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1. 发明专利

JP2009029808A Substituted pyrazolyl compound for treating inflammation 审中-公开
标题翻译：用于治疗炎症的替代吡唑啉化合物
公开(公告)号：JP2009029808A
公开(公告)日：2009-02-12
申请号：JP2008188020
申请日：2008-07-22
申请人： Pharmacia Corp , ファルマシアコーポレーション
发明人： BERGMANIS ARIJA A , BONAFOUX DOMINIQUE , CLARE MICHAEL , CRICH JOYCE Z , FLETCHER THERESA R , GENG LIFENG , HAGEN TIMOTHY J , HAMPER BRUCE C , HANSON GUNNAR J , HOUDEK STEPHEN C , HUANG HE , IULA DONNA M , KOSZYK FRANCIS J , LENNON PATRICK J , LIAO SHUYUAN , LIAO SUBO , METZ SUZANNE , MOHLER SCOTT B , NGUYEN MARIA , OBURN DAVID S , OWEN THOMAS J , PARTIS RICHARD A , SCATES ANGELA M , STEALEY MICHAEL A , TOLLEFSON MICHAEL B , VAZQUEZ MICHAEL L , WEIER RICHARD M , WOLFSON SERGE G , XU XIANGDONG
IPC分类号： C07D231/54 , A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/551 , A61P19/02 , A61P25/04 , A61P29/00 , A61P35/00 , C07D333/62 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
CPC分类号： C07D403/12 , C07D231/54 , C07D333/62 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： PROBLEM TO BE SOLVED: To provide a substituted pyrazolyl derivative for treating cancer, inflammation and inflammation-associated disorders such as arthritis. SOLUTION: A compound having a structural formula expressed by figure is cited as an example. The compound is 1-ä4-[(aminothio)peroxy]phenyl}-8-nitro-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供用于治疗癌症，炎症和炎症相关疾病如关节炎的取代的吡唑基衍生物。解决方案：以具有由图示表示的结构式的化合物作为例子。化合物是1-ä4-[（氨基硫代）过氧]苯基} -8-硝基-4,5-二氢-1H-苯并[g]吲唑-3-甲酰胺。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2006204918A Injection device for administering medication liquid 审中-公开
标题翻译：用于管理药物液体的注射装置
公开(公告)号：JP2006204918A
公开(公告)日：2006-08-10
申请号：JP2006014775
申请日：2006-01-24
申请人： Pharmacia Corp , ファルマシアコーポレイション
发明人： HJERTMAN BIRGER THURE YNGVAR , JAEGER HANS , MAYOR LAETITIA
IPC分类号： A61M5/24 , A61M1/36
CPC分类号： A61M5/3155 , A61M5/2448 , A61M5/3146 , A61M5/31538 , A61M5/31555 , A61M5/31563 , A61M5/3158 , A61M5/5013 , A61M5/502 , A61M2005/5033
摘要： PROBLEM TO BE SOLVED: To provide an injection device for administering a novel medication liquid. SOLUTION: This disposable injection device of a plurality of doses permanently adjusts the doses of the medication liquid to be administered by returning a medication to liquid before injection. This injection device cannot be wholly disassembled after the final use. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于施用新型药液的注射装置。解决方案：多次剂量的这种一次性注射装置通过在注射前将药物返回到液体来永久地调节要施用的药物液体的剂量。该注射装置在最终使用后不能完全拆卸。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2005306875A Antibody against tissue factor inhibitor 审中-公开
标题翻译：抗组织因子抑制剂抗体
公开(公告)号：JP2005306875A
公开(公告)日：2005-11-04
申请号：JP2005124415
申请日：2005-04-22
申请人： Pharmacia Corp , Washington Univ , フアルマシア・コーポレーシヨン , ワシントン・ユニバーシティWashington University School of Medicine
发明人： BROZE GEORGE JOHN JR , KRETZMER KUNIKO K , WUN TZE-CHEIN
IPC分类号： A61K38/16 , A61P7/02 , C07H21/04 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/745 , C07K14/81 , C07K16/38 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12R1/91 , G01N33/53 , G01N33/543
CPC分类号： C07K14/8114
摘要： PROBLEM TO BE SOLVED: To obtain an antibody against a human tissue factor inhibitor known as tissue factor inhibitor (TFI) or lipoprotein associated coagulation inhibitor (LACI).
