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1. 发明申请

WO2004009762A2 FLEA AND TICK OCTOPAMINE RECEPTOR NUCLEIC ACID MOLECULES, PROTEINS AND THEREOF 审中-公开
标题翻译： FLEA和TICK OCTOPAMINE受体核酸分子，蛋白质及其
公开(公告)号：WO2004009762A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/021706
申请日：2003-07-11
申请人： HESKA CORPORATION , BRANDT, Kevin, S.
发明人： BRANDT, Kevin, S.
IPC分类号： C12N
CPC分类号： C07K14/70571 , C07K14/43527 , C07K14/4359 , C12N2799/021 , Y10S530/858
摘要： The present invention relates to tick octopamine receptor nucleic acid molecules; to tick octopamine receptor proteins encoded by such nucleic acid molecules; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes inhibitory compounds, particularly those that specifically inhibit tick octopamine receptor activity, as well as the use of such compounds to treat animals.
摘要翻译：本发明涉及蜱八萜胺受体核酸分子; 挑选由这种核酸分子编码的章鱼胺受体蛋白; 针对这种蛋白质产生的抗体; 以及抑制这些蛋白质活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括抑制性化合物，特别是那些特异性抑制蜱八萜胺受体活性的化合物，以及这些化合物用于治疗动物的用途。

2. 发明申请

WO1997040058A1 FLEA PROTEASE PROTEINS, NUCLEIC ACID MOLECULES, AND USES THEREOF 审中-公开
标题翻译： FLEA蛋白质，核酸分子及其用途
公开(公告)号：WO1997040058A1
公开(公告)日：1997-10-30
申请号：PCT/US1997006121
申请日：1997-04-24
申请人： HESKA CORPORATION , GRIEVE, Robert, B. , RUSHLOW, Keith, E. , HUNTER, Shirley, Wu , FRANK, Glenn, R. , STEIGLER, Gary, L. , GAINES, Patrick, J. , SILVER, Gary
发明人： HESKA CORPORATION
IPC分类号： C07H21/00
CPC分类号： C12N9/6408 , A61K35/00 , C07K16/40 , C12N9/48 , C12N9/641 , C12N9/6424 , C12N9/6472
摘要： The present invention relates to flea serine protease proteins and flea cysteine protease proteins; to flea serine protease and cysteine protease nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease and/or cysteine protease activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.
摘要翻译：本发明涉及跳蚤丝氨酸蛋白酶蛋白和跳蚤半胱氨酸蛋白酶蛋白; 跳蚤丝氨酸蛋白酶和半胱氨酸蛋白酶核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶和/或半胱氨酸蛋白酶活性的化合物。本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物以及这种治疗组合物用于保护宿主动物免于跳蚤侵染的用途。

3. 发明申请

WO1998045408A2 NOVEL ECTOPARASITE SALIVA PROTEINS AND APPARATUS TO COLLECT SUCH PROTEINS 审中-公开
标题翻译：新型ECTOPARASITE SALIVA蛋白质和收集这种蛋白质的装置
公开(公告)号：WO1998045408A2
公开(公告)日：1998-10-15
申请号：PCT/US1997018669
申请日：1997-10-15
申请人： HESKA CORPORATION , WEBER, Eric, R.
发明人： HESKA CORPORATION
IPC分类号： C12N00/00
CPC分类号： C07K14/4359 , A61K39/00
摘要： The present invention is directed to a novel product and method for isolating ectoparasite saliva proteins, and a novel product and method for detecting and/or treating allergic dermatitis in an animal. The present invention also relates to ectoparasite saliva proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods to obtain such proteins and to use proteins to identify animals susceptible to or having allergic dermatitis. The present invention also includes therapeutic compositions comprising such proteins and their use to treat animals susceptible to or having allergic dermatitis.
摘要翻译：本发明涉及一种用于分离异位唾液蛋白的新产品和方法，以及用于在动物中检测和/或治疗过敏性皮炎的新产品和方法。本发明还涉及外寄生物唾液蛋白质，具有编码这种蛋白质的序列的核酸分子和针对这种蛋白质产生的抗体。本发明还包括获得这样的蛋白质和使用蛋白质鉴定易感或具有过敏性皮炎的动物的方法。本发明还包括包含这些蛋白质的治疗组合物及其用于治疗易感或具有过敏性皮炎的动物的用途。

4. 发明申请

WO1998027208A1 NOVEL FELINE Fc EPSILON RECEPTOR ALPHA CHAIN NUCLEIC ACID MOLECULES, PROTEINS AND USES THEREOF 审中-公开
标题翻译：新型菲罗尼林依托膦受体α链氨基酸分子，蛋白质及其用途
公开(公告)号：WO1998027208A1
公开(公告)日：1998-06-25
申请号：PCT/US1997023244
申请日：1997-12-16
申请人： HESKA CORPORATION
发明人： HESKA CORPORATION , FRANK, Glenn, Robert , PORTER, James, P. , RUSHLOW, Keith, E. , WASSOM, Donald, L. , WEBER, Eric, R.
IPC分类号： C12N15/12
CPC分类号： G01N33/6857 , A61K38/00 , C07K14/70535 , C12N2799/026
摘要： The present invention relates to feline Fc epsilon receptor alpha chain nucleic acid molecules, proteins encoded by such nucleic acid molecules, antibodies raised against such proteins, and inhibitors of such proteins. The present invention also includes methods to detect IgE using such proteins and antibodies. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to mediate Fc epsilon receptor-mediated biological responses.
摘要翻译：本发明涉及猫科动物Fcε受体α链核酸分子，由这种核酸分子编码的蛋白质，针对这种蛋白质产生的抗体，以及这种蛋白质的抑制剂。本发明还包括使用这种蛋白质和抗体检测IgE的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及这些治疗组合物用于介导Fcε受体介导的生物反应的治疗组合物。

