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1. 发明专利

TWI262083B 用於動物飼料之微生物表現的耐熱植酸 MICROBIALLY-EXPRESSED THERMOTOLERANT PHYTASE FOR ANIMAL FEED 有权
简体标题：用于动物饲料之微生物表现的耐热植酸 MICROBIALLY-EXPRESSED THERMOTOLERANT PHYTASE FOR ANIMAL FEED
公开(公告)号：TWI262083B
公开(公告)日：2006-09-21
申请号：TW091137674
申请日：2002-12-27
申请人：諾華國際作物公司 SYNGENTA PARTICIPATIONS AG , 戴維沙公司 DIVERSA CORPORATION
发明人：麥可B. 拉納翰 MICHAEL B. LANAHAN , 艾德華寇夫 EDWARD KOEPF , 凱斯奎姿 KEITH KRETZ
IPC分类号： A61K , C12N , C07H
CPC分类号： C12Y301/03008 , A23K10/14 , A23K20/189 , A23K40/20 , A23K40/25 , A23K50/00 , A23K50/30 , A23K50/75 , A23L5/25 , A23L11/33 , A23L29/06 , A23L33/195 , C12N9/16
摘要：本發明係提供製造及使用耐熱植酸之方法，如於飼料及食品加工中使用耐熱植酸之方法以及包括耐熱植酸之飼料或食品產物。
简体摘要：本发明系提供制造及使用耐热植酸之方法，如于饲料及食品加工中使用耐热植酸之方法以及包括耐热植酸之饲料或食品产物。

2. 发明专利

TW200306203A 用於動物飼料之微生物表現的耐熱植酸 MICROBIALLY-EXPRESSED THERMOTOLERANT PHYTASE FOR ANIMAL FEED 审中-公开
简体标题：用于动物饲料之微生物表现的耐热植酸 MICROBIALLY-EXPRESSED THERMOTOLERANT PHYTASE FOR ANIMAL FEED
公开(公告)号：TW200306203A
公开(公告)日：2003-11-16
申请号：TW091137674
申请日：2002-12-27
申请人：諾華國際作物公司 SYNGENTA PARTICIPATIONS AG , 戴維沙公司 DIVERSA CORPORATION
发明人：麥可B 拉納翰 MICHAEL B. LANAHAN , 艾德華寇夫 EDWARD DOEPF , 凱斯奎姿 KEITH KRETZ
IPC分类号： A61K , C12N , C07H
CPC分类号： C12Y301/03008 , A23K10/14 , A23K20/189 , A23K40/20 , A23K40/25 , A23K50/00 , A23K50/30 , A23K50/75 , A23L5/25 , A23L11/33 , A23L29/06 , A23L33/195 , C12N9/16
摘要：本發明係提供製造及使用耐熱植酸之方法，如於飼料及食品加工中使用耐熱植酸之方法以及包括耐熱植酸之飼料或食品產物。
简体摘要：本发明系提供制造及使用耐热植酸之方法，如于饲料及食品加工中使用耐热植酸之方法以及包括耐热植酸之饲料或食品产物。

