专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

TWI249526B (R)-��-(2,3-二甲氧基苯基)-1-[2-(4-氟苯基)乙基]-4-啶甲醇之新穎製法 NOVEL PROCESSES FOR THE PREPARATION OF (R)-��-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORPHENYL)ETHYL]-4-PIPERIDINEMETHANOL 失效
简体标题： (R)-��-(2,3-二甲氧基苯基)-1-[2-(4-氟苯基)乙基]-4-啶甲醇之新颖制法 NOVEL PROCESSES FOR THE PREPARATION OF (R)-��-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORPHENYL)ETHYL]-4-PIPERIDINEMETHANOL
公开(公告)号：TWI249526B
公开(公告)日：2006-02-21
申请号：TW088103619
申请日：1999-03-09
申请人：艾文提斯製藥股份有限公司 AVENTIS PHARMACEUTICALS INC. , 德國赫斯特麥樂羅素股份有限公司 HOECHST MARION ROUSSEL DEUTSCHLAND GMBH
发明人：艾倫賓納 BINA, ALAN G. , 艾德華多斯 DAUGS, EDWARD D. , 强納桑伊文斯 EVANS, JONATAN CHARLES , 漢斯-沃夫蘭.佛萊明 FLEMMING, HANS-WOLFRAM , 吉爾德.古勤摩 GUILLAMOT, GERARD , 羅伯特.賀松 HAWTHORNE, ROBERT A. , 湯瑪士.希伯特 HILPERT, THOMAS H.E. , 詹姆士.希特 HITT, JAMES E. , 奇辛.金 KING, CHI-HSIN R. , 强納斯.柯克 KOEK, JOHANNES N. , 費德瑞克.拉斯柯維斯 LASKOVICS, FREDERICK M. , 約翰.雷夫樂 LEFLER, JOHN R. , 亞勒斯.馬格林 MARGOLIN, ALEXEY LEONID , 雪倫.密尼希 MINISH, SHARON K. , 湯瑪斯.歐岱爾 ORTYL, THOMAS THEODORE , 利安.洛赫斯基 RAJEWSKI, LIAN G. , 馬文.沙克 SACK, MARVIN J. , 保羅.史卡特堤 SKULTETY, PAUL F. , 珊卓拉.史多茲-當恩 STOLZ-DUNN, SANDRA , 艾隆索.廷勒 TIGNER, ALONZO L. , 美國
IPC分类号： C07D , A61K
CPC分类号： C07D211/32 , C07D211/22
摘要：本發明提供(R)-α-(2，3-二甲氧基苯基)-1-〔2-(4-氟苯基)乙基〕-4-啶甲醇的多種製法。這些方法的特徵可藉下示反應流程圖顯示：
。
简体摘要：本发明提供(R)-α-(2，3-二甲氧基苯基)-1-〔2-(4-氟苯基)乙基〕-4-啶甲醇的多种制法。这些方法的特征可藉下示反应流程图显示：。

2. 发明申请

WO1999051577A1 (S)-2-(BIPHENYL-4-SULPHONYLAMINO)-3-(1H-INDOLYL)-PROPIONIC ACID DERIVATIVES AS MATRIX METAL PROTEIN INHIBITORS 审中-公开
标题翻译：（S）-2-（联苯-4-磺酰基氨基）-3-（1H-吲哚基） - 丙酸衍生物作为基质金属蛋白酶
公开(公告)号：WO1999051577A1
公开(公告)日：1999-10-14
申请号：PCT/EP1999001730
申请日：1999-03-17
申请人： HOECHST MARION ROUSSEL DEUTSCHLAND GMBH , SCHUDOK, Manfred , SCHWAB, Wilfried , THORWART, Werner , HAASE, Burkhard , WEITHMANN, Klaus-Ulrich
发明人： HOECHST MARION ROUSSEL DEUTSCHLAND GMBH
IPC分类号： C07D209/20
CPC分类号： C07D209/20
摘要： The invention relates to (S)-2-(biphenyl-4-sulphonylamino)-3-(1H-indolyl)-propionic acid derivatives. S enantiomers of the compound of formula (1) are suitable for the production of medicaments used in the prophylaxis and therapy of diseases in the course of which matrix-catabolic metal proteinases are involved.
摘要翻译：式（1）的化合物的S-对映体是适合于生产用于其涉及在使用过程中降解基质的金属蛋白酶的疾病的预防和治疗药物。