5. 发明申请

WO1998024912A2 RECOMBINANT PLAGUE VACCINE 审中-公开
标题翻译：重组游泳池
公开(公告)号：WO1998024912A2
公开(公告)日：1998-06-11
申请号：PCT/US1997022617
申请日：1997-12-04
申请人： HESKA CORPORATION , HAANES, Elizabeth, J. , THOMAS, Rex, E. , OSORIO, Jorge, E.
发明人： HESKA CORPORATION
IPC分类号： C12N15/31
CPC分类号： C07K14/24 , A61K39/00 , Y02A50/407
摘要： The present invention relates to a recombinant vaccine to protect animals against plague. More particularly, the invention includes recombinant molecules containing isolated nucleic acid molecules that encode proteins from Yersinia, Pasteurella, or Francisella bacteria expressed in eukaryotic cells. In one embodiment, the recombinant molecule is an animal virus genome; in another embodiment the recombinant molecule is a recombinant plasmid. The present invention also includes recombinant viruses comprising a recombinant animal virus genome and recombinant cells comprising either a recombinant virus or a recombinant plasmid. The present invention further includes therapeutic compositions comprising such recombinant molecules, viruses and cells, as well as methods to protect animals from plague.
摘要翻译：本发明涉及一种保护动物免疫瘟疫的重组疫苗。更具体地，本发明包括含有分离的核酸分子的重组分子，所述分离的核酸分子编码在真核细胞中表达的耶尔森氏菌，巴斯德氏菌或弗朗西斯细菌的蛋白质。在一个实施方案中，重组分子是动物病毒基因组; 在另一个实施方案中，重组分子是重组质粒。本发明还包括重组病毒，其包含重组动物病毒基因组和包含重组病毒或重组质粒的重组细胞。本发明还包括包含这种重组分子，病毒和细胞的治疗组合物，以及保护动物免于瘟疫的方法。

6. 发明申请

WO1998023964A1 METHOD TO DETECT IgE 审中-公开
标题翻译：检测IgE的方法
公开(公告)号：WO1998023964A1
公开(公告)日：1998-06-04
申请号：PCT/US1997021651
申请日：1997-11-24
申请人： HESKA CORPORATION
发明人： HESKA CORPORATION , FRANK, Robert, Glenn , PORTER, James, P. , RUSHLOW, Keith, E. , WASSOM, Donald, L.
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , G01N2333/70535 , G01N2800/24
摘要： The present invention includes a method to detect IgE using a human Fc epsilon receptor (Fc epsilon R) to detect IgE antibodies in a biological sample from a cat, a dog, or a horse. The present invention also relates to kits to perform such methods.
摘要翻译：本发明包括使用人Fcε受体（FcεR）检测来自猫，狗或马的生物样品中的IgE抗体的IgE的方法。本发明还涉及执行这些方法的试剂盒。

7. 发明申请

WO1998020034A2 NOVEL SERINE PROTEASE INHIBITOR NUCLEIC ACID MOLECULES, PROTEINS AND USES THEREOF 审中-公开
标题翻译：新型丝氨酸蛋白酶抑制剂核酸分子，蛋白质及其用途
公开(公告)号：WO1998020034A2
公开(公告)日：1998-05-14
申请号：PCT/US1997020678
申请日：1997-11-05
申请人： HESKA CORPORATION , WISNEWSKI, Nancy , BRANDT, Kevin, S. , SILVER, Gary, M. , MADDUX, Joely, D.
发明人： HESKA CORPORATION
IPC分类号： C07K14/14
CPC分类号： C07K14/8121 , A61K38/00 , Y02A50/473
摘要： The present invention relates to flea serine protease inhibitor proteins; to flea serine protease inhibitor nucleic acid molecules, including those that encode such serine protease inhibitor proteins; to antibodies raised against such serine protease inhibitor proteins; and to compounds that inhibit flea serine protease inhibitor activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous ectoparasite infestation.
摘要翻译：本发明涉及跳蚤丝氨酸蛋白酶抑制蛋白; 跳蚤丝氨酸蛋白酶抑制剂核酸分子，包括编码这种丝氨酸蛋白酶抑制蛋白的那些; 针对这种丝氨酸蛋白酶抑制蛋白产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶抑制剂活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括含有这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及使用这种治疗组合物来保护动物免受血液外寄生虫侵袭。

