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1. 发明申请

WO1989001513A1 FAST-ACTING PROUROKINASE 审中-公开
标题翻译：快速行动预防措施
公开(公告)号：WO1989001513A1
公开(公告)日：1989-02-23
申请号：PCT/JP1988000815
申请日：1988-08-18
申请人： SAGAMI CHEMICAL RESEARCH CENTER , CENTRAL GLASS COMPANY, LIMITED , HODOGAYA CHEMICAL COMPANY, LIMITED , NIPPON SODA COMPANY, LIMITED , NISSAN CHEMICAL INDUSTRIES, LIMITED , TOSOH CORPORATION , KOBAYASHI, Yoichi , OMORI, Muneki , YAMADA, Chikako
发明人： SAGAMI CHEMICAL RESEARCH CENTER , CENTRAL GLASS COMPANY, LIMITED , HODOGAYA CHEMICAL COMPANY, LIMITED , NIPPON SODA COMPANY, LIMITED , NISSAN CHEMICAL INDUSTRIES, LIMITED , TOSOH CORPORATION
IPC分类号： C12N09/72
CPC分类号： C12N9/6462 , C12Y304/21073
摘要： A human prourokinase-like polypeptide having an amino acid sequence represented by the following formula: (Met).Ser1-X156.Y157.Z158- (wherein Met represents an optionally existing methionine, Ser represents serine present at 1-position of the N-terminal, X represents arginine or other amino acid present at 156-position, Y represents proline, glycine, alanine or valine present at 157-position, Z represents lysine or arginine present at 158-position, and the solid line represents the same amino acid sequence as that of corresponding part of natural human prourokinase or human urokinase-like polypeptide wherein lysine at 135-position is replaced by other amino acid than basic amino acids) or having an amino acid sequence substantially the same as this is disclosed. In addition, a DNA segment which codes the above-described polypeptide; a plasmid containing said DNA segment; E. coli transformed by said plasmid; a process for preparing said polypeptide by culturing said E. coli; a medicine containing said polypeptide; use of said polypeptide for prophylaxis or treatment for formation of thrombus; and use of said polypeptide for preparing the medicine for the above purpose are also disclosed.

2. 发明申请

WO1988009343A1 FUSED PROTEIN CONTAINING LYMPHOTOXIN 审中-公开
标题翻译：含有LYMPHOTOXIN的融合蛋白
公开(公告)号：WO1988009343A1
公开(公告)日：1988-12-01
申请号：PCT/JP1988000525
申请日：1988-05-28
申请人： SAGAMI CHEMICAL RESEARCH CENTER , CENTRAL GLASS COMPANY LIMITED , HODOGAYA CHEMICAL COMPANY, LIMITED , NIPPON SODA COMPANY, LIMITED , NISSAN CHEMICAL INDUSTRIES, LIMITED , TOSOH CORPORATION , MIKI, Tetsuzo , KATO, Seishi , OSADA, Hiroshi
发明人： SAGAMI CHEMICAL RESEARCH CENTER , CENTRAL GLASS COMPANY LIMITED , HODOGAYA CHEMICAL COMPANY, LIMITED , NIPPON SODA COMPANY, LIMITED , NISSAN CHEMICAL INDUSTRIES, LIMITED , TOSOH CORPORATION
IPC分类号： C07K13/00
CPC分类号： C07K14/525 , A61K38/00 , C07K14/31 , C07K2319/00 , C07K2319/55 , C07K2319/705
摘要： This invention relates to a fused protein comprising a polypeptide containing an antibody combining site of protein A and a polypeptide of lymphotoxin and having biological activities derived from lymphotoxin and a capability of combining with an antibody. This invention also provides a process for preparing said fused protein, a DNA coding said fused protein necessary for said process, a plasmid containing said DNA and Escherichia coli transformed with said plasmid.

