专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

US20240157002A1 REUSABLE LIGHT-ACTIVATED STERILIZATION SYSTEM FOR MEDICAL DEVICES 审中-公开
公开(公告)号：US20240157002A1
公开(公告)日：2024-05-16
申请号：US18548726
申请日：2022-03-01
申请人： INEB - INSTITUTO NACIONAL DE ENGENHARIA BIOMÉDICA , UNIVERSIDADE DO PORTO
发明人： Inês DE CASTRO GONÇALVES DE ALMADA LOBO , Ana Patrícia CARVALHO HENRIQUES , Artur Daniel MOREIRA PINTO , Fernao Domingos de Montenegro Baptista Malheiro DE MAGALHAES
IPC分类号： A61L2/08 , A61L2/24
CPC分类号： A61L2/088 , A61L2/084 , A61L2/085 , A61L2/24 , A61L2202/24
摘要： The present invention relates to a reusable integrated light-activated sterilization system, as well as to a method of preparing the sterilization system. Additionally, the present invention relates to a catheter cap including the reusable light-activated sterilization system.

2. 发明申请

WO2018002853A1 NANOSTRUCTURATED LIPID CARRIERS, METHODS AND USES THEREOF 审中-公开
标题翻译：纳米结构化脂质载体，方法和用途
公开(公告)号：WO2018002853A1
公开(公告)日：2018-01-04
申请号：PCT/IB2017/053885
申请日：2017-06-28
申请人： INEB - INSTITUTO NACIONAL DE ENGENHARIA BIOMÉDICA , UNIVERSIDADE DO PORTO
发明人： LEAL SEABRA, Catarina , OLIVEIRA DE LACERDA NUNES PINHO, Cláudia Daniela , DE LA SALETTE DE FREITAS FERNANDES HIPÓLITO REIS DIAS RODRIGUES, Maria , TEIXEIRA LOPES DA COSTA PINTO LOPES MARTINS, Maria Cristina
IPC分类号： A61K31/722 , A61K9/00 , A61K9/107 , A61K9/51 , A61P31/04
摘要： The present disclosure relates to new nanostructured lipid carriers (NLCs - particles of imperfect crystal type, solid amorphous type (non-crystalline matrix) or multiple type) that are effective treatment for use in the treatment of disease induced by Helicobacter pylori. The present disclosure is also directed to compositions that comprise such nanoparticles and to a method of their production.
摘要翻译：本发明涉及用于治疗疾病的有效治疗的新型纳米结构脂质载体（NLCs-不完全晶型，固体无定形型（非晶态基质）或多种类型的颗粒）由幽门螺杆菌诱导。本公开还涉及包含这种纳米颗粒的组合物及其制备方法。

3. 发明申请

WO2014116132A1 BIOMATERIAL COMPRISING POLY(TRIMETHYLENE CARBONATE-CO-E-CAPROLACTONE) FOR PROMOTING AXONALL GROWTH AND NEURONAL REGENERATION 审中-公开
标题翻译：包含聚（三亚甲基碳酸酯 - 碳酸钙）的生物材料用于促进轴向生长和神经再生
公开(公告)号：WO2014116132A1
公开(公告)日：2014-07-31
申请号：PCT/PT2014/000006
申请日：2014-01-28
申请人： INEB - INSTITUTO NACIONAL DE ENGENHARIA BIOMÉDICA
发明人： PÊGO, Ana Paula , ROCHA, Daniela
IPC分类号： A61K31/765 , A61L27/58 , A61P25/00 , A61K31/198
CPC分类号： A61K31/765 , A61K31/198 , A61L27/18 , A61L27/34 , A61L27/54 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/252 , A61L2300/412 , A61L2430/32 , Y02A50/465 , C08L67/04 , C08L89/00
摘要： Mammalian central nervous system (CNS) neurons do not regenerate after injury due to the inhibitory environment formed by the glial scar, largely constituted by myelin debris. The use of biomaterials to bridge the lesion area and the creation of an environment favoring axonal regeneration is an appealing approach, currently under investigation. This work aimed at assessing the suitability of three candidate polymers - poly(?-caprolactone), poly(trimethylene carbonate-co- ?-caprolactone) (P(TMC-CL)) (11:89 mol%) and poly(trimethylene carbonate) - with the final goal of using these materials in medicine, namely in the development of conduits to promote spinal cord regeneration. Cortical neurons cultured on P(TMC-CL) in the presence of myelin were able to tame myelin inhibition in comparison with the control condition (glass substrate). This effect was found to be mediated by the glycogen synthase kinase 3p (GSK3p) signaling pathway with impact on the collapsin response mediator protein 4 (CRMP4), suggesting that nanomechanical properties were implicated in this process. The obtained results indicate P(TMC-CL) as a promising material for CNS regenerative applications as it promotes axonal growth, taming myelin inhibition.
摘要翻译：哺乳动物中枢神经系统（CNS）神经元由于由髓鞘碎片主要构成的胶质瘢痕形成的抑制环境，不能在损伤后再生。使用生物材料桥接病变区域和创造有利于轴突再生的环境是一种吸引人的方法，目前正在调查中。这项工作旨在评估三种候选聚合物 - 聚（ε-己内酯），聚（三亚甲基碳酸酯 - 共 - 己内酯）（P（TMC-CL））（11:89摩尔％）和聚（三亚甲基碳酸酯） - 最终目标是在医学中使用这些材料，即在开发导管以促进脊髓再生。与对照条件（玻璃底物）相比，在髓磷脂存在下在P（TMC-CL）上培养的皮质神经元能够驯化髓磷脂抑制。发现这种作用是由糖原合成酶激酶3p（GSK3p）信号通路介导的，其对皱缩蛋白反应介质蛋白4（CRMP4）具有影响，表明纳米机械性质参与了该过程。获得的结果表明，P（TMC-CL）作为CNS再生应用的有希望的材料，因为它促进轴突生长，驯化髓鞘抑制。