3. 发明授权

US06090190A Closure systems for chromatographic columns 有权
标题翻译：色谱柱封闭系统
公开(公告)号：US06090190A
公开(公告)日：2000-07-18
申请号：US209286
申请日：1998-12-11
申请人： Alfons Enhsen , Ralf Watkowiak
发明人： Alfons Enhsen , Ralf Watkowiak
IPC分类号： B01D15/08 , G01N30/60 , F16L37/20
CPC分类号： B01D15/08 , G01N30/6004 , F16L37/20
摘要： A device for establishing a flange connection, having a bearing which can act on a first flange, a counter-bearing which can act on a second flange, and a connecting lever between the two bearings is described. The invention is distinguished by the fact that the connecting lever is a lever with a drawing element. The drawing element and the lever each have a first and second end. The drawing element's first end engages the bearing and its second end jointedly mounts in between the first and second ends of the lever. The counter-bearing has at least one contact location for the first end of the lever and a recess for the drawing element.
摘要翻译：描述了一种用于建立凸缘连接的装置，其具有能够作用在第一凸缘上的轴承，可作用在第二凸缘上的反作用轴和两个轴承之间的连接杆。本发明的特征在于连接杆是具有拉伸元件的杠杆。绘图元件和杠杆各自具有第一和第二端。拉拔元件的第一端接合轴承，并且其第二端连接地安装在杆的第一和第二端之间。反轴承具有用于杆的第一端的至少一个接触位置和用于牵引元件的凹部。

4. 发明授权

US6034238A Heterocyclic compounds, their preparation and their use as leucocyte adhesion inhibitors and VLA-4-antagonists 有权
标题翻译：杂环化合物，它们的制备及其作为白细胞粘附抑制剂和VLA-4-拮抗剂的用途
公开(公告)号：US6034238A
公开(公告)日：2000-03-07
申请号：US158772
申请日：1998-09-23
申请人： Volkmar Wehner , Hans Ulrich Stilz , Wolfgang Schmidt , Dirk Seiffge
发明人： Volkmar Wehner , Hans Ulrich Stilz , Wolfgang Schmidt , Dirk Seiffge
IPC分类号： C07D233/76 , A61K31/00 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/42 , A61K31/425 , A61K38/00 , A61K38/05 , A61K38/06 , A61P1/00 , A61P3/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/08 , A61P17/00 , A61P25/00 , A61P27/00 , A61P27/14 , A61P29/00 , A61P35/00 , A61P35/04 , C07D233/02 , C07D233/84 , C07D233/86 , C07D263/34 , C07D277/32 , C07K5/02 , C07K5/023 , C07K5/06 , C07K5/078 , C07K5/097 , C07K5/117 , C07D413/00 , C07D233/40 , A61K31/535
CPC分类号： C07K5/0202 , C07K5/1024 , A61K38/00
摘要： Compounds of the formula I, ##STR1## in which B, E, W, Y, Z, R, R.sup.2, R.sup.2a, R.sup.2b, R.sup.3, g and h have the meanings indicated in the specifications. The compounds of the formula I are valuable pharmaceutical active compounds, which are suitable, for example, for the therapy and prophylaxis of inflammatory disorders, for example of rheumatoid arthritis, or of allergic disorders. The compounds of the formula I are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 belonging to the integrins group. They are generally suitable for the therapy or prophylaxis of illnesses which are caused by an undesired extent of leucocyte adhesion and/or leucocyte migration or are associated therewith, or in which cell-cell or cell-matrix interactions which are based on interactions of VLA-4 receptors with their ligands play a part. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use in the therapy and prophylaxis of the disease states mentioned and pharmaceutical preparations which contain the compounds of the formula I.
摘要翻译：其中B，E，W，Y，Z，R，R 2，R 2a，R 2b，R 3，g和h具有说明书中所示含义的式I化合物。式I的化合物是有价值的药物活性化合物，其适用于例如治疗和预防炎症性疾病，例如类风湿性关节炎或过敏性疾病。式I的化合物是属于整联蛋白组的粘附受体VLA-4的白细胞和/或拮抗剂的粘附和迁移的抑制剂。它们通常适用于治疗或预防由白细胞粘附和/或白细胞迁移的不期望程度或与之相关的疾病引起的疾病，或其中以基于VLA的相互作用为基础的细胞 - 细胞或细胞 - 基质相互作用 4受体与其配体发挥作用。本发明还涉及制备式I化合物的方法，它们在治疗和预防所述疾病状态中的用途以及含有式I化合物的药物制剂。