3. 发明申请

WO1986001226A1 FISH CALCITONIN DERIVATIVE, PROCESS FOR ITS PREPARATION, AND GENE SYSTEM THEREFOR 审中-公开
标题翻译：鱼类激素衍生物，其制备方法及其基因系统
公开(公告)号：WO1986001226A1
公开(公告)日：1986-02-27
申请号：PCT/JP1985000459
申请日：1985-08-16
申请人： SAGAMI CHEMICAL RESEARCH CENTER , CENTRAL GLASS COMPANY, LIMITED , HODOGAYA CHEMICAL COMPANY, LIMITED , NIPPON SODA COMPANY, LIMITED , NISSAN CHEMICAL INDUSTRIES, LIMITED , TOYO SODA MANUFACTURING COMPANY, LIMITED , OMORI, Muneki , MIKI, Tetsuzo , NARUSHIMA, Hiroyuki , IKARI, Takaomi , SAITO, Akemi , IKUSHIMA, Noriko , MATSUMOTO, Reiko , WATANABE, Kazuo
发明人： SAGAMI CHEMICAL RESEARCH CENTER , CENTRAL GLASS COMPANY, LIMITED , HODOGAYA CHEMICAL COMPANY, LIMITED , NIPPON SODA COMPANY, LIMITED , NISSAN CHEMICAL INDUSTRIES, LIMITED , TOYO SODA MANUFACTURING COMPANY, LIMITED
IPC分类号： C12N15/00
CPC分类号： C12N9/0069 , A61K38/00 , C07K14/585 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75 , C12N15/62 , C12N15/70 , C12Y113/11002
摘要： This derivative comprises 33 amino acids wherein glycine is added to the C-terminal of fish calcitonin composed of 32 amino acids. This derivative itself has a biological activity and can be converted into natural fish calcitonin composed of 32 amino acids wherein proline in the C-terminal is amidated, by treating it in a conventional manner.

4. 发明申请

WO1987004720A1 HYBRID PLASMINOGEN ACTIVATOR-LIKE POLYPEPTIDE 审中-公开
标题翻译：混合型PLASMINOGEN激活剂类似多肽
公开(公告)号：WO1987004720A1
公开(公告)日：1987-08-13
申请号：PCT/JP1987000065
申请日：1987-01-30
申请人： SAGAMI CHEMICAL RESEARCH CENTER , CENTRAL GLASS COMPANY, LIMITED , HODOGAYA CHEMICAL COMPANY, LIMITED , NIPPON SODA COMPANY, LIMITED , NISSAN CHEMICAL INDUSTRIES, LIMITED , TOYO SODA MANUFACTURING CO., LTD.
发明人： SAGAMI CHEMICAL RESEARCH CENTER , CENTRAL GLASS COMPANY, LIMITED , HODOGAYA CHEMICAL COMPANY, LIMITED , NIPPON SODA COMPANY, LIMITED , NISSAN CHEMICAL INDUSTRIES, LIMITED , TOYO SODA MANUFACTURING CO., LTD. , TAGAWA, Michito , WADA, Masakatsu , YAMANDA, Masayuki , YOKOYAMA, Midori , NUMAO, Naganori
IPC分类号： C12N15/00
CPC分类号： C12N9/6456 , A61K38/00 , C07K2319/00 , C12N15/70
摘要： A hybrid plasminogen activator-like polypeptide comprising a polypeptide region responsible for an affinity to fibrin derived from a tissue plasminogen activator polypeptide and a polypeptide region responsible for an enzyme activity derived from a prourokinase polypeptide; a DNA segment coding for the hybrid polypeptide; plasmid containing the DNA segment; a microorganism transformed with the DNA; and a process for production of the hybrid polypeptide comprising culturing the microorganism and recovering the hybrid polypeptide from the cultured cells.
摘要翻译：一种杂合纤维蛋白溶酶原激活剂样多肽，其包含负责来自组织纤溶酶原激活剂多肽的纤维蛋白亲和力的多肽区域和负责源自原尿激酶多肽的酶活性的多肽区域; 编码杂合多肽的DNA区段; 含有DNA片段的质粒; 用DNA转化的微生物; 以及杂交多肽的制备方法，包括培养微生物并从培养的细胞中回收杂交多肽。