4. 发明申请

WO2023075623A1 MACROPHAGE PHENOYPES FOR USE IN THE TREATMENT OF INTRAVERTEBRAL DISCS 审中-公开
公开(公告)号：WO2023075623A1
公开(公告)日：2023-05-04
申请号：PCT/PT2022/050028
申请日：2022-10-26
申请人： INEB (INSTITUTO NACIONAL DE ENGENHARIA BIOMÉDICA) , UNIVERSIDADE DO PORTO
发明人： DOS SANTOS CUNHA, Carla Marisa , DOS SANTOS BARBER, Susana Gomes , MONTEIRO DA ROCHA BARBOSA, Mário Adolfo , DA SILVA PEREIRA, Paulo Miguel
IPC分类号： C12N5/0786 , A61P19/02 , A61P29/00 , A61K35/15 , A61K48/00 , C12N2501/052 , C12N2501/15 , C12N2501/22 , C12N2501/2304 , C12N2501/2306 , C12N2501/231 , C12N2501/2313 , C12N2501/24 , C12N2501/25 , C12N2506/115 , C12N5/0645
摘要： The present invention refers to monocytes and macrophages for use in the treatment of intravertebral disc (IVD) herniation. Furthermore, the macrophage cell phenotype which is most effective for use in a phagocytosis immunotherapy is herein disclosed. Thus, the present invention provides compositions comprising such macrophage phenotypes and a method for differentiation, polarization, and purification of the most effective macrophage phenotype, as well as its preferred form of administration. Another aspect of the present invention refers to the compositions employed in the said polarization of the most effective macrophage phenotype. Yet another aspect of the present invention refers to the compositions employed in the purification of the most effective macrophage phenotype through negative selection. The uses, compositions and methods of the present invention can be advantageously employed in a cell-based therapy primarily for use in the treatment of intervertebral disc (IVD) herniation, as well as for other clinical conditions improved by the regression of regeneration-adverse reactive tissues, such as wound and surgery- related scar tissue, fibrosis and necrosis; the said clinical condition being selected from the list further consisting of myocardial infraction, endometriosis, pulmonary asthma, hepatic cirrhosis, spinal cord injury and cartilage injury.

5. 发明申请

WO2021124108A1 BIOCOMPOSITE, METHODS OF PRODUCTION AND USES THEREOF 审中-公开
公开(公告)号：WO2021124108A1
公开(公告)日：2021-06-24
申请号：PCT/IB2020/061974
申请日：2020-12-15
申请人： INEB - INSTITUTO NACIONAL DE ENGENHARIA BIOMÉDICA
发明人： MENDES MONTEIRO, Fernando Jorge , RIBEIRO E SOUSA MENDES DE FREITAS, Susana Maria , DA SILVA PADRÃO, Tatiana Cristina , CARDOSO COELHO, Catarina
IPC分类号： A61L27/34 , A61L27/42 , A61L27/54 , A61L27/56 , A61L2300/236 , A61L2300/406 , A61L2300/602 , A61L2400/12 , A61L2420/04 , A61L27/425
摘要： The present disclosure relates to a new heparinized biocomposite comprising nanohydroxyapatite/collagen granules ("HEPHAPC granules), a method of obtaining a new heparinized biocomposite comprising nanohydroxyapatite/collagen granules ("HEPHAPC granules), and uses thereof, preferably a heparinized biocomposite comprising nanohydroxyapatite/collagen granules ("HEPHAPC granules"). The new heparinized biocomposite comprising nanohydroxyapatite/collagen granules ("HEPHAPC granules) is able to release high concentrations of antibiotic improving the treatment of bone infection and osteomyelitis and thereafter induce new bone regeneration capability.

