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1. 发明专利

JPH0770185A COMPOUND WITH CYTOTOXICITY AND ANTIVIRAL CAPABILITY 失效
公开(公告)号：JPH0770185A
公开(公告)日：1995-03-14
申请号：JP4302494
申请日：1994-02-03
申请人： PHARMA MAR SA
发明人： POORU JIEI SHIYUUAA , MAAKU TEII HAMAN , DORORESU JII GURABAROSU
IPC分类号： A61K35/56 , A61K36/02 , A61K38/00 , A61P31/12 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/415

2. 发明专利

JPH0769884A CYTOTOXIC COMPOUND 失效
公开(公告)号：JPH0769884A
公开(公告)日：1995-03-14
申请号：JP4302394
申请日：1994-02-03
申请人： PHARMA MAR SA
发明人： TANAKA JUNICHI , HIGA TATSUO , KAANITSUTO SUWANOBORIRIYUU , CHIYAARUZU UIRIAMU JIEFUOODO , JIERARUDO BERUNARUDEINERI , DORORESU JII GURABUAROSU
IPC分类号： A61K31/19 , A61K31/215 , A61K31/335 , A61K31/357 , A61K35/56 , A61P31/12 , A61P35/00 , C07C59/11 , C07C69/675 , C07C69/708 , C07D319/02
摘要： PURPOSE: To obtain a new compound useful as an antitumor agent or an antiviral agent. CONSTITUTION: A compound of the formula (R is H or a lower alkyl; R is OH or CH3 ; R is OH or CH3 ), e.g. mycaperoxide A methyl ester. A compound of the formula is obtained by dipping a marine sponge such as Mycal-sp-sponge in methanol, concentrating the extract and extraction-treating the residue with methylene chloride.

3. 发明专利

JP2014133752A Antitumoral compounds 有权
标题翻译：抗肿瘤化合物
公开(公告)号：JP2014133752A
公开(公告)日：2014-07-24
申请号：JP2014080887
申请日：2014-04-10
申请人： Pharma Mar Sa , ファルマ・マール・ソシエダード・アノニマ
发明人： ALBERTO RODRIGUEZ VICENTE , MARIA GARRANZO GARCIA-IBARROLA , CARMEN MURCIA PEREZ , FRANCISCO SANCHEZ SANCHO , MARIA DEL CARMEN CUEVAS MARCHANTE , CRISTINA MATEO URBANO , ISABEL DIGON JUAREZ
IPC分类号： C07D309/32 , A61K31/351 , A61K31/695 , A61P35/00 , A61P43/00 , C07F7/18
CPC分类号： A61K31/695 , A61K31/351 , A61K31/366 , C07D309/10 , C07D309/30 , C07D309/32 , C07F7/1856 , Y02P20/55
摘要： PROBLEM TO BE SOLVED: To provide a compound useful in the treatment of cancer.SOLUTION: The present invention provides a compound of the general formula I specified in the figure for use in the treatment of cancer, where A, Y, W, R, R, R, R, Rand Rtake various meanings.
摘要翻译：要解决的问题：提供可用于治疗癌症的化合物。解决方案：本发明提供了用于治疗癌症的图中指定的通式I的化合物，其中A，Y，W，R， R，R，R，Rand Rtake各种含义。

