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1. 发明申请

WO2021220170A1 COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2-ALPHA AND THEIR METHODS OF USE 审中-公开
公开(公告)号：WO2021220170A1
公开(公告)日：2021-11-04
申请号：PCT/IB2021/053486
申请日：2021-04-27
申请人： NOVARTIS AG [CH]/[CH]
发明人： FAIRHURST, Robin Alec , FRITSCH, Christine , GERSPACHER, Marc , HINRICHS, Jürgen Hans-Hermann , LANGLOIS, Jean-Baptiste Georges Armand , LEBLANC, Catherine , LI, Tengfei , LORTHIOIS, Edwige Liliane Jeanne , MURA, Christophe , NIETO-OBERHUBER, Cristina Montserrat , TODOROV, Milen , VAUPEL, Andrea , WARIN, Nicolas , WILCKEN, Rainer
IPC分类号： C07D471/04 , C07D519/00 , A61P35/00 , A61K31/437
摘要： The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of disease. The compounds are inhibitors or modulators of HIF2alpha.

2. 发明申请

WO2022123482A1 USE OF MGLUR5 ANTAGONISTS FOR TREATING AMPHETAMINE ADDICTION 审中-公开
公开(公告)号：WO2022123482A1
公开(公告)日：2022-06-16
申请号：PCT/IB2021/061503
申请日：2021-12-09
申请人： NOVARTIS AG [CH]/[CH]
发明人： GASPARINI, Fabrizio , GOMEZ-MANCILLA, Baltazar
IPC分类号： A61K31/404 , A61P25/30
摘要： The invention relates to the mavoglurant, or a pharmaceutically acceptable salt thereof: in the treatment of substance use disorder, wherein the substance is an amphetamine-type stimulant; in a treatment in the reduction of substance use by a substance use disorder patient, wherein the substance is an amphetamine-type stimulant; in a treatment to prevent relapse into substance use by a substance use disorder patient, wherein the substance is an amphetamine-type stimulant; in a treatment to promote substance abstinence by a substance use disorder patient, wherein the substance is an amphetamine-type stimulant; in the treatment of the symptoms of depression or anxiety associated with substance use disorder, wherein the substance is an amphetamine-type stimulant.

3. 发明申请

WO2021124172A 3-(5-METHOXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF 审中-公开
公开(公告)号：WO2021124172A
公开(公告)日：2021-06-24
申请号：PCT/IB2020/062070
申请日：2020-12-16
申请人： NOVARTIS AG [CH]/[CH]
发明人： BONAZZI, Simone , CERNIJENKO, Artiom , COBB, Jennifer Stroka , DALES, Natalie , KERRIGAN, John Ryan , LAM, Philip , MALIK, Hasnain Ahmed , O'BRIEN, Gary , PATTERSON, Andrew W. , THOMSEN, Noel Marie-france , TING, Pamela
IPC分类号： A61P7/00 , C07D401/12 , C07D401/14 , A61K31/4035
摘要： The present disclosure relates to compounds of formula (I') and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

4. 发明申请

WO2021078120A COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES 审中-公开
公开(公告)号：WO2021078120A
公开(公告)日：2021-04-29
申请号：PCT/CN2020/122217
申请日：2020-10-20
申请人： NOVARTIS AG [CH]/[CH] , ZHU, Tingying [CN]/[CN] (SC)
发明人： ZHU, Tingying , BLAQUIERE, Nicole, Alice , HUANG, Richard, Yichong , KIRRANE, Thomas, Martin, Jr. , KORDIKOWSKI, Andreas , MATA, Anne-Catherine , SARKO, Christopher, Ronald , TAFT, Benjamin, Robert , WALDRON, Grace, Lamprecht , YOKOKAWA, Fumiaki
IPC分类号： C07D513/04 , C07D519/00 , A61K31/433 , A61P33/06
摘要： Provided herein are a compound of formula (Ia) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, solid forms, combinations of pharmacologically active agents, pharmaceutical compositions and methods of using such compounds and solid forms thereof to treat or prevent parasitic diseases, for example malaria.

5. 发明专利

YU26899A SREDSTVA ZA ZAŠTITU BILJAKA 未知
公开(公告)号：YU26899A
公开(公告)日：2002-06-19
申请号：YU26899
申请日：1997-12-11
申请人： NOVARTIS AG CH CH
发明人： PAUL MARGOT , GERTRUDE KNAUF-BEITER
IPC分类号： A01N37/24 , A01N37/50
摘要： Preparat mikrobicida za biljke, sa sadrzajem bar dve aktivne komponente sastojaka u kolicini koja proizvodi sinergisticnu aktivnost, zajedno sa odgovarajucim puniocem, naznacen time, sto je komponenta I 2-[α-| [(α-metil-3-trifluorometil-benzil)amino-oksi | -o-tolil]-metilestar glioksilicne kiseline-O-metiloksim, i komponenta II je jedinjenje izabrano iz grupe IIA) 5,5-dihloro-4-(4-fluorfenoksi)kvinolin ("Quinoxyfen"); IIB) 4-ciklopropil-6-metil-N-fenil-2-pirimidinamin ("Cyprodinil"); IIC) benzo(1,2,3)tiadiazol-7-S-metilestar karbotio-kiseline ("Acibenzolar-S-methyl"); IID) 3-anilino-5-metil-5-(4-fenoksifenil)-1,3-oksazolidin-2,4-dion ("Famoxadone"); IIE) 8-(1,1-dimetiletil)-N-etil-N-propil-1,4-dioksaspiro[4,5]dekan-2-metanamin ("Spiroxamin"); IIF) 4-(2,2-difluoro-1,3-benzodioksol-4-il)pirol-3-karbonitril ("Flusioxonil"); IIG) 4-(2,3-dihlorofenil)pirol-3-karbonitril ("Fenpiclonil"); IIF) 1-metil-cikloheksankarboksilicna kiselina-(2,3-dihloro-4-hidroksi-feniul)-amid ("Fenheksamid"); IIJ) 2-| 2-[6-(2-cijano-fenoksi)-pirimidin-4-iloksi[-fenil| -3-metoksi-metilestar akrilicnekiseline ("Azoxystrobin"); IIK) metoksimino-(2-o-toliloksimetil-fenil)-metilestar sircetne kiseline ("Kresoximmetil"); ili po jedna od soli ili metalnih kompleksa komponenata I i II.

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