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1. 发明专利

JPH11511172A 失效
公开(公告)号：JPH11511172A
公开(公告)日：1999-09-28
申请号：JP50946697
申请日：1996-08-12
申请人： HADASIT MED RES SERVICE , AGRICULTURAL RES ORG
IPC分类号： C07D401/06 , A61K31/00 , A61K31/505 , A61K31/517 , A61K31/529 , A61P9/00 , A61P35/00 , A61P43/00

2. 发明专利

JPH0835966A REAGENT, KIT AND METHOD FOR IMMUNOASSAY 失效
公开(公告)号：JPH0835966A
公开(公告)日：1996-02-06
申请号：JP8166095
申请日：1995-03-01
申请人： HADASIT MED RES SERVICE
发明人： YAAKOBU NAPARUSUTEKU
IPC分类号： G01N33/564
摘要： PURPOSE: To provide a novel reagent which is used in the connection and detection of an antibody found in urine of a patient who suffers from lupous disease, a kit which contains it, and a method thereof. CONSTITUTION: It is an immunoassay reagent which is used in the connection and detection of an antibody found in urine of a patinet who suffers from lupous disease which contains an extracellular substrate or laminin. It is a test kit for immunoassay which includes one or more vessels in which extracellular substrates or the lupous antibody connecting laminin lupous disease components are combined on an internal surface thereof and detects the antibody found in urine of the patient who suffers from lupous disease. It is a binding assay method for measuring the existence of the antibody found in urine of the patient who suffers from lupous disease which includes a specific process. It is the binding assay method for measuring a degree of progress in lupous disease of the patient which includes a specific process. It is also the binding assay method for estimating a period of activity of lupous disease in a patient who is likely to suffer from lupous disease which includes a specific process.

3. 发明申请

WO2014184796A3 GUIDED ENDOTRACHEAL INTUBATION SYSTEM 审中-公开
标题翻译：指导性内窥镜系统
公开(公告)号：WO2014184796A3
公开(公告)日：2015-02-26
申请号：PCT/IL2014050428
申请日：2014-05-16
申请人： YISSUM RES DEV CO , HADASIT MED RES SERVICE
发明人： HAYUT ITAI , FRIED ELCHANAN , PLANER DAVID , NAHMIAS YAAKOV
IPC分类号： A61B5/00 , A61M16/04
CPC分类号： A61B1/06 , A61B1/00009 , A61B1/04 , A61B1/0661 , A61B1/267 , A61M16/0488
摘要： A guided tracheal intubation system using an autonomous modulated light source, outputting modulated illumination at a constant level, and externally applied to the subject's larynx region. An optical imaging system receives a video stream from within the subject's throat, including modulated illumination from the subject's trachea. A display control system performs signal processing on the modulated content of the images, and outputs frames of those images in which the intensity level of illumination from the trachea can be controlled without any need to change the illumination output from the modulated light source. The light source has no connection with the rest of the system, and need contain no more than a battery, a power supply circuit and a light source. It can therefore be of low cost and can be made disposable, such as in the form of an adhesive patch applied to the subject's neck.
摘要翻译：一种使用自主调制光源的引导气管插管系统，输出恒定水平的调制照明，并且外部施加于受试者的喉部区域。光学成像系统从受试者的喉部内接收视频流，包括来自对象气管的调制照明。显示控制系统对图像的调制内容执行信号处理，并且输出可以控制来自气管的照明强度水平的那些图像的帧，而不需要改变调制光源的照明输出。光源与系统的其余部分无关，只需要包含电池，电源电路和光源。因此，其可以是低成本的并且可以被制成一次性的，例如以施加到受试者的脖子的粘贴剂的形式。

