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1. 发明专利

JP2014221784A 経口適用および局所適用のための脂質系薬学的調製物、ならびにそれらの組成物、方法、および使用有权
标题翻译：用于口腔和局部应用的基于脂质的药物制剂; 组合物，方法及其用途
公开(公告)号：JP2014221784A
公开(公告)日：2014-11-27
申请号：JP2014130194
申请日：2014-06-25
申请人：ジャイナファーマシューティカルズ,インコーポレーテッド , Jina Pharmaceuticals Inc , ジャイナファーマシューティカルズ,インコーポレーテッド
发明人： SHOUKATH M ALI , ATEEQ AHMAD , MOGHIS U AHMAD , SAIFUDDIN SHEIKH , IMRAN AHMAD
IPC分类号： A61K31/506 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/107 , A61K9/127 , A61K31/569 , A61K47/10 , A61K47/24 , A61K47/34 , A61K47/44 , A61P17/00 , A61P17/14 , A61P27/02 , A61P31/04 , A61P31/10
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/08 , A61K9/10 , A61K31/506 , A61K31/58 , A61K45/06 , A61K47/44 , A61K2300/00
摘要：【課題】アンドロゲン性脱毛症に対し、または脱毛を予防または減少させるためにヒト対象の局所治療または経皮治療として使用するための脂質組成物及び前記組成物を用いる脂質製剤の提供。【解決手段】固体のフィナステリド、ミノキシジル及びホスファチジルコリンを水、イソプロピルアルコール及び/又はプロピレングリコールを含む非毒性溶媒−水系中で合わせ、混合して透明な溶液を製造するプロセスによって製造される脂質組成物。更に、約200〜20,000の範囲の平均分子量を有するポリエチレングリコール(PEG)含むことが好ましく、イソプロパノール、エタノール、プロピルアルコール及びブタノールのうちの1つ以上を更に含むことが好ましい脂質組成物。【選択図】なし
摘要翻译：要解决的问题：提供一种脂质组合物以预防或减少与雄激素性脱发相关的脱发，并且用作人的局部治疗或透皮治疗，并使用该组合物提供脂质制剂。溶液：脂质组合物为通过在含有水，异丙醇和/或丙二醇的无毒溶剂 - 水性体系中混合和混合固体非那雄胺，米诺地尔和磷脂酰胆碱的方法产生，以产生透明溶液。并且脂质组合物优选含有平均分子量在约200至20,000范围内的聚乙二醇（PEG），并且更优选在异丙醇，乙醇，丙醇和丁醇中含有一种或多种。

2. 发明申请

US20200345849A1 Aqueous Systems For The Preparation Of Lipid Based Pharmaceutical Compounds; Compositions, Methods, And Uses Thereof 审中-公开
公开(公告)号：US20200345849A1
公开(公告)日：2020-11-05
申请号：US16924529
申请日：2020-07-09
申请人： JINA PHARMACEUTICALS, INC.
发明人： Shoukath M. Ali , Moghis U. Ahmad , Ateeq Ahmad , Saifuddin Sheikh , Imran Ahmad
IPC分类号： A61K47/28 , A61K9/00 , A61K9/19 , A61K9/127 , A61K9/51 , A61K47/54 , A61K9/107 , A61K9/16 , A61K31/337 , A61K31/436 , A61K31/704 , A61K31/7048 , A61K47/10 , A61K47/24
摘要： The present invention relates to a methods of preparing active compounds complexed with lipids using aqueous systems that are free of organic solvents, and methods of using the complexes, e.g., in treating a disease in a subject. In some embodiments, the present invention comprises a composition comprising a complex comprising at least one active compound, e.g., a polyene antibiotic, an immunosuppressant agent such as tacrolimus or a taxane or taxane derivative, and one or more lipids. In some embodiments, the present invention provides a method comprising preparing a composition comprising a lipid complex comprising at least one active compound and at least one lipid and administering the composition to a subject. In certain embodiments the subject is a mammal. In certain preferred embodiments, the subject is human.

3. 发明申请

WO2010036947A3 LIPID BASED PHARMACEUTICAL PREPARATIONS FOR ORAL AND TOPICAL APPLICATION; THEIR COMPOSITIONS, METHODS, AND USES THEREOF 审中-公开
公开(公告)号：WO2010036947A3
公开(公告)日：2010-04-01
申请号：PCT/US2009/058463
申请日：2009-09-25
申请人： ALI, Shoukath M. , AHAMD, Ateeq , AHMAD, Moghis U. , SHEIKH, Saifuddin , AHMAD, Imran , JINA PHARMACEUTICALS, INC.
发明人： ALI, Shoukath M. , AHAMD, Ateeq , AHMAD, Moghis U. , SHEIKH, Saifuddin , AHMAD, Imran
IPC分类号： A61K47/44 , A61P17/14 , A61K31/58 , A61K31/506
摘要： The present invention relates to the topical and oral delivery of a composition comprising one or more active agents for treating a disease or symptoms in a subject. In some embodiments, the present invention comprises a composition comprising at least one active compound, e.g., finasteride or minoxidil, and one or more lipids. In some embodiments, the present invention relates to composition and method of preparation for treating androgenic alopecia (AGA), prevention of hair loss and female hirsutism. In some embodiment, the present invention comprises finasteride and at least one lipid component for the treatment of benign prostatic hyperplasia. In some embodiment, the present invention comprises tacrolimus or amphotericin B and at least one lipid component for the treatment of skin or eye related diseases. The present invention provides a method of preparation of a composition comprising at least one active compound and at least one lipid and administering the composition to a subject by oral or topical delivery. In certain embodiments the subject is a mammal. In certain preferred embodiment, the subject is human.

