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1. 发明专利

AT519492T 未知
公开(公告)号：AT519492T
公开(公告)日：2011-08-15
申请号：AT04729596
申请日：2004-04-27
申请人： LI MIN PHARMACEUTICAL FACTORY OF LIVZON PHARMCEUTICAL GROUP
发明人： XIE WEIHONG , LIU XUEHUA , CHEN MAORU
IPC分类号： A61K36/258 , A61K31/704 , A61P9/10
摘要： The invention shows the saponins family of Radix notoginshen intravenous injection, a method for preparation thereof. The object is to provide an intravenous injection for prevention and treatment of cardiac and cerebral vascular disease and its sequelae. This injection has stable pH, could be used in large dosage, and with main active component of saponins family of Radix notoginshen. The main components for this injection includes saponins family of Radix notoginshen with a concentration of 0.1mg-14.0mg (Rgl), iso-osmotic solution with a concentration of 7.5-9.6mg/ml, and pH stabilizer with a concentration of 0.2-0.5mg/ml. The solvent for said injection is distilled water. The method for preparation of the saponins family of Radix notoginshen intravenous injection includes: (1) dissolution of iso-osmotic solution in distilled water to a concentration of 50-300mg/ml, and filtration through active carbon; (2) addition of the saponins family of Radix notoginshen intravenous injection to the filtrate to a concentration of 0.1 mg-14.0mg (Rgl); (3) addition of pH stabilizer to the filtrate to a concentration of 0.2-0.5mg/ml, filtration until clear, packaging and obtaining of the saponins family of Radix notoginshen intravenous injection.

2. 发明公开

EP2916130A4 METHOD FOR ESTABLISHING SHENQI FUZHENG INJECTION FINGERPRINT SPECTRUM 有权
标题翻译：用于生产参芪扶正喷射指纹图谱
公开(公告)号：EP2916130A4
公开(公告)日：2016-09-28
申请号：EP13851081
申请日：2013-11-01
申请人： LI MIN PHARMACEUTICAL FACTORY OF LIVZON PHARMCEUTICAL GROUP
发明人： SONG YANGANG , LIU XUEHUA , HUANG WENHUA , LIU DONGLAI
IPC分类号： G01N30/02 , G01N30/72 , G01N33/15
CPC分类号： G01N30/8686 , G01N30/7233 , G01N33/15 , G01N2030/8813

3. 发明授权

EP2916130B1 METHOD FOR ESTABLISHING SHENQI FUZHENG INJECTION FINGERPRINT SPECTRUM 有权
公开(公告)号：EP2916130B1
公开(公告)日：2022-05-25
申请号：EP13851081.3
申请日：2013-11-01
发明人： SONG, Yangang , LIU, Xuehua , HUANG, Wenhua , LIU, Donglai
IPC分类号： G01N30/02 , G01N30/72 , G01N33/15

4. 发明公开

EP2916130A1 METHOD FOR ESTABLISHING SHENQI FUZHENG INJECTION FINGERPRINT SPECTRUM 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG EINES深圳市福田兴业有限公司 - FINGERABDRUCKSPEKTRUMS
公开(公告)号：EP2916130A1
公开(公告)日：2015-09-09
申请号：EP13851081.3
申请日：2013-11-01
申请人： Li Min Pharmaceutical Factory of Livzon Pharmceutical Group
发明人： SONG, Yangang , LIU, Xuehua , HUANG, Wenhua , LIU, Donglai
IPC分类号： G01N30/02 , G01N30/72 , G01N33/15
CPC分类号： G01N30/8686 , G01N30/7233 , G01N33/15 , G01N2030/8813
摘要： A method for establishing a Shenqi Fuzheng injection fingerprint spectrum, comprising: employing an ultra-high voltage liquid chromatography mass spectrometer to test the Shenqi Fuzheng injection, the chromatography conditions including: chromatographic column: Agilent Zorbax Eclipse Plus C18, 2.1 mm x 100 mm, 1.8 µm; mobile phase: mobile phase A is 0.1 % formic acid aqueous solution, and mobile phase B is 0.1% formic acid acetonitrile solution; employing gradient elution procedure as follows: 0-0.5 min, 95% of mobile phase A, and 5% of mobile phase B; 0.5-10 min, 95%-75% of mobile phase A, and 5%-25% of mobile phase B; 10-15 min, 75%-45% of mobile phase A, and 25%-55% of mobile phase B; 15-18 min, 45%-0% of mobile phase A, and 55%-100% of mobile phase B; and 18-20 min, 0% of mobile phase A, and 100% of mobile phase B.
摘要翻译：一种建立神奇福正注射指纹谱的方法，包括：采用超高压液相色谱质谱仪对沉奇福正注射液进行检测，色谱条件为：色谱柱：Agilent Zorbax Eclipse Plus C18,2.1mm×100mm， 1.8μm; 流动相：流动相A为0.1％甲酸水溶液，流动相B为0.1％甲酸乙腈溶液; 采用梯度洗脱程序如下：0-0.5分钟，95％流动相A和5％流动相B; 0.5-10分钟，95％-75％流动相A和5％-25％流动相B; 10-15分钟，75％-45％流动相A和25％-55％流动相B; 15-18分钟，流动相A为45％-0％，流动相B为55％-100％; 和18-20分钟，流动相A为0％，流动相B为100％。

