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1. 发明申请

WO2018090008A2 MICROTOME 审中-公开
标题翻译：切片机
公开(公告)号：WO2018090008A2
公开(公告)日：2018-05-17
申请号：PCT/US2017/061551
申请日：2017-11-14
申请人： SAKURA FINETEK U.S.A., INC.
发明人： BUI, Xuan S. , RIOS, Alyicia Marie , VON BUEREN, Erico
IPC分类号： G01N1/06
摘要： The invention is generally directed to a microtome, including, for example, a microtome chuck having a light source, a generator, a storage system and/or a waste removal assembly.
摘要翻译：本发明总体上涉及一种切片机，其包括例如具有光源，发生器，储存系统和/或废物去除组件的切片机卡盘。

2. 发明申请

WO2014172530A1 METHOD FOR GENERATING A COMPOSITE IMAGE OF AN OBJECT COMPOSED OF MULTIPLE SUB-IMAGES 审中-公开
标题翻译：用于生成由多个子图像组成的对象的复合图像的方法
公开(公告)号：WO2014172530A1
公开(公告)日：2014-10-23
申请号：PCT/US2014/034477
申请日：2014-04-17
申请人： SAKURA FINETEK U.S.A., INC.
发明人： FUCHS, Frank
IPC分类号： G02B21/00
CPC分类号： G06T3/4038 , G02B21/16 , G02B21/367 , G06K9/342 , G06T5/50 , G06T2207/10024 , G06T2207/10056 , G06T2207/20221 , G06T2207/30004
摘要： The invention relates to a method for combining a composite image (4) of an object (8) composed of multiple sub-images (6) by means of so-called stitching. Multiple adjacent sub-images (6) of the object (8) are captured and are stitched by means of an image processing operation together to form a coherent composite image (4). In order to make it possible to stitch the sub-images (6) together in the correct position even in the case of little information about the image, it is proposed that the stitching of the sub-images (6) together to form the composite image in the image processing operation be performed using an optical pattern (30, 74) that is generated by means of a pattern means (44).
摘要翻译：本发明涉及一种通过所谓拼接来组合由多个子图像（6）构成的物体（8）的合成图像（4）的方法。拍摄对象（8）的多个相邻子图像（6），并通过图像处理操作将其缝合以形成相干合成图像（4）。为了使得即使在关于图像的信息很少的情况下，也可以将子图像（6）拼接在正确的位置，因此提出将子图像（6）的拼接在一起以形成复合物使用通过图案装置（44）产生的光学图案（30,74）来执行图像处理操作中的图像。

3. 发明申请

WO2012024627A1 DIGITAL MICROSCOPE 审中-公开
标题翻译：数字显微镜
公开(公告)号：WO2012024627A1
公开(公告)日：2012-02-23
申请号：PCT/US2011/048488
申请日：2011-08-19
申请人： SAKURA FINETEK U.S.A., INC. , HING, Paul , ROMER, Christian , HENSLER, Sven
发明人： HING, Paul , ROMER, Christian , HENSLER, Sven
IPC分类号： G02B21/36
CPC分类号： G02B21/367 , G02B21/361 , G02B21/365
摘要： A method and a computer-readable medium containing instructions to perform a method including sensing an image without magnification of a portion of a tissue sample on a substrate with a sensor; displaying the sensed image on a display at a sensor to display pixel ratio greater than one to one; and performing at least one of the following: refreshing the sensed image at a predetermined rate, storing the sensed image, modifying the sensor to display pixel ratio, and sensing a magnified view of an area of the portion of the tissue sample. An apparatus including a digital microscope (150) comprising: at least one image sensor (160); a stage (180) configured to support at least one microscope slide (210); a first optic (168) configured to project an image with a magnification of one or less; a second optic (170) disposed between the at least one sensor and the stage, the second optic configured to project an image with a magnification greater than one; and a light source (195, 196); and a computer (110) coupled to the digital microscope (150) and operable to direct an image capture by the at least one image sensor of a portion of a microslide on the stage projected through the first optic or the second optic.
摘要翻译：一种方法和计算机可读介质，其包含用于执行方法的指令，所述方法包括：在传感器的基板上不使组织样本的一部分放大的情况下感测图像; 在传感器的显示器上显示感测图像以显示大于1比1的像素比; 并且执行以下中的至少一个：以预定速率刷新感测到的图像，存储感测图像，修改传感器以显示像素比，以及感测组织样本的该部分区域的放大视图。一种包括数字显微镜（150）的设备，包括：至少一个图像传感器（160）; 构造成支撑至少一个显微镜载玻片（210）的平台（180）; 第一光学器件（168），被配置为以一个或更小的放大率投影图像; 设置在所述至少一个传感器和所述台之间的第二光学器件（170），所述第二光学器件被配置为以大于1的倍率投影图像; 和光源（195,196）; 以及联接到数字显微镜（150）的计算机（110），并且可操作以将所述至少一个图像传感器引导到通过所述第一光学器件或所述第二光学器件投射的所述台上的微滑块的一部分的图像捕获。