6. 发明申请

WO2017077520A1 A COMPOSITION FOR USE IN A METHOD FOR PREVENTION OR TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS INFECTIONS 审中-公开
标题翻译：用于预防或治疗人免疫缺陷病毒感染的方法中的组合物
公开(公告)号：WO2017077520A1
公开(公告)日：2017-05-11
申请号：PCT/IB2016/056695
申请日：2016-11-07
申请人： INEB - INSTITUTO NACIONAL DE ENGENHARIA BIOMÉDICA
发明人： GONÇALVES DAS NEVES, José Alberto , MEIRA MACHADO, Fátima Alexandra , DOS SANTOS CUNHA REIS, Cassilda Maria , CARMELINO CARDOSO SARMENTO, Bruno Filipe
IPC分类号： A61K9/00 , A61K47/34
CPC分类号： A61K9/0036 , A61K47/34
摘要： The present disclosure provides a new microbicide pharmaceutical composition for topical pre-exposure prophylaxis or topical post-exposure prophylaxis. The present disclosure relates to the incorporation of nanoparticles loaded with different antiretroviral compounds in soft and flexible vaginal films. Antiretroviral compounds may be present in films either as single agent or in combination with nanoparticles. Antiretroviral-loaded nanoparticles-in-vaginal films are to be administered in the vagina around the time of sexual intercourse in order to prevent the sexual transmission of HIV.
摘要翻译：本公开提供了用于局部预暴露预防或局部暴露后预防的新型杀微生物剂药物组合物。本公开涉及在柔软且柔韧的阴道膜中掺入装载有不同抗逆转录病毒化合物的纳米颗粒。抗逆转录病毒化合物可作为单一药剂或与纳米粒子组合存在于膜中。抗逆转录病毒负载的纳米阴道膜在性交时在阴道内施用以防止HIV的性传播。

7. 发明申请

WO2015162561A1 COMPOSITION FOR LOCAL AND CONTROLLED RELEASE OF DRUGS AND METHODS THEREOF 审中-公开
标题翻译：用于本地和控制释放药物的组合物及其方法
公开(公告)号：WO2015162561A1
公开(公告)日：2015-10-29
申请号：PCT/IB2015/052916
申请日：2015-04-21
申请人： INEB - INSTITUTO NACIONAL DE ENGENHARIA BIOMÉDICA , UNIVERSIDADE DO PORTO , ISEP - INSTITUTO SUPERIOR DE ENGENHARIA DO PORTO
发明人： MONTEIRO, Fernando Jorge , RIBEIRO E SOUSA MENDES DE FREITAS, Susana Maria , COELHO, Catarina , ALEGRETE DA SILVA, Nuno Paulo
IPC分类号： A61K9/00 , A61L27/12 , A61L27/20 , A61L27/24 , A61K38/14 , A61L27/54 , A61K9/16 , A61K31/43 , A61P19/00 , A61P19/08
CPC分类号： A61K33/42 , A61K9/0019 , A61K9/0024 , A61K9/1611 , A61K9/1658 , A61K9/5036 , A61K9/5052 , A61K9/5089 , A61K31/43 , A61K38/14 , A61K45/06 , A61L27/12 , A61L27/34 , A61L27/54 , A61L2300/236 , A61L2300/406 , A61L2300/602 , C08L89/06
摘要： The present disclosure relates to a composition for treatment and/or prevention of infections, namely bone diseases, in particular osteomyelitis, via a controlled release of antibiotics and subsequently induce regeneration of bone tissue that often undergoes necrosis due to infection. The present disclosure relates in particular to a pharmaceutical composition comprising one or more granules containing calcium phosphate, collagen and one or more polymers of heparin, and an antibiotic in an effective therapeutic amount, wherein the antibiotic is bound to the heparin polymers.
摘要翻译：本公开内容涉及用于治疗和/或预防感染的组合物，即骨疾病，特别是骨髓炎，经由受控释放的抗生素，随后诱导由于感染而经常坏死的骨组织的再生。本公开特别涉及包含一种或多种含有磷酸钙，胶原和一种或多种肝素聚合物的颗粒和有效治疗量的抗生素的药物组合物，其中所述抗生素与肝素聚合物结合。

