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1. 发明申请

WO2011153645A3 METHOD OF FORMING PATIENT-SPECIFIC IMPLANT 审中-公开
标题翻译：形成患者特异性植入物的方法
公开(公告)号：WO2011153645A3
公开(公告)日：2012-02-02
申请号：PCT/CA2011050357
申请日：2011-06-10
申请人： SUNNYBROOK HEALTH SCIENCES CT , ANTONYSHYN OLEH , EDWARDS GLENN , MAINPRIZE JAMES
发明人： ANTONYSHYN OLEH , EDWARDS GLENN , MAINPRIZE JAMES
IPC分类号： A61F2/02 , A61F2/28 , B22C9/22 , B22C13/00 , B29C43/02 , B29C43/36 , C08J5/00
CPC分类号： B29C51/082 , A61B17/8085 , A61B2017/568 , A61F2/28 , A61F2/2875 , A61F2/30942 , A61F2002/3096 , A61F2240/004 , B29C51/265 , B29C51/428 , B29C51/46 , B29K2101/12 , B29K2105/256 , B29K2995/0056 , B29L2031/7532 , B33Y50/00 , B33Y80/00
摘要： Methods and apparatus are provided for forming a patient-specific surgical implant based on mold system. The apparatus comprises a forming tool and a mold that may be generated using imaging and processing techniques and rapid prototyping methods. The mold apparatus includes at least two non-adjacent surface features for securing an implant forming material (such as a titanium mesh) during the forming process, enabling the implant forming material to be stretched beyond its elastic and thus permanently deformed with the correct patient-specific curvature. The implant may include one or more anatomic surface features for guidance and registration when transferring the implant to a patient.
摘要翻译：提供了用于基于模具系统形成患者特异性手术植入物的方法和装置。该装置包括可以使用成像和处理技术和快速成型方法产生的成形工具和模具。模具设备包括至少两个不相邻的表面特征，用于在成形过程中固定植入物形成材料（例如钛网），使得植入物形成材料能够被拉伸超过其弹性，从而使正确的患者 - 具体曲率。植入物可以包括一个或多个解剖表面特征，用于在将植入物转移到患者时进行引导和配准。

2. 发明申请

WO2014087289A3 CALIBRATION APPARATUS 审中-公开
标题翻译：校准装置
公开(公告)号：WO2014087289A3
公开(公告)日：2014-08-21
申请号：PCT/IB2013060261
申请日：2013-11-20
申请人： KONINKL PHILIPS NV , SUNNYBROOK HEALTH SCIENCES CT
发明人： BHARAT SHYAM , KRUECKER JOCHEN , RAVI ANANTH , DEHGHAN MARVAST EHSAN
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61B8/0841 , A61B34/20 , A61B90/39 , A61B2034/2051 , A61B2034/2061 , A61B2090/363 , A61B2090/3925 , A61B2090/3966 , A61B2560/0223 , A61N5/1001 , A61N5/1027 , A61N5/103 , A61N5/1075 , G06T7/337 , G06T7/70 , G06T7/80 , G06T7/97 , G06T2207/10132 , G06T2207/30081
摘要： The invention relates to a calibration apparatus for calibrating a system for introducing an influencing element like a radiation source into an object, particularly for calibrating a brachytherapy system. First and second images show a longish introduction device (12) like a catheter and a tracking device (16) like an electromagnetically trackable guidewire inserted into the introduction device as far as possible,and the introduction device and a calibration element(46)having the same dimensions as the influencing element and being inserted into the introduction device as far as possible. A spatial relation between the tracking device and the calibration element is determined based on the images for calibrating the system. Knowing this spatial relation allows accurately determining an influencing plan like a brachytherapy treatment plan and accurately positioning the influencing element in accordance with the influencing plan, which in turn allows for a more accurate influencing of the object.
摘要翻译：本发明涉及一种用于校准用于将诸如辐射源的影响元件引入到物体中的系统的校准装置，特别是用于校准近距离放射治疗系统。第一图像和第二图像显示出尽可能插入到引入装置中的类似于导管和跟踪装置（16）的漫长导入装置（12），并且引入装置和校准元件（46）具有与影响元件相同的尺寸并且尽可能地插入到引入装置中。基于用于校准系统的图像来确定跟踪装置和校准元件之间的空间关系。了解这种空间关系可以准确地确定影响方案，如近距离放射疗法治疗计划，并根据影响计划准确定位影响因素，从而进一步影响对象。

