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1. 发明专利

JP2014147800A Endoluminal medical access device 审中-公开
标题翻译：内镜医疗访问装置
公开(公告)号：JP2014147800A
公开(公告)日：2014-08-21
申请号：JP2014062445
申请日：2014-03-25
申请人： Karolinska Institutet Innovations Ab , カロリンスカインスティテュテットイノベーションズエービー
发明人： STAFFAN HOLMIN , STEFAN JONSSON , JOHAN LUNDBERG
IPC分类号： A61M25/00
CPC分类号： A61B17/3423 , A61B10/04 , A61B17/3494 , A61B2017/3425 , A61B2017/3492 , A61B2018/1892 , A61M25/0068 , A61M25/0069 , A61M25/0082 , A61M25/0084 , A61M25/06 , A61M2025/0042 , A61N1/05
摘要： PROBLEM TO BE SOLVED: To provide an endoluminal medical access device to prevent or avoid bleeding and safely perform endoluminal delivery to an extravascular target site in a vasculature site of a human or animal body vasculature such as a microvasculature.SOLUTION: An endoluminal medical access device 1 comprises: a hollow body 112 arranged around a continuous channel that ends in a distal end 100 comprises s a distal penetration portion 102. The distal penetration portion 102 extends across a tissue wall of the microvasculature site at an extravascular target site to provide communication with the extravascular target site through a channel 113. The endoluminal medical access device 1 comprises: a proximal connection section 101 which proximally adjoins the penetration portion 102 devised for at least partly apposition to the tissue wall; and intrusion depth limit units 116, 118 to provide a controllable separation of the penetration portion 102 from a connected proximal portion 110 of the hollow body 112.
摘要翻译：要解决的问题：提供一种腔内医疗进入装置，以预防或避免出血，并安全地进行腔内输送到人体或动物体脉管系统如微血管系统的脉管系统部位的血管外靶点部位。解剖：腔内医疗进入装置图1包括：围绕终端100的连续通道设置的中空本体112包括远端穿透部分102.远端穿透部分102在血管外靶点位置延伸穿过微血管部位的组织壁，以提供与血管内目标部位通过通道113.腔内医疗进入装置1包括：近端连接部分101，其近侧邻接穿透部分102，其设计成用于至少部分地邻接于组织壁; 和入侵深度限制单元116,118，以提供穿透部分102与中空本体112的连接的近端部分110的可控分离。

2. 发明申请

WO2012004165A1 NOVEL ENDOLUMINAL MEDICAL ACCESS DEVICE 审中-公开
标题翻译：新的内窥镜医疗访问设备
公开(公告)号：WO2012004165A1
公开(公告)日：2012-01-12
申请号：PCT/EP2011/060854
申请日：2011-06-28
申请人： LUNDBERG, Johan , HOLMIN, Staffan , JONSSON, Stefan , KAROLINSKA INSTITUTET INNOVATIONS AB
发明人： LUNDBERG, Johan , HOLMIN, Staffan , JONSSON, Stefan
IPC分类号： A61M25/00 , A61M25/06 , A61B17/00 , A61B18/14 , A61N1/05 , A61N5/00 , A61N5/10 , A61N5/06
CPC分类号： A61B18/082 , A61B17/3468 , A61B17/3478 , A61B18/1477 , A61B18/1492 , A61B2017/00247 , A61B2018/00404 , A61B2018/00577 , A61B2018/1495 , A61M25/0069 , A61M25/065 , A61M2025/0042 , A61N1/0587 , A61N5/1027 , A61N2001/0585 , A61N2005/0612 , A61N2005/063
摘要： An endoluminal medical access device (1) is disclosed that is devised for endoluminal delivery to an extravascular target site (5) at a vasculature site of a human or animal body vasculature, such as the microvasculature. The device (1) comprises a body (112) that ends in a distal end (100) and comprises a distal penetration portion (102) that is devised to extend across a tissue wall of said microvasculature said microvasculature site (4) at an extravascular target site in said body and devised for at least partly apposition to said tissue wall, and a proximal connection section (101), which proximally adjoins said penetration portion (102), and optionally comprises an intrusion depth limit unit (116, 118) and/or a separation section (115) devised to provide a controllable separation of the penetration portion (102) from a connected proximal portion (110) of the body. The distal portion comprises an outer surface (136) adapted to be in transceiving communication with the target site when arranged at the latter.
摘要翻译：公开了一种腔内医学通路装置（1），其被设计用于在人或动物体脉管系统（诸如微血管）的脉管系统位点处腔内递送至血管外靶位点（5）。所述装置（1）包括终止于远端（100）并且包括远端穿透部分（102）的主体（112），所述远端穿透部分被设计为在血管外血管的所述微血管部位（4）处延伸穿过所述微血管的组织壁目标位置并设计用于至少部分地与所述组织壁并置;以及近侧连接部分（101），所述近侧连接部分在近侧邻接所述穿透部分（102），并且可选地包括侵入深度限制单元（116,118）和 /或设计成提供穿透部分（102）与本体的连接的近侧部分（110）的可控分离的分离部分（115）。远端部分包括外表面（136），其适于在布置在目标部位时与目标部位进行收发通信。