4. 发明专利

JP2012149095A Composition and use of et743 for treating cancer 有权
标题翻译： ET743用于治疗癌症的组成和用途
公开(公告)号：JP2012149095A
公开(公告)日：2012-08-09
申请号：JP2012105249
申请日：2012-05-02
申请人： Pharma Mar Sa , ファルマ・マール・ソシエダード・アノニマ
发明人： CVITKOVIC ESTEBAN , DEMETRI GEORGE DANIEL , GUZMAN CECILIA , JIMENO JOSE , LOPEZ LAZARO LUIS , MISSET JEAN LOUIS , TWELVES C , VON HOFF DANIEL D
IPC分类号： A61K31/4985 , C07D515/22 , A61K31/4995 , A61K31/573 , A61K35/56 , A61P35/00 , A61P43/00
CPC分类号： A61K31/4995
摘要： PROBLEM TO BE SOLVED: To provide a use of ET743 in the preparation of a medicament for the treatment of the human body for cancer, a pharmaceutically prescribed medicament including ET743 for intravenous injection for treating human cancer, and a method for treating cancer in a human patient, including administering ET743.SOLUTION: The method includes: administering ET743 in a dose of 1,000 to 1,500 micrograms per 1 mof the body surface area over 24 hours by intravenous injection, or administering ET743 in a dose of 1,000 to 1,650 micrograms per 1 mof the body surface area over 3 hours by intravenous injection. The method is effective for advanced and/or metastatic previously-treated cancer and cancer resistant or refractory to other treatments, such as sarcoma, particularly, soft tissue sarcoma or bone sarcoma, and mammary cancer.
摘要翻译：待解决的问题：为了提供ET743在制备用于治疗癌症的人体的药物中的用途，包括用于静脉内注射用于治疗人类癌症的ET743的药学上规定的药物和治疗癌症的方法在人类患者中，包括给予ET743。该方法包括：通过静脉内注射24小时以每1m体重表面积1,000至1,500微克/ SP SP =“POST”> 2 的剂量施用ET743，或施用ET743 通过静脉内注射，每3小时通过体重表面积1000至1,650微克/ SP SP =“POST”> 2 。该方法对先前和/或转移的先前治疗的癌症和对其他治疗如癌症，特别是软组织肉瘤或骨肉瘤和乳腺癌的其它治疗具有抗药性或耐药性是有效的。版权所有（C）2012，JPO＆INPIT

5. 发明专利

JP2009292850A Anticancer treatment 审中-公开
标题翻译：抗癌治疗
公开(公告)号：JP2009292850A
公开(公告)日：2009-12-17
申请号：JP2009219607
申请日：2009-09-24
申请人： Ortho Biotech Products Lp , Pharma Mar Sa Soc Unipersonal , オート・バイオテック・プロダクツ・エル・ピーOrtho Biotech Products L.P. , ファルマ・マル・エス・アー, ソシエダッド・ユニペルソナルPharma Mar S.A., Sociedad Unipersonal
发明人： GILLES ERARD , STERNAS LARS-AXEL , TRIFAN OVID , VAN DE VELDE HELGI , TEITELBAUM APRIL
IPC分类号： A61K31/4995 , A61K9/127 , A61K31/704 , A61K47/34 , A61P35/00 , A61P43/00
CPC分类号： A61K31/704 , A61K9/0019 , A61K31/4995 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide further therapies that allow effective treatments of mammals, in particular humans, with ET-743, while reducing or eliminating its toxic side effects and minimizing further adverse effects.
SOLUTION: This invention relates to combination products, combination drug treatments and methods for treating patients afflicted with cancer, having fewer and less severe unwanted toxic effects. According to one aspect, the invention provides a method of treating the human body for cancer comprising administering an effective therapeutic amount of a Pegylated Liposomal form of anthracycline Doxorubicin (PLD), in combination with an effective therapeutic amount of ET-743.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供进一步的治疗方法，其允许用ET-743有效治疗哺乳动物，特别是人，同时减少或消除其毒副作用并最小化进一步的不利影响。解决方案：本发明涉及用于治疗患有癌症的患者的组合产品，组合药物治疗和方法，具有越来越少的不必要的毒性作用。一方面，本发明提供一种治疗癌症的人体的方法，其包括与有效治疗量的ET-743组合施用有效治疗量的蒽环类多柔比星（PLD）的聚乙二醇化脂质体形式。版权所有（C）2010，JPO＆INPIT

6. 发明专利

JPH07118274A SPONGE-DERIVED ACTIVE SUBSTANCE 失效
公开(公告)号：JPH07118274A
公开(公告)日：1995-05-09
申请号：JP8187094
申请日：1994-04-20
申请人： PHARMA MAR SA
发明人： ROBIN BURAIAN KINNERU , HENNINKU-PEETAA GAARUKEN , POORU YOZEFU SHIYUUA , DORORESU GARUSHIA GURABAROSU , GURIN TOOMASU FUEAKUROSU
IPC分类号： A61K31/495 , A61K35/56 , A61P31/04 , A61P31/10 , A61P35/00 , A61P37/06 , C07D487/22

7. 发明专利

JPH06122687A HALICHONDRINS 失效
公开(公告)号：JPH06122687A
公开(公告)日：1994-05-06
申请号：JP10179693
申请日：1993-03-23
申请人： PHARMA MAR SA
发明人： DORORESU JII GURABAROSU , ROBIN JIEI REIKU , JIYON DABURIYU BURANTO , MAREI EICHI JII MANRO , MAAKU SUTEFUAN FUIRIBAATO RITA
IPC分类号： A61K31/35 , A61K31/351 , A61K31/56 , A61P35/00 , C07D493/22 , C12P17/18