3. 发明申请

WO2010051634A9 HUMAN PROGENITOR T-CELLS 审中-公开
标题翻译：人类胎儿T细胞
公开(公告)号：WO2010051634A9
公开(公告)日：2010-07-08
申请号：PCT/CA2009001601
申请日：2009-11-06
申请人： SUNNYBROOK HEALTH SCIENCES CT , ZUNIGA-PFLUECKER JUAN CARLOS , AWONG GENEVE , LA MOTTE-MOHS ROSS
发明人： ZUNIGA-PFLUECKER JUAN CARLOS , AWONG GENEVE , LA MOTTE-MOHS ROSS
IPC分类号： A61K35/14 , A61P31/18 , A61P35/00 , A61P37/06 , C12N5/0783 , C12N5/10
CPC分类号： C12N5/0647 , A61K35/17 , A61K2035/124 , C12N5/0636 , C12N5/0646 , C12N5/0663 , C12N5/0669 , C12N2501/2302 , C12N2501/2307 , C12N2501/2315 , C12N2501/42 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2502/99 , C12N2506/02 , C12N2506/11 , C12N2506/45 , G01N33/5005
摘要： Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described The human progenitor T cells have the phenotype CD34+CD7+CD 1a-CD5- or CD34+CD7+CDla-CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells b\ coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4) Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
摘要翻译：描述了能够成功移植鼠胸腺并分化成成熟的人T和NK细胞的人祖细胞T细胞。人祖细胞T细胞具有表型CD34 + CD7 + CD1a-CD5-或CD34 + CD7 + CD1a-CD5 +和衍生自人类造血干细胞，胚胎干细胞和与表达Notch受体配体（OP9-DL1或OP9-DL4）的细胞共培养的诱导多能干细胞。这样的细胞可用于多种应用，包括免疫重建，治疗的免疫缺陷和用于基因治疗中使用的基因的载体。

4. 发明申请

WO2012103650A9 ULTRASONIC PROBE WITH ULTRASONIC TRANSDUCERS ADDRESSABLE ON COMMON ELECTRICAL CHANNEL 审中-公开
标题翻译：带有超声波传感器的超声探头可在通用电气通道上寻址
公开(公告)号：WO2012103650A9
公开(公告)日：2012-09-20
申请号：PCT/CA2012050057
申请日：2012-01-31
申请人： SUNNYBROOK HEALTH SCIENCES CT , COURTNEY BRIAN , THIND AMANDEEP
发明人： COURTNEY BRIAN , THIND AMANDEEP
IPC分类号： G01S15/89 , A61B8/00 , F16F1/14 , G01D5/48 , G01N21/64 , G01N21/65 , G01N29/14 , G01S7/52 , G01S7/527
CPC分类号： A61B8/12 , A61B8/14 , A61B8/445 , A61B8/4466 , B06B1/06 , G10K11/352
摘要： Methods and apparatus are provided for electrically addressing multiple ultrasonic transducers that are connected to a common electrical channel and housed within an imaging probe. An imaging probe may comprise an imaging ultrasonic transducer and a moveable element for controlling the direction of an emitted imaging beam, and an angle sensing ultrasonic transducer, where the angle sensing ultrasonic transducer is configured for determining the direction of an ultrasonic imaging beam. The angle-sensing transducer may be configured to direct an angle sensing ultrasonic beam towards an acoustically reflective substrate and provide a signal by detecting a reflected ultrasonic beam reflected from the acoustically reflective substrate, where the acoustically reflective substrate is positioned relative to the movable element such that motion of the movable element produces a change in the signal.
摘要翻译：提供了用于电寻址连接到公共电通道并容纳在成像探针内的多个超声换能器的方法和装置。成像探头可以包括成像超声换能器和用于控制发射的成像束的方向的可移动元件以及角度感测超声换能器，其中角感测超声换能器被配置用于确定超声成像束的方向。角度感测换能器可以被配置为引导角度感测超声波束朝向声学反射基板并且通过检测从声学反射基板反射的反射超声波束来提供信号，其中声学反射基板相对于可移动元件被定位，例如可动元件的运动产生信号的变化。

