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1. 发明授权

US5891179A Method and apparatus for monitoring and displaying lead impedance in real-time for an implantable medical device 失效
标题翻译：用于可植入医疗装置实时监测和显示引线阻抗的方法和装置
公开(公告)号：US5891179A
公开(公告)日：1999-04-06
申请号：US974438
申请日：1997-11-20
申请人： Siew Bee Er , Robert E. Smith, Jr.
发明人： Siew Bee Er , Robert E. Smith, Jr.
IPC分类号： A61N1/37 , A61N1/362
CPC分类号： A61N1/3706 , A61N1/37247
摘要： A real-time impedance monitoring system is provided for use with an implantable medical device having an implantable electrical lead. The impedance monitoring system includes components for determining the electrical impedance of the lead as a function of time, with the determination being made substantially in real-time, and components for graphically displaying the electrical impedance of the lead as a function of time, with the display also being generating substantially in real-time. In one specific example described herein, the implantable medical device is a pacemaker and the impedance monitoring system is within an external programmer device separate from the pacemaker. The programmer device includes a computer display screen or a computer printout device for presenting real-time graphical displays of the lead impedance. The programmer may alternatively generate graphical displays of lead impedance as a function of time based upon pre-recorded data.
摘要翻译：提供实时阻抗监测系统，用于具有可植入电线的可植入医疗装置。阻抗监测系统包括用于确定作为时间的函数的引线的电阻抗的组件，其确定基本上是实时的，以及用于图形地显示引线的电阻抗作为时间的函数的组件，其中显示器也基本上实时地产生。在本文所述的一个具体示例中，可植入医疗装置是起搏器，并且阻抗监测系统在与起搏器分离的外部编程器装置内。编程器装置包括用于呈现导线阻抗的实时图形显示的计算机显示屏或计算机打印输出装置。根据预先记录的数据，程序员还可以产生作为时间的函数的引线阻抗的图形显示。

2. 发明授权

US09421381B2 Systems and methods for optimizing multi-site left ventricular pacing based on interelectrode conduction delays 有权
标题翻译：基于电极间导电延迟优化多位点左心室起搏的系统和方法
公开(公告)号：US09421381B2
公开(公告)日：2016-08-23
申请号：US12607817
申请日：2009-10-28
申请人： Kyungmoo Ryu , Stuart Rosenberg , Allen Keel
发明人： Kyungmoo Ryu , Stuart Rosenberg , Allen Keel
IPC分类号： A61N1/368 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/368 , A61N1/3684
摘要： Techniques are provided for use with an implantable cardiac stimulation device equipped for multi-site left ventricular (MSLV) pacing using a multi-pole LV lead. In one example, MSLV interelectrode conduction delays are determined among the electrodes of the multi-pole LV lead. MSLV interelectrode pacing delays are then set based on the MSLV interelectrode conduction delays for use in delivering MSLV pacing. To this end, various criteria are exploited for determining optimal values for the pacing delays based on the interelectrode conduction delays. MSLV pacing is then controlled using the specified MSLV interelectrode pacing delays. In some examples, the optimization procedure is performed by the implantable device itself. In other examples, the procedure is performed by an external programmer device. In such an embodiment, the external device determines optimal MSLV interelectrode pacing delays and then transmits programming commands to the implantable device to program the device to use the pacing delays.
摘要翻译：提供技术用于使用多极LV引线配备用于多位点左心室（MSLV）起搏的可植入心脏刺激装置。在一个示例中，在多极LV引线的电极之间确定MSLV电极间导电延迟。然后根据MSLV电极间传导延迟来设置MSLV电极间起搏延迟，以用于传递MSLV起搏。为此，利用各种标准来确定基于电极间传导延迟的起搏延迟的最佳值。然后使用指定的MSLV电极间起搏延迟来控制MSLV起搏。在一些示例中，优化过程由可植入装置本身执行。在其他示例中，该过程由外部编程器设备执行。在这样的实施例中，外部设备确定最佳MSLV电极间起搏延迟，然后将编程命令发送到可植入设备，以对设备进行编程以使用起搏延迟。