5. 发明申请

WO1986004351A1 STABILIZED HUMAN PROUROKINASE 审中-公开
标题翻译：稳定人体免疫球蛋白
公开(公告)号：WO1986004351A1
公开(公告)日：1986-07-31
申请号：PCT/JP1986000031
申请日：1986-01-24
申请人： SAGAMI CHEMICAL RESEARCH CENTER , CENTRAL GLASS COMPANY, LIMITED , HODOGAYA CHEMICAL COMPANY, LIMITED , NIPPON SODA COMPANY, LIMITED , NISSAN CHEMICAL INDUSTRIES, LIMITED , TOYO SODA MANUFACTURING COMPANY, LIMITED , MIYAKE, Toshio , HIBINO, Yasuo , KOBAYASHI, Yoichi , WATABE, Ken , OMORI, Muneki , MIKI, Tetsuzo , YOKOYAMA, Midori , MATSUMOTO, Reiko , WATANABE, Kazuo , NUMAO, Naganori
发明人： SAGAMI CHEMICAL RESEARCH CENTER , CENTRAL GLASS COMPANY, LIMITED , HODOGAYA CHEMICAL COMPANY, LIMITED , NIPPON SODA COMPANY, LIMITED , NISSAN CHEMICAL INDUSTRIES, LIMITED , TOYO SODA MANUFACTURING COMPANY, LIMITED
IPC分类号： C12N09/72
CPC分类号： C12N9/6462 , C12N15/73 , C12Y304/21073
摘要： Stabilized human prourokinase-like polypeptides wherein the 135th lysine from the N-terminal of human prourokinase is substituted by an amino acid other than basic amino acids, the 157th phenylalanine is substituted by an acidic amino acid, or both of the amino acids are substituted as described above; DNA segment which codes said polypeptides; plasmid which contains said DNA segment; E. coli transformed by said plasmid; and a process for preparing said polypeptide by using said E. coli. The polypeptides are stable against proteases such as plasmin, thrombin, trypsin, etc., thus being easily purified and collected in a pure form. When applied to a living body, the polypeptides are expected to provide a persistent fibrinolytic activity.

6. 发明申请

US20100310537A1 METHOD FOR EXPANDING HEMATOPOIETIC STEM CELLS USING HETEROCYCLIC COMPOUND 有权
公开(公告)号：US20100310537A1
公开(公告)日：2010-12-09
申请号：US12746507
申请日：2008-12-05
申请人： Takanori Nakamura , Atsushi Miyamura , Taito Nishino , Norihisa Ishiwata , Katsuaki Miyaji
发明人： Takanori Nakamura , Atsushi Miyamura , Taito Nishino , Norihisa Ishiwata , Katsuaki Miyaji
IPC分类号： A61K35/12 , C12N5/078 , A61P37/00 , A61P35/00 , A61P7/00 , A61P9/10 , A61P35/02
CPC分类号： C12N5/0647 , A61K35/12 , C12N2501/125 , C12N2501/145 , C12N2501/999
摘要： An object of the present invention is to expand CD34+ cells ex vivo efficiently in a short term using a biologically safe and inexpensively obtainable low molecular weight compound. A still another object of the present invention is to provide an expansion agent for CD34+ cells useful for treatment of various hematopoietic disorders caused by dysfunctional hematopoietic stem cells and/or hematopoietic progenitor cells.A method for expanding CD34+ cells, which comprises culturing CD34+ cells ex vivo in the presence of a compound represented by the formula (I) (wherein A, B, L1, L2, L3, L4, R1, R2, R3, X and Y are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.