4. 发明申请

WO2005044979A2 GLYCOSYLATION ENZYMES AND SYSTEMS AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译：糖化酶和系统及其制备和使用方法
公开(公告)号：WO2005044979A2
公开(公告)日：2005-05-19
申请号：PCT/US2004/025015
申请日：2004-08-04
申请人： DIVERSA CORPORATION , TREFZER, Axel , GREEN, Brian, D. , BIBB, Mervyn , MASON, Dylan
发明人： TREFZER, Axel , GREEN, Brian, D. , BIBB, Mervyn , MASON, Dylan
IPC分类号： C12N
CPC分类号： C12P21/005 , A01N43/90
摘要： The invention provides a novel technology for glycosylation of natural products using novel genetically engineered strains of bacteria. These in vivo glycosylation systems of the invention express a heterologous glycosyltransferase and deoxysugar pathway that are capable of glycosylating a suitable substrate, which can be added to a culture broth. The invention also provides novel compounds glycosylated by these novel genetically engineered strains (the in vivo glycosylation systems of the invention), including novel peptides, mixed polyketide-peptides, or polyketides, including novel macrolides, e.g., glycosylated spinosyn derivatives, glycosylated derivatives of antibiotics such as erythromycin, tetracycline, rifampicin, glycosylated derivatives of anti-tumor drugs such as daunorubicin, mithramycin, derivatives of immunosuppressants such as rapamycin, FK520, FK506, glycosylated derivatives of anti-fungals such as amphotericin, glycosylated derivatives of antibacterials such as tylosin, glycosylated derivatives of antiparasitics such as avermectin, glycosylated derivatives of insecticides such as spinosyn, and methods for making these compounds using the in vivo glycosylation systems of the invention.
摘要翻译：本发明提供了一种使用新型遗传工程菌株进行天然产物糖基化的新技术。本发明的这些体内糖基化体系表达能够糖基化合适底物的异源糖基转移酶和脱氧糖通路，其可加入到培养液中。本发明还提供了通过这些新型遗传工程菌株（本发明的体内糖基化体系）糖基化的新型化合物，包括新型肽，混合聚酮化合物肽或聚酮化合物，包括新型大环内酯类，例如糖基化多杀菌素衍生物，抗生素糖基化衍生物例如红霉素，四环素，利福平，抗肿瘤药物如柔红霉素，霉素霉素，免疫抑制剂如雷帕霉素的衍生物，FK520，FK506，抗真菌剂如两性霉素的糖基化衍生物，抗菌药的糖基化衍生物如泰乐菌素，抗寄生虫的糖基化衍生物如除虫菌素，杀虫剂的糖基化衍生物如多杀菌素，以及使用本发明的体内糖基化系统制备这些化合物的方法。

5. 发明申请

WO2005040107A2 METHODS FOR MAKING SIMVASTATIN AND INTERMEDIATES 审中-公开
标题翻译：制备SIMVASTATIN和中间体的方法
公开(公告)号：WO2005040107A2
公开(公告)日：2005-05-06
申请号：PCT/US2004/034913
申请日：2004-10-20
申请人： DIVERSA CORPORATION , MORGAN, Brian , BURK, Mark , LEVIN, Michael , ZHU, Zoulin , CHAPLIN, Jennifer , KUSTEDJO, Karen , HUANG, Zilin , GREENBERG, William
发明人： MORGAN, Brian , BURK, Mark , LEVIN, Michael , ZHU, Zoulin , CHAPLIN, Jennifer , KUSTEDJO, Karen , HUANG, Zilin , GREENBERG, William
IPC分类号： C07D
CPC分类号： C12P17/06 , C07D309/30
摘要： The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.
摘要翻译：本发明提供了生产辛伐他汀和各种中间体的合成化学和化学酶学方法。在一个方面，酶如水解酶，例如酯酶，用于本发明的方法中。

6. 发明申请

WO2004085624A3 TRANSAMINASES, DEAMINASES AND AMINOMUTASES AND COMPOSITIONS AND METHODS FOR ENZYMATIC DETOXIFICATION 审中-公开
公开(公告)号：WO2004085624A3
公开(公告)日：2004-10-07
申请号：PCT/US2004/009054
申请日：2004-03-24
申请人： DIVERSA CORPORATION , ZHAO, Lishan , WEINER, David, Paul , HICKLE, Leslie
发明人： ZHAO, Lishan , WEINER, David, Paul , HICKLE, Leslie
IPC分类号： C12Q1/68 , C12P21/06 , C12N5/00 , C12N15/00 , C12N15/63 , C07H21/04
摘要： In one aspect, the invention provides methods of enzymatic detoxification of aminated toxins, e.g., mycotoxins, such as fumonisin. The invention provides methods to enzymatically detoxify plants, foods or feeds or any contaminated product or surface, including detoxification of mycotoxins, such as fumonisin, e.g., fumonisin B 1 and fumonisin B 2 . The invention provides methods to prevent the contamination of plants, foods or feeds or any contaminated product or surface by application or a polypeptide having a deaminase activity. In one aspect, the invention relates to polypeptides having an aminotransferase, an aminomutase and/or a deaminase activity, polynucleotides encoding these enzymes, methods of making and using these polynucleotides and polypeptides.

