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1. 发明申请

US20160252521A1 METHOD FOR DETERMINING HIGH-MANNOSE GLYCANS 审中-公开
标题翻译：用于测定高甘油糖的方法
公开(公告)号：US20160252521A1
公开(公告)日：2016-09-01
申请号：US15030367
申请日：2014-10-17
申请人： GENOVIS AB
发明人： Fredrik OLSSON , Stephen Georg BJOK , Maria NORDGREN , Sarah FREDRIKSSON
IPC分类号： G01N33/68
CPC分类号： G01N33/6857 , G01N2333/924
摘要： The present invention relates to methods for analysing molecules comprising immunoglobulin Fc regions for the presence or absence of high-mannose glycans, and to for carrying out such methods.
摘要翻译：本发明涉及用于分析包含免疫球蛋白Fc区域用于存在或不存在高甘露糖聚糖的分子的方法，以及用于进行这些方法。

2. 发明授权

US07361750B2 Streptoccal inhibitor of complement-mediated lysis, protein SIC 失效
标题翻译：补体介导的裂解链球菌抑制剂，蛋白质SIC
公开(公告)号：US07361750B2
公开(公告)日：2008-04-22
申请号：US10374535
申请日：2003-02-26
申请人： Per Akesson , Lars H. Björck , Anders Sjoholm
发明人： Per Akesson , Lars H. Björck , Anders Sjoholm
IPC分类号： C07H21/04
CPC分类号： C07K16/1275 , A61K38/00 , C07K14/315 , C07K14/47 , Y02A50/471
摘要： A protein from Streptococcus pyogenes, serotype M1 has been characterized. This protein, called protein SIC, plays a role in S. pyogenes pathogenicity and virulence. It inhibits hemolysis by interacting with the plasma proteins clusterin, and members of the cystatin protein super family such as histidine rich glycoprotein (HRG). The protein comprises at least one of the following partial amino acid sequences: (a) glu thr tyr thr ser arg asn phe; (b) asp trp ser gly asp asp trp pro glu asp asp trp; (c) arg ser gly val gly leu ser gln tyr gly trp ser; (d) trp ser ser asp lys lys asp glu thr glu asp lyr thr; (e) gly thr gly tyr glu lys arg asp asp trp gly gly pro gly; and (f) lys arg asp asp trp arg gly pro gly his ile pro lys pro. The protein and antibodies specific for the protein can be used in analytical procedures for determining the presence of virulent Streptococcus pyogenes in a sample. The protein can also be used in vaccine compositions.
摘要翻译：来自化脓性链球菌的血清型M1的蛋白质已被表征。称为蛋白质SIC的这种蛋白质在化脓性致病性和毒力中起作用。它通过与血浆蛋白聚集蛋白和半胱氨酸蛋白酶抑制蛋白超家族的成员如富含组氨酸糖蛋白（HRG）的相互作用来抑制溶血。所述蛋白质包含以下部分氨基酸序列中的至少一种：（a）葡萄糖; （b）asp trp ser gly asp asp trp pro glu asp asp trp; （c）参考文献（d）trp ser ser asp asp lys lys asp glu thr glu asp lyr thr; （e）糖基糖基糖苷arg asp asp trp gly gly pro gly; 和（f）lys arg asp asp trp arg gly pro gly his ile pro lys pro。蛋白质和蛋白质特异性抗体可用于测定样品中毒性化脓性链球菌的存在的分析程序。该蛋白质也可用于疫苗组合物中。

3. 发明申请

WO2016046220A1 METHOD FOR ANALYSING AGGREGATES IN ANTIBODY SAMPLES 审中-公开
标题翻译：用于分析抗体样品中聚集体的方法
公开(公告)号：WO2016046220A1
公开(公告)日：2016-03-31
申请号：PCT/EP2015/071771
申请日：2015-09-22
申请人： GENOVIS AB
发明人： FREDRIKSSON, Sarah , SANDBERG, Magdalena Widgren , OLSSON, Fredrik
IPC分类号： C12Q1/37 , G01N33/68
CPC分类号： G01N33/6854 , C12Q1/37 , G01N2333/315 , G01N2333/952
摘要： The invention providesmethods for analysing a sample of immunoglobulins to determine the amount of IgG aggregates present in the sample.
摘要翻译：本发明提供了分析免疫球蛋白样品以确定样品中存在的IgG聚集体的量的方法。