SOLUTION: There is provided a complete coding sequence and an amino acid sequence of a cDNA clone representing essentially the full length tissue factor inhibitor. In this regard, however, the antibody against the human tissue factor inhibitor is not bonded to the following inhibitors: bovine basic protease inhibitor precursor, bovine colostrum trypsin inhibitor, bovine serum basic protease inhibitor, edible snail isoinhibitor K, red sea turtle basic protease inhibitor, western sand viper venom basic protease inhibitor I, ringhals venom basic protease inhibitor II, and the like.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：获得称为组织因子抑制剂（TFI）或脂蛋白相关凝血抑制剂（LACI）的人组织因子抑制剂的抗体。解决方案：提供了基本上代表全长组织因子抑制剂的cDNA克隆的完整编码序列和氨基酸序列。然而，在这方面，针对人组织因子抑制剂的抗体不与以下抑制剂结合：牛碱性蛋白酶抑制剂前体，牛初乳胰蛋白酶抑制剂，牛血清碱性蛋白酶抑制剂，食用蜗牛异抑制剂K，红海龟碱性蛋白酶抑制剂，西沙毒蛇碱性蛋白酶抑制剂I，戒指毒液碱性蛋白酶抑制剂II等。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2007023053A Substituted pyridinone as modulator of p38 map kinase 有权
标题翻译：取代的吡啶酮作为P38 MAP激酶的调节剂
公开(公告)号：JP2007023053A
公开(公告)日：2007-02-01
申请号：JP2006263778
申请日：2006-09-28
申请人： Pharmacia Corp , ファルマシア・コーポレーション
发明人： DEVADAS BALEKUDRU , WALKER JOHN , SELNESS SHAUN R , BOEHM TERRI L , DURLEY RICHARD C , DEVRAJ RAJESH , HICKORY BRIAN S , RUCKER PAUL V , JEROME KEVIN D , MADSEN HEATHER M , ALVIRA EDGARDO , PROMO MICHELE A , BLEVIS-BAL RADHIKA M , MARRUFO LAURA D , HITCHCOCK JEFF , OWEN THOMAS , NAING WIN , XING LI , SHIEH HUEY S , SAMBANDAM ARUNA , LIU SHUANG , SCOTT IAN L , MCGEE KEVIN F
IPC分类号： C07D213/64 , A61K31/4412 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4535 , A61K31/4545 , A61K31/455 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P7/02 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/22 , A61P33/02 , A61P33/06 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/10
CPC分类号： C07D213/64 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/84 , C07D213/85 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/10
摘要： PROBLEM TO BE SOLVED: To provide a new compound useful as a modulator of a P38 MAP kinase. SOLUTION: The compound of the formula (wherein R 1 is an alkyl which may arbitrarily be substituted, or the like; R 2 is an arylalkoxy which may arbitrarily be substituted; R 3 is H, a halogen, an alkoxycarbonyl which may be arbitrarily substituted, or the like; R 4 is H or an alkyl which may arbitrarily be substituted; and R 5 is an aryl which may arbitrarily be substituted, an arylalkyl or the like) and a pharmaceutically acceptable salt thereof are provided. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供可用作P38 MAP激酶调节剂的新化合物。解决方案：式（其中R SB 1是可任意取代的烷基等）的化合物; R SB 2是芳烷氧基，其可任意地为 R 3是H，卤素，可任意取代的烷氧基羰基等; R 4是H或可任意取代的烷基;和提供可任意取代的芳基，芳基烷基等）及其药学上可接受的盐。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2006204916A Injection device for administering medication liquid 审中-公开
标题翻译：用于管理药物液体的注射装置
公开(公告)号：JP2006204916A
公开(公告)日：2006-08-10
申请号：JP2006014630
申请日：2006-01-24
申请人： Pharmacia Corp , ファルマシア・コーポレーション
发明人： HJERTMAN BIRGER THURE YNGVAR
IPC分类号： A61M5/315 , A61M39/00
CPC分类号： A61M5/31535 , A61M5/24 , A61M5/3155 , A61M5/31568 , A61M5/3158 , A61M5/31593 , A61M2005/3125 , A61M2005/3126 , A61M2205/583
