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1. 发明专利

JP2014148506A PROCESS FOR PRODUCING 4'-ETHYNYL d4T 审中-公开
标题翻译：生产4'-乙基d4T的方法
公开(公告)号：JP2014148506A
公开(公告)日：2014-08-21
申请号：JP2014008853
申请日：2014-01-21
申请人： Oncolys Biopharma Inc , オンコリスバイオファーマ株式会社
发明人： NAGAI KATSUYUKI , KIGUCHI SHINYA , FURUYAMA HIROYA , WILLIAM EWAN HUME , TSUJIMOTO SATOSHI
IPC分类号： C07D405/04
CPC分类号： C07D307/32 , C07D307/33 , C07D405/04
摘要： PROBLEM TO BE SOLVED: To provide a process for producing a compound simply, at a low cost, and in a large quantity, which becomes an active ingredient of a therapeutic medicament for an HIV infection: 4'-ethynyl-2',3'-didehydro-3'-deoxythymidine (4'-ethynyl d4T).SOLUTION: Provided is a process for producing 4'-ethynyl d4T comprising reacting a compound represented by a formula (III) and thymine, the compound being obtained by reacting a furfuryl alcohol derivative or levoglucosenone with a triple bond compound having H or a tri-substituted silyl group on one end and Li, Al, or monohalogenated Mg on another end, and introducing triple bond containing group. [Ror Rrepresents, H, an acyl group, an alkyl group, an alkenyl group, an aryl group, an aralkyl group, a cycloalkyl group, a heterocyclic group, a heterocyclic alkyl group, or a tri-substituted silyl group; and Rrepresents H or a tri-substituted silyl group.]
摘要翻译：要解决的问题：提供简单地，低成本和大量地生成化合物的方法，其成为用于HIV感染的治疗药物的活性成分：4'-乙炔基-2'，3' - 二脱氢-3'-脱氧胸苷（4'-乙炔基d4T）。溶液：提供一种生产4'-乙炔基d4T的方法，包括使由式（III）表示的化合物与胸腺嘧啶反应，该化合物是通过使糠基醇衍生物或左旋葡萄糖酮与一端具有H或三取代甲硅烷基的三键化合物，另一端为Li，Al或单卤代Mg，并引入含三键的基团。酰基，烷基，烯基，芳基，芳烷基，环烷基，杂环基，杂环烷基或三取代甲硅烷基; R代表H或三取代甲硅烷基。]

2. 发明专利

JP2007015997A Telomelysin-containing agent overcoming antitumor agent resistance 审中-公开
标题翻译：含TELOMELYSIN的含有抗肿瘤药物抗性的试剂
公开(公告)号：JP2007015997A
公开(公告)日：2007-01-25
申请号：JP2005201156
申请日：2005-07-11
申请人： Oncolys Biopharma Inc , オンコリスバイオファーマ株式会社
发明人： FUJIWARA TOSHIYOSHI , TANAKA KISHO , URATA YASUO
IPC分类号： A61K48/00 , A61K31/337 , A61K31/4745 , A61K31/475 , A61K35/76 , A61P35/00 , A61P43/00 , C12N7/00 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a telomelysin-containing agent overcoming antitumor agent resistance containing recombinant virus recombined with a polynucleotide containing human telomerase promotor, E1A gene, IRES sequence and E1B gene in this order. SOLUTION: The telomelysin-containing agent overcoming antitumor agent resistance comprises the recombinant virus recombined with the polynucleotide containing the human telomerase promotor, E1A gene, IRES sequence and E1B gene in this order. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供含有含有端粒聚糖的试剂克服含有重组病毒的抗肿瘤剂抗性，其与含有人端粒酶启动子，E1A基因，IRES序列和E1B基因的多核苷酸重组。解决方案：克服抗肿瘤药物抗性的含有端粒酶的试剂包含与依次包含人端粒酶启动子，E1A基因，IRES序列和E1B基因的多核苷酸重组的重组病毒。版权所有（C）2007，JPO＆INPIT