4. 发明申请

WO2004024910A1 PARTICLE FOR MAGNETICALLY INDUCED MEMBRANE TRANSPORT 审中-公开
标题翻译：用于磁性诱导膜运输的颗粒
公开(公告)号：WO2004024910A1
公开(公告)日：2004-03-25
申请号：PCT/SE2003/001412
申请日：2003-09-11
申请人： GENOVIS AB , FREDRIKSSON, Sarah , KRIZ, Dario
发明人： FREDRIKSSON, Sarah , KRIZ, Dario
IPC分类号： C12N13/00
CPC分类号： C12N15/87 , A61N2/00 , C12M35/00
摘要： The present invention relates to particles, for use in transport of substances through biological membranes, the particle being characterised in that it contains at least one magnetically inducible material and at least one difunctional molecule with at least one binding site for said biological membrane. Moreover the invention concerns both production of the same particles and applications thereof.
摘要翻译：本发明涉及用于通过生物膜运输物质的颗粒，该颗粒的特征在于其含有至少一种磁诱导材料和至少一个具有至少一个所述生物膜结合位点的双功能分子。此外，本发明涉及相同颗粒的生产和其应用。

5. 发明申请

WO2022223818A1 IMMUNOGLOBULIN CLEAVING ENZYME 审中-公开
公开(公告)号：WO2022223818A1
公开(公告)日：2022-10-27
申请号：PCT/EP2022/060766
申请日：2022-04-22
申请人： GENOVIS AB
发明人： LOOD-ALAYÓN, Rolf , OLSSON, Fredrik
IPC分类号： C12N9/54 , A61K38/48 , C12N9/64
摘要： The present invention relates to a novel polypeptide which displays protease activity against immunoglobulins, particularly human IgG, and in vivo, in vitro and ex vivo uses thereof. Uses of the polypeptide include methods for the analysis of IgG and the generation of antibody fragments, as well as methods for the prevention or treatment of diseases and conditions mediated by IgG.

6. 发明申请

WO2007021236A1 A NANOPARTICLE SUITABLE FOR DELIVERY OF A BIOMOLECULE INTO OR OUT OF A MEMBRANE ENCLOSED CELL OR CELL ORGANELLE 审中-公开
标题翻译：一种适用于将生物分子输入或输出到膜包裹的细胞或细胞有机物的纳米粒子
公开(公告)号：WO2007021236A1
公开(公告)日：2007-02-22
申请号：PCT/SE2006/000960
申请日：2006-08-21
申请人： GENOVIS AB , FREDRIKSSON, Sarah , KOIVUNEN, Sylvia , OLSSON, Fredrik , TOFTEVALL, Hanna-Karin
发明人： FREDRIKSSON, Sarah , KOIVUNEN, Sylvia , OLSSON, Fredrik , TOFTEVALL, Hanna-Karin
IPC分类号： A61N2/04 , C12N15/87
CPC分类号： C12N15/87 , A61K41/0028 , A61K41/0052 , A61K47/6907 , A61K47/6923 , A61K47/6929 , A61N2/02 , B82Y5/00 , C12N15/88
摘要： A nano sized particle for in vitro or ex vivo biomolecule delivery to cell cultures through heat induced endosomal release comprising a superparamagnetic core coated in a heat sensitive coating, comprising membrane disruptive components and binding sites for attachment of biomolecules and markers to be delivered. A method for introducing the release effect of a plurality of said biomolecule and endosomal disrupture molecules by applying an alternating field to a cell culture harbouring the particle described by the invention.
摘要翻译：一种用于体外或离体生物分子通过热诱导的内体内释放递送至细胞培养物的纳米尺寸颗粒，其包含涂覆在热敏涂层中的超顺磁性核心，其包含膜破坏性组分和用于附着生物分子和待递送标记物的结合位点。通过对包含本发明所述的颗粒的细胞培养物施加交变场来引入多个所述生物分子和内体破坏分子的释放作用的方法。