4. 发明申请

WO2017180160A1 METHODS TO REDUCE EVAPORATION DURING ELEVATED TEMPERATURE 审中-公开
标题翻译：减少高温蒸发的方法
公开(公告)号：WO2017180160A1
公开(公告)日：2017-10-19
申请号：PCT/US2016/027945
申请日：2016-04-15
申请人： SAKURA FINETEK U.S.A., INC.
发明人： YAMANISHI, Douglas T. , HOM, Clifford , SHAH, Amit D.
IPC分类号： C12Q1/68
摘要： A method including contacting a tissue or cellular sample with a reagent including an evaporation reducing agent(s) having the general formula X 1 - R - X 2 , wherein R is an alkyl, alkenyl, alkynyl or an aromatic moiety of 1 or more carbon atoms that may be substituted with an oxygen, nitrogen or sulfur and X 1 and X 2 are independently selected to be moiety that is susceptible to hydrogen bonding and processing the tissue or cellular sample. A reagent used in the processing of a tissue or cellular sample with the reagent containing an evaporation reducing agent.
摘要翻译：包括使组织或细胞样品与包含具有通式X 1 -X 1 -X 2的蒸发减少剂的试剂接触，其中R是可以被氧，氮或硫取代的1个或更多个碳原子的烷基，烯基，炔基或芳族部分，并且X 1和X 2 被独立选择为对氢键和加工组织或细胞样品敏感的部分。用于处理含有蒸发减少剂的试剂的组织或细胞样品中的试剂。

5. 发明申请

WO2019074941A1 TISSUE CASSETTE READER 审中-公开
公开(公告)号：WO2019074941A1
公开(公告)日：2019-04-18
申请号：PCT/US2018/055037
申请日：2018-10-09
申请人： SAKURA FINETEK U.S.A., INC.
发明人： VON BUEREN, Erico , GREENLEE, Joshua
IPC分类号： G01N1/31 , G01N35/00 , G01N1/36
摘要： An apparatus and system including an apparatus to identify an identifier on a tissue cassette in an assembly of a plurality of tissue cassettes including a light source operable to illuminate a plurality of tissue cassettes; a sensor operable to automatically capture an identifier on an individual tissue cassette or an image of the plurality of tissue cassettes in the assembly; and where the sensor is operable to capture reflected light from the light source of an image of the plurality of tissue cassettes, a converter to convert image data into an electronic signal. The system may include a processor operable to compare an identifier with a tissue processing protocol. A method including sensing identifiers on tissue cassettes each containing a tissue sample in an assembly comprising a plurality of tissue cassettes; and determining or verifying a tissue processing protocol of a tissue sample based on the sensed identifier.

6. 发明申请

WO2014150049A1 BIOLOGICAL SPECIMEN HANDLING APPARATUS AND METHOD 审中-公开
标题翻译：生物标本处理设备和方法
公开(公告)号：WO2014150049A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/022003
申请日：2014-03-07
申请人： SAKURA FINETEK U.S.A., INC.
发明人： MCCORMICK, James B.
IPC分类号： G01N1/36
CPC分类号： G01N1/36
摘要： Mold (14) for receiving a tissue specimen and molten embedding material improving the ease of withdrawing the embedded tissue specimen. The mold has a barrier coating (40) intimately bonded to one or more surfaces of the mold that repels the attraction of the embedding material to the one or more mold surfaces and produces a positive meniscus of the embedding material in the mold.
摘要翻译：用于接收组织样本和熔融包埋材料的模具（14），改善了提取嵌入的组织样本的容易性。模具具有紧密地结合到模具的一个或多个表面上的阻挡涂层（40），其将嵌入材料的吸引力排斥到一个或多个模具表面，并且在模具中产生嵌入材料的正弯液面。

7. 发明申请

WO2013095972A2 RECIPROCATING MICROTOME DRIVE SYSTEM 审中-公开
标题翻译：往复式MICROTOME DRIVE系统
公开(公告)号：WO2013095972A2
公开(公告)日：2013-06-27
申请号：PCT/US2012/068747
申请日：2012-12-10
申请人： SAKURA FINETEK U.S.A., INC.
发明人： YANG, Hwai-Jyh Michael , BUI, Xuan S.
IPC分类号： G01N1/06
CPC分类号： G01N1/06 , G01N2001/065 , G05B15/02 , Y10S83/9155 , Y10T83/04 , Y10T83/50 , Y10T83/6475 , Y10T83/6512 , Y10T83/654 , Y10T83/6563 , Y10T83/6572
摘要： An apparatus having a sample sectioning device including a cutting mechanism that is operable to cut sections from a sample and a sample holder that is operable to hold the sample. The apparatus further includes a drive system coupled with the sample holder to drive movement of the sample holder and a reciprocating member coupled to the drive system to drive vertical movement of the drive system. The reciprocating member to move in a reciprocating manner within an angle of rotation of less than 180 degrees. A surface orientation sensor may further be provided that is operable to sense an orientation of a surface of the sample held by the sample holder.
摘要翻译：一种具有样本切片装置的设备，所述样本切片装置包括切割机构，所述切割机构可操作以切割来自样本的部分和可操作以保持所述样本的样本保持器。该设备还包括驱动系统，该驱动系统与样本保持器耦合以驱动样本保持器的运动以及耦合到驱动系统的往复运动构件以驱动驱动系统的垂直运动。往复运动构件以小于180度的旋转角度往复运动。还可以提供表面取向传感器，该表面取向传感器可操作用于感测样本架所保持的样本的表面的取向。