8. 发明专利

JP2011026331A Antitumoral analog 审中-公开
标题翻译：抗肿瘤模拟
公开(公告)号：JP2011026331A
公开(公告)日：2011-02-10
申请号：JP2010209928
申请日：2010-09-17
申请人： Pharma Mar Sa , ファルマ・マール・ソシエダード・アノニマ
发明人： MARTINEZ VALENTIN , GALLEGO PILAR , CUEVAS CARMEN , MUNT SIMON , MANZANARES IGNACIO
IPC分类号： C07D515/22 , A61K31/4995 , A61P35/00
CPC分类号： C07D515/22
摘要： PROBLEM TO BE SOLVED: To provide new compounds having most suitable characteristics of cytotoxicity and selectivity to tumor, decreased in systemic toxicity and improved in pharmacokinetic properties. SOLUTION: There are provided derivatives of ecteinascidin 736 of general formula I; [wherein, R 1 , R 2 , R 3 , R 4 and R 5 are each independently selected from the group consisting of H, OH, OR', SH, SR', SOR', SO 2 R', C(=O)R', C(=O)OR', NO 2 , NH 2 , NHR', N(R') 2 , NHC(O)R', CN, halogen, =O and the like; X is independently selected from OR', CN, (=O), or H; each R' is independently selected from the group consisting of H, OH, NO 2 , NH 2 , SH, CN, halogen, =O, C(=O)H, C(=O)CH 3 , CO 2 H and the like; m is 0, 1 or 2; and n is 0, 1, 2, 3 or 4]. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供具有最适合肿瘤细胞毒性和选择性特征的新化合物，降低全身毒性，提高药代动力学性质。解决方案：提供通式I的星虫素抗生素736的衍生物; [其中，R SB 1，R SB 2，R SB 3，R SB 4和R SB 5， SB>各自独立地选自H，OH，OR'，SH，SR'，SOR'，SO 2，R'，C（= O）R'，C（= O ）OR'，NO 2 ，NH 2，NHR'，N（R'）2 SBB，NHC（O）R' 卤素，= O等; X独立地选自OR'，CN，（= O）或H; 每个R'独立地选自H，OH，NO，SO 2，SO 2，SO，CH，CN，卤素，= O，C（= O）H ，C（= O）CH 3，SO 2，H 2等; m为0,1或2; 和n为0,1,2,3或4]。版权所有（C）2011，JPO＆INPIT

9. 发明专利

JPH08176124A NEW ANTITUMOR COMPOUND 失效
公开(公告)号：JPH08176124A
公开(公告)日：1996-07-09
申请号：JP14762495
申请日：1995-06-14
申请人： PHARMA MAR SA
发明人： DORORESU JII GURABAROSU , YOERU KASHIYUMAN , AMIRA RUDEI , JIIZASU ANGERU DE RA FUENTE
IPC分类号： A61K31/135 , A61K31/42 , A61K31/421 , A61K35/56 , A61P35/00 , C07D263/32

10. 发明专利

JP2012167097A Culture of sessile marine animals 审中-公开
标题翻译： SESSILE海洋动物文化
公开(公告)号：JP2012167097A
公开(公告)日：2012-09-06
申请号：JP2012091927
申请日：2012-04-13
申请人： Pharma Mar Sa , ファルマ・マール・ソシエダード・アノニマ
发明人： KUEKUERTCUE TARGOTAY BULLENT , NARANJO LOZANO SANTIAGO , BARBERO GARCIA CARLOS , MARTIN BENITEZ SILVIA
IPC分类号： A61K35/56 , A01K61/00 , A01K67/033 , A61K31/4525 , A61P35/00
CPC分类号： A01K67/033 , A01K61/00 , A01K61/54 , Y02A40/81 , Y02A40/822
摘要： PROBLEM TO BE SOLVED: To enable harvest of a large quantity of pharmaceutical substances from sessile marine organisms.SOLUTION: The present invention relates to the culture of sessile marine organisms. Sessile marine organisms are the source of a large number of marine pharmaceutical substances. The present invention provides a method for manufacturing such marine pharmaceutical substances. The method involves placing a plurality of substrate-like materials in sea water, growing the organism on the plurality of the substrates, harvesting the grown organism, and subsequently extracting a pharmaceutical substance from the harvested organism.

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