7. 发明申请

WO2018215657A1 ENZYMES FOR GLYCAN ANALYSIS 审中-公开
公开(公告)号：WO2018215657A1
公开(公告)日：2018-11-29
申请号：PCT/EP2018/063833
申请日：2018-05-25
申请人： GENOVIS AB
发明人： LEO, Fredrik , LOOD, Rolf , BJORK, Stephan , MEJARE, Malin , OLSSON, Fredrik
IPC分类号： C12N9/24 , G01N33/68
摘要： The present invention relates to enzymes and combinations thereof useful for studying glycoproteins, and corresponding methods of use. In particular, the invention relates to a sialidase composition comprising an additional protease and/or glycosidase, preferably an O-glycoprotein-specific endoprotease and/or an O-glycosidase.

8. 发明申请

WO2018215656A9 PROTEASE AND BINDING POLYPEPTIDE FOR O-GLYCOPROTEINS 审中-公开
公开(公告)号：WO2018215656A9
公开(公告)日：2018-11-29
申请号：PCT/EP2018/063832
申请日：2018-05-25
申请人： GENOVIS AB
发明人： LEO, Fredrik , LOOD, Rolf , BJORK, Stephan , MEJARE, Malin , OLSSON, Fredrik
IPC分类号： C12N9/24 , C12Q1/37 , G01N33/68 , C12N9/52
摘要： The present invention relates to a novel endoprotease, mutants thereof having binding but lacking or having reduced hydrolyzing activity, and use in methods of studying and isolating O-linked glycoproteins.

9. 发明申请

WO2018215656A1 PROTEASE AND BINDING POLYPEPTIDE FOR O-GLYCOPROTEINS 审中-公开
公开(公告)号：WO2018215656A1
公开(公告)日：2018-11-29
申请号：PCT/EP2018/063832
申请日：2018-05-25
申请人： GENOVIS AB
发明人： LEO, Fredrik , LOOD, Rolf , BJORK, Stephan , MEJARE, Malin , OLSSON, Fredrik
IPC分类号： C12N9/24 , C12Q1/37 , G01N33/68 , C12N9/52
摘要： The present invention relates to a novel endoprotease, mutants thereof having binding but lacking or having reduced hydrolyzing activity, and use in methods of studying and isolating O-linked glycoproteins.

10. 发明授权

US08323908B2 Method of assessing glycosylation state or functional quality of an IgG containing sample 有权
标题翻译：评估含IgG样品的糖基化状态或功能质量的方法
公开(公告)号：US08323908B2
公开(公告)日：2012-12-04
申请号：US12677680
申请日：2008-09-11
申请人： Maria Allhorn , Anders Olin , Falk Nimmerjahn , Mattias Collin
发明人： Maria Allhorn , Anders Olin , Falk Nimmerjahn , Mattias Collin
IPC分类号： G01N33/53
CPC分类号： C07K14/70535 , C07K16/00 , C07K2317/41 , C07K2317/52 , C12N9/2402 , C12N9/641 , C12Y302/01096 , G01N33/6854 , G01N33/6857 , G01N2400/00
摘要： The inventions provides methods and kits for the dissociation of Fcγ-receptor-IgG complexes, and methods and kits for the isolation of IgG and Fc and Fab fragments of IgG.
摘要翻译：本发明提供了用于解离Fcγ受体-IgG复合物的方法和试剂盒，以及用于分离IgG的IgG和Fc片段和Fab片段的方法和试剂盒。

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