3. 发明申请

WO2014115859A3 COMBINATION MOLECULARLY TARGETED DRUG FOR TUMOR THERAPY AND PREVENTION 审中-公开
标题翻译：用于肿瘤治疗和预防的组合分子靶向药物
公开(公告)号：WO2014115859A3
公开(公告)日：2014-10-16
申请号：PCT/JP2014051589
申请日：2014-01-25
申请人： SAKAI TOSHIYUKI , ONCOLYS BIOPHARMA INC
发明人： SAKAI TOSHIYUKI
IPC分类号： A61K31/395 , A61K31/5377 , A61K45/00 , A61P35/00 , A61P43/00
CPC分类号： A61K31/395 , A61K31/4439 , A61K31/4745 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： In order to provide a therapeutic and preventative means for a wide range of cancers and tumors including cancers exhibiting PI3K/Akt pathway activation or p53 loss, and tumors for which conventional therapies such as chemotherapy, radiotherapy and hormone therapy have low effectiveness, the present invention combines the use of OBP-801 and different molecularly targeted drugs that act as PI3K inhibitors, suitably LY294002, BKM120, GDC-0941, BEZ235, BYL719 or CH5132799. Thus enabled is the provision of a novel, clinically effective strategy for the therapy and prevention of tumors and applicable to a wide range of tumors, the strategy enabling the simultaneous achievement of various significant pharmacological effects, which could not be achieved by the prescription of the molecularly targeted drugs as a single agent, namely the synergistic activation of capsase pathways, enhanced Bim expression, increased accumulation of intracellular reactive oxygen species, and inhibited survivin and XIAP protein expression.
摘要翻译：为了提供广泛的癌症和肿瘤的治疗和预防手段，包括表现出PI3K / Akt通路激活或p53丧失的癌症，以及诸如化学疗法，放射疗法和激素疗法的常规治疗效果低的肿瘤，本发明结合使用OBP-801和作为PI3K抑制剂的适当LY294002，BKM120，GDC-0941，BEZ235，BYL719或CH5132799的不同分子靶向药物。因此，提供了一种新颖的临床有效的治疗和预防肿瘤的策略，适用于广泛的肿瘤，这种策略能够同时实现各种显着的药理作用，这些策略无法通过处方分子靶向药物作为单一药剂，即协同活化的辣椒素途径，增强Bim表达，增加细胞内活性氧的积累，并抑制存活蛋白和XIAP蛋白的表达。

4. 发明专利

ES2455127T3 Virus oncolíticos que crecen de manera selectiva en células tumorales 未知
公开(公告)号：ES2455127T3
公开(公告)日：2014-04-14
申请号：ES03741222
申请日：2003-07-07
申请人： KANSAI TECH LICENSING ORG CO , ONCOLYS BIOPHARMA INC
发明人： SHIRAKIYA YOSHIKO , KAWASHIMA TAKESHI , KYO SATORU , FUJIWARA TOSHIYOSHI , TANAKA NORIAKI
IPC分类号： C12N15/09 , A61K35/76 , A61K35/761 , A61K38/00 , A61K48/00 , A61P35/00 , C07K14/075 , C12N7/00 , C12N7/01 , C12N9/12 , C12N15/861
摘要： Un polinucleótido que comprende el promotor hTERT, un gen de adenovirus E1A, una secuencia IRES y un gen de adenovirus E1B en este orden, donde el promotor hTERT consiste en la secuencia SEC ID Nº 4, el gen de adenovirus E1A consiste en la secuencia de nucleótidos SEC ID Nº 1, la secuencia IRES consiste en la secuencia de nucleótidos SEC ID Nº 3, y el gen de adenovirus E1B consiste en la secuencia de nucleótidos SEC ID Nº 2.

5. 发明专利

DK1553178T3 Onkolytisk virus til selektiv vækst i tumorceller 未知
公开(公告)号：DK1553178T3
公开(公告)日：2014-05-19
申请号：DK03741222
申请日：2003-07-07
申请人： ONCOLYS BIOPHARMA INC
发明人： SHIRAKIYA YOSHIKO , KYO SATORU , FUJIWARA TOSHIYOSHI , TANAKA NORIAKI , KAWASHIMA TAKESHI
IPC分类号： C12N15/09 , A61K35/76 , A61K35/761 , A61K38/00 , A61K48/00 , A61P35/00 , C07K14/075 , C12N7/00 , C12N7/01 , C12N9/12 , C12N15/861

6. 发明专利

AU2003281310B2 Tumor-lysing virus growing selectively in tumor cells 未知
公开(公告)号：AU2003281310B2
公开(公告)日：2008-02-21
申请号：AU2003281310
申请日：2003-07-07
申请人： KANSAI TECHNOLOGY LICENSING ORGANIZATION CO LTD , ONCOLYS BIOPHARMA INC
发明人： FUJIWARA TOSHIYOSHI , SHIRAKIYA YOSHIKO , KYO SATORU , TANAKA NORIAKI , KAWASHIMA TAKESHI
IPC分类号： C12N15/09 , A61K35/76 , A61K35/761 , A61K38/00 , A61K48/00 , A61P35/00 , C07K14/075 , C12N7/00 , C12N7/01 , C12N9/12 , C12N15/861
摘要： By using a virus having a gene sequence comprising a telomerase promoter and an E1 gene (preferably a sequence comprising E1A gene, IRES sequence and E1B gene) or by using an anticancer agent comprising the virus, the virus replicates in cancer cells to thereby produce an efficient anticancer effect.

