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    • 10. 发明申请
    • PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES
    • 制备2-氨基-5-氰基苯甲酸衍生物的方法
    • US20110003998A1
    • 2011-01-06
    • US12920401
    • 2009-03-04
    • Donald J. Dumas
    • Donald J. Dumas
    • C07D401/04C07D231/00C07C255/50
    • C07C253/14C07C255/58C07D231/16
    • Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with a metal cyanide reagent, a copper(I) salt reagent, an iodide salt reagent and at least one compound of Formula 3 wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; X is Br or Cl; and R5, R6, R7 and R8 are as defined in the disclosure.Also disclosed is a method for preparing a compound of Formula 4 wherein R11, R12, R13 and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.
    • 公开了一种制备式1化合物的方法,包括使式2化合物与金属氰化物试剂,铜(I)盐试剂,碘化物盐试剂和至少一种式3化合物(其中R1是NHR3或OR4)接触 ; R2是CH3或Cl; R3是H,C1-C4烷基,环丙基,环丙基环丙基,环丙基甲基或甲基环丙基; R4是H或C1-C4烷基; X是Br或Cl; 并且R5,R6,R7和R8如本公开所定义。 还公开了制备式4化合物的方法,其中R 11,R 12,R 13和Z如本公开所定义,使用式1化合物,其特征在于通过上述方法制备式1化合物或使用化合物 通过上述方法制备。