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1. 发明申请

WO1997048712A1 ASIALOTRISACCHARIDE MORANOLINE DERIVATIVES AND DRUGS 审中-公开
标题翻译： ASIALOTRISACCHARIDE MORANOLINE DORIVATIVES AND DRUGS
公开(公告)号：WO1997048712A1
公开(公告)日：1997-12-24
申请号：PCT/JP1997002069
申请日：1997-06-16
申请人： NIPPON SHINYAKU CO., LTD. , OHGI, Tadaaki , ISHIYAMA, Kouichi , MORI, Kazuya
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07H17/02
CPC分类号： C07H17/02
摘要： Novel asialotrisaccharide moranoline derivatives represented by general formula (I) which inhibit selectins and thus are useful in the treatment of diseases such as inflammation wherein R represents (a) or (b); one of R and R represents galactopyranosyl optionally substituted at all or some of the hydroxyl groups by -SO3H, -CH2COOH or (c) while another represents fucopyranosyl; A represents -(CH2)m-NR -CO-O-, -CO-O-, -(CH2)n-CO-O-, -C2H4(OC2H4)z-NR -CO-O-, -C2H4(OC2H4)y-OCH2-CO-O- or -(CH2)n-O-; R and R are the same or different and each represents a saturated or unsaturated hydrocarbon group or a saturated or unsaturated fatty acid residue; R and R are the same or different and each represents hydroxy, alkyl or alkoxy; and R represents H or alkyl.
摘要翻译：抑制选择素的由通式（I）表示的新型脱二羟基山梨醇衍生物衍生物，因此可用于治疗诸如炎症的疾病，其中R代表（a）或（b）; R 1和R 2中的一个表示通过-SO 3 H，-CH 2 COOH或（c）任选地在所有或一些羟基上被取代的吡喃半乳糖基，而另一个代表fucopyranosyl; A表示 - （CH 2）m -NR 6 -CO-O-，-CO-O-， - （CH 2）n -CO-O-，-C 2 H 4（OC 2 H 4）z -NR NR -CO-O - ， - C 2 H 4（OC 2 H 4）y -OCH 2 -CO-O-或 - （CH 2）n O-; R a和R b相同或不同，各自表示饱和或不饱和烃基或饱和或不饱和脂肪酸残基; R c和R d相同或不同，各自表示羟基，烷基或烷氧基; R e表示H或烷基。

2. 发明申请

WO1997025987A1 ISCHEMIC HEART MUSCLE PROTECTIVE AGENTS 审中-公开
标题翻译： ISCHEMIC HEART MUSCLE保护剂
公开(公告)号：WO1997025987A1
公开(公告)日：1997-07-24
申请号：PCT/JP1997000071
申请日：1997-01-17
申请人： NIPPON SHINYAKU CO., LTD. , FUJIWARA, Hisayoshi , YOSHIKUNI, Yoshiaki , OCHI, Seishi
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： A61K31/445
CPC分类号： C07D471/04 , A61K31/437 , C07C215/42 , C07C2601/14 , C07D211/46
摘要： Ischemic heart muscle protecting agents and remedies for angina pectoris containing as the active ingredient compounds represented by general formula (I), wherein R , R and R are the same or different and each represents hydrogen, acyl, cyclohexanecarbonyl, alkoxyacetyl, naphthylcarbonyl, phenylalkanoyl, cinnamoyl, pyridinecarbonyl, dihydropyridinecarbonyl, thiophenecarbonyl, furylcarbonyl or benzyl; and A represents CH or N; provided that when A represents CH, then R represents hydroxy, R represents alkylamino and R represents hydroxymethyl or acyloxymethyl; while when A represents N, then R represents hydrogen, R represents hydroxymethyl or acyloxy, R represents alkyl, aryloxyalkyl or arylalkenyl, or R and R are combined together so that general formula (I) is represented by general formula (II).
摘要翻译：缺血性心肌保护剂和含有作为由通式（I）表示的活性成分化合物的心绞痛的治疗剂，其中R 1，R 2和R 3相同或不同，各自表示氢，酰基环己烷羰基，烷氧基乙酰基，萘基羰基，苯基烷酰基，肉桂酰基，吡啶羰基，二氢吡啶羰基，噻吩羰基，呋喃基羰基或苄基; A表示CH或N; 条件是当A表示CH时，R 4表示羟基，R 5表示烷基氨基，R 6表示羟甲基或酰氧基甲基; 而当A表示N时，R 6表示氢，R 4表示羟甲基或酰氧基，R 5表示烷基，芳氧基烷基或芳基烯基，或R 4和R 5组合在一起，式（I）由通式（II）表示。