4. 发明申请

WO2008070463A3 ENDOXIFEN METHODS AND COMPOSITIONS 审中-公开
公开(公告)号：WO2008070463A3
公开(公告)日：2008-11-06
申请号：PCT/US2007085443
申请日：2007-11-21
申请人： JINA PHARMACEUTICALS INC , AHMAD ATEEQ , ALI SHOUKATH M , AHMAD MOGHIS U , SHEIKH SAIFUDDIN , AHMAD IMRAN
发明人： AHMAD ATEEQ , ALI SHOUKATH M , AHMAD MOGHIS U , SHEIKH SAIFUDDIN , AHMAD IMRAN
IPC分类号： A61K9/127 , A61K9/12
CPC分类号： A61K31/138 , A61K9/0014 , A61K9/127 , A61K9/19 , A61K31/35 , C07D309/10
摘要： The present invention provides compositions containing endoxifen, formulations and liposomes of endoxifen, methods of preparation of such agents and formulations, and use of such agents and formulations for the treatment of breast cancer and other breast diseases and diseases susceptible to endoxifen. In particular, the compositions of the present invention include liposomes, complexes, vesicles, emulsions, micelles and mixed micelles of endoxifen in which the compositions further contain any of a variety of neutral or charged lipids and desirably, cholesterol and cholesterol derivatives, sterols, Z- and E- guggulsterones, phospholipids, fatty acids, vitamin D, and vitamin E. The present invention also provides methods of preparing endoxifen. The present invention provides methods for treating and preventing breast cancer and other breast related diseases by administrating novel formulations or compositions comprising a therapeutically effective amount of endoxifen.

5. 发明申请

WO2008058156A2 GUGGULPHOSPHOLIPID METHODS AND COMPOSITIONS 审中-公开
标题翻译： GUGGPHPHPHPHIPIPI方法和组合物
公开(公告)号：WO2008058156A2
公开(公告)日：2008-05-15
申请号：PCT/US2007083832
申请日：2007-11-06
申请人： JINA PHARMACEUTICALS INC , AHMAD MOGHIS U , ALI SHOUKATH M , AHMAD ATEEQ , SHEIKH SAIFUDDIN , AHMAD IMRAN
发明人： AHMAD MOGHIS U , ALI SHOUKATH M , AHMAD ATEEQ , SHEIKH SAIFUDDIN , AHMAD IMRAN
IPC分类号： A01N65/00
CPC分类号： C07J13/007 , A61K31/337 , A61K47/554 , A61K47/6907 , A61K47/6911 , C07J7/0005 , C07J31/006 , C07J41/0005 , C07J41/0088 , C07J51/00 , C12N15/85
摘要： The present invention relates to the methods for preparing synthetic guggulphospholipids, their fatty acid analogues and other bioactive molecules. The present invention relates to E-guggulsterone and Z-guggulsterone or mixture of E- and Z-guggulsterones; and E-guggulsterol and Z-guggulsterol or mixture of E- and Z-guggulsterols synthetically modified to guggulphospholipids and analogues and salts thereof, fatty acid analogues of guggulsterols, guggulsulfate and salts thereof, guggulphosphate and salts thereof; and guggulsterols conjugated with drugs for use as prodrugs. Also the present invention provides a novel method for the preparation of E-guggulsterol and Z-guggulsterol or mixture of E-and Z-guggulsterols from a mixture of E- and Z-guggulsterones. The present invention further relates to guggulphospholipids and other bioactive molecules incorporated into complexes such as liposomes, complexes, emulsions, vesicles, micelles, and mixed micelles, which can include other active agents, such as hydrophobic or hydrophilic drugs for use, e.g., in treatment of human and animal diseases.
摘要翻译：本发明涉及制备合成瓜瓜磷脂，其脂肪酸类似物和其它生物活性分子的方法。本发明涉及戊二酮和Z-鬼臼酮或E-和Z-格鲁酮的混合物; 合成修饰成瓜瓜尔斯醇和Z-guggulsterol或者合成修饰成瓜瓜尔斯醇及其类似物及其盐的瓜尔豆甾醇和Z-瓜格尔斯醇的混合物，瓜焦糖醇，巨硫酸盐及其盐的脂肪酸类似物，磷酸瓜瓜酯及其盐; 和与药物缀合的糖苷醇用作前药。本发明还提供了一种从E-和Z-格鲁酮的混合物制备E-guggulsterol和Z-guggulsterol或E-和Z-苦瓜甾醇的混合物的新方法。本发明还涉及结合到诸如脂质体，复合物，乳液，囊泡，胶束和混合胶束的复合物中的瓜瓜磷脂和其它生物活性分子，其可以包括其它活性剂，例如用于治疗的疏水或亲水药物的人类和动物疾病。

