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1. 发明授权

US09381197B2 Processes for the preparation of dipyridamole 有权
公开(公告)号：US09381197B2
公开(公告)日：2016-07-05
申请号：US14574652
申请日：2014-12-18
申请人： GENERICS [UK] LIMITED
发明人： Dattatrey Kokane , Bindu Manojkumar , Vinayak Govind Gore
IPC分类号： C07D487/00 , A61K31/519 , C07D487/04
CPC分类号： A61K31/519 , C07D487/04
摘要： The present invention relates to the active pharmaceutical ingredient dipyridamole. In particular, it relates to efficient processes for the preparation of dipyridamole which are amenable to large scale commercial production and provide the required product with improved yield and purity. The present invention also relates to a novel crystallization method for the purification of dipyridamole.

2. 发明授权

US09162974B2 Process for the preparation of vorinostat 有权
标题翻译：维生素A的制备方法
公开(公告)号：US09162974B2
公开(公告)日：2015-10-20
申请号：US14506741
申请日：2014-10-06
申请人： GENERICS [UK] LIMITED
发明人： Vinayak G. Gore , Madhukar S. Patil , Rahul A. Bhalerao , Hemant M. Mande , Sandeep G. Mekde
IPC分类号： A61K31/19 , A01N37/28 , C07C259/06 , A61K31/167
CPC分类号： C07C259/06 , A61K31/167
摘要： The present invention relates to an improved process for the preparation of the active pharmaceutical ingredient vorinostat. In particular it relates to a process for preparing vorinostat substantially free from impurities.
摘要翻译：本发明涉及制备活性药物成份伏立诺他的改进方法。特别涉及制备基本上不含杂质的伏立诺他胺的方法。

3. 发明申请

US20140249175A1 ANHYDRATE OF TIOTROPIUM BROMIDE 有权
标题翻译：溴化硼的无机物
公开(公告)号：US20140249175A1
公开(公告)日：2014-09-04
申请号：US14246291
申请日：2014-04-07
申请人： GENERICS [UK] LIMITED
发明人： Vinayak Govind GORE , Bindu MANOJKUMAR , Dattatraya SHINDE , Dattatrey KOKANE
IPC分类号： C07D491/18
CPC分类号： C07D491/18 , C07D451/10
摘要： The present invention relates to a novel form of anhydrous tiotropium bromide, processes for the preparation of anhydrous tiotropium bromide, pharmaceutical compositions comprising anhydrous tiotropium bromide and uses of the compositions.
摘要翻译：本发明涉及一种新型无水噻托溴铵，制备无水噻托溴铵的方法，含有无水噻托溴铵的药物组合物和组合物的用途。

4. 发明授权

US08710241B2 Crystalline form of zofenopril calcium 有权
标题翻译：佐芬普利钙的结晶形式
公开(公告)号：US08710241B2
公开(公告)日：2014-04-29
申请号：US12671328
申请日：2008-08-08
申请人： Axel Becker
发明人： Axel Becker
IPC分类号： A61K31/40 , C07D207/04
CPC分类号： C07D207/04 , A61K31/40 , C07D207/16
摘要： The present invention relates to a novel anhydrous crystalline form of zofenopril calcium of formula (I), chemically known as (4S)-1-[(2S)-3-(benzoylthio)-2-methylpropionyl]-4-(phenylthio)-L-proline calcium salt or hemi-calcium salt. The present invention further relates to a process for the preparation of the new crystalline form of zofenopril calcium, its use in pharmaceutical compositions and the use of the new crystalline form and compositions in the treatment of hypertension and various other diseases.
摘要翻译：本发明涉及化学上称为（4S）-1 - [（2S）-3-（苯甲酰硫基）-2-甲基丙酰基] -4-（苯硫基） - 苯并 - 嗪的式（I）的佐芬普利钙的新的无水结晶形式 L-脯氨酸钙盐或半钙盐。本发明还涉及制备佐芬普利钙的新结晶形式的方法，其用于药物组合物中，以及使用新的结晶形式和组合物来治疗高血压和各种其它疾病。