3. 发明申请

WO1996022276A1 ETHYLAMINE DERIVATIVES AND DRUGS 审中-公开
标题翻译：乙酰胺衍生物和药物
公开(公告)号：WO1996022276A1
公开(公告)日：1996-07-25
申请号：PCT/JP1996000086
申请日：1996-01-19
申请人： NIPPON SHINYAKU CO., LTD. , MURASE, Masao , HAMADA, Kozo , ASAKI, Tetsuo
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07C215/50
CPC分类号： C07C219/28 , C07C215/50 , C07C271/44
摘要： A compound of general formula (I) or a pharmaceutically acceptable salt thereof or its hydrate, wherein R and R are each independently alkyl or alkenyl; R is optionally substituted aryl or an optionally substituted aromatic heterocyclic group having at least one heteroatom selected from the group consisting of nitrogen, oxygen and sulfur in the aromatic heterocycle; R is hydrogen, acyl, alkoxycarbonyl or optionally mono- or di-alkyl substituted carbamoyl; and R is hydrogen, halogeno or alkyl.
摘要翻译：通式（I）的化合物或其药学上可接受的盐或其水合物，其中R 1和R 2各自独立地为烷基或烯基; R 3是在芳族杂环中具有至少一个选自氮，氧和硫的杂原子的任选取代的芳基或任选取代的芳族杂环基; R 4是氢，酰基，烷氧基羰基或任选的单或二烷基取代的氨基甲酰基; R 5为氢，卤代或烷基。

4. 发明申请

WO1996000217A1 OPTICALLY ACTIVE QUINOLINECARBOXYLIC ACID DERIVATIVE AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：光活性喹啉羧酸衍生物及其制备方法
公开(公告)号：WO1996000217A1
公开(公告)日：1996-01-04
申请号：PCT/JP1995001255
申请日：1995-06-23
申请人： NIPPON SHINYAKU CO., LTD. , SEGAWA, Jun , MATSUOKA, Masato , AMIMOTO, Isao
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07D215/56
CPC分类号： C07D215/56
摘要： Diastereomers (Ia) and (Ib) obtained by reacting a compound (III) with a chiral carboxylic or amino acid or a reactive derivative thereof, chlorinating the reaction product (II), and separating the obtained diastereomeric mixture (I), wherein R represents hydrogen, halogeno, etc.; R represents hydrogen, etc.; R represents alkyl, etc.; R represents a chiral acyl or amino acid residue; and X represents halogen, or (un)substituted cyclic amino or phenyl.
摘要翻译：通过使化合物（III）与手性羧酸或氨基酸或其活性衍生物反应获得的非对映体（Ia）和（Ib），氯化反应产物（II），并分离得到的非对映体混合物（I） 1>表示氢，卤素等; R 2表示氢等; R 3表示烷基等; R 4表示手性酰基或氨基酸残基; X表示卤素，或（un）取代的环状氨基或苯基。