3. 发明申请

WO2009124990A1 ENDOLUMINAL MEDICAL ACCESS DEVICE 审中-公开
标题翻译：内镜医疗访问装置
公开(公告)号：WO2009124990A1
公开(公告)日：2009-10-15
申请号：PCT/EP2009/054273
申请日：2009-04-08
申请人： Karolinska Institutet Innovations AB , HOLMIN, Staffan , JONSSON, Stefan , LUNDBERG, Johan
发明人： HOLMIN, Staffan , JONSSON, Stefan , LUNDBERG, Johan
IPC分类号： A61M25/00 , A61M25/06
CPC分类号： A61B17/3423 , A61B10/04 , A61B17/3494 , A61B2017/3425 , A61B2017/3492 , A61B2018/1892 , A61M25/0068 , A61M25/0069 , A61M25/0082 , A61M25/0084 , A61M25/06 , A61M2025/0042 , A61N1/05
摘要： An endoluminal medical access device (1) is disclosed that is devised for endoluminal delivery to an extravascular target site (5) at a vasculature site of a human or animal body vasculature, such as the microvasculature. The device (1 ) comprises a hollow body (112) arranged around a continuous channel (113) that ends in a distal end (100) and comprises a distal penetration portion (102) that is devised to extend across a tissue wall of said microvasculature said microvasculature site (4) at an extravascular target site in said body to provide communication with said extravascular target site through said channel (113) and devised for at least partly apposition to said tissue wall, and a proximal connection section (101 ), which proximally adjoins said penetration portion (102), and optionally comprises an intrusion depth limit unit (116, 118) and/or a hollow separation section (115) devised to provide a controllable separation of the penetration portion (102) from a connected proximal portion (110) of the hollow body.
摘要翻译：公开了一种管腔内医疗进入装置（1），其被设计用于在诸如微血管系统的人或动物体脉管系统的脉管系统部位处的血管内递送到血管外靶点部位（5）。装置（1）包括围绕连续通道（113）布置的中空本体（112），其终止于远端（100）并且包括远端穿透部分（102），其设计成延伸穿过所述微血管的组织壁所述微血管系统位点（4）位于所述体内的血管外靶点部位，以通过所述通道（113）提供与所述血管外靶点部位的连通性，并设计用于至少部分地与所述组织壁连接;以及近端连接部分（101）近端邻接所述穿透部分（102），并且可选地包括入侵深度限制单元（116,118）和/或空心分离部分（115），其设计成提供穿透部分（102）与连接的近端部分（110）。

