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1. 发明申请

WO2008150933A3 METHOD AND APPARATUS FOR SIMPLIFIED PRECISE MECHANICAL GAS MIXING AND DELIVERY FOR ANIMAL RESEARCH 审中-公开
标题翻译：简化精密机械气体混合动力学研究的方法与装置
公开(公告)号：WO2008150933A3
公开(公告)日：2011-07-14
申请号：PCT/US2008065175
申请日：2008-05-29
申请人： STARR LIFE SCIENCES CORP , HETE BERNARD F
发明人： HETE BERNARD F
IPC分类号： A61D7/00 , A61M16/00 , F17C7/00
CPC分类号： A61M16/12 , A61M2202/0208 , A61M2202/0266
摘要： An apparatus for supplying a precise oxygen-nitrogen gas mixture to an animal comprises (i) A source of pressurized oxygen gas, (ii) A source of pressurized nitrogen gas, (iii) A mechanical two-gas blending valve having a first and second gas inlet couplings, and an outlet coupling, the gas blending valve having a manual selector that can incrementally adjust the oxygen- nitrogen gas mixture within a range of mixtures, and a face plate on the blending valve including markings adjacent to the manual selector that are indicative of specific oxygen-nitrogen mixtures, wherein the gas inlets are coupled to the sources of oxygen and nitrogen, respectively, (iv) A gas dispenser coupled to the outlet of the mechanical two gas blending valve; and (v) An animal interface coupling to deliver the gas mixture to the subject animal. The apparatus may be provided for mixtures of air and any gas of interest.
摘要翻译：用于向动物供应精确的氧 - 氮气体混合物的装置包括（i）加压氧气源，（ii）加压氮气源，（iii）机械二气混合阀，其具有第一和第二气体入口联接器和出口联接器，气体混合阀具有手动选择器，其可以在混合物的范围内逐渐调节氧 - 氮气体混合物，并且混合阀上的面板包括与手动选择器相邻的标记指示特定的氧 - 氮混合物，其中气体入口分别与氧和氮源连接;（iv）与机械两气体混合阀的出口相连的气体分配器; 和（v）耦合以将气体混合物输送到受试动物的动物界面。可以为空气和感兴趣的任何气体的混合物提供装置。

2. 发明申请

WO2010053811A2 IMPLANTABLE SMALL ANIMAL PULSE OXIMETRY SENSOR 审中-公开
标题翻译：可植入的小型动物脉搏氧化传感器
公开(公告)号：WO2010053811A2
公开(公告)日：2010-05-14
申请号：PCT/US2009062446
申请日：2009-10-28
申请人： STARR LIFE SCIENCES CORP , STARR ERIC W
发明人： STARR ERIC W
IPC分类号： A61B5/145 , A61B5/1455
CPC分类号： A61B5/6814 , A61B5/14552 , A61B2503/40
摘要： An implantable photoplethysmographic sensor for animals such as small rodents, namely rats and mice is provided. This involves making photoplethysmographic measurements on, or more precisely through, the head of the subject specifically, but also subcutaneously by applying sensors directly to the skull of the animal. Not only does the skull provide a location where blood flow will always be available, it also provides a platform for adhering sensor pads such that noise that results from motion of the animal is minimized. The reason is that when sensors are glued to the skull, they cannot move relative to the bone, but more importantly to the brain tissue underneath, assuming that the brain does not "slosh around" while the animal is moving.
摘要翻译：提供了用于动物例如小啮齿动物，即大鼠和小鼠的可植入光电容积脉搏波传感器。这涉及到特别是在受试者的头部上或更确切地说是通过对受试者的头部进行光电容积脉搏波测量，而且还通过将传感器直接施加到动物的头骨上来进行皮下测量。头骨不仅提供了血流始终可用的位置，而且还提供了用于粘附传感器垫的平台，使得由动物运动产生的噪音被最小化。原因在于，当传感器粘在头骨上时，假设在动物移动时大脑不会“晃动”，它们不能相对于骨骼移动，但更重要的是移动到下面的脑组织。