8. 发明申请

WO1998012563A1 METHOD TO DETECT DIROFILARIA IMMITIS INFECTION 审中-公开
标题翻译：检测DIROFILARIA IMMITIS感染的方法
公开(公告)号：WO1998012563A1
公开(公告)日：1998-03-26
申请号：PCT/US1997016535
申请日：1997-09-18
申请人： HESKA CORPORATION
发明人： HESKA CORPORATION , GRIEVE, Robert, B. , FRANK, Glenn, R. , MONDESIRE, Roy, R. , PORTER, James, P. , WISNEWSKI, Nancy
IPC分类号： G01N33/569
CPC分类号： C07K14/4354 , G01N33/569 , G01N2333/4353
摘要： The present invention includes a method to detect D. immitis infection in a host animal using a D. immitis Di33 protein to detect anti-D. immitis Di33 antibodies in a bodily fluid of the animal. Also included is a method to detect D. immitis infection in a host animal using a D. immitis anti-Di33 protein to detect Di33 proteins in a bodily fluid of the animal. The present invention also relates to D. immitis detection kits that include either a Di33 protein or an anti-Di33 antibody; such kits also include a composition to detect an immunocomplex between the anti-Di33 antibody and D. immitis Di33 protein. The present invention also includes Di33 proteins, nucleic acid molecules encoding such proteins, as well as recombinant molecules and recombinant cells comprising such nucleic acid molecules, and anti-Di33 antibodies. Also included are methods to produce such proteins, nucleic acid molecules and antibodies.
摘要翻译：本发明包括使用D.Imitmiti Di33蛋白检测宿主动物中的D. immitis感染以检测抗-D的方法。 immitis Di33抗体在动物的体液中。还包括在宿主动物中使用D.emmitis抗-Di33蛋白检测动物体内的Di33蛋白的方法。本发明还涉及包含Di33蛋白或抗-Di33抗体的D.IMIITIS检测试剂盒; 这样的试剂盒还包括用于检测抗Di33抗体和D.Imitmiti Di33蛋白之间的免疫复合物的组合物。本发明还包括Di33蛋白，编码这种蛋白质的核酸分子，以及重组分子和包含这种核酸分子的重组细胞和抗Di33抗体。还包括产生这种蛋白质，核酸分子和抗体的方法。

9. 发明申请

WO1997029766A1 PARASITIC HELMINTH LARVAL THIOL SPECIFIC ANTIOXIDANT PROTEINS, NUCLEIC ACID MOLECULES, AND USES THEREOF 审中-公开
标题翻译： PARASITIC HELMINTH LARVAL THIOL特异性抗氧化蛋白，核酸分子及其用途
公开(公告)号：WO1997029766A1
公开(公告)日：1997-08-21
申请号：PCT/US1997002361
申请日：1997-02-13
申请人： HESKA CORPORATION , KLIMOWSKI, Laura , TRIPP, Cynthia, Ann
发明人： HESKA CORPORATION
IPC分类号： A61K38/00
CPC分类号： C07K14/43536 , A61K38/00 , C07K14/4354 , C07K16/18 , C07K2319/00 , C12N2799/023
摘要： The present invention relates to parasitic helminth thiol specific antioxidant (TSA) larval proteins; to parasitic helminth larval TSA nucleic acid molecules, including those that encode such TSA proteins; to antibodies raised against such TSA proteins; and to compounds that inhibit parasititc helminth larval TSA activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译：本发明涉及寄生蠕虫硫醇特异性抗氧化剂（TSA）幼虫蛋白质; 寄生虫寄生虫幼虫TSA核酸分子，包括编码这种TSA蛋白的那些; 针对这种TSA蛋白产生的抗体; 以及抑制寄生虫蠕虫幼虫TSA活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及使用这些治疗组合物来保护动物免受寄生蠕虫引起的疾病。

10. 发明申请

WO2004030721A2 FLUID COLLECTING DEVICE, METHODS OF PRODUCTION AND USES THEREOF 审中-公开
标题翻译：流体收集装置，生产方法及其用途
公开(公告)号：WO2004030721A2
公开(公告)日：2004-04-15
申请号：PCT/US2003/031225
申请日：2003-10-02
申请人： HESKA CORPORATION , JENSEN, Wayne, A. , LEE, Kenneth, W. , SELLINS, Karen, S. , POWELL, Timothy
发明人： JENSEN, Wayne, A. , LEE, Kenneth, W. , SELLINS, Karen, S. , POWELL, Timothy
IPC分类号： A61M
CPC分类号： G01N33/548 , A01K23/005 , A61B10/0051 , A61B10/0064 , A61B10/007 , B01L3/5023 , G01N2333/76
摘要： The present invention relates to sample collection devices for collecting samples suspected of containing one or more target analytes. After collection, the sample is released from the device and tested for the target analyte. The invention further provides methods of producing the devices and methods of using the devices to collect samples. Kits containing the devices and associated components are also provided.
摘要翻译：本发明涉及用于收集怀疑含有一种或多种目标分析物的样品的样品收集装置。收集后，样品从装置中释放出来并测试目标分析物。本发明还提供了制造这些装置的方法和使用这些装置来采集样品的方法。还提供包含设备和相关组件的套件。

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