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1. 发明申请

WO1987003623A1 AN ELECTROLYTIC PROCESS FOR THE SIMULTANEOUS DEPOSITION OF GOLD AND REPLENISHMENT OF ELEMENTAL IODINE 审中-公开
标题翻译：用于同时沉积金和电解液的电解过程
公开(公告)号：WO1987003623A1
公开(公告)日：1987-06-18
申请号：PCT/US1985002426
申请日：1985-12-06
申请人： IN-SITU, INC. , NIPPON MINING COMPANY LIMITED
发明人： IN-SITU, INC. , NIPPON MINING COMPANY LIMITED , MURPHY, Jack, W.
IPC分类号： C22B11/04
CPC分类号： C01G7/00 , C22B11/04 , C25C1/20 , E21B43/28
摘要： An improved process for recovering gold from gold-containing materials by iodide/iodine leaching wherein the pregnant lixiviant containing solubilized gold and iodine is treated in an electrolytic cell to reduce gold in solution to elemental gold for recovery and reduce iodine to iodide at the cathode, so as to prevent iodine from interfering with subsequent gold recovery processes, and at the same time reoxidize iodide present at the anode to elemental iodine to regenerate the leach solution to the desired iodide:iodine weight ratio, e.g. about 2:1 to about 10:1. Gold is precipitated in the cathode compartment, and if desired, the cathode effluent may be treated for further removal of traces of gold before being passed to the anode compartment. A method for preventing iron contamination of the cathode is also provided comprising buffering the lixivant solution to a pH of about 5.
摘要翻译：一种通过碘化物/碘浸出从含金属材料中回收金的改进方法，其中在电解池中处理含有溶解的金和碘的怀孕浸液，以减少金属溶液中的金，用于回收并在阴极将碘还原成碘，以防止碘干扰随后的金回收过程，并且同时将存在于阳极的碘化物再氧化成元素碘以将浸出溶液再生成所需的碘：碘重量比，例如约2：1至约10：1。金沉淀在阴极室中，如果需要，阴极流出物可以在被传递到阳极室之前进一步去除痕迹的金。还提供了一种用于防止阴极的铁污染的方法，包括将浸取溶液缓冲至约5的pH。

2. 发明申请

WO1992015610A1 HIRUDIN ANALOGUE OR SALT THEREOF, PRODUCTION THEREOF, AND ANTICOAGULANT CONTAINING THE SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译：其仿制品或其盐，其生产方式及其含有活性成分的抗凝剂
公开(公告)号：WO1992015610A1
公开(公告)日：1992-09-17
申请号：PCT/JP1992000253
申请日：1992-03-04
申请人： NIPPON MINING COMPANY LIMITED , FUJI YAKUHIN KOGYO KABUSHIKI KAISHA , MURAMATSU, Ryo , SUKESADA, Akiko , MISAWA, Satoru , NIKUI, Eriko , WADA, Koichi , NAKANO, Masaharu , MORIKAWA, Tadanori , KOBASHI, Kyoichi
发明人： NIPPON MINING COMPANY LIMITED , FUJI YAKUHIN KOGYO KABUSHIKI KAISHA
IPC分类号： C07K07/08
CPC分类号： C07K14/815 , A61K38/00
摘要： A hirudin analogue having high antithrombin activity and platelet aggregation resistance, represented by formula Phe-Glu-A-Ile-Pro-B-Tyr(R)-Tyr(R) and having a tyrosine residue with its hydroxyl group optionally sulfated. In the said formula, A represents Glu or Pro; B represents Glu, Tyr(R), Glu-Asp or Glu-Tyr(R); and (R) represents the hydroxyl group of a tyrosine residue or the sulfate thereof (-O-SO3H). A process for producing a hirudin analogue by sulfating the hydroxyl group of the tyrosine residue. An anticoagulant containing the hirudin analogue (I) as the active ingredient.

3. 发明申请

WO1992008736A1 HIRUDINE MUTANT, PRODUCTION THEREOF, ANTICOAGULANT, SECRETORY VECTOR, MICROORGANISM TRANSFORMED BY SAID VECTOR, AND PRODUCTION OF PRODUCT FROM SAID MICROORGANISM 审中-公开
标题翻译： HIRUDINE突变体，其生产，抗生素，秘密向量，由所述载体转化的微生物以及来自微生物产物的生产
公开(公告)号：WO1992008736A1
公开(公告)日：1992-05-29
申请号：PCT/JP1991001533
申请日：1991-11-08
申请人： NIPPON MINING COMPANY LIMITED , MISAWA, Satoru , MATSUDA, Hitoshi , INOUE, Yoshifumi , FURUYA, Hideyuki
发明人： NIPPON MINING COMPANY LIMITED
IPC分类号： C07K13/00
CPC分类号： C07K14/815 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C07K2319/33 , C12N9/16 , C12N15/10
摘要： A hirudine mutant HVIC3 prepared by replacing an amino acid sequence starting with the 53rd amino acid residue of hirudine HV1 by an amino acid sequence starting with the 53rd amino acid residue of hirudine HV3, said mutant not only having a high antithrombin effect, but also serving to inhibit the elongation of bleeding time. Escherichia coli transformed by a foreign protein secretory vector comprising a DNA sequence containing an origin (ori) of pUC plasmid, a DNA sequence of tac promoter or trp promoter, a DNA sequence coding for signal peptide and a DNA sequence coding for foreign protein, which secretes and produces foreign proteins in large amounts outside the cells.