4. 发明申请

WO2011036665A3 LEPTIN FOR USE IN INCREASING LIVER REGENERATION 审中-公开
标题翻译： LEPTIN用于增加肝脏再生
公开(公告)号：WO2011036665A3
公开(公告)日：2011-05-19
申请号：PCT/IL2010000790
申请日：2010-09-21
申请人： YISSUM RES DEV CO , HADASIT MED RES SERVICE , PIKARSKY ELI , BERGMAN YEHUDIT , LAUFER NERI , GIELCHINSKY YUVAL , WEITMAN EFRAIM
发明人： PIKARSKY ELI , BERGMAN YEHUDIT , LAUFER NERI , GIELCHINSKY YUVAL , WEITMAN EFRAIM
IPC分类号： A61K38/22
CPC分类号： A61K38/2264
摘要： Activators of the AKT/mTOR pathway, in particular leptin, are useful in methods and compositions for increasing regeneration of liver, increasing liver mass or improving liver function, or a combination thereof.
摘要翻译： AKT / mTOR途径的激活剂，特别是瘦蛋白，可用于增加肝脏再生，增加肝脏质量或改善肝功能的方法和组合物，或其组合。

5. 发明申请

WO2010131253A3 STETHOSCOPE DISINFECTION DEVICE 审中-公开
标题翻译： STETHOSCOPE消毒装置
公开(公告)号：WO2010131253A3
公开(公告)日：2011-01-06
申请号：PCT/IL2010000385
申请日：2010-05-13
申请人： HADASIT MED RES SERVICE , NAHMAN DEAN , CAHAN AMOS
发明人： NAHMAN DEAN , CAHAN AMOS
IPC分类号： A61B7/02 , A61B19/00 , A61L2/16
CPC分类号： A61B7/02 , A61L2/16
摘要： The present invention provides a system adapted to disinfect a stethoscope head wherein said system comprises: (a) a plurality of disposable pads having adhesive and disinfection agents absorbed therein, said pads being adapted to adhere to and disinfect said stethoscope head; and, (b) a portable dispenser adapted for serially dispensing said disposable pads, said dispenser comprising: a. a front face having an aperture adapted to accommodate said stethoscope head, and a back face; b. a cover for encasing said aperture, said cover being at least partially removable from said front face during use of said system; c. a container adapted to accommodate said disposable pads.
摘要翻译：本发明提供一种适于对听诊器头进行消毒的系统，其中所述系统包括：（a）多个一次性垫，其中吸收有粘合剂和消毒剂，所述垫适于粘附并消毒所述听诊器头; 和（b）适于串联分配所述一次性垫的便携式分配器，所述分配器包括：a。具有适于容纳所述听诊器头部的孔的前表面和背面; 湾用于封装所述孔的盖，所述盖在所述系统的使用期间至少部分地可从所述前表面移除; C。适于容纳所述一次性垫的容器。

6. 发明申请

WO2009093250A2 TARGETING OF INNATE IMMUNE RESPONSE TO TUMOR SITE 审中-公开
标题翻译：针对肿瘤部位的免疫免疫应答
公开(公告)号：WO2009093250A2
公开(公告)日：2009-07-30
申请号：PCT/IL2009000097
申请日：2009-01-25
申请人： GAVISH GALILEE BIO APPL LTD , HADASIT MED RES SERVICE , PITCOVSKI JACOB , SHAHAR EHUD , GORODETSKY RAPHAEL
发明人： PITCOVSKI JACOB , SHAHAR EHUD , GORODETSKY RAPHAEL
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： A61K47/48584 , A61K9/485 , A61K9/5052 , A61K9/5073 , A61K39/00 , A61K39/38 , A61K39/385 , A61K47/6807 , A61K47/6855 , A61K47/6921 , C07K16/32 , C07K2317/24 , C07K2317/40
摘要： The invention provides microparticles or nanoparticles for treatment of tumors comprising: (i) a targeting agent to the tumor or the tumor environment; and (ii) at least one inducer that stimulates a desired immune response in the tumor environment, leading to tumor apoptosis, wherein components (i) and (ii) are non-covalently or covalently attached to the surface of said microparticles or nanoparticles. The targeting agent is an agent that recognizes and binds to an antigen, a receptor or other molecules found on the surface of tumor cells or in the tumor environment and are preferably antibodies.
摘要翻译：本发明提供用于治疗肿瘤的微粒或纳米颗粒，包括：（i）肿瘤或肿瘤环境的靶向剂; 和（ii）刺激肿瘤环境中期望的免疫应答的至少一种诱导剂，导致肿瘤细胞凋亡，其中组分（i）和（ii）非共价或共价连接到所述微粒或纳米颗粒的表面。靶向剂是识别和结合到在肿瘤细胞表面或肿瘤环境中发现的抗原，受体或其他分子的试剂，优选为抗体。