5. 发明申请

WO1995028835A1 PROCESS FOR PRODUCING PESTICIDE-CONTAINING WAX MATRIX AND AGRICULTURAL PREPARATION 审中-公开
标题翻译：生产含农药的WAX矩阵和农业准备的方法
公开(公告)号：WO1995028835A1
公开(公告)日：1995-11-02
申请号：PCT/JP1995000780
申请日：1995-04-20
申请人： NIPPON SHINYAKU CO., LTD. , NAKAMICHI, Kouichi , IZUMI, Shougo , YASUURA, Hiroyuki
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： A01N25/10
CPC分类号： A01N25/08
摘要： A process for producing a pesticide-containing wax matrix capable of coping with environmental changes, which comprises treating a number of waxes having different properties and a pesticide as the essential ingredient in one batch on a multi-screw extruder. As the waxes having different properties can be mixed with one another sufficiently homogeneously, the pesticide can be released in a highly controlled manner.
摘要翻译：一种能够应对环境变化的含农药蜡基质的方法，其包括在多螺杆挤出机上一批处理许多具有不同性质的蜡和作为必需成分的农药的蜡。由于具有不同性质的蜡可以彼此充分地相互混合，因此可以以高度可控的方式释放农药。

6. 发明申请

WO1995006057A1 GALACTOSYLMORANOLINE DERIVATIVE 审中-公开
标题翻译：糖醇衍生物衍生物
公开(公告)号：WO1995006057A1
公开(公告)日：1995-03-02
申请号：PCT/JP1994001371
申请日：1994-08-19
申请人： NIPPON SHINYAKU CO., LTD. , OHGI, Tadaaki , KYOTANI, Yohsuke , OGAWA, Hirotsugu , EZURE, Yohji
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07H17/02
CPC分类号： C07H17/02
摘要： A novel galactosylmoranoline derivative represented by general formula [I], which is an intermediate for a sialyl-Lewis sugar chain derivative useful as a medicine, wherein R represents C1-C20 alkyl, C10 or lower alkenyl, C10 or lower alkynyl or C10 or lower aralkyl, each of which may be substituted by carboxy, lower alkoxycarbonyl, lower alkoxycarbonylaryloxy, lower alkoxycarbonylamino, amino, aroylamino, lower alkoxyamino, lower alkylamino, carbamoyl, lower alkylcarbamoyl, hydroxy, lower alkoxy, aroyl, aryloxycarbonyl, aralkyloxy, lower alkyl, lower cycloalkyl, epoxy or aryl; R represents hydroxy or acetamido; and R and R are different from each other and each represents hydroxy or 1-galactosyl.
摘要翻译：由通式[I]表示的新型半乳糖基吗啉衍生物衍生物，其是用作药物的唾液酸 - 路易斯糖链衍生物的中间体，其中R 1表示C1-C20烷基，C10或低级烯基，C10或低级炔基或可以被羧基，低级烷氧基羰基，低级烷氧基羰基氧基，低级烷氧基羰基氨基，氨基，芳酰基氨基，低级烷氧基氨基，低级烷基氨基，氨基甲酰基，低级烷基氨基甲酰基，羟基，低级烷氧基，芳酰基，芳氧基羰基，芳烷氧基，低级烷基，低级环烷基，环氧基或芳基; R 2表示羟基或乙酰氨基; R 3和R 4彼此不同，各自表示羟基或1-半乳糖基。

7. 发明申请

WO1994008568A1 METHOD OF MANUFACTURING WAX MATRICES 审中-公开
标题翻译：制作WAX矩阵的方法
公开(公告)号：WO1994008568A1
公开(公告)日：1994-04-28
申请号：PCT/JP1993001472
申请日：1993-10-14
申请人： NIPPON SHINYAKU CO., LTD. , NAKAMICHI, Kouichi , IZUMI, Shougo , YASUURA, Hiroyuki
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： A61K09/26
CPC分类号： A61K9/1694 , A61K9/1617
摘要： A method capable of manufacturing wax matrices efficiently in large quantities at once characterized in that a multiscrew extruder is used to achieve the object.
摘要翻译：一种能够一次大量有效制造蜡基质的方法，其特征在于使用多螺旋挤出机来实现该目的。