8. 发明申请

WO2022035335A1 FABRICATION OF MICROACTUATOR AND IN-LINE DEGASSER IN ORGAN-ONA_CHIP DEVICES AND METHODS THEREOF 审中-公开
公开(公告)号：WO2022035335A1
公开(公告)日：2022-02-17
申请号：PCT/PT2021/050027
申请日：2021-08-12
申请人： INEB (INSTITUTO NACIONAL DE ENGENHARIA BIOMÉDICA) , IPATIMUP (INSTITUTO DE PATOLOGIA E IMUNOLOGIA DA UNIVERSIDADE DO PORTO)
发明人： GONÇALVES FERREIRA, Daniel André , ERTL, Peter , GONÇALVES DE OLIVEIRA, Carla Isabel , LOPES GRANJA, Pedro
IPC分类号： C12M3/06 , C12M1/42
摘要： The present invention refers to a method for the fabrication of complex organ-on-a-chip devices with incorporated mechanical microactuator and bubble degasser. The method herein described is based on the micro-structuring of polydimethylsiloxane (PDMS) laminates, using a cutting plotter to generate multi-layered, membrane integrated biochips in a matter of hours, using low-cost benchtop equipment. Furthermore, a material permeable to gas exchange placed directly underneath the flow chamber and a degassing step allows to operate an integrated bubble degasser. The present invention also describes examples of a device for cell culture of gastric fibroblasts and an epithelial gastric cell line with no cytotoxic effects or impact on cellular homeostasis, stepping towards an advanced model of the stomach mucosa. The devices and methods herein described can be advantageously used in the early stages of organ-on-a-chip development by reducing three of the main burdens facing a microfabrication laboratory, namely production time, cost and space requirement. Fabricated devices retain several desirable qualities such as transparency, flexibility for mechanical actuation, biocompatibility and capability of gaseous exchanges with the exterior environment, allowing elimination of air bubbles formed during operation, which is one of the major challenges during biochip handling.

9. 发明申请

WO2022184670A2 REUSABLE LIGHT-ACTIVATED STERILIZATION SYSTEM FOR MEDICAL DEVICES 审中-公开
公开(公告)号：WO2022184670A2
公开(公告)日：2022-09-09
申请号：PCT/EP2022/055057
申请日：2022-03-01
申请人： INEB - INSTITUTO NACIONAL DE ENGENHARIA BIOMÉDICA , UNIVERSIDADE DO PORTO
发明人： DE CASTRO GONÇALVES DE ALMADA LOBO, Inês , CARVALHO HENRIQUES, Ana Patrícia , MOREIRA PINTO, Artur Daniel , DE MAGALHAES, Fernao Domingos de Montenegro Baptista Malheiro
IPC分类号： A61L2/08 , A61B90/70 , A61M25/00 , C01B32/00 , A61L2/084 , A61L2/085 , A61L2/088 , A61L2202/24 , A61M2025/0019 , C01B32/198
摘要： The present invention relates to a reusable integrated light-activated sterilization system, as well as to a method of preparing the sterilization system. Additionally, the present invention relates to a catheter cap including the reusable light-activated sterilization system.

10. 发明申请

WO2020109631A1 LAMININ IMMOBILIZATION, METHODS AND USES THEREOF 审中-公开
公开(公告)号：WO2020109631A1
公开(公告)日：2020-06-04
申请号：PCT/EP2019/083366
申请日：2019-12-02
申请人： INEB - INSTITUTO NACIONAL DE ENGENHARIA BIOMÉDICA
发明人： GOMES MOREIRA PÊGO, Ana Paula , SANTANA RAMOS DE FREITAS AMARAL, Isabel Maria , DOS SANTOS BARROS, Daniela Filipa
IPC分类号： G01N33/543 , G01N33/545
摘要： Laminin immobilization into diverse biological and synthetic matrices has been explored to replicate the microenvironment of stem cell niches and gain insight into the role of extracellular matrix (ECM) on stem cell behaviour. However, the site-specific immobilization of this heterotrimeric glycoprotein and, consequently, control over its orientation and bioactivity has been a challenge that has limited many of the explored strategies to date. An affinity-based approach was established that takes advantage of the native high affinity interaction between laminin and the human N-terminal agrin (hNtA) domain.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式