3. 发明申请

WO2008086472A3 TECHNIQUES FOR ACCURATELY DERIVING PHYSIOLOGIC PARAMETERS OF A SUBJECT FROM PHOTOPLETHYSMOGRAPHIC MEASUREMENTS 审中-公开
标题翻译：从光学影像学测量中准确推导受试者生理参数的技术
公开(公告)号：WO2008086472A3
公开(公告)日：2008-10-30
申请号：PCT/US2008050749
申请日：2008-01-10
申请人： STARR LIFE SCIENCES CORP , HETE BERNARD F , AYERS ERIC J
发明人： HETE BERNARD F , AYERS ERIC J
IPC分类号： A61B5/024
CPC分类号： A61B5/02416 , A61B5/02405 , A61B5/0816 , A61B5/0823 , A61B5/1455 , A61B5/7207 , A61B5/7253 , A61B5/7257
摘要： Several techniques are disclosed for isolating either heart or breath rate data from a photoplethysmograph, which is a time domain signal such as from a pulse oximeter. The techniques involve the use of filtering in the frequency domain, after a Fast Fourier Transform (FFT) has been conducted on a given photoplethysmograph also references as a given set of discrete time-domain data. The filtering may be applied to an identified fundamental frequency and one or more harmonics for heart related parameters. The filter may be truncated to the frequency data set and further applied multiple times to improve roll off. After filtering, an Inverse FFT (IFFT) is used to reconstruct the time-domain signal, except with undesirable frequency content eliminated or reduced. Calculation or measurement of parameters is then conducted on this reconstructed time-domain signal.
摘要翻译：公开了几种用于从光电容积描记器分离心脏或呼吸频率数据的技术，该光电容积描记器是诸如来自脉搏血氧计的时域信号。这些技术涉及在给定的光电容积描记器上进行快速傅里叶变换（FFT）之后，在频域中使用滤波也参考作为给定的一组离散时域数据。该滤波可以应用于识别的基频以及用于心脏相关参数的一个或多个谐波。滤波器可以截断到频率数据集并进一步应用多次以改善滚降。经过滤波之后，使用逆FFT（IFFT）来重构时域信号，除了消除或减少不需要的频率内容。然后对重建的时域信号进行参数计算或测量。

4. 发明申请

WO2010068713A3 NONINVASIVE PHOTOPLETHYSMOGRAPHIC SENSOR MEASUREMENTS OF AWAKE ANIMALS 审中-公开
标题翻译：非挥发性光电传感器AWAKE动物测量
公开(公告)号：WO2010068713A3
公开(公告)日：2010-10-14
申请号：PCT/US2009067406
申请日：2009-12-09
申请人： STARR LIFE SCIENCES CORP , HETE BERNARD F , AYERS ERIC J , STARR ERIC W
发明人： HETE BERNARD F , AYERS ERIC J , STARR ERIC W
IPC分类号： A61B5/022 , A61B5/026
CPC分类号： A61B5/02416 , A61B5/7257 , A61B2503/40
摘要： A noninvasive photoplethysmographic sensor system for mobile animals such as small rodents, namely rats and mice is useful such as in a laboratory research environment. The noninvasive photoplethysmographic sensor for mobile animals such as small rodents utilizes multiple FFT's in the processing of the phtotoplethysmograophic signal, where each FFT has a different time record of the signals such as a number of points, or a zero padded FFTs. The noninvasive photoplethysmographic sensor for mobile animals provides actigraphy measurements for the animal.
摘要翻译：用于诸如小鼠和小鼠之类的移动动物的无创光电体积描记传感器系统是有用的，例如在实验室研究环境中。用于诸如小型啮齿动物的移动动物的非侵入性光电容积描记传感器在处理噬菌体同位素信号时利用多个FFT，其中每个FFT具有诸如点数或零填充FFT之类的信号的不同时间记录。用于移动动物的无创光电体积描记传感器为动物提供了动态测量。

5. 发明申请

WO2008150933A2 METHOD AND APPARATUS FOR SIMPLIFIED PRECISE MECHANICAL GAS MIXING AND DELIVERY FOR ANIMAL RESEARCH 审中-公开
标题翻译：简化精密机械气体混合动力学研究的方法与装置
公开(公告)号：WO2008150933A2
公开(公告)日：2008-12-11
申请号：PCT/US2008/065175
申请日：2008-05-29
申请人： STARR LIFE SCIENCES CORP. , HETE, Bernard, F.
发明人： HETE, Bernard, F.
CPC分类号： A61M16/12 , A61M2202/0208 , A61M2202/0266
摘要： An apparatus for supplying a precise oxygen-nitrogen gas mixture to an animal comprises (i) A source of pressurized oxygen gas, (ii) A source of pressurized nitrogen gas, (iii) A mechanical two-gas blending valve having a first and second gas inlet couplings, and an outlet coupling, the gas blending valve having a manual selector that can incrementally adjust the oxygen- nitrogen gas mixture within a range of mixtures, and a face plate on the blending valve including markings adjacent to the manual selector that are indicative of specific oxygen-nitrogen mixtures, wherein the gas inlets are coupled to the sources of oxygen and nitrogen, respectively, (iv) A gas dispenser coupled to the outlet of the mechanical two gas blending valve; and (v) An animal interface coupling to deliver the gas mixture to the subject animal. The apparatus may be provided for mixtures of air and any gas of interest.
摘要翻译：用于向动物供应精确的氧 - 氮气体混合物的装置包括（i）加压氧气源，（ii）加压氮气源，（iii）机械二气混合阀，其具有第一和第二气体入口联接器和出口联接器，气体混合阀具有手动选择器，其可以在混合物的范围内逐渐调节氧 - 氮气体混合物，并且混合阀上的面板包括与手动选择器相邻的标记指示特定的氧 - 氮混合物，其中气体入口分别与氧和氮源连接;（iv）与机械两气体混合阀的出口相连的气体分配器; 和（v）耦合以将气体混合物输送到受试动物的动物界面。可以为空气和感兴趣的任何气体的混合物提供装置。