5. 发明申请

WO2010057067A3 FOCUSED ULTRASOUND SYSTEM 审中-公开
标题翻译：聚焦超声系统
公开(公告)号：WO2010057067A3
公开(公告)日：2010-08-12
申请号：PCT/US2009064506
申请日：2009-11-16
申请人： SUNNYBROOK HEALTH SCIENCES CT , CHOPRA RAJIV , HYNYNEN KULLERVO , CHAU ANTHONY , WASPE ADAM CHRISTIAN
发明人： CHOPRA RAJIV , HYNYNEN KULLERVO , CHAU ANTHONY , WASPE ADAM CHRISTIAN
IPC分类号： A61B8/00 , A61B5/055
CPC分类号： A61N7/02 , A61B8/0816 , A61B34/70 , A61B2017/00084 , A61B2017/00106 , A61B2017/0084 , A61B2090/374 , A61N2007/0082
摘要： A focused ultrasound system includes an ultrasound transducer configured to emit focused ultrasound energy toward a subject and a positioning system configured to position the ultrasound transducer to localize the focused ultrasound energy within a target location. The positioning system includes a drive apparatus to translate the ultrasound transducer along at least one axis of motion and a motor controller to control the drive apparatus. The focused ultrasound system also includes a control system connected to the motor controller that is programmed to receive imaging/location data from an imaging system, determine positional coordinates of the target location based on the imaging/location data, and register the positional coordinates of the target location with the positioning system. The positional coordinates are sent to the motor controller via an input signal to cause the motor controller to control the drive apparatus so as to translate the ultrasound transducer.
摘要翻译：聚焦超声系统包括配置成朝向受试者发射聚焦的超声能量的超声换能器和配置成定位超声换能器以定位目标位置内的聚焦超声能量的定位系统。定位系统包括驱动装置，用于沿着至少一个运动轴平移超声波换能器和马达控制器以控制驱动装置。聚焦超声系统还包括连接到电动机控制器的控制系统，其被编程为从成像系统接收成像/位置数据，基于成像/位置数据确定目标位置的位置坐标，并且记录目标位置与定位系统。位置坐标通过输入信号发送到电动机控制器，使得电动机控制器控制驱动装置以便平移超声换能器。

6. 发明申请

WO2008086616B1 SCANNING MECHANISMS FOR IMAGING PROBE 审中-公开
标题翻译：成像探针的扫描机制
公开(公告)号：WO2008086616B1
公开(公告)日：2008-09-12
申请号：PCT/CA2008000092
申请日：2008-01-21
申请人： SUNNYBROOK HEALTH SCIENCES CT , COURTNEY BRIAN , MUNCE NIGEL ROBERT , THIND AMANDEEP SINGH , YANG VICTOR XIAO DONG , FOSTER FRANCIS STUART
发明人： COURTNEY BRIAN , MUNCE NIGEL ROBERT , THIND AMANDEEP SINGH , YANG VICTOR XIAO DONG , FOSTER FRANCIS STUART
IPC分类号： A61B1/045 , A61B1/07 , A61B8/12 , G01D5/347
CPC分类号： A61B5/0035 , A61B1/00112 , A61B1/00172 , A61B1/00183 , A61B5/0062 , A61B5/0066 , A61B5/0084 , A61B5/0095 , A61B5/6852 , A61B5/7207 , A61B5/742 , A61B8/12 , A61B8/4281 , A61B8/445 , A61B8/4461 , A61B8/483 , A61B8/5238 , A61B8/5292 , A61B8/543 , G02B6/00 , G02B6/3604 , G10K11/002
摘要： The present invention provides scanning mechanisms for imaging probes using for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and/or optical coherence tomography. The imaging probes include adjustable rotational drive mechanism for imparting rotational motion to an imaging assembly containing either optical or ultrasound transducers which emit energy into the surrounding area. The imaging assembly includes a scanning mechanism having including a movable member configured to deliver the energy beam along a path out of said elongate hollow shaft at a variable angle with respect to said longitudinal axis to give forward and side viewing capability of the imaging assembly. The movable member is mounted in such a way that the variable angle is a function of the angular velocity of the imaging assembly.
摘要翻译：本发明提供了用于使用高分辨率成像（包括高频超声波和/或光学相干断层扫描）对哺乳动物组织和结构进行成像的成像探针的扫描机制。成像探头包括可调旋转驱动机构，用于将旋转运动传递给包含将能量发射到周围区域的光学或超声波换能器的成像组件。所述成像组件包括扫描机构，所述扫描机构具有可移动构件，所述可移动构件被配置为沿着相对于所述纵向轴线以可变角度从所述细长中空轴出来的路径传送所述能量束，以提供所述成像组件的前方和侧面观察能力。可移动构件以这样的方式安装，即可变角度是成像组件的角速度的函数。