7. 发明申请

WO2009074985A2 METHOD AND SYSTEM FOR DETECTION OF PRE-FAINTING AND OTHER CONDITIONS HAZARDOUS TO THE HEALTH OF A PATIENT 审中-公开
标题翻译：检测预防和危及患者健康的其他条件的方法和系统
公开(公告)号：WO2009074985A2
公开(公告)日：2009-06-18
申请号：PCT/IL2008001600
申请日：2008-12-10
申请人： HADASIT MED RES SERVICE , BEN-OREN ILAN , ILAN YARON
发明人： BEN-OREN ILAN , ILAN YARON
IPC分类号： A61B5/16
CPC分类号： A61B5/024 , A61B5/01 , A61B5/021 , A61B5/026 , A61B5/0402 , A61B5/053 , A61B5/0816 , A61B5/145 , A61B5/14532 , A61B5/14546 , A61B5/4094 , A61B5/4261 , A61B5/4839 , A61B5/7275 , G16H40/63 , G16H50/20 , G16H50/50
摘要： The invention is a method and system for the detection and warning of the presence of pre-fainting and other conditions that are hazardous to the health of a patient having one or more types of disease or disorder. A wide range of physiological and physical parameters are monitored and at least two of the monitored parameters are logically and/or mathematically combining to form a function that is used to determine the value of a new parameter called the risk parameter alpha. The parameters that appear in the function are selected according to the patient's known pathological condition. An initial threshold value for alpha based on known normal values of the monitored parameters as determined by statistical studies is determined. The current value of alpha, defined as alpha(t), is determined from the function and compared to the initial value of alpha. If the comparison shows that there exists danger of the onset of a pre-fainting and/or other medically hazardous condition a warning signal is emitted. The values of alpha and the terms and parameters that comprise the function used to determine alpha(t) are continually determined and, if relevant, updated according to the history of the patient. In preferred embodiments of the invention self learning techniques are used to update the values of alpha and the function.
摘要翻译：本发明是用于检测和警告对具有一种或多种类型的疾病或病症的患者的健康有害的预晕化和其它状况的检测和警告的方法和系统。监测范围广泛的生理和物理参数，并且所监视的参数中的至少两个在逻辑上和/或数学上组合以形成用于确定称为风险参数α的新参数的值的函数。根据患者已知的病理状况选择功能中出现的参数。确定基于通过统计学研究确定的所监测参数的已知正常值的α的初始阈值。 α的当前值，定义为α（t），从该函数确定并与α的初始值进行比较。如果比较表明存在发生预晕和/或其他医疗危险状况的危险，则发出警告信号。 α和包含用于确定α（t）的函数的术语和参数的值是不断确定的，并且如果相关的话根据患者的病史更新。在本发明的优选实施例中，使用自学习技术来更新α和功能的值。