6. 发明专利

PL2344198T3 PREPARATY FARMACEUTYCZNE NA BAZIE LIPIDÓW DO STOSOWANIA MIEJSCOWEGO 未知
公开(公告)号：PL2344198T3
公开(公告)日：2021-05-31
申请号：PL09816940
申请日：2009-09-25
申请人： JINA PHARMACEUTICALS INC
发明人： ALI SHOUKATH M , AHAMD ATEEQ , AHMAD MOGHIS U , SHEIKH SAIFUDDIN , AHMAD IMRAN
IPC分类号： A61K47/44 , A61K8/14 , A61K8/49 , A61K8/63 , A61K9/00 , A61K9/08 , A61K9/10 , A61K31/506 , A61K31/58 , A61K45/06 , A61K47/24 , A61P17/14 , A61Q7/00

7. 发明专利

HRP20201860T1 FARMACEUTSKI PRIPRAVCI NA BAZI LIPIDA ZA TOPIKALNU PRIMJENU 未知
公开(公告)号：HRP20201860T1
公开(公告)日：2021-04-16
申请号：HRP20201860
申请日：2020-11-23
申请人： JINA PHARMACEUTICALS INC
发明人： ALI SHOUKATH M , AHAMD ATEEQ , AHMAD MOGHIS U , SHEIKH SAIFUDDIN , AHMAD IMRAN
IPC分类号： A61K47/44 , A61K8/14 , A61K8/49 , A61K8/63 , A61K9/00 , A61K9/08 , A61K9/10 , A61K31/506 , A61K31/58 , A61K45/06 , A61K47/24 , A61P17/14 , A61Q7/00

8. 发明专利

LT2344198T FARMACINIAI PREPARATAI LIPIDŲ PAGRINDU, SKIRTI VIETINIAM NAUDOJIMUI 未知
公开(公告)号：LT2344198T
公开(公告)日：2021-02-25
申请号：LT09816940
申请日：2009-09-25
申请人： JINA PHARMACEUTICALS INC
发明人： ALI SHOUKATH M , AHAMD ATEEQ , AHMAD MOGHIS U , SHEIKH SAIFUDDIN , AHMAD IMRAN
IPC分类号： A61K47/44 , A61K8/14 , A61K8/49 , A61K8/63 , A61K9/00 , A61K9/08 , A61K9/10 , A61K31/506 , A61K31/58 , A61K45/06 , A61K47/24 , A61P17/14 , A61Q7/00

9. 发明专利

PT2101731T ENDOXIFENO PARA UTILIZAÇÃO NO TRATAMENTO DE CANCRO 未知
公开(公告)号：PT2101731T
公开(公告)日：2018-04-18
申请号：PT07871563
申请日：2007-11-21
申请人： JINA PHARMACEUTICALS INC
发明人： SHOUKATH M ALI , MOGHIS U AHMAD , IMRAN AHMAD , ATEEQ AHMAD , SAIFUDDIN SHEIKH
IPC分类号： A61K9/00 , A61K9/127 , A61K9/19 , A61K31/138 , A61K31/35 , A61P35/00 , C07D309/10

10. 发明专利

CA2669355C GUGGULPHOSPHOLIPID METHODS AND COMPOSITIONS 未知
公开(公告)号：CA2669355C
公开(公告)日：2012-10-30
申请号：CA2669355
申请日：2007-11-06
申请人： JINA PHARMACEUTICALS INC
发明人： AHMAD MOGHIS U , ALI SHOUKATH M , AHMAD ATEEQ , SHEIKH SAIFUDDIN , AHMAD IMRAN
IPC分类号： C07J7/00 , A61K9/127 , A61K47/48 , A61K48/00 , C07J31/00 , C07J41/00 , C07J51/00 , C12N15/87 , C12N15/88
摘要： The present invention relates to the methods for preparing synthetic guggulphospholipids, their fatty acid analogues and other bioactiv molecules. The present invention relates to E-guggulsterone and Z- guggulsterone or mixture of E- and Z-guggulsterones. The present invention also provides a novel method for the preparation of E-guggulsterol and Z- guggulsterol or mixture of E-and Z-guggulsterols from a mixture of E- and Z- guggulsterones. The present invention further relates to guggulphospholipids and other bioactive molecules incorporated into complexes such as liposomes, complexes, emulsions, vesicles, micelles, and mixed micelles, which can include othe active agents, such as hydrophobic or hydrophilic drugs for use, e.g., in treatment of human and animal diseases.

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