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1. 发明专利

AU636270B2 METHOD AND APPARATUS FOR GENERATING A HIGH PURITY CHROMATOGRAPHY ELUENT 未知
公开(公告)号：AU636270B2
公开(公告)日：1993-04-22
申请号：AU6820990
申请日：1990-12-18
申请人： DIONEX CORPORATION
发明人： PURNENDU K. DASGUPTA , DOUGLAS L. STRONG , JOHN R. STILLIAN , KEITH A. FRIEDMAN
IPC分类号： G01N30/26 , B01D19/00 , B01D61/44 , B01D61/48 , G01N30/02 , G01N30/34 , G01N30/60 , G01N30/96
摘要： Apparatus suitable for generating a high purity, aqueous product stream including one or more selected ionic species and using it as a chromatography eluent, comprises eluent generating means defining a source channel and a product channel, and comprises a permselective ion exchange membrane partitioning said source channel and product channel, said ion exchange membrane including exchangeable ions of the same charge as said selected ionic species and allowing transmembrane passage to ions of the same charge as said exchangeable ions and being resistant to transmembrane passage of ions of the opposite charge, means for applying an electrical potential between said source channel and product channel, chromatographic separating means, conduit means for directing aqueous product stream from said product channel to said chromatographic separation means, and means for supplying a liquid sample to said chromatographic separating means.

2. 发明申请

WO2019178327A1 METHOD FOR PREPARING MONOLITHIC COATED SURFACES 审中-公开
公开(公告)号：WO2019178327A1
公开(公告)日：2019-09-19
申请号：PCT/US2019/022209
申请日：2019-03-14
申请人： DIONEX CORPORATION
发明人： POHL, Christopher, A. , RIVIELLO, John, M.
IPC分类号： B01J20/26 , B01J20/32 , B01J20/281 , G01N1/40 , G01N30/00
摘要： A carrier for adsorption a compound, comprising a support; and a shrink-fitted monolithic body attached to and surrounding at least a portion of the support. The monolithic body can be porous and configured to bind compounds in a solution either for the isolation or depletion of the compounds from the solution.

3. 发明申请

WO2016066452A1 CHROMATOGRAPHIC MATERIAL AND METHOD FOR PREPARATION THEREOF 审中-公开
标题翻译：色谱材料及其制备方法
公开(公告)号：WO2016066452A1
公开(公告)日：2016-05-06
申请号：PCT/EP2015/073995
申请日：2015-10-16
申请人： DIONEX CORPORATION , THERMO ELECTRON MANUFACTURING LIMITED
发明人： LIU, Xiaodong , WILLIAMS, Richard T. , CUI, Xiao
IPC分类号： B01D15/36 , B01D15/38 , B01J20/286 , B01J20/289 , B01J20/32
CPC分类号： C07F7/0856 , B01D15/305 , B01D15/325 , B01D15/364 , B01D15/3847 , B01J20/286 , B01J20/289 , B01J20/3204 , B01J20/3246 , B01J20/3259 , B01J20/3285 , C07B63/00 , C07F7/0885
摘要： A chromatographic materialcomprisinga zwitterionic ligand covalently bound to a substrate, the ligand preferably has a formula II: wherein R 1 , R 2 , R 3 are independently selected from an oxygen atom that is configured to connect to a substrate atom in the substrate, an oxygen atom that is configured to connect to a silicon atom of an adjacent ligand, a hydroxyl group, a halogen atom, an alkoxy group, a dialkylamino group, an acyl group, an alkyl group, or an aryl group; L 1 , L 2 and L 3 are independently hydrophobic moieties; each containing 2 to 30 carbon atoms, wherein there are at least 10 carbon atoms in the combined chain lengths of L 1 , L 2 and L 3 ; X is an O atom, S atom, amide group or sulfonamide group; n is 0 or 1; R 4 , R 5 are independently selected from a hydrogen atom or a hydrocarbon moiety containing 1 to 20 carbon atoms; and Rf is a negatively charged moiety comprising a sulfonic, carboxylic, or phosphonic functional group.
摘要翻译：共价键合到底物的两性离子配体的色谱材料，配体优选具有式II：其中R 1，R 2，R 3独立地选自被配置为连接到底物中的底物原子的氧原子，被配置为连接到相邻配体，羟基，卤素原子，烷氧基，二烷基氨基，酰基，烷基或芳基的硅原子; L1，L2和L3独立地是疏水部分; 每个含有2至30个碳原子，其中在L1，L2和L3的组合链长度中存在至少10个碳原子; X是O原子，S原子，酰胺基或磺酰胺基; n为0或1; R 4，R 5独立地选自氢原子或含有1至20个碳原子的烃部分; 并且Rf是包含磺酸，羧酸或膦酸官能团的带负电荷的部分。

