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1. 发明申请

WO0203404A3 IMPLANTABLE MEDICAL DEVICE HAVING SPECIALIZED ANODE SHEETS 审中-公开
标题翻译：具有特殊阳极片的可植入医疗器械
公开(公告)号：WO0203404A3
公开(公告)日：2003-02-27
申请号：PCT/US0119732
申请日：2001-06-21
申请人： METRONIC INC
发明人： YAN JENN-FENG , UNTEREKER DARREL F
IPC分类号： A61N1/39 , H01G9/00 , H01G9/04 , H01G9/055 , H01G9/14
CPC分类号： H01G9/055 , A61N1/3956 , A61N1/3968
摘要： This invention relates to implantable medical devices (IMDs) and their various components, including flat electrolytic capacitors with optimised anode layer surface areas, and methods of making and using thereof. In particular, it relates to capacitors formed of a plurality of stacked capacitor layers each having anode layers formed of one or a plurality of partially through-etched bearing an oxide layer and/or through-hole punctured anode sheets.
摘要翻译：本发明涉及可植入医疗器械（IMD）及其各种部件，包括具有优化的阳极层表面积的扁平电解电容器及其制造和使用方法。具体地，涉及由多个堆叠的电容器层形成的电容器，每个层叠电容器层具有由一个或多个部分通过蚀刻的轴承形成的具有氧化物层和/或通孔刺穿的阳极片的阳极层。

2. 发明申请

WO2006078518A1 MULTIPLE BAND COMMUNICATIONS FOR AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于可植入医疗器械的多通带通信
公开(公告)号：WO2006078518A1
公开(公告)日：2006-07-27
申请号：PCT/US2006/000961
申请日：2006-01-12
申请人： METRONIC, INC. , HAUBRICH, Gregory. J , TWETAN, Len, D , ROSAR, George, C
发明人： HAUBRICH, Gregory. J , TWETAN, Len, D , ROSAR, George, C
IPC分类号： A61N1/372 , H04Q7/20 , A61B5/00
CPC分类号： A61N1/37252 , A61B5/0031 , G06F19/00 , G06F19/3418
摘要： In some embodiments, a medical device system may include one or more of the following features: (a) an external medical device (EMD), (b) an implantable medical device (IMD) disposed within a hermetically sealed housing adapted for implantation in the body of a patient to provide a therapy delivery and/or monitoring function, (c) two or more transmitters disposed within the EMD, the two or more transmitters uplinking telemetry transmissions generated by the EMD, (d) two or more receivers disposed within the IMD, the two or more receivers downlinking the telemetry transmissions, and (e) the IMD processing the telemetry transmission received by a selected one of the two or more receivers, the selection being based on which receiver is receiving the best quality signal transmission reception.
摘要翻译：在一些实施例中，医疗设备系统可以包括以下特征中的一个或多个：（a）外部医疗设备（EMD），（b）设置在密封壳体内的可植入医疗设备（IMD），其适于植入提供治疗递送和/或监测功能，（c）设置在EMD内的两个或更多个发射机，两个或更多个发射机上行由EMD生成的遥测传输，（d）两个或更多个接收机设置在 IMD，两个或更多个接收器，用于下行传播遥测传输，以及（e）IMD处理由两个或多个接收机中所选择的接收机接收的遥测传输，所述选择基于哪个接收机正在接收最佳质量信号传输接收。

3. 发明专利

AT418356T 未知
公开(公告)号：AT418356T
公开(公告)日：2009-01-15
申请号：AT05739021
申请日：2005-04-22
申请人： METRONIC INC
发明人： MIESEL KEITH , BLANCO JUSTIN
IPC分类号： A61M39/22 , A61M1/00 , A61M5/142 , A61M5/168 , A61M25/00 , A61M27/00 , A61M31/00 , A61M39/10 , F16K1/40 , F16K47/12 , G01F1/68
摘要： Catheter systems including one or more flow restrictors are disclosed. The catheter systems may include two or more delivery branches. The delivery branches may be connected to a supply catheter section using a branching catheter connector that may include one or more flow restrictors. The flow restrictors may include a restrictor body located within a lumen with a channel located between the restrictor body and interior surface of the lumen, the channel restricting flow through the lumen past the flow restrictor. The channel may be defined by a groove formed in the restrictor body and/or the interior surface of the lumen. Methods of providing pressure relief by flowing fluid past a flow restrictor are also disclosed.

