobutene from 3-methylcrotonyl-CoA comprising the steps of: (a) enzymatically converting 3-methylcrotonyl-CoA into 3-methylbutyric acid; and (b) further enzymatically converting the thus produced 3-methylbutyric acid into isobutene. The conversion of 3-methylcrotonyl-CoA into 3-methylbutyric acid can be achieved by first enzymatically converting 3-methylcrotonyl-CoA into 3-methylbutyryl-CoA and further enzymatically converting the thus produced 3-methylbutyryi-CoA into 3-methylbutyric acid. Alternatively, the conversion of 3-methylcrotonyl-CoA into 3-methylbutyric acid can be achieved by first enzymatically converting 3- methylcrotonyl-CoA into 3-methylcrotonic acid and then further enzymatically converting the thus produced 3-methylcrotonic acid into 3-methylbutyric acid.
摘要翻译：描述了由3-甲基巴豆酰辅酶A生产异丁烯的方法，其包括以下步骤：（a）将3-甲基巴豆酰辅酶A酶促转化为3-甲基丁酸; 和（b）将由此产生的3-甲基丁酸进一步酶促转化为异丁烯。 3-甲基巴豆酰辅酶A向3-甲基丁酸的转化可以通过首先将3-甲基巴豆酰辅酶A酶促转化为3-甲基丁酰辅酶A并进一步酶促将如此产生的3-甲基丁酰辅酶A转化成3-甲基丁酸来实现。或者，3-甲基巴豆酰辅酶A向3-甲基丁酸的转化可以通过首先将3-甲基巴豆酰辅酶A酶促转化成3-甲基巴豆酸然后将由此产生的3-甲基巴豆酸进一步酶促转化成3-甲基丁酸来实现。

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