4. 发明申请

WO2014043180A1 MULTI-COMPONENT ELUENT GENERATING SYSTEM AND METHOD 审中-公开
标题翻译：多分量线性发生系统及方法
公开(公告)号：WO2014043180A1
公开(公告)日：2014-03-20
申请号：PCT/US2013/059168
申请日：2013-09-11
申请人： DIONEX CORPORATION
发明人： LIU, Yan , JANDIK, Petr , POHL, Christopher, A.
IPC分类号： G01N30/96 , G01N30/34 , B01D15/36
CPC分类号： C25B9/18 , B01D15/166 , B01D15/361 , B01D61/44 , C25B1/02 , C25B1/14 , C25B3/00 , C25B13/00 , G01N30/16 , G01N30/34 , G01N30/96 , G01N2030/965 , Y02E60/34 , Y10T137/0318
摘要： A system and method to generate a concentration gradient eluent flow are described. The concentration gradient eluent flow ca n include at least two different generants. A liquid can be pumped to an eluent generating device. A first controlling signal can be applied to a first eluent generator to generate a first generant. A second controlling signal can be applied to a second eluent generator to generate a second generant. Either the first and/or the second controlling signal can be varied as a function of time to generate the concentration gradient eluent flow.
摘要翻译：描述了产生浓度梯度洗脱流的系统和方法。浓度梯度洗脱液流速至少包括两种不同的生成剂。液体可以泵送到洗脱液生成装置。第一控制信号可以应用于第一洗脱液发生器以产生第一发生器。第二控制信号可以应用于第二淋洗液发生器以产生第二发生器。第一和/或第二控制信号可以作为时间的函数而变化以产生浓度梯度洗脱液流。

5. 发明申请

WO2014036378A1 APPARATUS FOR PARALLEL ACCELERATED SOLVENT EXTRACTION 审中-公开
标题翻译：平行加速溶剂萃取装置
公开(公告)号：WO2014036378A1
公开(公告)日：2014-03-06
申请号：PCT/US2013/057473
申请日：2013-08-30
申请人： DIONEX CORPORATION
发明人： SRINIVASAN, Kannan , ULLAH, SM Rahmat
IPC分类号： B01D11/02 , G01N1/34
CPC分类号： B01D11/0207 , B01D11/0219 , B01D11/0284 , G01N1/34 , G01N2030/085
摘要： A parallel accelerated solvent extraction system includes a plurality of extraction cells, a temperature controlled zone for maintaining the plurality of extraction cells at a desired temperature, a plurality of collection vessels, each fluidly coupled to a respective extraction cell via a flow restrictor configured to maintain a pressure, a solvent pump for supplying extraction solvent to the plurality of extraction cells, and a switching valve for sequentially directing extraction solvent flowing from the solvent pump to respective ones of the plurality of extraction cells. A method of parallel accelerated solvent extraction is also disclosed.
摘要翻译：并行加速溶剂提取系统包括多个提取单元，用于将多个提取单元保持在期望温度的温度控制区，多个收集容器，每个收集容器通过限流器流体耦合到相应的提取单元，流量限制器被配置为维持压力，用于向所述多个提取单元提供提取溶剂的溶剂泵;以及切换阀，用于将从所述溶剂泵流出的萃取溶剂顺序地引导到所述多个提取单元中的各个提取单元。还公开了并行加速溶剂萃取的方法。