7. 发明申请

WO2004085615A2 GLUCOSIDASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：葡萄球菌，核酸编码及其制备和使用方法
公开(公告)号：WO2004085615A2
公开(公告)日：2004-10-07
申请号：PCT/US2004/008541
申请日：2004-03-18
申请人： DIVERSA CORPORATION , GRAY, Kevin , GARRETT, James, B. , ABOUSHADI, Nahla, M. , KNOWLES, Ryan , O'DONOGHUE, Eileen , WATERS, Elizabeth
发明人： GRAY, Kevin , GARRETT, James, B. , ABOUSHADI, Nahla, M. , KNOWLES, Ryan , O'DONOGHUE, Eileen , WATERS, Elizabeth
IPC分类号： C12N
CPC分类号： C12N15/8257 , A01K2217/05 , C12C1/027 , C12C5/004 , C12N9/2405 , C12N15/8245
摘要： The invention is directed to polypeptides having a glucosidase activity, including an alpha-glucosidase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention are used as alpha-glucosidases to catalyze the hydrolysis of starch into sugars, e.g., to convert liquefied starch to glucose. In one aspect, the polypeptides of the invention can catalyze the hydrolysis of both alpha-(1,4) and alpha-(1,6) glucose linkages. In one aspect, the polypeptides of the invention can catalyze the hydrolysis of both malto-oligosaccharides and liquefied starch.
摘要翻译：本发明涉及具有葡糖苷酶活性的多肽，包括α-葡糖苷酶活性，编码多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一个方面，本发明的多肽用作α-葡糖苷酶以催化淀粉水解成糖，例如将液化的淀粉转化成葡萄糖。在一个方面，本发明的多肽可以催化α-（1,4）和α-（1,6）葡萄糖键的水解。一方面，本发明的多肽可以催化麦芽低聚糖和液化淀粉的水解。

8. 发明申请

WO2004066945A2 ENZYMES AND THE NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：酶和核酸编码它们及其制备和使用它们的方法
公开(公告)号：WO2004066945A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/002242
申请日：2004-01-26
申请人： DIVERSA CORPORATION , BARTON, Nelson , ROBERTSON, Dan , CHANG, Kristine , ELKINS, James
发明人： BARTON, Nelson , ROBERTSON, Dan , CHANG, Kristine , ELKINS, James
IPC分类号： A61K
CPC分类号： C12N9/00
摘要： The invention provides enzymes having a deacetylase, an amidase, a cellulase, an esterase, a glycosidase, a xylanase, an amylase, a transaminase, a laminarinase, a beta-galactosidase, a beta-mannosidase, a pullulanase, and/or a phosphatase activity, and the nucleic acids that encode them, and antibodies that specifically bind to them. This invention provides enzymes for the control of biofilms, polynucleotides and methods of making and using these polynucleotides and polypeptides. The invention provides products comprising these biofilm control compositions. In one aspect, the biofilm-control compositions of the invention have an amidase activity, e.g., the ability to hydrolyze amides, including enzymes having secondary amidase activity, including a peptidase, a protease and/or a hydantoinase activity. In one aspect, the biofilm control compositions of the invention have an amidase, a cellulase, an esterase, a glycosidase, a xylanase, an amylase, a transaminase, a laminarinase, a beta-galactosidase, a beta-mannosidase, a pullulanase, and/or a phosphatase activity.
摘要翻译：本发明提供了具有脱乙酰酶，酰胺酶，纤维素酶，酯酶，糖苷酶，木聚糖酶，淀粉酶，转氨酶，昆布糖酶，β-半乳糖苷酶，β-甘露糖苷酶，支链淀粉酶和/或磷酸酶活性和编码它们的核酸，以及特异性结合它们的抗体。本发明提供了用于控制生物膜，多核苷酸的酶，以及制备和使用这些多核苷酸和多肽的方法。本发明提供包含这些生物膜控制组合物的产品。一方面，本发明的生物膜对照组合物具有酰胺酶活性，例如水解酰胺的能力，包括具有仲酰胺酶活性的酶，包括肽酶，蛋白酶和/或乙内酰脲酶活性。一方面，本发明的生物膜控制组合物具有酰胺酶，纤维素酶，酯酶，糖苷酶，木聚糖酶，淀粉酶，转氨酶，昆布糖酶，β-半乳糖苷酶，β-甘露糖苷酶，支链淀粉酶和 /或磷酸酶活性。