6. 发明申请

WO2008036876A3 PULSE OXIMETER BASED TECHNIQUES FOR CONTROLLING ANESTHESIA LEVELS AND VENTILATION LEVELS IN SUBJECTS 审中-公开
标题翻译：基于脉搏血氧仪的技术来控制对象的麻醉水平和通气水平
公开(公告)号：WO2008036876A3
公开(公告)日：2008-06-12
申请号：PCT/US2007079126
申请日：2007-09-21
申请人： STARR LIFE SCIENCES CORP , AYERS ERIC J , STARR ERIC W , HETE BERNARD F
发明人： AYERS ERIC J , STARR ERIC W , HETE BERNARD F
IPC分类号： A61B5/02
CPC分类号： A61B5/14551 , A61B5/0205 , A61B5/14552 , A61B5/4821 , A61B5/7257 , A61B2503/40
摘要： Medical devices and techniques derive breath rate, breath distention, and pulse distention measurements of a subject from a pulse oximeter system coupled to the subject. These parameters together with the conventional physiologic parameters obtained from a pulse oximeter system can be used to assist in controlling the ventilation levels and the anesthesia levels of the subject. The development has human applications and particular application for animal research.
摘要翻译：医疗设备和技术从耦合到对象的脉搏血氧仪系统导出对象的呼吸率，呼吸膨胀和脉搏扩张测量。这些参数以及从脉搏血氧仪系统获得的常规生理参数可用于帮助控制受试者的通气水平和麻醉水平。该开发具有人类应用和动物研究的特殊应用。

7. 发明申请

WO2010068713A2 NONINVASIVE PHOTOPLETHYSMOGRAPHIC SENSOR MEASUREMENTS OF AWAKE ANIMALS 审中-公开
标题翻译：无创光动力学体视传感器测量清醒动物
公开(公告)号：WO2010068713A2
公开(公告)日：2010-06-17
申请号：PCT/US2009/067406
申请日：2009-12-09
申请人： STARR LIFE SCIENCES CORP. , HETE, Bernard, F. , AYERS, Eric, J. , STARR, Eric, W.
发明人： HETE, Bernard, F. , AYERS, Eric, J. , STARR, Eric, W.
IPC分类号： A61B5/022 , A61B5/026
CPC分类号： A61B5/02416 , A61B5/7257 , A61B2503/40
摘要： A noninvasive photoplethysmographic sensor system for mobile animals such as small rodents, namely rats and mice is useful such as in a laboratory research environment. The noninvasive photoplethysmographic sensor for mobile animals such as small rodents utilizes multiple FFT's in the processing of the phtotoplethysmograophic signal, where each FFT has a different time record of the signals such as a number of points, or a zero padded FFTs. The noninvasive photoplethysmographic sensor for mobile animals provides actigraphy measurements for the animal.
摘要翻译：用于移动动物例如小鼠，即大鼠和小鼠的无创光电容积脉搏波传感器系统是有用的，例如在实验室研究环境中。用于诸如小型啮齿动物的移动动物的非侵入式光电容积脉搏波传感器在处理phtotoplethysmograophic信号时使用多个FFT，其中每个FFT具有不同的信号时间记录，例如多个点或零填充的FFT。用于移动动物的无创光电容积脉搏波传感器为动物提供了动脉测量的测量结果。