6. 发明申请

WO2012125493A1 ELECTROSTATICALLY BOUND HYPERBRANCHED ANION EXCHANGE SURFACE COATING PREPARED VIA CONDENSATION POLYMERIZATION USING TERTIARY AMINE LINKERS FOR IMPROVED DIVALENT ANION SELECTIVITY 审中-公开
标题翻译：通过使用苛性氨基连接剂进行缩合聚合制备的静电粘合的超薄膜阴离子交换表面涂层，用于改进的多种阴离子选择性
公开(公告)号：WO2012125493A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/028586
申请日：2012-03-09
申请人： DIONEX CORPORATION , POHL, Christopher, A. , SRINIVASAN, Kannan , BHARDWAJ, Sheetal
发明人： POHL, Christopher, A. , SRINIVASAN, Kannan , BHARDWAJ, Sheetal
IPC分类号： B01J39/26 , B01J41/04 , B01J41/20 , B01J47/00 , B01J41/12 , B01D15/36
CPC分类号： B01J39/26 , B01D15/361 , B01J41/13 , B01J41/20 , B01J47/016 , Y10T428/1393
摘要： The present invention provides a new design for high capacity stationary phases for dianion selective ion chromatography. The stationary phases include one or more layers which are products of condensation polymerization. Multiple components are of use in forming the first polymer layer and the condensation polymer structure, thereby providing a stationary phase that can be engineered to have a desired property such as ion capacity, ion selectivity, and the like. Exemplary condensation polymers are formed by the reaction of at least one polyfunctional compound with at least one compound of complimentary reactivity, e.g., a nucieophilic polyfunctional compound reacting with an eiectrophilic compound.
摘要翻译：本发明提供了用于双阴离子选择性离子色谱法的高容量固定相的新设计。固定相包括一个或多个作为缩聚产物的层。多个组分可用于形成第一聚合物层和缩聚物结构，从而提供可被工程化以具有所需性质如离子容量，离子选择性等的固定相。示例性缩合聚合物通过至少一种多官能化合物与至少一种互补反应性化合物的反应形成，例如与亲水性化合物反应的亲油性多官能化合物。

7. 发明申请

WO2012112553A1 NANOMETER SIZE CHEMICAL MODIFIED MATERIALS AND USES 审中-公开
标题翻译：纳米尺寸化学改性材料及用途
公开(公告)号：WO2012112553A1
公开(公告)日：2012-08-23
申请号：PCT/US2012/025049
申请日：2012-02-14
申请人： DIONEX CORPORATION , LIU, Xiaodong , POHL, Christopher, A.
发明人： LIU, Xiaodong , POHL, Christopher, A.
IPC分类号： B01J20/32 , B01J20/286 , B01J20/289 , B01J20/287
CPC分类号： G01N1/405 , B01J20/286 , B01J20/287 , B01J20/289 , B01J20/3219 , B01J20/3246 , B01J20/3257 , B01J2220/54 , C07F7/21
摘要： There are provided ligand compositions and stationary phases comprising a polyhedral oligomeric silsequioxane moiety. Also provided are chromatographic devices comprising the stationary phases, and methods of making and using the ligands, stationary phases and chromatographic devices of the invention.
摘要翻译：提供配体组合物和包含多面体低聚硅氧烷部分的固定相。还提供了包含固定相的色谱装置，以及制备和使用本发明的配体，固定相和色谱装置的方法。

8. 发明申请

WO2011106613A1 ANALYTIC DEVICE WITH PHOTOVOLTAIC POWER SOURCE 审中-公开
标题翻译：具有光伏电源的分析装置
公开(公告)号：WO2011106613A1
公开(公告)日：2011-09-01
申请号：PCT/US2011/026196
申请日：2011-02-25
申请人： DIONEX CORPORATION , VANA, Martin , CASE, William, Dale
发明人： VANA, Martin , CASE, William, Dale
IPC分类号： G01N27/00
CPC分类号： G01N30/64 , G01N30/96
摘要： An analytical device including a sensor, an analytical circuit, and a power source. The power source includes an optical coupler formed of a light source and a photovoltaic cell for producing an electromotive force in response to light from the light source. The optical coupler is configured to provide the electromotive force to the analytical circuit. The power source may be configured for separation between the power supply and the resulting electromotive force supplied to the analytical circuit. Various aspects of the invention are directed to providing a powrer source for one or more components of an electrochemical detector. A method of providing power to an analytical instrument is also disclosed.
摘要翻译：包括传感器，分析电路和电源的分析装置。电源包括由光源和用于响应于来自光源的光产生电动势的光伏电池形成的光耦合器。光耦合器被配置为向分析电路提供电动势。电源可以被配置为在电源和提供给分析电路的所得电动势之间分离。本发明的各个方面涉及为电化学检测器的一个或多个部件提供电源。还公开了向分析仪器提供电力的方法。

