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    • 3. 发明申请
    • ELECTROTRANSPORT DEVICES, METHODS AND DRUG ELECTRODE ASSEMBLIES
    • 电子运动装置,方法和药物电极组件
    • WO2009006349A3
    • 2009-03-12
    • PCT/US2008068671
    • 2008-06-27
    • POLYPLUS BATTERY CO INCVISCO STEVEN JNIMON YEVGENIY SKATZ BRUCE
    • VISCO STEVEN JNIMON YEVGENIY SKATZ BRUCE
    • A61N1/30
    • A61N1/0448A61N1/0436A61N1/0444
    • A drug electrode assembly usefully employed in an electrotransport device for the delivery of drugs across a tissue surface includes an electrode, a drug reservoir which stores the drug (including an ionized (e.g., anionic) or neutrally charged drug species), and a liquid impermeable solid-state assist ion conducting barrier layer interposed between the electrode and the drug reservoir. The barrier layer can be a single-ion conductor of a specific (unique) species of ion called the assist ion. During drug delivery, the assist ion moves across the barrier layer into or out of the drug reservoir, and as the assist ion crosses the barrier layer/drug reservoir interphase, the drug species moves to the tissue surface. The assist ion can be, for example, sodium ions (Na+), and the electrode can be an electrode of the assist ion (i.e., a sodium electrode).
    • 在电转运装置中有用的用于穿过组织表面递送药物的药物电极组件包括电极,存储药物(包括离子化(例如阴离子)或中性电荷药物物质)的药物储存器和液体不可渗透的 介于电极和药物储存器之间的固态辅助离子传导阻挡层。 阻挡层可以是称为辅助离子的特定(独特)离子种类的单离子导体。 在药物递送期间,辅助离子穿过阻挡层移入或移出药物储存器,并且随着辅助离子穿过阻挡层/药物储存器中间相,药物物质移动到组织表面。 辅助离子可以是例如钠离子(Na +),电极可以是辅助离子的电极(即,钠电极)。
    • 8. 发明申请
    • PROTECTED LITHIUM ELECTRODES FOR ELECTRO-TRANSPORT DRUG DELIVERY
    • 用于电子输送药物递送的保护的锂电极
    • WO2008067409A3
    • 2008-08-28
    • PCT/US2007085802
    • 2007-11-28
    • POLYPLUS BATTERY CO INCVISCO STEVEN JNIMON YEVGENIY SKATZ BRUCE
    • VISCO STEVEN JNIMON YEVGENIY SKATZ BRUCE
    • A61F13/00
    • A61K33/00A61K33/24A61N1/0436A61N1/044A61N1/0448A61N1/306
    • This invention provides new and novel devices and methods for administering lithium (Li) ions to a mammalian subject, especially the delivery of lithium (Li) ions to a body component for example across a body or tissue surface such as skin or a mucosal membrane, or for delivery of lithium ions directly to bodily fluids in a controllable and reproducible manner. In certain embodiments the device comprises a donor electrode that is a donor of a lithium ion; a protective architecture that is ionically conductive to the lithium ion, configured for application to a skin surface and positioned to isolate said donor electrode from the skin surface; and a counter electrode assembly configured for application to a skin surface, where said counter electrode assembly comprises a counter electrode operably coupled to said donor electrode.
    • 本发明提供了用于向哺乳动物受试者施用锂(Li)离子的新的和新颖的装置和方法,特别是将锂(Li)离子递送到身体组分,例如穿过身体或组织表面如皮肤或粘膜, 或以可控和可重复的方式将锂离子直接递送到体液。 在某些实施方案中,该装置包括作为锂离子的供体的供体电极; 对锂离子进行离子导电的保护结构,被配置为施加到皮肤表面并定位成将所述供体电极与皮肤表面隔离; 以及配置用于施加到皮肤表面的对电极组件,其中所述对电极组件包括可操作地耦合到所述施主电极的对电极。