8. 发明申请

WO2009076325A3 NONINVASIVE PHOTOPLETHYSMOGRAPHIC SENSOR PLATFORM FOR MOBILE ANIMALS 审中-公开
标题翻译：非移动光电子传感器平台移动动物
公开(公告)号：WO2009076325A3
公开(公告)日：2009-08-13
申请号：PCT/US2008085994
申请日：2008-12-08
申请人： STARR LIFE SCIENCES CORP , TRUITT PATRICK , HETE BERNARD F , STARR ERIC W
发明人： TRUITT PATRICK , HETE BERNARD F , STARR ERIC W
IPC分类号： A61B5/00
CPC分类号： A61B5/14552 , A61B2503/40
摘要： A noninvasive photoplethysmographic sensor platform for mobile animals such as small rodents, namely rats and mice is useful such as in a laboratory research environment. The noninvasive photoplethysmographic sensor platform may be a collar which provides an easily affixed, adjustable attachment mechanism that encircles the animal, such as the neck. The neck of the animal provides several particular advantages as a sensor mounting platform for photoplethysmographic sensors. For pulse oximetry, the neck location will provide significant blood flow under all conditions. For small mammals, such as rats and mice, transmittance pulse oximetry through the neck of the subject remains possible. The neck mounted collar also offers inherent bite resistance to the sensor platform.
摘要翻译：用于诸如小鼠和小鼠的移动动物的无创光电体积描记传感器平台是有用的，例如在实验室研究环境中。无创光电体积描记传感器平台可以是一个套环，提供一个环绕动物（如颈部）的容易固定的可调节的附接机构。作为光电容积传感器的传感器安装平台，动物的颈部提供了几个特殊的优点。对于脉搏血氧饱和度测量，颈部位置将在所有条件下提供显着的血流量。对于小型哺乳动物，如大鼠和小鼠，穿过受试者颈部的透射脉搏血氧饱和度仍然是可能的。颈部安装的衣领还为传感器平台提供了固有的抗咬伤性。

9. 发明申请

WO2009076325A2 NONINVASIVE PHOTOPLETHYSMOGRAPHIC SENSOR PLATFORM FOR MOBILE ANIMALS 审中-公开
标题翻译：用于移动动物的无创血压光动力学传感器平台
公开(公告)号：WO2009076325A2
公开(公告)日：2009-06-18
申请号：PCT/US2008/085994
申请日：2008-12-08
申请人： STARR LIFE SCIENCES CORP. , TRUITT, Patrick , HETE, Bernard, F. , STARR, Eric, W.
发明人： TRUITT, Patrick , HETE, Bernard, F. , STARR, Eric, W.
IPC分类号： A61B5/00
CPC分类号： A61B5/14552 , A61B2503/40
摘要： A noninvasive photoplethysmographic sensor platform for mobile animals such as small rodents, namely rats and mice is useful such as in a laboratory research environment. The noninvasive photoplethysmographic sensor platform may be a collar which provides an easily affixed, adjustable attachment mechanism that encircles the animal, such as the neck. The neck of the animal provides several particular advantages as a sensor mounting platform for photoplethysmographic sensors. For pulse oximetry, the neck location will provide significant blood flow under all conditions. For small mammals, such as rats and mice, transmittance pulse oximetry through the neck of the subject remains possible. The neck mounted collar also offers inherent bite resistance to the sensor platform.
摘要翻译：用于移动动物例如小鼠，即大鼠和小鼠的无创光电容积脉搏波传感器平台是有用的，例如在实验室研究环境中。无创光电容积脉搏波传感器平台可以是提供容易固定，可调节的附接机构的套环，其包围动物，诸如颈部。动物颈部作为光电容积脉搏波传感器的传感器安装平台提供了几个特别的优势。对于脉搏血氧仪，颈部位置将在所有条件下提供显着的血流量。对于小型哺乳动物，例如大鼠和小鼠，通过受试者颈部的透射脉搏血氧饱和度仍然是可能的。颈部安装的衣领还提供固有的对传感器平台的抗咬性。

10. 发明申请

WO2008036872A3 PULSE OXIMETRY SYSTEM AND TECHNIQUES FOR DERIVING CARDIAC AND BREATHING PARAMETERS FROM EXTRA-THORACIC BLOOD FLOW MEASUREMENTS 审中-公开
标题翻译：脉搏血氧测定系统和从胸外血流测量中导出心脏和呼吸参数的技术
公开(公告)号：WO2008036872A3
公开(公告)日：2008-07-03
申请号：PCT/US2007079122
申请日：2007-09-21
申请人： STARR LIFE SCIENCES CORP , HETE BERNARD F , STARR ERIC W , AYERS ERIC J
发明人： HETE BERNARD F , STARR ERIC W , AYERS ERIC J
IPC分类号： A61B5/02
CPC分类号： A61B5/14551 , A61B5/0205 , A61B5/14552 , A61B5/4821 , A61B5/7257 , A61B2503/40
摘要： Medical devices and techniques derive breath rate, breath distention, and pulse distention measurements of a subject from a pulse oximeter system coupled to a subject. These parameters, together with the conventional physiologic parameters obtained from a pulse oximeter system, can be used to assist in controlling the ventilation levels and the anesthesia levels of the subject. The development has human applications and particular applications for animal research.
摘要翻译：医疗设备和技术从耦合到对象的脉搏血氧仪系统导出对象的呼吸率，呼吸膨胀和脉搏扩张测量。这些参数以及从脉搏血氧仪系统获得的常规生理参数可用于帮助控制受试者的通气水平和麻醉水平。该开发具有人类应用和动物研究的特定应用。

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