7. 发明专利

AU2005288034A1 Telomelysin-GFP gene-containing recombinant virus 未知
公开(公告)号：AU2005288034A1
公开(公告)日：2006-04-06
申请号：AU2005288034
申请日：2005-09-28
申请人： ONCOLYS BIOPHARMA INC
发明人： MIZUGUCHI HIROYUKI , KYO SATORU , HAYAKAWA TAKAO , FUJIWARA TOSHIYOSHI , TANAKA NORIAKI
IPC分类号： C12Q1/04 , A61K35/76 , A61K35/761 , A61K35/768 , A61K38/51 , A61K48/00 , A61K49/00 , A61P35/00 , A61P35/02 , A61P35/04 , A61P43/00 , C12N7/00 , C12N7/01 , C12N15/09 , C12N15/86 , G01N21/78 , G01N33/48 , G01N33/58
摘要： A reagent for cancer cell detection or cancer diagnosis comprises a recombinant adenovirus where a replication cassette comprising a promoter from human telomerase, an adenovirus E1A gene, an IRES sequence and an adenovirus E1B gene in this order is integrated in E1 region of the viral genome and a labeling cassette comprising a gene encoding a labeling protein and a promoter capable of regulating the expression of the gene encoding the labeling protein is integrated in E3 region of the adenovirus genome.

8. 发明专利

PT1553178E VÍRUS ONCOLÍTICO QUE CRESCE SELECTIVAMENTE EM CÉLULAS TUMORAIS 未知
公开(公告)号：PT1553178E
公开(公告)日：2014-06-12
申请号：PT03741222
申请日：2003-07-07
申请人： ONCOLYS BIOPHARMA INC
发明人： FUJIWARA TOSHIYOSHI , KYO SATORU , SHIRAKIYA YOSHIKO , KAWASHIMA TAKESHI , TANAKA NORIAKI
IPC分类号： C12N15/09 , A61K35/76 , A61K35/761 , A61K38/00 , A61K48/00 , A61P35/00 , C07K14/075 , C12N7/00 , C12N7/01 , C12N9/12 , C12N15/861

9. 发明专利

EA011880B1 РЕКОМБИНАНТНЫЙ ВИРУС, СОДЕРЖАЩИЙ ГЕН ТЕЛОМЕЛИЗИНА-GFP 未知
公开(公告)号：EA011880B1
公开(公告)日：2009-06-30
申请号：EA200700694
申请日：2005-09-28
申请人： ONCOLYS BIOPHARMA INC
发明人： FUJIWARA TOSHIYOSHI , TANAKA NORIAKI , KYO SATORU , MIZUGUCHI HIROYUKI , HAYAKAWA TAKAO
IPC分类号： C12Q1/04 , A61K35/76 , A61K35/761 , A61K35/768 , A61K38/51 , A61K48/00 , A61K49/00 , A61P35/00 , A61P35/02 , A61P35/04 , A61P43/00 , C12N7/00 , C12N7/01 , C12N15/09 , C12N15/86 , G01N21/78 , G01N33/48 , G01N33/58
摘要： Настоящееизобретениеотноситсяк созданиюреагентадлявыявленияраковыхклетоки длядиагностированиярака. Вчастности, данноеизобретениеотноситсяк созданиюреагентадлявыявленияраковыхклеток, включающегорекомбинантныйвирус, вкоторомрепликационнаякассета, включающаяпромоторизтеломеразычеловека, генЕ1А, последовательность IRES игенЕ1Вв такомпорядке, интегрированав областьЕ1 геномавирусаи маркирующаякассетас геном, кодирующиммаркирующийбелок, ипромотором, способнымрегулироватьэкспрессиюгена, кодирующегомаркирующийбелок, интегрированав областьЕ3 геномавируса.

10. 发明专利

NZ554799A Telomelysin-GFP gene-containing recombinant virus 未知
公开(公告)号：NZ554799A
公开(公告)日：2009-03-31
申请号：NZ55479905
申请日：2005-09-28
申请人： ONCOLYS BIOPHARMA INC
发明人： FUJIWARA TOSHIYOSHI , TANAKA NORIAKI , KYO SATORU , MIZUGUCHI HIROYUKI , HAYAKAWA TAKAO
IPC分类号： A61K35/76 , A61K35/761 , A61K35/768 , A61K38/51 , A61K48/00 , A61K49/00 , A61P35/00 , A61P35/02 , A61P35/04 , A61P43/00 , C12N7/00 , C12N7/01 , C12N15/09 , C12N15/86 , C12Q1/04 , G01N21/78 , G01N33/48 , G01N33/58
摘要： Disclosed is a regent for detecting cancer cells or diagnosing cancer. In particular a reagent containing a recombinant virus in which a replication cassette having a human telomerase promoter, E1A gene, IRES sequence and E1B gene in this order is integrated into the E1 region of the virus genome while a labelling cassette having a gene encoding a labelled protein and a promoter capable of regulating the expression of the gene is integrated into the E3 region of the virus genome. Further disclosed is a related death-inducing agent further comprising a cell death-inducing protein and it's a promoter, and uses thereof.

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