摘要： PROBLEM TO BE SOLVED: To provide an injection device for administering medication liquid by dividing the liquid into a plurality of doses. SOLUTION: The injection device (1) comprises: a housing (2); a cartridge (6) which is stored with medication liquid or a precursor component of the medication liquid, the cartridge (6) being constituted in such a way that the rear part is closed by a movable wall (10) and the medication liquid is moved forward to the opposite side of the cartridge (6) by displacement of the movable wall (10) and is sent outward through the opposite end; and an operating means (16) which actuates the movable wall (10) via a plunger (14), the plunger (14) being moved forward in the housing by an actuator (16) disposed on the proximal end (18) of the housing (2) and operated by a user. The injection device (1) further comprises a means (30) cooperating with a scale which follows and moves with the plunger (14) and is inclined against the axial line of the whole forward movement of the plunger (14) on the injection device (1). COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种通过将液体分成多个剂量来投与药液的注射装置。注射装置（1）包括：壳体（2）; 与药液或药液的前体成分一起存储的药筒（6），药筒（6）以后部由可动壁（10）封闭，药液移动通过可移动壁（10）的位移向前移动到盒（6）的相对侧，并通过相对端向外传送; 以及经由柱塞（14）致动所述可动壁（10）的操作装置（16），所述柱塞（14）通过设置在所述壳体的近端（18）上的致动器（16）在所述壳体中向前移动（2）并由用户操作。注射装置（1）还包括与标尺协作的装置（30），其随着并随着柱塞（14）移动并且相对于注射装置上的柱塞（14）的整个向前运动的轴线倾斜 1）。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2005119946A Tin oxide causing electrochromism 审中-公开
标题翻译：氧化铅引起电致变色
公开(公告)号：JP2005119946A
公开(公告)日：2005-05-12
申请号：JP2004243253
申请日：2004-08-24
申请人： Pharmacia Corp , フアルマシア・コーポレーシヨン
发明人： COLEMAN JAMES P
IPC分类号： C01G19/02 , C09K9/00 , C09K9/02 , G02F1/15 , H01B1/08 , H01B5/00 , H01B5/14
CPC分类号： C09K9/02 , C09K9/00 , G02F1/1523 , H01B1/08 , Y10T428/2982
摘要： PROBLEM TO BE SOLVED: To provide tin oxide doped with an electrochromically effective amount of a metal such as antimony or niobium. SOLUTION: Antimony or niobium provides a color change when the doped tin is exposed to an electrochemical potential in the presence of mobile ions. Particles of the electrochromically doped tin oxide, e.g. coated on a white or pastel color pigment substrate and causing the electrochromism have a contrast ratio of larger than 1.2, where the contrast ratio is a measure of electrochromic functionality of a material and is the ratio of the reflectance of the material in an oxidized state to the color of the material in a reduced state and where color is a photodiode measurement of the value of light emitted from a constant source of light shining on the oxidized or reduced material and reflected from the material. Such the doped tin oxide-containing particles are useful as an electrochromic material in a display device. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供掺杂有电化学有效量的金属如锑或铌的氧化锡。解决方案：当在存在移动离子时，掺杂的锡暴露于电化学电位时，锑或铌会发生颜色变化。电致变色氧化锡的颗粒，例如涂布在白色或柔和的彩色颜料基体上，并且使电致变色具有大于1.2的对比度，其中对比度是材料的电致变色功能的度量，并且是氧化态的材料的反射率与材料的颜色处于降低状态，并且其中颜色是从照射在氧化或还原材料上并从材料反射的恒定光源发射的光的光电二极管测量值。这种掺杂的含氧化锡的颗粒可用作显示装置中的电致变色材料。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2004201696A Human tissue factor inhibitor 审中-公开
标题翻译：人体组织因子抑制剂
公开(公告)号：JP2004201696A
公开(公告)日：2004-07-22
申请号：JP2004120081
申请日：2004-04-15
申请人： Pharmacia Corp , Washington Univ , フアルマシア・コーポレーシヨン , ワシントン・ユニバーシティWashington University School of Medicine
发明人： BROZE GEORGE JOHN JR , KRETZMER KUNIKO K , WUN TZE-CHEIN
IPC分类号： A61K38/16 , A61P7/02 , C07H21/04 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/745 , C07K14/81 , C07K16/38 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12R1/91 , G01N33/53 , G01N33/543
CPC分类号： C07K14/8114