7. 发明申请

US20070155897A1 Coating film having low refractive index and large water contact angle 审中-公开
$Coating film having low refractive index and large water contact angle$
标题翻译：涂膜具有低折射率和大的接触角
公开(公告)号：US20070155897A1
公开(公告)日：2007-07-05
申请号：US10583559
申请日：2004-12-17
申请人： Yoshihiro Tani , Kenichi Motoyama
发明人： Yoshihiro Tani , Kenichi Motoyama
IPC分类号： B05D3/02 , C08K3/22 , B60C1/00 , C08G77/06
CPC分类号： C08G77/50 , C09D5/1675 , C09D183/14
摘要： To provide a process for forming an improved coating film on a substrate, particularly to provide a coating film formed on a substrate, as adhered to the surface of the substrate, having a refractive index of from 1.28 to 1.38 and a contact angle with water of from 90° to 115°. A coating film having a refractive index of from 1.28 to 1.38 and a contact angle with water of from 90° to 115°, which is formed as adhered to a substrate surface by forming a reaction mixture comprising a silicon compound (A) of the formula Si(OR)4, a silicon compound (B) of the formula (R1O)3SiCH2CH2(CF2)nCH2CH2Si(OR1)3, an alcohol (C) of the formula R2CH2OH, and oxalic acid (D), in a specific ratio; heating this reaction mixture at a temperature of from 50 to 180° C. in the absence of water, to form a solution of a polysiloxane; then applying a coating fluid comprising the polysiloxane solution on a substrate surface to form a coating; and heat-curing the coating at a temperature of from 80 to 450° C.; a method for forming such a coating film; and a process for producing such a coating fluid.
摘要翻译：为了提供一种在基材上形成改进的涂膜的方法，特别是提供一种形成在基材上的涂膜，粘合到基材表面上，折射率为1.28-1.38，与水的接触角为从90°到115°。 1.一种涂膜，其折射率为1.28〜1.38，与水的接触角为90〜115°，通过形成含有式（I）的硅化合物（A） Si（OR）4 S，式（R 1 O 2）3 SiCH 2的硅化合物（B）3 （CH 2）2 CH 2（OR 2）2（CH 2）2 CH 2 3，将式R 2 CH 2 OH的醇（C）和草酸（ D），具体比例; 在不存在水的情况下，在50〜180℃的温度下加热该反应混合物，形成聚硅氧烷溶液; 然后将包含所述聚硅氧烷溶液的涂布液涂布在基材表面上以形成涂层; 并在80至450℃的温度下热固化涂层; 形成这种涂膜的方法; 以及这种涂布液的制造方法。

8. 发明申请

US20020095013A1 Polymers 失效
标题翻译：聚合物
公开(公告)号：US20020095013A1
公开(公告)日：2002-07-18
申请号：US09991649
申请日：2001-11-26
申请人： Nissan Chemical Industries Limited
发明人： Poopathy Kathirgamanathan , Subramaniam Ganeshamurugan
IPC分类号： C08G069/00
CPC分类号： C08G73/026 , Y10T428/31551
摘要： A method of production of a homopolymer or copolymer or homo-oligomer or co-oligomer product characterised in that the product is obtained by condensation reaction of a diaminoanthracene, substituted or not, optionally with a diiminoanthracene substituted or not in the absence of anthraquinone substituted or not.
摘要翻译：制备均聚物或共聚物或均聚低聚物或共低聚物产物的方法，其特征在于产物是通过二氨基蒽的缩合反应获得的，所述二氨基蒽被取代或未被任选取代或未被取代或不与蒽醌取代或取代的二亚氨基蒽不。