7. 发明申请

WO2007139697A2 APPARATUS AND METHOD FOR RENDERING FOR DISPLAY FORWARD-LOOKING IMAGE DATA 审中-公开
标题翻译：用于显示向前看图像数据的渲染的装置和方法
公开(公告)号：WO2007139697A2
公开(公告)日：2007-12-06
申请号：PCT/US2007011665
申请日：2007-05-16
申请人： NOVELIS INVESTMENTS CANADA , SUNNYBROOK HEALTH SCIENCES CT , MAGNIN PAUL A , GOODNOW JOHN W , BOWDEN RUSSELL W , WRIGHT GRAHAM A , DICK ALEXANDER J , RADAU PERRY , GRAHAM JOHN J
发明人： MAGNIN PAUL A , GOODNOW JOHN W , BOWDEN RUSSELL W , WRIGHT GRAHAM A , DICK ALEXANDER J , RADAU PERRY , GRAHAM JOHN J
IPC分类号： G06T15/00
CPC分类号： A61B8/12 , A61B5/0062 , A61B5/0066 , A61B5/0084 , A61B5/743 , A61B8/483 , G06T3/0012 , G06T15/10 , G06T19/003 , G06T2210/41
摘要： An apparatus and method for rendering for display forward-looking image data. The apparatus includes rendering for display image data from a forward-looking conical section of tissue collected by an image data collection device, comprising a data input unit configured to receive the image data; and an image data processing unit configured to rasterize the image data onto a projected three-dimensional geometric model to produce a rasterized image, thereby giving the appearance of three-dimensions when displayed The method includes a method of rendering for display image data from a forward-looking conical section of tissue collected by an image data collecting device, comprising receiving the image data; and rasterizing the image data onto a projected three-dimensional geometric model to produce a rasterized image, thereby giving the appearance of three dimensions when displayed.
摘要翻译：一种用于显示前瞻性图像数据的装置和方法。该装置包括用于从由图像数据收集装置收集的组织的前瞻性锥形部分显示图像数据的渲染，包括被配置为接收图像数据的数据输入单元; 以及图像数据处理单元，被配置为将图像数据光栅化到投影的三维几何模型上以产生光栅化图像，从而在显示时给出三维的外观。该方法包括一种用于从前向显示图像数据的方法由图像数据收集装置收集的组织的俯视锥形部分，包括接收图像数据; 并且将图像数据光栅化到投影的三维几何模型上以产生光栅化图像，从而在显示时给出三维的外观。

8. 发明公开

EP3071935A4 ULTRASONIC TRANSDUCER WITH BACKING HAVING SPATIALLY SEGMENTED SURFACE 无效
标题翻译： ULTRASCHALLWANDLER MITRÜCKSEITEMITRÄUMLICHSEGMENTIERTEROBERFLÄCHE
公开(公告)号：EP3071935A4
公开(公告)日：2017-06-28
申请号：EP14863293
申请日：2014-11-21
申请人： SUNNYBROOK HEALTH SCIENCES CT
发明人： LUKACS MARC , COURTNEY BRIAN , MUNDING CHELSEA
IPC分类号： G01D5/48 , A61B8/12 , B06B1/06 , G01N29/36 , G01S7/52 , G01S15/89 , G10K11/00
CPC分类号： B06B1/0685 , A61B8/12 , A61B8/4483 , B06B1/0622 , G01D5/48 , G01S15/8909 , G10K11/002

9. 发明公开

EP2726152A4 SYSTEM AND METHOD FOR CONTROLLING FOCUSED ULTRASOUND TREATMENT 有权
标题翻译：系列VERFAHREN ZUR STEUERUNG EINER FOKUSSIERTEN ULTRASCHALLBEHANDLUNG
公开(公告)号：EP2726152A4
公开(公告)日：2015-06-24
申请号：EP12804850
申请日：2012-06-29
申请人： SUNNYBROOK HEALTH SCIENCES CT
发明人： O'REILLY MEAGHAN ANNE , HYNYNEN KULLERVO HENRIK
IPC分类号： A61N7/00
CPC分类号： A61B8/481 , A61B8/0808 , A61B8/4488 , A61B2017/00106 , A61B2090/374 , A61N7/02 , A61N2007/0091 , A61N2007/0095
摘要： A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.
摘要翻译：提供了一种用于控制对受试者的超声能量递送的系统和方法。特别地，这种系统和方法能够安全地破坏血脑屏障。输送超声能量以在选定的压力值下产生超声造影剂的空化。在空化后获得声信号，产生信号频谱。分析信号频谱是否存在谐波，如次谐波或超谐波。当存在次谐波或超谐波时，随后的超声波的压力值会降低。如果先前的超声处理导致不产生亚谐波或超谐波，则可以增加压力值。以这种方式，可以有利地破坏血脑屏障，同时减轻超声处理的潜在有害影响。

10. 发明公开

EP2964096A4 SYSTEM AND METHOD FOR MEASURING AND CORRECTING ULTRASOUND PHASE DISTORTIONS INDUCED BY ABERRATING MEDIA 有权
标题翻译：系统和方法用于测量和校正超声相位失真分心MEDIA
公开(公告)号：EP2964096A4
公开(公告)日：2017-02-15
申请号：EP14760248
申请日：2014-03-04
申请人： SUNNYBROOK HEALTH SCIENCES CT
发明人： HYNYNEN KULLERVO HENRIK , O'REILLY MEAGHAN ANNE
IPC分类号： A61B8/08 , A61B8/00 , A61B8/06
CPC分类号： A61B8/15 , A61B8/06 , A61B8/0808 , A61B8/0891 , A61B8/4494 , A61B8/481 , A61B8/5207 , A61B8/5269 , A61B8/54 , A61N2007/0021 , A61N2007/0039 , A61N2007/0052 , A61N2007/0078

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