8. 发明申请

WO1993021895A1 SCALP CARE PRODUCT COMPOSITION 审中-公开
标题翻译： SCALP CARE产品组合物
公开(公告)号：WO1993021895A1
公开(公告)日：1993-11-11
申请号：PCT/JP1993000531
申请日：1993-04-23
申请人： SHISEIDO COMPANY, LTD. , NIPPON SHINYAKU CO., LTD. , HANZAWA, Chika , UZUKA, Makoto , MATSUDA, Hajime , SAKAI, Tetsuya , NISHI, Toyoyuki
发明人： SHISEIDO COMPANY, LTD. , NIPPON SHINYAKU CO., LTD.
IPC分类号： A61K07/06
CPC分类号： A61Q5/006 , A61K8/97 , A61Q7/00
摘要： A scalp care product composition containing plant extracts for inhibiting the loss of hair of a mammal and promoting the hair growth. Efficacious plant extracts are those of the plants of the family Annonaceae, including ones belonging to the genera Annona L., Anomianthus Sincl., Ellipeiopsis R.E. Fries, Artabotrys R.Br., Molodorum Griff. and Goniothalamus Hook.f. In particular, extracts from the leaves, barks, woods, branches, sarcocarps, pericarps, roots or stems of these plants have not only the effects of promoting the hair growth and preventing the loss of hair, but also the effect of preventing dandruff and itch.
摘要翻译：一种头皮护理产品组合物，其含有用于抑制哺乳动物头发损失并促进毛发生长的植物提取物。有效的植物提取物是家蚕科植物的植物提取物，包括属于芸苔属（Annona L.），Anomianthus Sincl。，Ellipeiopsis R.E。的植物提取物。 Fries，Artabotrys R.Br.，Molodorum Griff。和Goniothalamus Hook.f. 特别是，这些植物的叶，树皮，树皮，树枝，s arks，果皮，根或茎的提取物不仅具有促进毛发生长和防止头发损失的效果，而且还具有防止头皮屑和瘙痒的效果。

9. 发明申请

WO1992012629A1 MOUSE WHICH MANIFESTS MORBIDITY 审中-公开
标题翻译：显示MORBIDITY的鼠标
公开(公告)号：WO1992012629A1
公开(公告)日：1992-08-06
申请号：PCT/JP1992000045
申请日：1992-01-22
申请人： NIPPON SHINYAKU CO., LTD. , MIYAWAKI, Shigeki , YOSHIDA, Haruyoshi
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： A01K67/027
CPC分类号： A01K67/027
摘要： A morbidity model mouse which presents spontaneously with IgA nephropathy in an early stage. A morbidity model mouse which presents with hyper-IgA-emia of 100 mg/dl or above up to the age of four months.
摘要翻译：一种发病模型小鼠，在早期阶段自发出现IgA肾病。一种发病率模型小鼠，其呈现出超过IgA-emia为100mg / dl或更高至四个月龄。

10. 发明申请

WO1992007552A1 LYOPHILIZED PREPARATION AND PRODUCTION THEREOF 审中-公开
标题翻译： LYOPHILIZED的准备和生产
公开(公告)号：WO1992007552A1
公开(公告)日：1992-05-14
申请号：PCT/JP1991001509
申请日：1991-11-05
申请人： NIPPON SHINYAKU CO., LTD. , SEKI, Junzo , YAMAMOTO, Hirofumi , YAMANE, Shuji , TAKAHASHI, Yutaka , USHIMARU, Kouichi
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： A61K09/14
CPC分类号： A61K31/70 , A61K9/0019 , A61K9/1075 , A61K9/19 , A61K47/10 , A61K47/26
摘要： A lyophilized preparation which releases a fat emulsion, wherein the emulsion particle has a mean diameter of 10 to 100 nm, when redissolved prior to use. This preparation is produced by adding maltose in an arbitrary stage of the production of said emulsion prior to lyophilization.

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