5. 发明授权

EP1637152B1 A NOTOGINSENG SAPONIN INTRAVENOUS INJECTION AND THE METHOD FOR PREPARING THIS INJECTION 失效转让
标题翻译：静脉注射三七皂苷注射液和方法制备本注射液
公开(公告)号：EP1637152B1
公开(公告)日：2011-08-10
申请号：EP04729596.9
申请日：2004-04-27
申请人： Li Min Pharmaceutical Factory of Livzon Pharmceutical Group
发明人： XIE, Weihong , LIU, Xuehua , CHEN, Maoru
IPC分类号： A61K36/258
CPC分类号： A61K36/258 , A61K2300/00
摘要： The present invention discloses a notoginseng saponin large capacity intravenous injection and the method for preparing this injection. The injection of the present invention consists of notoginseng saponin, isoosmotic agent, PH regulator; the solvent of the injection is injection distilled water. A refined injection is prepared through dissolving isoosmotic agent by injection distilled water; adding acticarbon, filtering; adding notoginseng saponin in the filtertes, agitating to dissolution; adding PH regulator, filtering to clarification, asepticizing, packing, then notoginseng saponin large capacity intravenous injection is prepared.

6. 发明公开

EP1637152A8 A NOTOGINSENG SAPONIN INTRAVENOUS INJECTION AND THE METHOD FOR PREPARING THIS INJECTION 失效转让
标题翻译：静脉注射三七皂苷注射液和方法制备本注射液
公开(公告)号：EP1637152A8
公开(公告)日：2006-08-23
申请号：EP04729596.9
申请日：2004-04-27
申请人： Li Min Pharmaceutical Factory of Livzon Pharmceutical Group
发明人： XIE, Weihong , LIU, Xuehua , CHEN, Maoru
IPC分类号： A61K36/00
CPC分类号： A61K36/258 , A61K2300/00
摘要： The invention shows the saponins family of Radix notoginshen intravenous injection, a method for preparation thereof. The object is to provide an intravenous injection for prevention and treatment of cardiac and cerebral vascular disease and its sequelae. This injection has stable pH, could be used in large dosage, and with main active component of saponins family of Radix notoginshen. The main components for this injection includes saponins family of Radix notoginshen with a concentration of 0.1mg-14.0mg (Rgl), iso-osmotic solution with a concentration of 7.5-9.6mg/ml, and pH stabilizer with a concentration of 0.2-0.5mg/ml. The solvent for said injection is distilled water. The method for preparation of the saponins family of Radix notoginshen intravenous injection includes: (1) dissolution of iso-osmotic solution in distilled water to a concentration of 50-300mg/ml, and filtration through active carbon; (2) addition of the saponins family of Radix notoginshen intravenous injection to the filtrate to a concentration of 0.1 mg-14.0mg (Rgl); (3) addition of pH stabilizer to the filtrate to a concentration of 0.2-0.5mg/ml, filtration until clear, packaging and obtaining of the saponins family of Radix notoginshen intravenous injection.

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