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1. 发明授权

US06881746B2 Glucagon antagonists/inverse agonists 失效
标题翻译：胰高血糖素拮抗剂/反向激动剂
公开(公告)号：US06881746B2
公开(公告)日：2005-04-19
申请号：US10448529
申请日：2003-05-30
申请人： Jesper Lau , Inge Thoger Christensen , Peter Madsen , Paw Bloch , Carsten Behrens , Janos Tibor Kodra , Poul Enrico Nielsen
发明人： Jesper Lau , Inge Thoger Christensen , Peter Madsen , Paw Bloch , Carsten Behrens , Janos Tibor Kodra , Poul Enrico Nielsen
IPC分类号： A61K31/195 , A61K31/198 , A61K31/41 , A61K31/4439 , A61K45/06 , A61K31/425 , A61P3/00 , C07D277/04
CPC分类号： A61K45/06 , A61K31/195 , A61K31/198 , A61K31/41 , A61K31/4439 , A61K2300/00
摘要： Novel compounds that act to antagonize the action of the glucagon peptide hormone on the glucagon receptor. More particularly, it relates to glucagon antagonists or inverse agonists.
摘要翻译：用于拮抗胰高血糖素肽激素对胰高血糖素受体的作用的新型化合物。更具体地，涉及胰高血糖素拮抗剂或反向激动剂。

2. 发明授权

US6039942A Phytase polypeptides 失效
公开(公告)号：US6039942A
公开(公告)日：2000-03-21
申请号：US993359
申请日：1997-12-18
申请人： Soren Flensted Lassen , Lisbeth Bech , Anders Ohmann , Jens Breinholt , Claus Crone Fuglsang , Peter Rahbek Ostergaard
发明人： Soren Flensted Lassen , Lisbeth Bech , Anders Ohmann , Jens Breinholt , Claus Crone Fuglsang , Peter Rahbek Ostergaard
IPC分类号： A23K1/165 , A23L1/015 , A23L1/03 , A63B57/00 , C12N9/16 , C12P3/00 , A61K38/46 , C12N9/14 , C12N1/20 , C12N15/00
CPC分类号： C12Y301/03026 , A23K20/189 , A23L29/06 , A23L5/25 , A63B57/357 , A63B57/40 , C12N9/16 , C12P3/00 , A63B57/00
摘要： The present invention relates to isolated polypeptides having phytase activity, the corresponding cloned DNA sequences, a process for preparing such polypeptides, and the use thereof for a number of industrial applications. In particular, the invention relates to phytases derived from the phyllum Basidiomycota, phytases of certain consensus sequences and fungal 6-phytases.

3. 发明授权

US06960610B2 Use of glycogen phosphorylase inhibitors for treatment of cardiovascular diseases 失效
标题翻译：使用糖原磷酸化酶抑制剂治疗心血管疾病
公开(公告)号：US06960610B2
公开(公告)日：2005-11-01
申请号：US10429626
申请日：2003-05-05
申请人： Klaus Asger Rytved , Nils Dragsted , Niels Chresten Berg Nyborg , Lars Iversen , Marit Kristiansen
发明人： Klaus Asger Rytved , Nils Dragsted , Niels Chresten Berg Nyborg , Lars Iversen , Marit Kristiansen
IPC分类号： A61K31/40 , A61K31/4015
CPC分类号： A61K31/4015 , A61K31/40
摘要： The present invention provides methods which may effectively be used in the treatment and prevention of early cardiac and early cardiovascular diseases, for example of ischemic origin, such as left ventricular hypertrophy, coronary artery disease, essential hypertension, acute hypertensive emergency, cardiomyopathy, heart insufficiency, exercise tolerance, chronic heart failure, arrhythmia, cardiac dysrhythmia, syncopy, arteriosclerosis, mild chronic heart failure, angina pectoris, cardiac bypass reocclusion, intermittent claudication (arteriosclerosis oblitterens), diastolic dysfunction and systolic dysfunction, as well as improving the success of heart transplantations, through administration of glycogen phosphorylase inhibitor compounds.
摘要翻译：本发明提供了可有效地用于治疗和预防早期心脏和早期心血管疾病的方法，例如缺血来源，例如左心室肥大，冠状动脉疾病，原发性高血压，急性高血压紧急，心肌病，心脏功能不全，运动耐力，慢性心力衰竭，心律失常，心律失常，复位，动脉硬化，轻度慢性心力衰竭，心绞痛，心脏旁路再闭塞，间歇性跛行（动脉硬化闭塞），舒张功能障碍和收缩功能障碍，以及改善心脏的成功通过施用糖原磷酸化酶抑制剂化合物进行移植。