摘要： PROBLEM TO BE SOLVED: To provide the determined complete coding sequence and amino acid sequence of a cDNA clone representing essentially a full size tissue factor inhibitor. SOLUTION: A recombinant peptide that is produced, purified and isolated in a host cell which is not HepG2 hepatoma cell contains an amino acid sequence selected from the groups consisting of a specific sequence. COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：待解决的问题：提供确定的完全编码序列和代表基本上全尺寸组织因子抑制剂的cDNA克隆的氨基酸序列。解决方案：在不是HepG2肝癌细胞的宿主细胞中产生，纯化和分离的重组肽含有选自特定序列的氨基酸序列。版权所有（C）2004，JPO＆NCIPI

8. 发明专利

JP2007238620A Process for making substituted pyrazole 审中-公开
标题翻译：制备替代吡唑的方法
公开(公告)号：JP2007238620A
公开(公告)日：2007-09-20
申请号：JP2007100476
申请日：2007-04-06
申请人： Pharmacia Corp , ファルマシア・コーポレーション
发明人： ALLEN KIMBERLEY C , ANDERSON DENNIS K , BALDUS JOHN E , BOEHLOW TODD , CLARK JERRY D , DUKESHERER DANIEL R , EDNEY ALBERT D , FEVIG TOM , KUNDA SASTRY , LAWSON JON P , LAU PATRICK H , MCDERMOTT LISA L , MAO MICHAEL K , MOE JODI L , MUDIPALLI PARTHA , NAING WIN , SELNESS SHAUN D , SEYMOUR CHRISTINE B , SCHILKE TOBIN C , VISWANATH SHEKHAR , WALKER JOHN K , YALAMANCHILI GOPICHAND
IPC分类号： C07D401/14 , A61K20060101 , A61K31/506 , A61P1/04 , A61P1/16 , A61P3/10 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P11/08 , A61P13/12 , A61P15/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/22 , A61P33/06 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , C07D211/36 , C07D211/62 , C07D401/04 , C07D401/06
CPC分类号： C07D401/06 , C07D401/14
摘要： PROBLEM TO BE SOLVED: To provide generally a process for making a substituted pyrazole, tautomers of the substituted pyrazole, and a salt of the substituted pyrazole or a tautomer. SOLUTION: The structure of a substituted pyrazole corresponds to formula (I), wherein R 3A , R 3B , R 3C , Y 1 , Y 2 , Y 3 , Y 4 , and Y 5 are specific substituents. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：通常提供制备取代的吡唑的方法，取代的吡唑的互变异构体和取代的吡唑的盐或互变异构体。解决方案：取代的吡唑的结构对应于式（I），其中R 3，R 3，R 3，S 3， 1 ，Y 2 ，Y 3 ，Y 4 和Y 5 具体取代基。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JP2007126460A Substituted polycyclic aryl and heteroaryl tertiary heteroalkylamine useful for inhibiting cholesterol ester transfer protein activity 审中-公开
标题翻译：取代的多环芳烃和异羟肟酸异喹啉酮有助于抑制胆固醇转运蛋白活性
公开(公告)号：JP2007126460A
公开(公告)日：2007-05-24
申请号：JP2006305973
申请日：2006-11-10
申请人： Pharmacia Corp , ファルマシア・コーポレーション
发明人： SIKORSKI JAMES A , DURLEY RICHARD C , MISCHKE DEBORAH A , REINHARD EMILY J , FOBIAN YVETTE M , TOLLEFSON MICHAEL B , WANG LIJUAN , GRAPPERHAUS MARGARET L , HICKORY BRIAN S , MASSA MARK A , NORTON MONICA B , VERNIER WILLIAM F , PARNAS BARRY L , PROMO MICHELE A , HAMME ASHTON T , SPANGLER DALE P , RUEPPEL MELVIN L
IPC分类号： C07C215/08 , C07D251/46 , A61K31/135 , A61K31/136 , A61K31/137 , A61K31/145 , A61K31/16 , A61K31/166 , A61K31/167 , A61K31/17 , A61K31/18 , A61K31/196 , A61K31/222 , A61K31/235 , A61K31/24 , A61K31/245 , A61K31/277 , A61K31/33 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/395 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/41 , A61K31/4164 , A61K31/417 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/438 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/4418 , A61K31/4453 , A61K31/4465 , A61K31/451 , A61K31/455 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/53 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K31/695 , A61P3/06 , A61P9/08 , A61P9/10 , A61P43/00 , B01J31/12 , C07B57/00 , C07B61/00 , C07C213/04 , C07C215/16 , C07C215/28 , C07C215/32 , C07C215/50 , C07C215/68 , C07C215/76 , C07C217/58 , C07C217/82 , C07C217/84 , C07C217/86 , C07C217/88 , C07C217/90 , C07C217/92 , C07C219/06 , C07C219/34 , C07C221/00 , C07C225/22 , C07C229/60 , C07C233/65 , C07C233/69 , C07C233/75 , C07C233/80 , C07C235/38 , C07C235/56 , C07C237/30 , C07C237/38 , C07C239/20 , C07C255/16 , C07C255/54 , C07C255/55 , C07C255/58 , C07C271/28 , C07C271/44 , C07C271/58 , C07C275/34 , C07C275/40 , C07C291/04 , C07C311/04 , C07C311/08 , C07C311/21 , C07C311/24 , C07C311/60 , C07C317/14 , C07C317/32 , C07C317/36 , C07C319/20 , C07C323/19 , C07C323/20 , C07C323/25 , C07C323/31 , C07C323/32 , C07C323/36 , C07C323/37 , C07C323/44 , C07C323/65 , C07C327/22 , C07D207/32 , C07D207/323 , C07D207/335 , C07D209/08 , C07D209/14 , C07D209/32 , C07D209/86 , C07D211/14 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/53 , C07D213/61 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/66 , C07D213/70 , C07D213/80 , C07D213/84 , C07D213/85 , C07D215/12 , C07D215/60 , C07D217/24 , C07D225/08 , C07D233/60 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/34 , C07D251/16 , C07D251/42 , C07D257/04 , C07D263/06 , C07D265/16 , C07D271/06 , C07D277/20 , C07D277/34 , C07D295/10 , C07D295/12 , C07D295/135 , C07D295/192 , C07D307/14 , C07D307/42 , C07D307/52 , C07D307/91 , C07D309/12 , C07D333/20 , C07D333/28 , C07D333/34 , C07D333/56 , C07D491/113 , C07F7/18
CPC分类号： C07D207/335 , A61K31/135 , A61K31/33 , C07C215/16 , C07C215/50 , C07C215/76 , C07C217/58 , C07C217/84 , C07C217/86 , C07C217/88 , C07C217/90 , C07C219/34 , C07C225/22 , C07C229/60 , C07C233/69 , C07C235/38 , C07C237/30 , C07C237/38 , C07C255/55 , C07C255/58 , C07C275/34 , C07C291/04 , C07C311/04 , C07C311/21 , C07C311/24 , C07C311/60 , C07C317/32 , C07C317/36 , C07C323/19 , C07C323/25 , C07C323/31 , C07C323/32 , C07C323/37 , C07C323/44 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07C2603/18 , C07D209/08 , C07D213/26 , C07D213/30 , C07D213/643 , C07D213/66 , C07D213/85 , C07D239/34 , C07D251/16 , C07D251/42 , C07D263/06 , C07D295/135 , C07D295/192 , C07D307/14 , C07D307/42 , C07D307/52 , C07D309/12 , C07D333/20 , C07D333/28
摘要： PROBLEM TO BE SOLVED: To provide a compound and a composition effective for inhibiting the activity of a CETP [cholesterol ester transfer protein (plasma lipid transfer protein-1)] and useful for treating especially atherosclerosis and other coronary arterial diseases. SOLUTION: The compound is a polycyclic aryl and heteroaryl tertiary heteroalkylamine compound. For example, 3-[(3-fluorophenyl)-[[3-(trifluoromethyl)phenyl]methyl]amino]-1,1,1-trifluoro-2-propanol is cited as the polycyclic arylamine compound. COPYRIGHT: (C)2007,JPO&INPIT

10. 发明专利

JP2006321820A STABLE AMORPHOUS CELECOXIB COMPOSITE AND PROCESS THEREFOR 审中-公开
公开(公告)号：JP2006321820A
公开(公告)日：2006-11-30
申请号：JP2006242052
申请日：2006-09-06
申请人： PHARMACIA CORP
发明人： ZHUANG HONGCHUN , GAO PING
IPC分类号： A61K31/415 , A61K31/635 , A61K47/32 , A61K47/38 , A61P29/00 , A61P43/00 , C07D231/12
摘要： PROBLEM TO BE SOLVED: To provide a process for preparing a celecoxib-crystallization inhibitor composite wherein at least a detectable amount of celecoxib is in amorphous form. SOLUTION: The composition prepared according to such the process is also provided. Also provided is a method of treating a medical condition or disorder in a subject where treatment with a cyclooxygenase-2 inhibitor is indicated, comprising administering, for example orally, the composition of the invention in a therapeutically effective amount. COPYRIGHT: (C)2007,JPO&INPIT

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