4. 发明申请

US20100211130A1 Treatment of the Autonomic Nervous System 有权
标题翻译：治疗自主神经系统
公开(公告)号：US20100211130A1
公开(公告)日：2010-08-19
申请号：US12706608
申请日：2010-02-16
申请人： Valerio Cigaina
发明人： Valerio Cigaina
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61B5/02405 , A61B5/0456 , A61B5/4035 , A61N1/36085
摘要： Systems and methods are provided for modulating the autonomic nervous system by the electrical stimulation of the neuro-muscular system of a patient, and include an implantable electrical system for gastrointestinal stimulation which incorporates a heart rate sensor to indicate the neurovegetative patient condition, to initiate and terminate stimulation at specific locations, and an algorithm to automatically control electrical stimulation frequency, interval, amplitude, or a combination of such parameters for adaptive treatment of obesity, anorexia, other eating disorders, diseases related with the so called “metabolic syndrome” (e.g., impaired glucose tolerance and diabetes type 2, GERD, systemic hypertension, early arterovascular degeneration, early senility, and the like), and disorders related to a pathologic inbalance of the autonomic nervous system.
摘要翻译：提供了系统和方法，用于通过对患者的神经 - 肌肉系统的电刺激来调节自主神经系统，并且包括用于胃肠刺激的可植入电气系统，其包括心率传感器以指示神经递质患者状况，以启动和在特定位置终止刺激，以及自动控制电刺激频率，间隔，幅度或这些参数的组合的算法，用于适应性治疗肥胖症，厌食症，其他进食障碍，与所谓的“代谢综合征”相关的疾病（例如，，糖耐量异常和2型糖尿病，GERD，全身高血压，早期动脉血管变性，早衰等），以及与自主神经系统的病理性失衡相关的疾病。

5. 发明专利

ES2017411A6 ELECTRODO DE IONTOFORESIS. 未知
公开(公告)号：ES2017411A6
公开(公告)日：1991-02-01
申请号：ES8903651
申请日：1989-10-27
申请人： METRONIC INC
发明人： PHIPPS JOSEPH B
IPC分类号： A61N1/30 , A61N1/04
摘要： ELECTRODO DE IONTOFORESIS. UN ELECTRODO DE IONTOFORESIS MEJORADO QUE EMPLEA UN MIEMBRO DE DISTRIBUCION Y UN RECIPIENTE DE DROGA QUE CONTIENE UNA DROGA IONICA. EL MIEMBRO DE DISTRIBUCION DE LA CORRIENTE ESTA SEPARADO DEL RECIPIENTE DE DROGA POR MEDIO DE UNA MEMBRANA O MATERIAL SELECTIVO PARA IONES QUE TIENE UNA CARGA OPUESTA A LA CARGA DE LA DROGA IONICA. EL MATERIAL SELECTIVO SE APLICA DIRECTAMENTE AL MIEMBRO DE DISTRIBUCION DE LA CORRIENTE.

6. 发明专利

GB1240172A IMPLANTABLE ELECTRODE APPARATUS 未知
公开(公告)号：GB1240172A
公开(公告)日：1971-07-21
申请号：GB4752668
申请日：1968-10-07
申请人： METRONIC INC
发明人： HAGFORS NORMAN RODNEY
IPC分类号： A61N1/05 , A61N1/375
摘要： 1,240,172. Implantable electrode apparatus. MEDTRONIC, Inc. 7 Oct., 1968, No. 47526/ 68. Heading ASR. An electrode apparatus implantable in the body of an animal or human being to stimulate a nerve electrically comprises a first electrode 22, Fig. 4, lying between second and third electrodes 23, 24 in current guarding relation to said first electrode, a lead 26 connected to the first electrode, a lead 28 connected to the second and third electrodes, a head 12 formed of an electrically insulating substance inert to body fluids and tissues, such as silicone rubber, encapsulating the leads 26, 28 and a first portion of said three electrodes, and a neck portion 14 of an electrically insulating &c material leading to a source of electrical signal energy 11, which may be implanted in the body or be exterior of it. The head 12 comprises upper and lower layers (15), (13) Fig. 2 (not shown) separated by a slot 21 and has a groove (20) in the lower layer shaped to house a nerve 27 and having second open portions of the three electrodes shaped thereto in contact with the nerve. The upper layer may be fastened to the lower layer by means of sutures (29), Fig. 5, (not shown). The electrodes are made of metal inert to body fluids such as stainless steel or platinum,. and the leads may be made of coiled stainless steel.

7. 发明申请

US20090270729A1 Implantable Device and Method for Monitoring Venous Diameter 有权
标题翻译：可植入装置及监测静脉直径的方法
公开(公告)号：US20090270729A1
公开(公告)日：2009-10-29
申请号：US12109408
申请日：2008-04-25
申请人： Giorgio Corbucci , Josephus P.A. Smit , Johannes S. Van Der Veen , Geert Van Lembergen , Marinus C.J. Verschelling
发明人： Giorgio Corbucci , Josephus P.A. Smit , Johannes S. Van Der Veen , Geert Van Lembergen , Marinus C.J. Verschelling
IPC分类号： A61B5/0205 , A61B5/053 , A61B8/08
CPC分类号： A61B5/1076 , A61B5/02007 , A61B5/02028 , A61B5/0205 , A61B5/02152 , A61B5/02158 , A61B5/0538 , A61B5/0816 , A61B5/7275 , A61B5/7278 , A61B5/7282 , A61B8/0891 , A61B8/12
摘要： An implantable medical device system and associated method receive a signal from an implantable sensor operatively positioned relative to a vein, the signal being responsive to changes in a diameter of the vein. A diameter of the vein is determined in response to the sensor signal and used in estimating central venous pressure (CVP).
摘要翻译：植入式医疗装置系统和相关方法从相对于静脉可操作地定位的可植入传感器接收信号，所述信号响应于静脉直径的变化。根据传感器信号确定静脉的直径，并用于估计中心静脉压（CVP）。