4. 发明申请

WO2008142567A2 MICRORNA MOLECULES ASSOCIATED WITH INFLAMMATORY SKIN DISORDERS 审中-公开
标题翻译： MICRORNA分子与炎症性皮肤病有关
公开(公告)号：WO2008142567A2
公开(公告)日：2008-11-27
申请号：PCT/IB2008/001877
申请日：2008-05-13
申请人： KAROLINSKA INSTITUTET INNOVATIONS AB , PIVARCSI, Andor , SONKOLY, Eniko
发明人： PIVARCSI, Andor , SONKOLY, Eniko
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： This invention relates to the finding that inflammatory skin disorders, such as psoriasis and atopic eczema, are characterised by- changes in the expression of specific microRNA molecules (miRNAs). These miRNAs may therefore be useful as biomarkers for inflammatory skin disorders as well as therapeutic targets. Methods of diagnosis and treatment of inflammatory skin disorders are provided, as well as methods of screening for therapeutic compounds.
摘要翻译：本发明涉及炎症性皮肤病，如牛皮癣和特应性湿疹，其特征在于特异性微小RNA分子（miRNA）表达的变化。因此，这些miRNA因此可用作炎症性皮肤病以及治疗靶标的生物标志物。提供了炎症性皮肤病的诊断和治疗方法，以及筛选治疗化合物的方法。

5. 发明申请

WO2009006935A1 STEREOTACTIC SURGERY SYSTEM 审中-公开
标题翻译：立体手术系统
公开(公告)号：WO2009006935A1
公开(公告)日：2009-01-15
申请号：PCT/EP2007/056910
申请日：2007-07-06
申请人： Karolinska Institutet Innovations AB , ULFARSSON, Elfar , NORDELL, Anders , NORDELL, Bo
发明人： ULFARSSON, Elfar , NORDELL, Anders , NORDELL, Bo
IPC分类号： A61B19/00
CPC分类号： A61B19/20 , A61B5/055 , A61B5/062 , A61B5/064 , A61B6/032 , A61B90/10 , A61B90/11 , A61B90/14 , A61B90/36 , A61B90/39 , A61B2034/2068 , A61B2034/207 , A61B2090/3916 , A61B2090/3983 , A61N5/10
摘要： A fiducial marker system comprising a first unit (8) and a second unit (9), wherein said first unit (8) is patient affixable and comprises a partly spherical inner surface having a first center point that is adapted to receive a touch probe measurement head for measuring said spatial position of said center point, and said second unit (9) is releasably attachable to an outer surface of said first unit (8), and has a second center point, wherein said first center point and said second center point are substantially identical when said second unit (9) is attached to said first unit (8), and wherein said outer surface of said first unit (8) is configured to receive an arm of a stereotactic frame when said second unit (9) is detached from said first unit. Stereotactic surgery is facilitated as thus frameless imaging is provided in a stereotactic surgery system.
摘要翻译：一种基准标记系统，包括第一单元（8）和第二单元（9），其中所述第一单元（8）是患者可固定的，并且包括部分球形的内表面，其具有适于接收探针测量的第一中心点用于测量所述中心点的所述空间位置的头部，并且所述第二单元（9）可释放地附接到所述第一单元（8）的外表面，并且具有第二中心点，其中所述第一中心点和所述第二中心点当所述第二单元（9）附接到所述第一单元（8）时，所述第一单元（8）的所述外表面被构造成当所述第二单元（9）为与所述第一单元分离。促进立体定向手术，因为在立体定向手术系统中提供无框架成像。