5. 发明申请

US20130203826A1 Pure Intermediate 有权
标题翻译：纯中间体
公开(公告)号：US20130203826A1
公开(公告)日：2013-08-08
申请号：US13818815
申请日：2011-08-26
申请人： Vinayak Govind Gore , Vinay Kumar Shukla , Sandeep Mekde , Suresh Hasbe , Shreyas Bhandari , Dhananjay Shinde , Madhukar Shaligram Patil
发明人： Vinayak Govind Gore , Vinay Kumar Shukla , Sandeep Mekde , Suresh Hasbe , Shreyas Bhandari , Dhananjay Shinde , Madhukar Shaligram Patil
IPC分类号： C07D249/08
CPC分类号： C07D249/08 , A61K31/4196
摘要： The present invention relates to an improved process for the preparation of Letrozole (I) and its synthetic intermediate 4-[(1-(1,2,4-triazoly)methyl]benzonitrile (III). In particular, it relates to a process to prepare Letrozole and its intermediate (III) substantially free from regioisomeric impurities. The present invention further relates to acid addition salts of 4-[(1-(1,2,4-triazoly)methyl]benzonitrile (III) such as the oxalate salt, and also to Letrozole (I), the intermediate (III) and salts thereof preparable by the processes of the present invention.
摘要翻译：本发明涉及一种制备来曲唑（I）及其合成中间体4 - [（1-（1,2,4-三唑基）甲基]苄腈（III））的改进方法，特别涉及一种方法本发明还涉及4 - [（1-（1,2,4-三唑））甲基]苄腈（III）的酸加成盐，例如草酸盐盐，以及来曲唑（I），其中间体（III）及其盐可以通过本发明的方法制备。

6. 发明授权

US08119662B2 Crystalline compounds 有权
标题翻译：结晶化合物
公开(公告)号：US08119662B2
公开(公告)日：2012-02-21
申请号：US11961695
申请日：2007-12-20
申请人： Vinayak G. Gore , Ashok D. Pehere , Avinash C. Gaikwad , Priyesh S. Vijaykar
发明人： Vinayak G. Gore , Ashok D. Pehere , Avinash C. Gaikwad , Priyesh S. Vijaykar
IPC分类号： A61K31/40
CPC分类号： C07D207/16
摘要： The present invention relates to a novel crystalline form of zofenopril calcium of formula (I), chemically known as (4S)-1-[(2S)-3-(benzoylthio)-2-methylpropionyl]-4-(phenylthio)-L-proline calcium salt. The present invention further relates to a process for the preparation of the new crystalline form of zofenopril calcium and its use in pharmaceutical preparations.
摘要翻译：本发明涉及化学式为（4S）-1 - [（2S）-3-（苯甲酰硫基）-2-甲基丙酰基] -4-（苯硫基）-L-苯并呋喃脯氨酸钙盐。本发明还涉及制备佐芬普利钙的新结晶形式的方法及其在药物制剂中的用途。

7. 发明申请

US20120029046A1 CRYSTALLINE FORM OF SUNITINIB AND PROCESSES FOR ITS PREPARATION 审中-公开
标题翻译： SUNITINIB的结晶形式及其制备方法
公开(公告)号：US20120029046A1
公开(公告)日：2012-02-02
申请号：US13060331
申请日：2009-08-24
申请人： Vinayak Gore , Bharati Choudhari , Mahesh Hublikar , Prakash Bansode
发明人： Vinayak Gore , Bharati Choudhari , Mahesh Hublikar , Prakash Bansode
IPC分类号： A61K31/404 , A61P35/00 , C07D403/06
CPC分类号： C07D403/06
摘要： The present invention relates to a novel crystalline form of sunitinib free base designated form I and to processes for its preparation. The invention also relates to its use as an API and in the preparation of various forms of sunitinib. Further, the invention relates to pharmaceutical compositions comprising the novel crystalline form and salts, solvates and hydrates prepared according to the invention, and to the uses of said pharmaceutical compositions in the treatment and/or prevention of cancer.
摘要翻译：本发明涉及一种指定为I型的舒尼替尼游离碱的新结晶形式及其制备方法。本发明还涉及其作为API和用于制备各种形式的舒尼替尼的用途。此外，本发明涉及包含根据本发明制备的新结晶形式和盐，溶剂合物和水合物以及所述药物组合物在治疗和/或预防癌症中的用途的药物组合物。