8. 发明专利

DE602005011957D1 未知
公开(公告)号：DE602005011957D1
公开(公告)日：2009-02-05
申请号：DE602005011957
申请日：2005-04-22
申请人： METRONIC INC
发明人： MIESEL KEITH A , BLANCO JUSTIN A
IPC分类号： A61M39/22 , A61M1/00 , A61M5/142 , A61M5/168 , A61M25/00 , A61M27/00 , A61M31/00 , A61M39/10 , F16K1/40 , F16K47/12 , G01F1/68
摘要： Catheter systems including one or more flow restrictors are disclosed. The catheter systems may include two or more delivery branches. The delivery branches may be connected to a supply catheter section using a branching catheter connector that may include one or more flow restrictors. The flow restrictors may include a restrictor body located within a lumen with a channel located between the restrictor body and interior surface of the lumen, the channel restricting flow through the lumen past the flow restrictor. The channel may be defined by a groove formed in the restrictor body and/or the interior surface of the lumen. Methods of providing pressure relief by flowing fluid past a flow restrictor are also disclosed.

9. 发明申请

US20090299432A1 IMPEDANCE VARIABILITY ANALYSIS TO IDENTIFY LEAD-RELATED CONDITIONS 有权
标题翻译：阻碍可变性分析来识别与铅相关的条件
公开(公告)号：US20090299432A1
公开(公告)日：2009-12-03
申请号：US12180304
申请日：2008-07-25
申请人： Robert W. Stadler , Bruce D. Gunderson , Amisha S. Patel
发明人： Robert W. Stadler , Bruce D. Gunderson , Amisha S. Patel
IPC分类号： A61N1/37 , A61B5/053
CPC分类号： A61N1/36521 , A61N1/3706 , A61N2001/083
摘要： In general, the disclosure relates to techniques for calculating mean impedance values and impedance variability values to detect a possible condition with a lead or device-lead pathway or connection. In one example, a device may be configured to determine an impedance value for an electrical path based on a plurality of measured impedance values for the electrical path, wherein the electrical path comprises a plurality of electrodes, and to determine an impedance variability value based on at least one of the plurality of measured impedance values. The device may be further configured to determine a threshold value based on the determined impedance value and the impedance variability value, compare a newly measured impedance value for the electrical path to the threshold value, and indicate a possible condition of the electrical path based on the comparison.
摘要翻译：通常，本公开涉及用于计算平均阻抗值和阻抗变异性值以用于检测具有引线或器件引导路径或连接的可能状况的技术。在一个示例中，设备可以被配置为基于用于电路径的多个测量的阻抗值来确定电路径的阻抗值，其中电路径包括多个电极，并且基于以下方式确定阻抗变异性值：所述多个测量的阻抗值中的至少一个。该装置还可以被配置为基于所确定的阻抗值和阻抗变异性值来确定阈值，将新测量的电通路的阻抗值与阈值进行比较，并且基于该路径指示电路径的可能状态比较。

10. 发明专利

DE60128362T2 未知
公开(公告)号：DE60128362T2
公开(公告)日：2008-01-10
申请号：DE60128362
申请日：2001-06-21
申请人： METRONIC INC
发明人： YAN JENN-FENG , UNTEREKER DARREL F
IPC分类号： H01G9/055 , A61N1/39 , H01G9/00 , H01G9/04 , H01G9/14
摘要： Implantable medical devices (IMDs) and their various components, including flat electrolytic capacitors for same, and methods of making and using same, particularly an improved electrolytic capacitor with optimized ESR and anode layer surface area. An electrode stack assembly and electrolyte are located within the interior case chamber of a hermetically sealed capacitor case. The electrode stack assembly comprises a plurality of capacitor layers stacked in registration upon one another, each capacitor layer comprising a cathode layer having a cathode tab, an anode sub-assembly comprising at least one anode layer having an anode tab, and a separator layer located between adjacent anode and cathode layers, whereby all adjacent cathode layers and anode layers of the stack are electrically insulated from one another by a separator layer. Anode terminal means extend through the capacitor case side wall for electrically connecting a plurality of the anode tabs to one another and providing an anode connection terminal at the exterior of the case. Cathode terminal means extend through or to an encapsulation area of the capacitor case side wall for electrically connecting a plurality of the cathode tabs to one another and providing a cathode connection terminal at the exterior of the case. A connector assembly is electrically attached to the anode connection terminal for making electrical connection with the anode tabs and to the cathode connection terminal for making electrical connection with the cathode tabs. The anode layers are formed of one or more partially through-etched anode sheet bearing an oxide layer and formed with a plurality of punctures therethrough.

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