6. 发明授权

US08110350B2 Human Bocavirus and methods of diagnosis and treatment 有权
标题翻译：人类博卡病毒及其诊断和治疗方法
公开(公告)号：US08110350B2
公开(公告)日：2012-02-07
申请号：US12094135
申请日：2006-08-16
申请人： Tobias Allander , Bjorn Andersson
发明人： Tobias Allander , Bjorn Andersson
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/525 , A61K2039/53 , C12N7/00 , C12N2750/14322 , G01N2333/015 , G01N2469/10 , G01N2469/20
摘要： Human parvovirus, genus Bocavirus, associated with respiratory tract infections in children. Nucleic acid and polypeptide sequences of the virus. Methods and products for diagnosing presence of bocavirus in a sample using nucleic acid probes or primers, or specific binding members such as antibodies. Methods and products for diagnosing past or present infection of bocavirus in an individual e.g. by serology testing. Viral nucleic acid, polypeptide and/or viral particles for generating immune response in an individual, including vaccine compositions.
摘要翻译：人类细小病毒属，博卡病毒属，与儿童呼吸道感染有关。病毒的核酸和多肽序列。使用核酸探针或引物或特异性结合成员（例如抗体）诊断样品中bocavirus存在的方法和产品。用于诊断个体中bocavirus的过去或现在感染的方法和产品，例如通过血清学检测。用于在个体中产生免疫应答的病毒核酸，多肽和/或病毒颗粒，包括疫苗组合物。

7. 发明申请

US20110098722A1 Stereotactic Therapy System 失效
标题翻译：立体定向治疗系统
公开(公告)号：US20110098722A1
公开(公告)日：2011-04-28
申请号：US12668019
申请日：2008-07-07
申请人： Elfar Ulfarsson , Anders Nordell , Bo Nordell
发明人： Elfar Ulfarsson , Anders Nordell , Bo Nordell
IPC分类号： A61B19/00
CPC分类号： A61B19/20 , A61B5/055 , A61B5/062 , A61B5/064 , A61B6/032 , A61B90/10 , A61B90/11 , A61B90/14 , A61B90/36 , A61B90/39 , A61B2034/2068 , A61B2034/207 , A61B2090/3916 , A61B2090/3983 , A61N5/10
摘要： A fiducial marker system (210a-c) comprises a first unit and a second unit. The first unit is patient affixable and comprises a partly spherical inner surface having a first center point that is adapted to receive a touch probe measurement head for measuring the spatial position of the center point. The second unit is releasably attachable to an outer surface of the first unit, and has a second center point, wherein the first center point and the second center point are substantially identical when the second unit is attached to the first unit. For stereotactic therapy, a patient is imaged with the first and second unit assembled. Then the second unit is detached. A stereotactic frame (300) is attached to the first units via arms. Thus frameless imaging is provided in a frame based stereotactic surgery system with high precision. Repeated assembly of the frame (300) to the first units, remaining in the patient, provides advantageous fractionized stereotactic radiotherapy.
摘要翻译：基准标记系统（210a-c）包括第一单元和第二单元。第一单元是可耐用的，并且包括部分球形的内表面，其具有适于接收用于测量中心点的空间位置的测头测量头的第一中心点。第二单元可释放地附接到第一单元的外表面，并且具有第二中心点，其中当第二单元附接到第一单元时，第一中心点和第二中心点基本相同。对于立体定向治疗，患者以第一和第二单元组装成像。然后第二个单元是分离的。立体定向框架（300）通过臂附接到第一单元。因此，在基于帧的立体定向手术系统中提供无框架成像，其精度高。保留在患者体内的框架（300）重复组装到第一单元提供有利的分级立体定向放射治疗。