3. 发明授权

US09457193B2 Dual chamber leadless pacemaker programmer and method 有权
标题翻译：双室无引线起搏器程序员和方法
公开(公告)号：US09457193B2
公开(公告)日：2016-10-04
申请号：US14931118
申请日：2015-11-03
申请人： Pacesetter, Inc.
发明人： Gleb Klimovitch , Timothy Edward Ciciarelli , Benjamin T. Persson
IPC分类号： A61N1/372 , A61N1/362 , A61N1/375 , H04W52/04 , H04W56/00 , A61N1/365 , A61N1/37
CPC分类号： A61N1/37288 , A61N1/3622 , A61N1/36514 , A61N1/3702 , A61N1/37217 , A61N1/37235 , A61N1/3756 , H04B17/318 , H04W52/04 , H04W52/245 , H04W56/001
摘要： Systems and methods for providing communications between an external device and first and second leadless pacemakers (LPs) located in a heart are provided. A method includes receiving first and second event messages from the first and second LPs, the first and second event messages received at different points in time at the external device, determining the signal strengths of the first and second event messages, respectively, as received at the external device, adjusting first and second LP discrimination thresholds based on the received signal strengths of the first and second event messages, respectively, and utilizing the first and second LP discrimination thresholds to identify which of the first and second LP transmits subsequent event messages, in order for the external device to independently communicate with the first and second LPs.
摘要翻译：提供了用于在外部设备与位于心脏中的第一和第二无引线起搏器（LP）之间提供通信的系统和方法。一种方法包括从第一和第二LP接收第一和第二事件消息，在外部设备处在不同时间点接收的第一和第二事件消息，分别确定第一和第二事件消息的信号强度，如第外部设备，分别基于第一和第二事件消息的接收信号强度来调整第一和第二LP鉴别阈值，并利用第一和第二LP鉴别阈值来识别第一和第二LP中的哪一个传送后续事件消息，以便外部设备独立地与第一和第二LP通信。

4. 发明授权

US5836981A Pacemaker circuit and associated methods for generating electrical stimulation signals 失效
标题翻译：起搏器电路和相关的产生电刺激信号的方法
公开(公告)号：US5836981A
公开(公告)日：1998-11-17
申请号：US785193
申请日：1997-01-17
申请人： Steve Chang , Robert R. Weyant
发明人： Steve Chang , Robert R. Weyant
IPC分类号： A61N1/362 , A61N1/378
CPC分类号： A61N1/362 , A61N1/378
摘要： A DC-to-DC converter circuit is disclosed for use in a pacemaker. The DC-to-DC converter circuit is capable of producing a pulse burst and boosting the voltage of the pulse burst up to an effective pacing amplitude, thereby eliminating the need for the multiple pump capacitors and the output capacitor. The DC-to-DC converter circuit uses a transformer to amplify the battery voltage to the required pacing amplitude. By using a transformer, DC leakage current is eliminated without the use of a decoupling capacitor, thereby achieving lower pacing thresholds. Also, each patient may be individually tested to determine their response to high frequency pulse bursts and a "customized" pacing waveshape can be produced by varying the duty cycle, polarity or pulse burst of each stimulation signal. The DC-to-DC converter circuit also reduces the polarization effect of the tissue around the electrodes.
摘要翻译：公开了用于起搏器的DC-DC转换器电路。 DC-DC转换器电路能够产生脉冲串并将脉冲脉冲的电压升高到有效的起搏幅度，从而不再需要多个泵浦电容器和输出电容器。 DC-DC转换器电路使用变压器将电池电压放大到所需的起搏幅度。通过使用变压器，可以消除直流泄漏电流，而不需要使用去耦电容，从而实现较低的起搏阈值。此外，每个患者可以单独测试以确定其对高频脉冲串的响应，并且可以通过改变每个刺激信号的占空比，极性或脉冲串来产生“定制的”起搏波形。 DC-DC转换器电路还降低了围绕电极的组织的极化效应。

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