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1. 发明专利

JP2008289498A Purified multimerase 审中-公开
标题翻译：纯化多媒体
公开(公告)号：JP2008289498A
公开(公告)日：2008-12-04
申请号：JP2008195106
申请日：2008-07-29
申请人： Immuno Ag , イムノ・アクチエンゲゼルシャフトImmuno Aktiengesellschaft
发明人： FURLAN MIHA , LAEMMLE BERNHARD , HANSUUPEETAA SHIYUBUARUTSU , TURECEK PETER , YOHAN AIBURU
IPC分类号： C12N9/64 , A61K31/00 , A61K38/00 , A61K38/46 , A61P7/00 , A61P7/02 , A61P7/04 , A61P43/00 , C07K5/065 , C07K5/083 , C07K7/06 , C07K14/755 , C07K16/18 , C07K16/40 , C12Q1/37 , G01N30/88 , G01N33/573
CPC分类号： C07K14/755 , A61K38/00 , C12N9/6421 , Y10S435/814
摘要： PROBLEM TO BE SOLVED: To provide an enzyme activity of processing von Willebrand Factor (vWF) in a physiologic manner by protein hydrolysis and as necessary decomposing vWF and to provide a preparation containing such enzyme activity. SOLUTION: A purified multimerase has an indirect or direct proteolytic activity, can convert vWF having a singlet structure into vWF having a satellite structure and is active in the presence of the serine protease inhibitor diisopropyl fluorophosphate (DFP) or the calpain protease inhibitor Z-Leu-Leu-Tyr-CHN 2 , and a preparation containing the multimerase is provided. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供通过蛋白质水解以生理方式处理血管性血友病因子（vWF）的酶活性，并根据需要分解vWF并提供含有该酶活性的制剂。解决方案：纯化的多聚水解酶具有间接或直接的蛋白水解活性，可以将具有单重结构的vWF转化为具有卫星结构的vWF，并且在丝氨酸蛋白酶抑制剂二异丙基氟磷酸酯（DFP）或钙蛋白酶蛋白酶抑制剂存在下具有活性 Z-Leu-Leu-Tyr-CHN 2 ，并提供含有多聚合酶的制剂。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JPH1045620A MEDICAL PREPARATION FOR TREATMENT OF BLOOD COAGULATION DISEASE 失效
公开(公告)号：JPH1045620A
公开(公告)日：1998-02-17
申请号：JP10801397
申请日：1997-03-21
申请人： IMMUNO AG
发明人： TURECEK PETER , SCHWARZ HANS-PETER , EIBL JOHANN
IPC分类号： G01N33/86 , A61K31/435 , A61K31/60 , A61K38/00 , A61K38/36 , A61K38/43 , A61K38/48 , A61K38/55 , A61K38/57 , A61K45/00 , A61K47/48 , A61P3/14 , A61P7/02 , A61P7/04 , A61P39/02 , C07K1/18 , C07K1/20 , C07K1/36 , C07K14/745 , C12N9/64 , C12N9/74
摘要： PROBLEM TO BE SOLVED: To obtain the subject preparation capable of simple administration, effective start of the action, increasing half life and preventing adverse reaction of agglomeration by including specific components which are clotting factors. SOLUTION: The preparation contains at least two clotting factors which are the components of prothrombinase or pro-prothrombinase, not containing phospholipid. The preparation contains at least one of the factors activated, has at least two clotting factors selected from factors II, V, Va, X and Xa, practically factors II and X or Xa (capable of accompanying V or Va freely), the factor exists as a conjugate, preferably containing magnesium ion but free from free calcium ion.

3. 发明专利

JP2521354B2 失效
公开(公告)号：JP2521354B2
公开(公告)日：1996-08-07
申请号：JP19790889
申请日：1989-07-28
申请人： IMMUNO AG
发明人： IENDORA RINNAU , ERUNSUTO HETSUTSURU
IPC分类号： A61K38/46 , A61P7/02 , C12N9/68 , C12S3/14

4. 发明专利

JP2511631B2 失效
公开(公告)号：JP2511631B2
公开(公告)日：1996-07-03
申请号：JP9753293
申请日：1993-04-23
申请人： IMMUNO AG
发明人： YOHAN AIBURU , FURIIDORITSUHI ERUJINGAA , HERUBERUTO GURITSUCHU , IENDORA RINNAU , OTSUTOO SHUARUTSU , PEETAA TORECHEKU , GYUNTAA UEEBAA
IPC分类号： A61K38/43 , A61K38/00 , A61K38/37 , A61L2/04 , A61L2/16 , A61L2/18 , A61P7/04 , C07K1/14 , C07K1/16 , C07K14/435 , C07K14/745 , C07K14/755 , C12N9/74