8. 发明授权

US08876792B2 Endoluminal medical access device 有权
标题翻译：腔内医疗检查装置
公开(公告)号：US08876792B2
公开(公告)日：2014-11-04
申请号：US12936825
申请日：2009-04-08
申请人： Staffan Holmin , Stefan Jonsson , Johan Lundberg
发明人： Staffan Holmin , Stefan Jonsson , Johan Lundberg
IPC分类号： A61M31/00 , A61M25/00 , A61B17/34 , A61N1/05 , A61B18/18 , A61M25/06
CPC分类号： A61B17/3423 , A61B10/04 , A61B17/3494 , A61B2017/3425 , A61B2017/3492 , A61B2018/1892 , A61M25/0068 , A61M25/0069 , A61M25/0082 , A61M25/0084 , A61M25/06 , A61M2025/0042 , A61N1/05
摘要： An endoluminal medical access device (1) is disclosed that is devised for endoluminal delivery to an extravascular target site (5) at a vasculature site of a human or animal body vasculature, such as the microvasculature. The device (1) comprises a hollow body (112) arranged around a continuous channel (113) that ends in a distal end (100) and comprises a distal penetration portion (102) that is devised to extend across a tissue wall of said microvasculature said microvasculature site (4) at an extravascular target site in said body to provide communication with said extravascular target site through said channel (113) and devised for at least partly apposition to said tissue wall, and a proximal connection section (101), which proximally adjoins said penetration portion (102), and optionally comprises an intrusion depth limit unit (116, 118) and/or a hollow separation section (115) devised to provide a controllable separation of the penetration portion (102) from a connected proximal portion (110) of the hollow body.
摘要翻译：公开了一种管腔内医疗进入装置（1），其被设计用于在诸如微血管系统的人或动物体脉管系统的脉管系统部位处的血管内递送到血管外靶点部位（5）。装置（1）包括围绕连续通道（113）布置的中空本体（112），其终止于远端（100）并且包括远端穿透部分（102），该远端穿透部分设计成延伸穿过所述微血管的组织壁所述微血管系统位点（4）位于所述体内的血管外靶点部位，以通过所述通道（113）提供与所述血管外靶点部位的连通性，并设计用于至少部分地与所述组织壁连接;以及近端连接部分（101）近端邻接所述穿透部分（102），并且可选地包括入侵深度限制单元（116,118）和/或空心分离部分（115），其设计成提供穿透部分（102）与连接的近端部分（110）。

9. 发明申请

US20100202973A1 MICRORNA MOLECULES ASSOCIATED WITH INFLAMMATORY SKIN DISORDERS 审中-公开
标题翻译： MICRORNA分子与炎症性皮肤病有关
公开(公告)号：US20100202973A1
公开(公告)日：2010-08-12
申请号：US12600744
申请日：2008-05-13
申请人： Andor Pivarcsi , Eniko Sonkoly
发明人： Andor Pivarcsi , Eniko Sonkoly
IPC分类号： A61K49/00 , C12Q1/68 , A61K31/7105 , G01N33/53 , A61P17/06
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： This invention relates to the finding that inflammatory skin disorders, such as psoriasis and atopic eczema, are characterized by changes in the expression of specific microRNA molecules (miRNAs). These miRNAs may therefore be useful as biomarkers for inflammatory skin disorders as well as therapeutic targets. Methods of diagnosis and treatment of inflammatory skin disorders are provided, as well as methods of screening for therapeutic compounds.
摘要翻译：本发明涉及炎症性皮肤病，如牛皮癣和特应性湿疹，其特征在于特异性微小RNA分子（miRNA）的表达变化。因此，这些miRNA因此可用作炎症性皮肤病以及治疗靶标的生物标志物。提供了炎症性皮肤病的诊断和治疗方法，以及筛选治疗化合物的方法。

10. 发明申请

US20220002810A1 METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH PROSTATE CANCER RISK 有权
公开(公告)号：US20220002810A1
公开(公告)日：2022-01-06
申请号：US17177568
申请日：2021-02-17
申请人： Wake Forest University Health Sciences , Karolinska Institutet Innovations AB , The Johns Hopkins University
发明人： Jianfeng Xu , S. Lilly Zheng , Henrik Grönberg , William B. Isaacs
IPC分类号： C12Q1/6886
摘要： The present invention provides a method of identifying a subject as having an increased risk of developing prostate cancer, comprising detecting in the subject the presence of various polymorphisms associated with an increased risk of developing prostate cancer.

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