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    • 2. 发明申请
    • PROCESS FOR THE PREPARATION OF PIPERIDINES
    • 制备哌啶的方法
    • WO1998003483A1
    • 1998-01-29
    • PCT/JP1997002495
    • 1997-07-18
    • KOEI CHEMICAL CO., LTD.
    • KOEI CHEMICAL CO., LTD.HARADA, Katsutoshi
    • C07D211/02
    • C07D295/023C07D211/02
    • A process for the preparation of piperidines by catalytic reduction of pyridines, whereby the catalytic reduction of a pyridine can be completed even with a relatively small amount of a catalyst and the formation of by-products having boiling points near that of an objective piperidine can be inhibited to attain the preparation of the piperidine in a high yield, characterized by charging a pyridine and at least 2 % by weight (based on the pyridine) of a stabilized nickel catalyst into a pressure reactor and conducting the catalytic reduction of the pyridine under agitation at a reaction temperature of 140 to 250 DEG C under a hydrogen pressure kept at 30 to 100 kgf/cm (2.9 x 10 to 9.8 x 10 Pa) by introducing hydrogen into the reactor.
    • 通过吡啶的催化还原制备哌啶的方法,即使使用相对少量的催化剂也可以完成吡啶的催化还原,并且形成沸点接近目标哌啶的副产物可以是 抑制以高产率制备哌啶,其特征在于将吡啶和至少2重量%(基于吡啶)的稳定的镍催化剂装入压力反应器中并在搅拌下进行催化还原吡啶 在140〜250℃的反应温度下,通过将氢气引入反应器中,在氢气压力保持在30〜100kgf / cm 2(2.9×10 6〜9.8×10 6 Pa)的条件下进行。
    • 5. 发明申请
    • PROCESS FOR PREPARING ACID SALTS OF 'gamma'-(PIPERIDYL)BUTYRIC ACID
    • 制备γ-(哌啶)丁酸的酸盐的方法
    • WO1998015531A1
    • 1998-04-16
    • PCT/JP1997003594
    • 1997-10-07
    • KOEI CHEMICAL CO., LTD.SAKAI, ToshitoNAGAOKA, MasayoKANNO, Ken
    • KOEI CHEMICAL CO., LTD.
    • C07D211/34
    • C07D211/34C07D213/55
    • A process for preparing acid salts (2) of gamma -(piperidyl)butyric acid by hydrogenating an acid salt (1) of gamma -(pyridyl)butyric acid (preferably, one prepared through the following steps (a) and (b) and having a content of acid salts (3) of bis(pyridylethyl)acetic acid of not more than 3 % by weight) in a solvent in the presence of a catalyst, wherein a rhodium, palladium or ruthenium catalyst is used as the catalyst. Step (a): a vinylpyridine compound (4) is reacted with a diester (5) of malonic acid in the presence of a base to prepare a diester (6) of 2-(pyridylethyl)malonic acid. Step (b): the diester (6) prepared in the step (a) is hydrolyzed and decarboxylated in an aqueous acid solution to prepare the acid salt (1) of gamma -(pyridyl)butyric acid.
    • 通过氢化γ-(吡啶基)丁酸的酸性盐(1)(优选通过以下步骤(a)和(b)制备的酸)的盐酸盐(1),制备γ-(哌啶基)丁酸的酸式盐(2) 在催化剂存在下,在溶剂中含有不超过3重量%的双(吡啶基乙基)乙酸的酸式盐(3)的含量,其中使用铑,钯或钌催化剂作为催化剂。 步骤(a):将乙烯基吡啶化合物(4)与丙二酸二酯(5)在碱的存在下反应,制备2-(吡啶基乙基)丙二酸二酯(6)。 步骤(b):将步骤(a)中制备的二酯(6)在酸性水溶液中水解脱羧,制备γ-(吡啶基)丁酸的酸式盐(1)。