9. 发明申请

WO2009137275A1 FUNCTIONALIZED SUBSTRATES WITH ION-EXCHANGE PROPERTIES 审中-公开
标题翻译：具有离子交换特性的功能化基底
公开(公告)号：WO2009137275A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/041563
申请日：2009-04-23
申请人： DIONEX CORPORATION , LIU, Xiaodong , POHL, Christopher, A. , CHEN, Jinhua , WOODRUFF, L., Andy
发明人： LIU, Xiaodong , POHL, Christopher, A. , CHEN, Jinhua , WOODRUFF, L., Andy
IPC分类号： B01D15/36 , B01J20/287 , B01J43/00
CPC分类号： B01D15/362 , B01D15/325 , B01D15/361 , B01D15/363 , B01D15/3847 , B01J20/28097 , B01J20/3221 , B01J20/3285 , B01J20/3295 , B01J39/26 , B01J43/00 , B01J41/20
摘要： The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions include a porous solid support (e.g., silica gels, silica monoliths or synthetic organic resins) having an exterior surface and pore openings defined by "interior walls". To the solid support are covalently bound organic ion-exchange ligands (e.g., silyl ligands), which incorporate at least one ion-exchange group (e.g., ionic or ionizable group). The compositions further include micro-particles (e.g., latex particles) incorporating ion-exchange groups having a charge that is opposite to the charge found on the support. The micro-particles are bound to the exterior surface of the support (e.g., via electrostatic forces). The micro-particles have a size that is sufficient to minimize the number of particles that can enter the pores of the support thereby reducing or essentially preventing binding of the micro-particles to the interior walls of the pores. While the pores are essentially too small for the micro-particles, they can still be accessed by the analytes present in a chromatographic sample. The physical separation of ion-exchange groups located within the pores and the surface of the micro-particles, respectively, prevents reactions (e.g., formation of salt-bridges) between the oppositely charged groups and provides compositions with both anion-exchange and cation-exchange capabilities within the same stationary phase. The ligands bound to the solid support can optionally include additional (e.g., reverse-phase) functionalities creating multi-modal (e.g., trimodal) stationary phases.
摘要翻译：本发明提供了用于各种色谱应用的固定相的组合物，例如高效液相色谱（HPLC）和固相萃取（SPE）。组合物包括具有由“内壁”限定的外表面和孔开口的多孔固体支持物（例如硅胶，二氧化硅整料或合成有机树脂）。固体支持物是共价结合的有机离子交换配体（例如，甲硅烷基配体），其结合至少一个离子交换基团（例如离子或可离子化基团）。组合物还包括结合离子交换基团的微粒（例如胶乳颗粒），其具有与载体上发现的电荷相反的电荷。微粒子结合到支撑体的外表面（例如通过静电力）。微粒具有足以使能够进入载体的孔的颗粒数量最小化的尺寸，从而减少或基本上防止微粒与孔内壁的结合。虽然孔对于微粒基本上太小，但是它们仍然可以通过色谱样品中存在的分析物进行访问。分别位于孔和微粒表面之间的离子交换基团的物理分离防止相反电荷基团之间的反应（例如，形成盐桥），并提供具有阴离子交换和阳离子交换的组合物，交换能力在同一个固定阶段。与固体支持物结合的配体可以任选地包括产生多模态（例如，三峰）固定相的另外的（例如反相）官能团。

10. 发明申请

WO2008036486A1 MEMBRANE SUPPRESSOR WITH AN OUTLET SUBSTANTIALLY NON-RETENTIVE FOR IONIC SPECIES 审中-公开
标题翻译：具有出口的膜抑制剂对于离子物质具有非常重要的作用
公开(公告)号：WO2008036486A1
公开(公告)日：2008-03-27
申请号：PCT/US2007/076211
申请日：2007-08-17
申请人： DIONEX CORPORATION , LIU, Yan , BARRETO, Victor , POHL, Christopher, A.
发明人： LIU, Yan , BARRETO, Victor , POHL, Christopher, A.
IPC分类号： G01N30/02
CPC分类号： G01N30/96 , G01N2030/965
摘要： An apparatus for ion chromatography comprising a suppressor comprising a housing and a liquid conduit segment disposed in the housing, the liquid conduit segment including a membrane, the membrane having an inlet section adjacent the inlet of the conduit segment and an outlet section adjacent the outlet of the conduit segment, the inlet section having ion exchange sites capable of transmitting ions of one charge, positive or negative, and the outlet section being substantially non-retentive electrostatically for charged ionic species. Also, the method of using the apparatus.
摘要翻译：一种用于离子色谱的装置，包括抑制器，其包括壳体和设置在壳体中的液体导管段，液体导管段包括膜，所述膜具有邻近导管段入口的入口部分和邻近出口的出口部分导管部分，入口部分具有能够传输一个电荷的离子的正离子或负离子的离子交换位置，并且对于带电离子物质，出口部分静电地基本上是非保持性的。另外，使用该装置的方法。

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