4. 发明授权

US5767235A Anticoagulant hirudin variants and methods for their production 失效
标题翻译：抗凝血水蛭素变体及其生产方法
公开(公告)号：US5767235A
公开(公告)日：1998-06-16
申请号：US367758
申请日：1995-01-03
申请人： Eriko Nukui , Koichi Wada , Masaharu Nakano , Tadanori Morikawa , Kyoichi Kobashi , Ryo Muramatsu , Akiko Sukesada , Satoru Misawa
发明人： Eriko Nukui , Koichi Wada , Masaharu Nakano , Tadanori Morikawa , Kyoichi Kobashi , Ryo Muramatsu , Akiko Sukesada , Satoru Misawa
IPC分类号： A61K38/00 , C07K14/815 , A61K38/08
CPC分类号： C07K14/815 , A61K38/00
摘要： The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients. Hirudin variants shown in formula (I) having tyrosine residues or having their hydroxyl group sulfated. Methods for producing hirudin variants by sulfating hydroxyl group of said tyrosine residues, and anti-coagulants having hirudin variants shown in formula (I) as active ingredients. Phe-Glu-A-Ile-Pro-B-Tyr(R)-Tyr(R) (I) �In the formula, A represents Glu or Pro, B represents Glu, Tyr (R), Glu-Asp or Glu-Tyr(R), and (R) represents the hydroxy group or its sulfated ester (--O--SO.sub.3 H) of tyrosine residue.!
摘要翻译：本发明涉及具有高抗凝血酶和抗血小板活性的水蛭素变体，其制备方法和具有所述变体作为活性成分的抗凝血剂。具有酪氨酸残基或其羟基硫酸化的式（I）所示的水蛭素变体。通过将所述酪氨酸残基的羟基硫酸化制备水蛭变体的方法和具有式（I）所示水蛭素变体的抗凝血剂作为活性成分。Phe-Glu-A-Ile-Pro-B-Tyr（R）-Tyr R）（I）[式中，A表示Glu或Pro，B表示Glu，Tyr（R），Glu-Asp或Glu-Tyr（R），（R）表示羟基或其硫酸酯（ - O-SO3H）酪氨酸残基。

5. 发明授权

US5194139A Pretreating solution for silver plating and silver plating treating process using the solution 失效
标题翻译：使用溶液镀银和镀银处理工艺的预处理溶液
公开(公告)号：US5194139A
公开(公告)日：1993-03-16
申请号：US666731
申请日：1991-03-08
申请人： Takashi Kinase , Yoshiyuki Hisumi
发明人： Takashi Kinase , Yoshiyuki Hisumi
IPC分类号： C25D3/46 , C25D5/34
CPC分类号： C25D5/34
摘要： An acidic pretreating solution for silver plating, which comprises as an agent for preventing the silver deposition by displacement, an inorganic acid and/or an organic acid, and a silver plating process which uses this pretreating solution. The pretreating solution provides long lasting preventive effect against silver deposition by displacement and the resulting silver plated layer firmly adheres to a metal substrate surface.
摘要翻译：一种用于镀银的酸性预处理溶液，其包括作为防止通过置换银沉积的试剂，无机酸和/或有机酸以及使用该预处理溶液的银镀工艺。预处理溶液通过位移提供对银沉积的持久的预防效果，并且所得到的镀银层牢固地粘附到金属基材表面。

6. 发明授权

US5026639A Method to improve mRNA translation and use thereof for production of platelet factor-4 失效
标题翻译：改善mRNA翻译的方法及其用于制备血小板因子-4的方法
公开(公告)号：US5026639A
公开(公告)日：1991-06-25
申请号：US143731
申请日：1988-01-14
申请人： Paul H. Johnson
发明人： Paul H. Johnson
IPC分类号： C12N1/21 , A61K38/00 , C07K1/22 , C07K14/00 , C07K14/52 , C07K14/745 , C12N15/62 , C12N15/67 , C12P21/00 , C12R1/19
CPC分类号： C12N15/62 , C07K14/522 , C12N15/67 , A61K38/00 , C07K2319/00 , C07K2319/75
摘要： The present invention provides a method to improve the expression of a poorly expressed recombinant protein, such as platelet factor 4, by constructing a gene fusion such that unfavorable secondary structure formed between the region of the messenger RNA specifying the recombinant protein and the region of the messenger RNA containing the ribosome binding site is disrupted. The gene fusion is constructed by inserting a DNA segment of sufficient length to disrupt unfavorable long-range folding interactions which render the ribosome binding site inaccesible to ribosomes thereby interfering with the translation of mRNA. The invention further provides for the expression of recombinant platelet factor 4 and provides recombinant DNA vectors and methods for the bacterial production and recovery of said platelet factor 4.

