会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 6. 发明申请
    • PEPTIDE-BASED PEROXIDASE INHIBITORS AND METHODS OF USING SAME
    • 基于肽的过氧化物酶抑制剂及其使用方法
    • WO2011044096A1
    • 2011-04-14
    • PCT/US2010/051425
    • 2010-10-05
    • MCW RESEARCH FOUNDATION, INC.ZHANG, HaoSHI, YangXU, HaoPRITCHARD, Kirkwood, A., Jr.
    • ZHANG, HaoSHI, YangXU, HaoPRITCHARD, Kirkwood, A., Jr.
    • A61K38/00A61K38/06
    • A61K38/06A61K38/02
    • The present invention provides peptide -based peroxidase inhibitors having the formula AA 1 -AA 2 - AA 3 , wherein AA1is a positively charged, negatively charged or neutral amino acid, AA 2 is a redox active amino acid, and AA 3 is an amino acid possessing a reducing potential such that AA 3 is capable of undergoing a redox reaction with a radical of amino acid AA 2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti- inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
    • 本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂,其中AA1为带正电荷,带负电荷或中性氨基酸,AA2为氧化还原活性氨基酸,AA3为具有还原电位的氨基酸, 该AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。 这种组合的结果是高度有效的过氧化物酶活性抑制剂,其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。 示例性的三肽有效抑制过氧化物酶介导的LDL氧化,增加SCD小鼠的血管舒张,抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积,抑制急性肺损伤,减少心脏缺血性损伤。