5. 发明专利

JPH07304658A STABLE PREPARATION FOR CURING BLOOD COAGULATION DISEASE 失效
公开(公告)号：JPH07304658A
公开(公告)日：1995-11-21
申请号：JP10945895
申请日：1995-05-08
申请人： IMMUNO AG
发明人： EIBL JOHANN , SCHWARZ HANS PETER , SIEKMANN JUERGEN , TURECEK PETER
IPC分类号： A61K9/127 , A61K9/14 , A61K38/43 , A61K38/48 , A61K38/55 , A61P7/02 , C12N9/64 , C12N9/96 , A61K9/19
摘要： PURPOSE: To obtain the subject preparation, containing a protein lipid complex in a vesicular form, subjected to a treatment for the inactivation of potentially present viruses and useful for treating blood coagulation disorders containing a coagulation active protein. CONSTITUTION: This stable virally safe preparation contains a protein bound in and/or on lipid vesicles (preferably a coagulation active protein) and is subjected to a treatment for inactivation of potentially present viruses (preferably heat treatment). The preparation preferably contains a blood coagulation factor of an endogenous or an exogenous blood coagulation, preferably an active type blood coagulation factor (e.g. a vitamin K-dependent protein, IIa factor or VIIa factor). The preparation is useful for intravenous injection.

6. 发明专利

JPH07181182A PROCESSING OF SAMPLE CONTAINING LIPOPROTEIN 失效
公开(公告)号：JPH07181182A
公开(公告)日：1995-07-21
申请号：JP24514794
申请日：1994-10-11
申请人： IMMUNO AG
发明人： EEBUARUTO MORINARI , PEETAA PIHIRAA , HARUTOMUUTO RANGU
IPC分类号： G01N33/53 , B01J19/00 , G01N33/531 , G01N33/92
摘要： PURPOSE: To reduce turbidity inherent to a biochemical fluid and analyze an antigen in a sample without fail by using a sample conditioner composed of a dilution buffer solution containing amino acid and an antibody against an antigen to be measured. CONSTITUTION: This method uses a sample conditioner composed of a dilution buffer solution containing amino acid and an antibody against lipoprotein to be measured, so as to treat a lipoprotein contained sample and measure an antigen with the immunoassay. In this case, the dilution cushion buffer is effective, when made to further contain a reactive accelerator, for example, polyethylene glycol. Also, the concentration of the amino acid is between 0.05M and 3M, or preferably between 0.1M and 0.5M. Proline is particularly suitable for removing the turbidity of a hyperlipemia sample or a turbid sample, regardless of the pre-treatment of the sample. Also, the first sample conditioner component containing a buffer material and amino acid, and the second sample conditioner component containing an antibody against an antigen to be measured with the immunoassay are used as a conditioning kit.

7. 发明专利

JPH0698791A METHOD OF SEVERING PROTEIN BY ENZYMATIC DECOMPOSITION AND METHOD FOR ITS USE 失效
公开(公告)号：JPH0698791A
公开(公告)日：1994-04-12
申请号：JP7949193
申请日：1993-04-06
申请人： IMMUNO AG
发明人： PEETAA TOURECHIETSUKU
IPC分类号： A61K38/48 , C12N9/48 , C12N9/74 , C12N11/14 , C12P21/06 , A61K37/475

8. 发明专利

JPH0686674A METHOD OF ACTIVATING BLOOD COAGULATION FACTOR 失效
公开(公告)号：JPH0686674A
公开(公告)日：1994-03-29
申请号：JP7949093
申请日：1993-04-06
申请人： IMMUNO AG
发明人： IENDORA RINNAU
IPC分类号： C12N9/74 , C12N9/64 , C12N9/76 , C12N11/00

9. 发明专利

JPH0630793A USE OF PROTHROMBIN FRAGMENT 失效
公开(公告)号：JPH0630793A
公开(公告)日：1994-02-08
申请号：JP11279893
申请日：1993-05-14
申请人： IMMUNO AG
发明人： HARUTOMUUTO RANGU , BERUTA MOORITSUTSU
IPC分类号： A61K38/49 , C12Q1/56 , G01N33/86

10. 发明专利

JPH0585529B2 失效
公开(公告)号：JPH0585529B2
公开(公告)日：1993-12-07
申请号：JP5080484
申请日：1984-03-15
申请人： IMMUNO AG
发明人： JOAN AIBURU , IENDORA RINAU , OTSUTO SHUARUTSU
IPC分类号： A61K39/395 , A61K35/16 , A61K38/00 , A61K49/00 , C07K16/06 , G01N33/15

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