9. 发明授权

US4247480A Process for producing amineoxide 失效
标题翻译：生产氧化胺的方法
公开(公告)号：US4247480A
公开(公告)日：1981-01-27
申请号：US65338
申请日：1979-08-09
申请人： Atsuo Murata , Syuji Tsuchiya , Akihiro Konno , Fumiyoshi Arima , Hisao Ikeda
发明人： Atsuo Murata , Syuji Tsuchiya , Akihiro Konno , Fumiyoshi Arima , Hisao Ikeda
IPC分类号： C07B61/00 , B01J27/00 , C07C291/04 , C07C135/02
CPC分类号： C07C291/04
摘要： An amine oxide is produced by oxidizing a tertiary amine having the formula ##STR1## wherein R.sub.1 and R.sub.2 respectively represent methyl or ethyl group; and R.sub.3 represent a C.sub.8 -C.sub.14 alkyl or alkenyl group in the presence of carbon dioxide and in the presence or absence of an improver selected from the group consisting of ethylenediaminetetraacetic acid, its salts, stanates, polyphosphates, salts of hydroxycaboxylic acid and salts of polycarboxylic acid.
摘要翻译：通过氧化具有式“IMAGE”的叔胺制备氧化胺，其中R1和R2分别表示甲基或乙基; 并且R 3在二氧化碳的存在下和在存在或不存在选自乙二胺四乙酸，其盐，甾烷酸酯，多磷酸盐，羟基羧酸的盐和多元羧酸盐的存在或不存在的情况下代表C 8 -C 14烷基或烯基酸。

10. 发明授权

US4208391A Process for producing aqueous solution of calcium nitrite 失效
标题翻译：亚硝酸钙水溶液的制备方法
公开(公告)号：US4208391A
公开(公告)日：1980-06-17
申请号：US933582
申请日：1978-08-14
申请人： Makoto Endo , Kohji Kusahara
发明人： Makoto Endo , Kohji Kusahara
IPC分类号： C01B21/50 , B01D53/56 , C01F11/00 , C04B22/08 , C23F11/18 , C01B21/20
CPC分类号： C23F11/181 , B01D53/56 , C01F11/00 , C04B22/085
摘要： An aqueous solution of calcium nitrite having high purity and high concentration is obtained by contacting a nitrogen oxides containing gas with an aqueous slurry of calcium hydroxide.It is necessary to use the aqueous slurry having high calcium hydroxide content such as 20 to 40 wt. %, whereby it is necessary to feed the gas having high nitrogen oxides concentration such as 5 to 10 vol. % to give high conversion to calcium nitrite. In order to prevent a formation of a by-product of calcium nitrate, a nitrogen oxides containing gas having 5 to 10 vol. % of a nitrogen oxides concentration and 1.2 to 1.5 of a molar ratio of NO/NO.sub.2 is fed as a first stage and then, the unabsorbed gas is oxidized and the resulting gas having 1 to 3 vol. % of a nitrogen oxides concentration and 1.2 to 1.5 of molar ratio of NO/NO.sub.2 is fed to the aqueous slurry having 3 to 10 wt. % of a calcium hydroxide obtained in the first stage so as to convert the residual calcium hydroxide to calcium nitrite without forming a by-product of calcium nitrate. The process is preferably carried out as continuous process having a first reaction zone and a second reaction zone.
摘要翻译：通过使含有氮氧化物的气体与氢氧化钙的水性浆液接触，可以获得高纯度和高浓度的亚硝酸钙水溶液。需要使用氢氧化钙含量高的含水浆料，例如20〜40重量％％，因此有必要将具有高的氮氧化物浓度的气体例如5〜10体积份。％以提供高亚硝酸钙转化率。为了防止硝酸钙的副产物的形成，含有5〜10体积％氮氧化物浓度的％和NO1 / NO2的摩尔比为1.2〜1.5作为第一阶段进料，然后，未吸收的气体被氧化，得到的气体具有1〜3体积％将氮氧化物浓度的％和NO1 / NO2的摩尔比为1.2〜1.5进料到含有3〜10重量％在第一阶段获得的氢氧化钙的百分比，以便将残留的氢氧化钙转化成亚硝酸钙而不形成硝酸钙的副产物。该方法优选作为具有第一反应区和第二反应区的连续方法进行。

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