9. 发明申请

WO2004044129A2 XYLOSE ISOMERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： XYLOSE异构体，编码它们的核酸及其制备和使用它们的方法
公开(公告)号：WO2004044129A2
公开(公告)日：2004-05-27
申请号：PCT/US2003/034008
申请日：2003-10-23
申请人： DIVERSA CORPORATION , CALLEN, Walter
发明人： CALLEN, Walter
IPC分类号： C12N
CPC分类号： C12P19/02 , A01K2217/05 , C12N9/92
摘要： In one aspect, the invention provides xylose isomerase enzymes, polynucleotides encoding the enzymes, methods of making and using these polynucleotidesand polypeptides. The polypeptides of the invention can be used in a variety of agricultural and industrial contexts. For example, the polypeptides of the invention can be used for converting glucose to fructose or for manufacturing high content fructose syrups in large quantities. Other examples include use of the polypetides of the invention in confectionary, brewing, alcohol and soft drinks production, and in diabetic foods and sweetners.
摘要翻译：一方面，本发明提供木糖异构酶，编码酶的多核苷酸，制备和使用这些多核苷酸和多肽的方法。本发明的多肽可用于各种农业和工业环境。例如，本发明的多肽可用于将葡萄糖转化为果糖或大量制造高含量果糖糖浆。其他实例包括在糖果，酿造，酒精和软饮料生产中使用本发明的多肽，以及在糖尿病食品和甜味剂中的使用。

10. 发明申请

WO2004035729A2 ESTERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译： ESTERASES，NUCLEIC ACID ENCODING THEM AND METHODS OF MAKING AND USING THEM
公开(公告)号：WO2004035729A2
公开(公告)日：2004-04-29
申请号：PCT/US2002/022336
申请日：2002-07-10
申请人： DIVERSA CORPORATION , ROBERTSON, Dan , MURPHY, Dennis , REID, John , MAFFIA, Anthony, III. , LINK, Steven , SWANSON, Ronald, V. , WARREN, Patrick, V. , LENOX, Anna , SHORT, Jay, M. , MATHUR, Eric, J.
发明人： ROBERTSON, Dan , MURPHY, Dennis , REID, John , MAFFIA, Anthony, III. , LINK, Steven , SWANSON, Ronald, V. , WARREN, Patrick, V. , LENOX, Anna , SHORT, Jay, M. , MATHUR, Eric, J.
IPC分类号： C12N
CPC分类号： C12N9/18 , A01K2217/05 , A61K38/00 , C12N9/16 , C12P13/04
摘要： The invention is directed to enzymes having an esterase activity, including thermostable and thermotolerant esterase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The esterase activities of the enzymes of the invention include lipase activity (in the hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), in ester synthesis, and ester interchange reactions. The enzymes of the invention are used in organic synthesis reactions in the manufacture of medicaments, pesticides or intermediates thereof.
摘要翻译：本发明涉及具有酯酶活性的酶，包括耐热和耐热酯酶活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的酶的酯酶活性包括脂肪酶活性（脂质水解），酸解反应（用游离脂肪酸代替酯化的脂肪酸），酯交换反应（甘油三酯之间的脂肪酸交换），酯合成和酯交换反应。本发明的酶用于制备药物，农药或其中间体的有机合成反应中。

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