7. 发明授权

US4968322A Fuel composition and fuel additive 失效
标题翻译：燃料组成和燃料添加剂
公开(公告)号：US4968322A
公开(公告)日：1990-11-06
申请号：US334457
申请日：1989-04-07
申请人： Shintaro Miyawaki , Kiyomi Ishii , Mamoru Yamane
发明人： Shintaro Miyawaki , Kiyomi Ishii , Mamoru Yamane
IPC分类号： C10L1/18 , C10L1/188 , C10L1/30 , C10L1/32
CPC分类号： C10L1/1881 , C10L1/1886
摘要： Disclosed herein are a fuel composition comprising a fuel oil added with at least two kinds of soaps selected from cerium, neodymium and lanthanum soaps and a fuel additive comprising an organic solution that contains at least two kinds of soaps selected from cerium, neodymium and lanthanum soaps.
摘要翻译：本文公开了一种燃料组合物，其包含添加有选自铈，钕和镧肥皂中的至少两种皂的燃料油和包含选自铈，钕和镧肥皂中的至少两种皂的有机溶液的燃料添加剂。

8. 发明授权

US5284977A Process for producing high-purity organic phosphine 失效
标题翻译：生产高纯度有机膦的方法
公开(公告)号：US5284977A
公开(公告)日：1994-02-08
申请号：US874696
申请日：1992-04-28
申请人： Toru Imori , Takayuki Ninomiya , Kazuhiro Kondoh , Kouichi Nakamura , Kouhei Ushikubo
发明人： Toru Imori , Takayuki Ninomiya , Kazuhiro Kondoh , Kouichi Nakamura , Kouhei Ushikubo
IPC分类号： C07F9/50 , C07F9/02
CPC分类号： C07F9/5095
摘要： A high-purity organic phosphine is obtained by washing organic phosphine or an organic solvent solution thereof with water, an alkaline aqueous solution or an acidic aqueous solution, whereby impurities, particularly, silicon compounds, 2-methoxy ethanol, and organic halides, contained in organic phosphine can be removed, so that such high-purity organic phosphine may be used as a raw material for high-performance compound semiconductor thin film with Groups III and V elements of the Periodic Table.
摘要翻译：通过用水，碱性水溶液或酸性水溶液洗涤有机膦或其有机溶剂溶液来获得高纯度有机膦，由此杂质，特别是硅化合物，2-甲氧基乙醇和有机卤化物包含在可以除去有机膦，使得这种高纯度有机膦可以用作具有元素周期表III族和V族元素的高性能化合物半导体薄膜的原料。

9. 发明授权

US5184393A Method of manufacturing flying magnetic head 失效
标题翻译：制造飞行磁头的方法
公开(公告)号：US5184393A
公开(公告)日：1993-02-09
申请号：US781478
申请日：1991-10-17
申请人： Kazuhiro Saito , Nobuo Imazeki
发明人： Kazuhiro Saito , Nobuo Imazeki
IPC分类号： G11B5/127 , G11B5/10 , G11B5/105 , G11B5/31 , G11B5/60 , G11B21/21
CPC分类号： G11B5/10 , G11B5/105 , G11B5/3103 , Y10T29/49032
摘要： In a method of manufacturing a flying magnetic head, the following surfaces are mirror-finished: a bonding surface 18a of a core block 18, a surface 18b of the core block 18 which is on the opposite side of the bonding surface 18a, a surface 19a of a core block 19, and a bonding end surface 2a of a slider 2 formed of a non-magnetic material such as ceramics and having a rectangular sectional configuration. Then, high-melting-point bonding glass layers m are deposited on these surfaces by sputtering or the like. Afterwards, the core blocks 18 and 19 and the slider 2 are put together and simultaneously bonded with each other by heating under pressure through the bonding glass layers m, thereby forming a flying magnetic head block.

10. 发明授权

US4348498A Accelerated hardening of unsaturated polyester resins 失效
标题翻译：不饱和聚酯树脂的加速硬化
公开(公告)号：US4348498A
公开(公告)日：1982-09-07
申请号：US148355
申请日：1980-05-09
申请人： Hiroyoshi Kamio , Yukio Ogino , Kouichi Nakamura
发明人： Hiroyoshi Kamio , Yukio Ogino , Kouichi Nakamura
IPC分类号： C08F4/00 , C08F4/40 , C08F283/01 , C08F299/00 , C08F299/04 , C08L67/06
CPC分类号： C08F299/0464
摘要： Hardening of an unsaturated polyester resin is accelerated by use of (a) a zirconium and/or titanium chelate compound and (b) a cobalt and/or manganese compound as a hardening accelerator.
摘要翻译：通过使用（a）锆和/或钛螯合物和（b）作为硬化促进剂的钴和/或锰化合物来加速不饱和聚酯树脂的硬化。

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