8. 发明申请

WO2008001368A3 USE OF STILBENE DERIVATIVES FOR TREATMENT AND PREVENTION OF AQUATIC MOLD INFECTIONS 审中-公开
标题翻译：用于治疗和预防水肿感染的STILBENE衍生物的使用
公开(公告)号：WO2008001368A3
公开(公告)日：2009-04-30
申请号：PCT/IL2007000784
申请日：2007-06-27
申请人： HADASIT MED RES SERVICE , ISRAEL STATE , POLACHECK ITZHACK , TINMAN SIMON , FALK RAMA
发明人： POLACHECK ITZHACK , TINMAN SIMON , FALK RAMA
IPC分类号： A61K31/53
CPC分类号： A61K31/53
摘要： The invention relates to methods of treatment and prevention of aquatic mold infections in aquatic organisms and methods of disinfecting equipment used in raising aquatic organisms. The methods comprise use of one or more stilbene derivatives, including 4,4'-bis-(1,3,5-triazinylamino)stilbene-2,2'-disulfonic acid derivatives.
摘要翻译：本发明涉及治疗和预防水生生物体内的水生菌感染的方法以及用于养殖水生生物的设备的消毒方法。该方法包括使用一种或多种二苯乙烯衍生物，包括4,4'-双 - （1,3,5-三嗪基氨基）芪-2,2'-二磺酸衍生物。

9. 发明申请

WO2007138574A3 MONITORING RESPONSIVENESS TO AND SCREENING FOR THERAPEUTIC COMPOUNDS THAT MODULAT COMPOSITION AND STRUCTURE OF CELL MEMBRANES 审中-公开
标题翻译：监测调节组合物和细胞膜结构的治疗化合物的反应和筛选
公开(公告)号：WO2007138574A3
公开(公告)日：2009-04-23
申请号：PCT/IL2007000633
申请日：2007-05-24
申请人： HADASIT MED RES SERVICE , ILAN YARON
发明人： ILAN YARON
IPC分类号： A61K31/7028 , C12Q1/02 , G01N33/53
CPC分类号： G01N33/5047
摘要： The present invention relates to modulation of structure and composition of cell membranes by a given therapeutic compound, preferably, a ß-glycolipid and thereby to modulation and treatment of pathologic disorders. More particularly, the invention relates to the use of modulation of structure and composition of immune cell membranes by a candidate therapeutic compound as a diagnostic marker for prediction and monitoring of response to treatment. The invention further provides a method of screening for substances which modulate the structure and composition of cell membranes, as well as compositions and methods using the substances identified by the screening method of the invention, for the treatment of pathologic disorders.
摘要翻译：本发明涉及通过给定的治疗化合物，优选β-糖脂调节细胞膜的结构和组成，从而调节和治疗病理性疾病。更具体地，本发明涉及通过候选治疗化合物调节免疫细胞膜的结构和组成的用途，作为对治疗反应的预测和监测的诊断标记。本发明还提供了筛选调节细胞膜的结构和组成的物质的方法，以及使用通过本发明的筛选方法鉴定的物质用于治疗病理性疾病的组合物和方法。

10. 发明申请

WO2007141789A3 INFLATABLE IMMOBILIZATION DEVICE AND METHOD FOR USE THEREOF 审中-公开
标题翻译：可充气的固定装置及其使用方法
公开(公告)号：WO2007141789A3
公开(公告)日：2009-04-09
申请号：PCT/IL2007000687
申请日：2007-06-06
申请人： HADASIT MED RES SERVICE , YISSUM RES DEV CO , DOMB AVI , CAHAN AMOS
发明人： DOMB AVI , CAHAN AMOS
IPC分类号： A61B19/00
CPC分类号： A61F5/012 , A61F5/05816 , C08G18/4081 , C08G18/6484 , C08G2101/00 , C08G2101/005 , C08G2101/0083 , C08G2105/02 , C08G2290/00 , C08G2350/00
摘要： The present invention discloses an inflatable immobilization device adapted for inflating from a thin-film envelope configuration to a three-dimensional body support configuration having a predetermined shape, characterized in that said inflating occurs by a foaming reaction that occurs substantially after said device has been positioned on the body. The invention also presents methods method for immobilizing a part of a body of a subject by said inflatable device.
摘要翻译：本发明公开了一种可膨胀的固定装置，其适于从薄膜包络结构充气到具有预定形状的三维体支撑构型，其特征在于，所述膨胀通过基本上在所述装置定位之后发生的发泡反应发生在身上。本发明还提出了通过所述可充气装置固定受试者身体的一部分的方法的方法。

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