8. 发明申请

WO2014042873A1 MICROTOME SECTIONABLE GEL SUPPORT STRUCTURE AND METHODS 审中-公开
标题翻译： MICROTOME SECTIONABLE凝胶支持结构和方法
公开(公告)号：WO2014042873A1
公开(公告)日：2014-03-20
申请号：PCT/US2013/057001
申请日：2013-08-28
申请人： BIOPATH AUTOMATION, L.L.C. , SAKURA FINETEK U.S.A., INC.
发明人： WILLIAMSON, Warren, P. , DAPSON, Richard, W. , SHAH, Amit, D.
IPC分类号： B01L3/00 , G01N1/18 , G01N1/28 , G01N1/36
CPC分类号： G01N1/31 , G01N1/06 , G01N1/36 , G01N2001/368
摘要： A sectionable tissue sample support structure (12) including a gel compound formed into a self supporting geometric shape for retention and orientation of at least one tissue sample (16) during a histopathology process including processing, embedding and microtome slicing of the tissue sample (1 6). A method of orienting, processing, embedding and microtome slicing a tissue sample (16) using a gel compound preformed into a self supporting geometric shape (12). A combination including the sectionable tissue sample support structure (12) and a package (40, 42) containing the sectionable tissue sample support structure (12).
摘要翻译：一种可切片的组织样本支持结构（12），包括形成为自支撑几何形状的凝胶化合物，用于在组织病理学过程期间保留和取向至少一个组织样品（16），包括组织样品（1）的加工，包埋和切片切片 6）。使用预成形为自支撑几何形状（12）的凝胶化合物来定向，加工，包埋和切片切片组织样品（16）的方法。包括可切片组织样本支持结构（12）和包含可切片组织样本支撑结构（12）的包装（40,42）的组合。

9. 发明申请

WO2005019092A2 FLUID DISPENSING APPARATUS 审中-公开
标题翻译：流体分配装置
公开(公告)号：WO2005019092A2
公开(公告)日：2005-03-03
申请号：PCT/US2004/025960
申请日：2004-08-11
申请人： SAKURA FINETEK U.S.A., INC. , HERSCH, Michael , PALERMO, Henry, W.
发明人： HERSCH, Michael , PALERMO, Henry, W.
IPC分类号： B67D
CPC分类号： B01L3/0265 , B01L3/0206 , B01L2200/0605 , B01L2400/0478 , B01L2400/0633 , B01L2400/0666 , G01F11/021 , G01N35/1002 , Y10T436/112499 , Y10T436/2575
摘要： A fluid dispensing apparatus includes a mounting assembly having a plurality of mounting apertures and a plurality of fluid dispensing cartridges positioned within the mounting apertures. The mounting apertures and cartridges include matching cross-sectional profiles preferably that lack symmetry. Each fluid dispensing cartridge includes a fluid reservoir, at least one valve, a metering chamber and a displaceable member.
摘要翻译：流体分配装置包括具有多个安装孔的安装组件和位于安装孔内的多个流体分配筒。安装孔和盒包括优选地缺乏对称性的匹配横截面轮廓。每个流体分配筒包括流体储存器，至少一个阀，计量室和可移位构件。

10. 发明申请

WO2018090008A3 MICROTOME 审中-公开
公开(公告)号：WO2018090008A3
公开(公告)日：2018-05-17
申请号：PCT/US2017/061551
申请日：2017-11-14
申请人： SAKURA FINETEK U.S.A., INC.
发明人： BUI, Xuan, S. , RIOS, Alyicia, Marie , VON BUEREN, Erico
IPC分类号： G01N1/06 , G01N21/17
摘要： A microtome (100, 1202) chuck having: a mounting portion (204) having a mating surface (1406, 1606) operable to removably attach the mounting portion (204) to a sample (116, 126) sectioning device (1100), and an electrical contact operable to electrically connect the mounting portion (204) to a power source (1104, 518); a sample receiving portion (202, 204, 210) coupled to the mounting portion (204), the sample receiving portion (202, 204, 210) having a sample receiving surface (206) dimensioned to receive a sample (116, 126); a light source (1120, 116) coupled to the sample receiving portion (202, 204, 210), the light source (1120, 116) operable to emit a light from the sample receiving surface (206) and through a sample (116, 126) positioned along the sample receiving surface (206); and circuitry (516, 616) electrically connecting the light source (1120, 116) to the electrical contact of the mounting portion (204).

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