4. 发明申请

US20100041657A1 HALOALKYLSULFONE SUBSTITUTED COMPOUNDS USEFUL FOR TREATING OBESITY AND DIABETES 审中-公开
标题翻译：用于治疗肥胖和糖尿病的HALOALKYLSULFONE替代化合物
公开(公告)号：US20100041657A1
公开(公告)日：2010-02-18
申请号：US11913720
申请日：2006-05-11
申请人： Preben Houlberg Olesen , Holger Claus Hansen , Lise Brown Christiansen , Flemming Elmelund Nielsen , Anders Klarskov Petersen
发明人： Preben Houlberg Olesen , Holger Claus Hansen , Lise Brown Christiansen , Flemming Elmelund Nielsen , Anders Klarskov Petersen
IPC分类号： A61K31/5375 , C07C233/64 , A61K31/165 , C07D333/38 , A61K31/381 , C07D295/00 , C07C69/76 , A61K31/24 , C07C311/15 , A61K31/18 , A61P3/04 , A61P3/10
CPC分类号： C07C317/46 , C07C317/40 , C07C317/50 , C07C323/42 , C07C323/62 , C07C2602/08 , C07C2602/10 , C07C2603/72 , C07D295/26 , C07D307/79 , C07D317/60 , C07D333/38
摘要： The present invention relates to compounds of formula I, in which at least one of R5, R6 and R7 is SR12, S(O)R12 or S(O)2R12 group where R12 is a C1-6haloalkyl group, that act, as chemical uncouplers. Compounds of the invention are useful in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
摘要翻译：本发明涉及式I化合物，其中R 5，R 6和R 7中的至少一个是SR 12，S（O）R 12或S（O）2 R 12基团，其中R 12是C 1-6卤代烷基，其作为化学解偶联本发明的化合物可用于治疗，包括预防肥胖症，糖尿病以及与其相关的许多疾病或病症。

5. 发明授权

US07014625B2 Needle insertion device 有权
标题翻译：针插入装置
公开(公告)号：US07014625B2
公开(公告)日：2006-03-21
申请号：US10679631
申请日：2003-10-06
申请人： Henrik Bengtsson
发明人： Henrik Bengtsson
IPC分类号： A61M37/00
CPC分类号： A61M5/14248
摘要： The invention relates to a needle insertion device comprising a housing with a mounting surface adapted for application to the skin of a subject, where the mounting surface defines a general plane and has a needle aperture formed therein. Adhesive means is arranged on the mounting surface for adhering the insertion device to the skin of the subject, the adhesive means surrounding the needle aperture. A needle comprises a distal pointed end adapted to penetrate the skin of the subject, the pointed end being arranged within the housing in respect of the general plane. The mounting surface surrounding the needle aperture is moveable between a first position in which the pointed end of the needle is arranged within the housing, and a second position in which the pointed end of the needle projects through the needle aperture, thereby pulling the skin portion corresponding to the intended site of needle insertion against the needle.
摘要翻译：本发明涉及一种针插入装置，其包括具有适于施加到受试者皮肤的安装表面的壳体，其中安装表面限定了一般平面并且在其中形成有针孔。粘合装置设置在安装表面上，用于将插入装置粘附到被检体的皮肤上，围绕针孔的粘合装置。针包括适于穿透被检体的皮肤的远端尖端，尖端相对于总平面布置在壳体内。围绕针孔的安装表面可以在其中针的尖端布置在壳体内的第一位置和针的尖端穿过针孔的第二位置之间移动，从而拉动皮肤部分对应于针针针对针的预期位置。

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