8. 发明授权

US07897613B2 Crystalline polymorphs of clopidogrel 有权
标题翻译：氯吡格雷的结晶多晶型物
公开(公告)号：US07897613B2
公开(公告)日：2011-03-01
申请号：US10571419
申请日：2004-09-09
申请人： Ramakrishnan Arul , Ajay Singh Rawat , Maheshkumar Gadakar , Rajesh Rao , Abhinay Pise , Jason Gray
发明人： Ramakrishnan Arul , Ajay Singh Rawat , Maheshkumar Gadakar , Rajesh Rao , Abhinay Pise , Jason Gray
IPC分类号： C07D495/04 , A61K31/4365 , A61P7/02
CPC分类号： C07D495/04
摘要： The present invention relates to novel crystalline forms of the platelet aggregation inhibitor (+)-(S)-methyl-2-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate, clopidogrel (1), in the form of hydrogen bromide salts, identified as polymorph forms 1, 2 and 3. The present invention further relates to processes for preparing such forms, pharmaceutical compositions comprising such forms, and uses for such forms and compositions. The pharmaceutical compositions may be used, in particular, for inhibiting platelet aggregation or for treating, preventing or managing thrombosis, atherothrombosis, an atherothrombotic event, ischaemic stroke, myocardial infarction, non-Q-wave myocardial infarction, atherosclerosis, peripheral arterial disease, or unstable angina. The present invention also relates to methods of treating said disorders. Formula (1).
摘要翻译：本发明涉及血小板聚集抑制剂（+） - （S） - 甲基-2-（2-氯苯基） - （6,7-二氢-4H-噻吩并[3,2-c]吡啶-3-基）（1），以溴化氢的形式，被鉴定为多晶型形式1,2和3.本发明还涉及制备这些形式的方法，包含这些形式的药物组合物和用于这种形式和组成。药物组合物可特别用于抑制血小板聚集或治疗，预防或控制血栓形成，动脉粥样硬化血栓形成，动脉粥样硬化血栓形成事件，缺血性中风，心肌梗塞，非Q波心肌梗塞，动脉粥样硬化，外周动脉疾病或不稳定型心绞痛本发明还涉及治疗所述疾病的方法。公式1）。

9. 发明申请

US20100324139A1 PROCESS TO PREGABALIN 审中-公开
标题翻译： PREGABALIN过程
公开(公告)号：US20100324139A1
公开(公告)日：2010-12-23
申请号：US12810244
申请日：2008-12-19
申请人： Abhay Gaitonde , Debashish Datta , Bindu Manojkumar , Sunanda Phadtare
发明人： Abhay Gaitonde , Debashish Datta , Bindu Manojkumar , Sunanda Phadtare
IPC分类号： C07C227/04 , C07C201/10 , C07C227/34 , C07C69/716 , C07C69/675 , C07C69/63 , C07C229/08 , A61K31/197 , A61P29/00 , A61P9/10 , A61P25/24 , A61P25/22 , A61P25/08 , A61P25/18
CPC分类号： C07C227/32 , C07B2200/07 , C07C67/307 , C07C67/31 , C07C67/343 , C07C201/12 , C07C227/04 , C07C229/08 , C07C309/65 , C12P7/42 , C12P41/002 , C07C69/63 , C07C69/675 , C07C69/716 , C07C205/51
摘要： The present invention relates to a novel method for the preparation of racemic pregabalin (1) or a single enantiomer thereof, (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid (2).
摘要翻译：本发明涉及一种制备外消旋普瑞巴林（1）或其单一对映异构体（S） - （+） - 3-（氨基甲基）-5-甲基 - 己酸（2）的新方法。

10. 发明申请

US20080096946A1 Process For The Preparation Of Anastrozole 失效
标题翻译：阿那曲唑的制备方法
公开(公告)号：US20080096946A1
公开(公告)日：2008-04-24
申请号：US11630421
申请日：2005-06-22
申请人： Abhay Gaitonde , Chitra Vaidya , Sanjay Pawar
发明人： Abhay Gaitonde , Chitra Vaidya , Sanjay Pawar
IPC分类号： A61K31/4196 , A61P35/00 , C07D249/08
CPC分类号： C07D249/08
摘要： A process for the preparation of anastrozole.
摘要翻译：一种制备阿那曲唑的方法。

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