5. 发明申请

US20030064514A1 MODIFIED ANTISENSE NUCLEOTIDES COMPLEMENTARY TO A SECTION OF THE HUMAN HA-RAS GENE 失效
标题翻译：人类HA-RAS基因部分修饰的抗体核苷酸
公开(公告)号：US20030064514A1
公开(公告)日：2003-04-03
申请号：US09423198
申请日：2000-02-17
申请人： HOECHST MARION ROUSSEL DEUTSCHLAND GmbH
发明人： EUGEN UHLMANN , ANUSCHIRWAN PEYMAN , DAVID WILLIAM WILL , ESTHER CHANG , KATHLEEN PIROLLO , ANTONINA RAIT
IPC分类号： A61K048/00 , C07H021/04
CPC分类号： C07H21/02 , A61K38/00 , C12N15/1135 , C12N2310/11 , C12N2310/315 , C12N2310/322 , C12N2310/345 , C12N2310/351 , C12N2310/3531
摘要： The invention relates to a specific modified oligonucleotide complementary to a section of the human Hs-ras gene and mRNA, and its use to specifically regulate, modulate, or inhibit expression of the Ha-ras gene, and its use as a pharmaceutical for the treatment of conditions arising from the abnormal expression of the Ha-ras gene, in particular in combination with chemotherapy and radiotherapy. The modified oligodeoxynucleotide according to the invention has the sequence: 5null-TxAxTxTxCxCxGxTxCxAxTx-3null-OnullPO2nullOnullR, wherein x is o or s, with the proviso that x is at least 4 times s and at maximum 9 times s and o means a phosphodiester internucleoside linkage, s means a phosphorothioate internucleoside linkage, R means a C8-C21 alkyl group, null(CH2-CH2O)nnull(CH2)mnullCH3 or nullCH2nullCH(OH)CH2Onull(CH2)qnullCH3 wherein n is an integer from 1 to 6, m is an integer from 0 to 20 and q is an integer from 7 to 20 and A is 2null-deoxyadenosine, G is 2null-deoxyguanosine, C is 2null-deoxycytidine and T is thymadine.
摘要翻译：本发明涉及与人Hs-ras基因和mRNA的部分互补的特异性修饰寡核苷酸及其用于特异性调节，调节或抑制Ha-ras基因表达的用途及其作为治疗药物的用途由Ha-ras基因异常表达引起的疾病，特别是与化学疗法和放疗相结合。根据本发明的修饰的寡脱氧核苷酸具有以下序列：5'-TxAxTxTxCxCxGxTxCxAxTx-3'-O-PO2-OR，其中x为o或s，条件是x为至少4倍，最大为9倍， o表示磷酸二酯核苷间键，s表示硫代磷酸酯核苷间键，R表示C8-C21烷基， - （CH2-CH2O）n-（CH2）m-CH3或-CH2-CH（OH）CH2O-（CH2） q-CH 3，其中n为1至6的整数，m为0至20的整数，q为7至20的整数，A为2'-脱氧腺苷，G为2'-脱氧鸟苷，C为2'- 脱氧胞苷和T是胸腺嘧啶。

6. 发明授权

US6015822A Sulfonamide-substituted fused 5-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them 有权
标题翻译：磺酰胺取代的稠合的5元环化合物，它们作为药物的用途，以及包含它们的药物制剂
公开(公告)号：US6015822A
公开(公告)日：2000-01-18
申请号：US188181
申请日：1998-11-09
申请人： Joachim Brendel , Uwe Gerlach , Hans Jochen Lang , Klaus Weidmann
发明人： Joachim Brendel , Uwe Gerlach , Hans Jochen Lang , Klaus Weidmann
IPC分类号： A61K31/00 , A61K31/18 , A61K31/33 , A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/44 , A61K31/4409 , A61P1/00 , A61P1/04 , A61P1/12 , A61P9/00 , A61P43/00 , C07C311/07 , C07C311/10 , C07D209/34 , C07D209/40 , C07D213/38 , C07D213/42 , C07D307/82 , C07D307/83 , C07D333/64 , C07D333/66
CPC分类号： C07D213/42 , C07C311/07 , C07D333/66 , C07C2102/08
摘要： Compounds of the formula I ##STR1## having the meanings of the substituents indicated in the claims are outstandingly active substances for the production of medicaments for the prophylaxis and for the therapy of cardiovascular disorders, in particular arrhythmias, for the treatment of ulcers of the gastro-intestinal region or for the treatment of diarrheal illnesses.
摘要翻译：具有权利要求书中所示取代基的含义的式I化合物是用于生产用于预防和治疗心血管疾病特别是心律失常的药物用于治疗胃肠道溃疡的突出活性物质或治疗腹泻病。

7. 发明申请

US20040097544A1 Use of an inhibitor of the Na+/H+ exchanger for the production of a medicament for the treatment or prophylaxis of disturbances of the central nervous system 审中-公开
标题翻译：使用Na + / H +交换剂的抑制剂来生产用于治疗或预防中枢神经系统紊乱的药物
公开(公告)号：US20040097544A1
公开(公告)日：2004-05-20
申请号：US10424107
申请日：2003-04-28
申请人： Hoechst Marion Roussel Deutschland GMBH
发明人： Hans Jochen Lang , Klaus Wirth , Dieter Bingmann , Udo Bonnet , Martin Wiemann
IPC分类号： A61K031/47 , A61K031/404 , A61K031/255 , A61K031/165
CPC分类号： A61K31/166 , A61K31/00 , A61K31/155
摘要： The use of an inhibitor of the Nanull/Hnull exchanger for the production of a medicament for the treatment or prophylaxis of disorders of the central nervous system. Inhibitors of the Nanull/Hnull exchanger are outstandingly suitable for the production of a medicament for the treatment or prophylaxis of disorders of the central nervous system; derivatives of guanidine are particularly highly suitable; cariporide (HOE 642) is especially suitable.
摘要翻译：使用Na + / H +交换剂的抑制剂来生产用于治疗或预防中枢神经系统病症的药物。 Na + / H +交换剂的抑制剂非常适合于生产用于治疗或预防中枢神经系统疾病的药物; 胍的衍生物特别高度适用; 卡泊里德（HOE 642）特别适合。

8. 发明授权

US6008245A Sulfonamide-substituted benzopyran derivatives, processes for their preparation, their use as a medicament, and pharmaceutical preparations comprising them 有权
标题翻译：磺酰胺取代的苯并吡喃衍生物，其制备方法，它们作为药物的用途，以及包含它们的药物制剂
公开(公告)号：US6008245A
公开(公告)日：1999-12-28
申请号：US184110
申请日：1998-11-02
申请人： Joachim Brendel , Uwe Gerlach , Hans Jochen Lang , Klaus Weidmann
发明人： Joachim Brendel , Uwe Gerlach , Hans Jochen Lang , Klaus Weidmann
IPC分类号： C07D311/68 , A61K31/00 , A61K31/35 , A61K31/352 , A61K31/353 , A61P1/00 , A61P1/04 , A61P9/00 , A61P9/06 , A61P43/00 , C07D311/72 , C07D405/12 , C07D409/12 , C07D417/12 , C07D419/12 , C07D311/04
CPC分类号： C07D311/72
摘要： Sulfonamide-substituted benzopyran derivatives, processes for their preparation, their use as a medicament, and pharmaceutical preparations comprising them Compounds of the formula I ##STR1## having the meanings of the substituents indicated in the claims are outstandingly active substances for the production of medicaments for the prophylaxis and for the therapy of cardiovascular disorders, in particular arrhythmias, for the treatment of ulcers of the gastrointestinal region or for the treatment of diarrheal diseases.
摘要翻译：磺酰胺取代的苯并吡喃衍生物，其制备方法，它们作为药物的用途以及包含它们的药物制剂具有权利要求中所示取代基的含义的式I化合物是用于生产药物的突出活性物质，用于预防和用于治疗心血管疾病，特别是心律不齐，用于治疗胃肠道区域的溃疡或用于治疗腹泻疾病。

9. 发明授权

US06008023A Cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion proteins in E. coli 失效
公开(公告)号：US06008023A
公开(公告)日：1999-12-28
申请号：US630820
申请日：1996-04-10
申请人： Martin Opper , Klaus Bosslet , Joerg Czech
发明人： Martin Opper , Klaus Bosslet , Joerg Czech
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , C07H21/04 , C07K16/00 , C07K19/00 , C12N9/24 , C12N15/00 , C12N15/13 , C12N15/62 , C12R1/19 , C07H21/02 , C12N15/03
CPC分类号： C12Y302/01031 , C07K16/00 , C12N15/62 , C12N9/2434 , A61K38/00 , C07K2319/00 , C07K2319/30 , C07K2319/61 , Y10S424/801 , Y10S435/849
摘要： The invention relates to the cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion molecules in E. coli. In particular, antibody fragment fusion molecules having an antibody moiety which is directed against tumors and an enzyme moiety which cleaves a nontoxic prodrug to give the toxic drug can be advantageously prepared in this way while retaining their respective functional properties.

10. 发明申请

US20020042381A1 Aryl-substituted propanolamine derivatives, their preparation, pharmaceuticals comprising them, and their use 有权
标题翻译：芳基取代的丙醇胺衍生物，其制备方法，包含它们的药物及其应用
公开(公告)号：US20020042381A1
公开(公告)日：2002-04-11
申请号：US09833676
申请日：2001-04-13
申请人： Hoechst Marion Roussel Deutschland GmbH
发明人： Wendelin Frick , Reinhard Kirsch , Heiner Glombik , Werner Krammer , Hans-Ludwig Schafer
IPC分类号： A61K031/706 , C07H019/048
CPC分类号： C07H15/18
摘要： Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described. Also described are compounds of formula I 1 in which the radicals have the abovementioned meanings, and their physiologically tolerated salts, physiologically functional derivates and processes for their preparation. The compounds are suitable as, for example, hypolipidemics.
摘要翻译：描述了取代的丙醇胺衍生物，其药学上可耐受的盐及其生理功能衍生物。还描述了其中基团具有上述含义的式I化合物及其生理上耐受的盐，生理功能衍生物及其制备方法。该化合物适合作为例如降血脂药。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式