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1. 发明专利

JP4252728B2 I graduated lumen catheter and how to use it 有权
公开(公告)号：JP4252728B2
公开(公告)日：2009-04-08
申请号：JP2000532161
申请日：1999-02-16
申请人：サイティック・コーポレイションCytyc Corporation
发明人：ミヤモト，カーティス , ラクスタリス，ダニエル , ロングトン，ウォレス，エイ
IPC分类号： A61M25/00 , A61B17/00 , A61F2/958 , A61M25/01 , A61M25/095 , A61N5/10
CPC分类号： A61N5/1002 , A61M25/0108 , A61M25/10 , A61M2025/0008 , A61N5/1014

2. 发明专利

JP3723494B2 Cell preservation solution 有权
公开(公告)号：JP3723494B2
公开(公告)日：2005-12-07
申请号：JP2001348123
申请日：2001-11-13
申请人：サイティックコーポレーションCytyc Corporation
发明人：エイ．ハーレイアン , シー．ラペンダニエル , エス．オードピーター
IPC分类号： C12Q1/02 , A01N1/02 , C12N1/04 , C12N5/02 , C12N5/06 , G01N1/28 , G01N33/48
CPC分类号： A01N1/0221 , A01N1/02 , A01N1/0226 , C12N1/04 , Y10S436/826 , Y10T436/10 , Y10T436/107497 , Y10T436/108331

3. 发明专利

JP2004526430A Nucleic acid extraction solution and its usage 审中-公开
公开(公告)号：JP2004526430A
公开(公告)日：2004-09-02
申请号：JP2002556785
申请日：2002-01-15
申请人：サイティックコーポレーションCytyc Corporation
发明人：メナシエイ．コヘンフォード， , ブライアンレンチュリチア，
IPC分类号： G01N33/50 , C12N15/09 , C12N15/10 , C12Q1/68
CPC分类号： C12N15/1003
摘要：核酸を生物学的サンプルから抽出するための、方法および組成物を開示する。特に、核酸抽出溶液、および細胞、細胞破片またはそれらの両方を含む生物学的サンプルから、核酸配列を抽出するために、そのような溶液を使用する方法を開示する。本核酸抽出溶液は、式Ｒ
１Ｏ−ＣＨ
２ −ＣＨ
２ −ＯＲ
２を有する分子を含み、ここでＲ
１およびＲ
２は、水素およびアルキル基からなる群から独立して選択される。本出願は、生物学的サンプルから核酸を抽出するのに十分な量の分子を含む核酸抽出溶液であって、この分子は、式Ｒ
１Ｏ−ＣＨ
２ −ＣＨ
２ −ＯＲ
２を有し、ここでＲ
１およびＲ
２は、水素およびアルキル基からなる群から独立に選択される、核酸抽出溶液を開示する。

4. 发明申请

WO2011031750A1 METHODS AND SYSTEMS FOR COLLECTING CELLS OF A BIOLOGICAL SPECIMEN 审中-公开
标题翻译：收集生物样本细胞的方法和系统
公开(公告)号：WO2011031750A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048117
申请日：2010-09-08
申请人： CYTYC CORPORATION , KAUFMAN, Howard, B. , HUNT, Barry
发明人： KAUFMAN, Howard, B. , HUNT, Barry
IPC分类号： G01N1/28
CPC分类号： G01N1/2813 , G01N1/4077 , G01N2001/4088
摘要： Methods and systems for collecting cells on a filter disposed in a specimen fluid containing suspended cells of a biological specimen. A short vacuum pulse is applied across a filter to sip specimen fluid. A percentage or portion of the filter surface area covered by cells is determined is representative of or correlates to the density of cells in the specimen fluid. A maximum vacuum amplitude and/or duration are determined utilizing the determined filter coverage. A longer, continuous vacuum or slurp is applied across the filter to collect cells on the filter while limiting the amplitude and/or duration of the slurp based at least in part upon the determined maximum vacuum amplitude and/or duration.
摘要翻译：在设置在含有生物样本的悬浮细胞的样本液中的过滤器上收集细胞的方法和系统。在过滤器上施加短的真空脉冲以汲取样品流体。由细胞覆盖的过滤器表面积的百分比或部分被确定为样品流体中的细胞的密度或与之相关。使用确定的滤波器覆盖来确定最大真空振幅和/或持续时间。至少部分地基于所确定的最大真空振幅和/或持续时间，在过滤器上施加更长的连续真空或絮凝物以收集过滤器上的细胞，同时限制浆液的幅度和/或持续时间。

5. 发明申请

WO2010093576A1 FLEXIBLE MULTI-LUMEN BRACHYTHERAPY DEVICE 审中-公开
标题翻译：柔性多层式BRACHYTHERAPY设备
公开(公告)号：WO2010093576A1
公开(公告)日：2010-08-19
申请号：PCT/US2010/023454
申请日：2010-03-16
申请人： CYTYC CORPORATION , DAMARATI, John
发明人： DAMARATI, John
IPC分类号： A61M25/10 , A61N5/10
CPC分类号： A61N5/1015 , A61M25/0029 , A61M25/10 , A61M25/1027 , A61M2025/0037 , A61M2025/004 , A61N5/1007 , A61N2005/1003 , A61N2005/1004 , A61N2005/1018 , Y10T29/49838 , Y10T156/10
摘要： A flexible, multi-lumen brachytherapy device includes a plurality of loose lumens extend through a hub towards a single point of attachment at a distal rigid section. Because the lumens are attached at only a single distal location, the lumens are free to move axially and rotatably, thereby increasing the overall flexibility of the device to thereby decrease intermittent device movement while increasing patient comfort. A novel keyed stylet can be selectively inserted to increase the rigidity of the device as needed. The ability to dynamically modify the rigidity of the brachytherapy device provides a comprehensive brachytherapy solution that satisfies concerns of the patient, the surgeon and the radiologists.
摘要翻译：灵活的多腔近距离放射治疗装置包括多个松散腔，其在远侧刚性部分处经由毂朝向单个附接点延伸。因为腔仅在单个远端位置附接，所以腔可以自由地轴向和可旋转地移动，从而增加装置的整体灵活性，从而减少间歇装置运动同时增加患者的舒适度。可以选择性地插入新颖的带键探针，以根据需要增加装置的刚性。动态修改近距离放射治疗装置的刚性的能力提供了一种全面的近距离放射治疗解决方案，可以满足患者，外科医生和放射科医师的顾虑。

6. 发明申请

WO2008079748A1 METHOD AND SYSTEM FOR LOCATING AND FOCUSING ON FIDUCIAL MARKS ON SPECIMEN SLIDES 审中-公开
标题翻译：用于定位和聚焦在标本滑块上的FIDUCAL MARKS的方法和系统
公开(公告)号：WO2008079748A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/087652
申请日：2007-12-14
申请人： CYTYC CORPORATION , ZAHNISER, Michael
发明人： ZAHNISER, Michael
IPC分类号： G06K9/46 , G06T7/00 , G02B21/00
CPC分类号： G06K9/4647 , G02B21/244 , G06T7/73 , G06T2207/30024
摘要： Methods are disclosed for locating and focusing on a fiducial mark on a specimen slide. A plurality of pixels are identified as candidate pixels. A pixel is identified as a candidate pixel based on a number of empty pixels in an area defined by boundary lines extending from the pixel, and one or more dimensions, such as the perimeter, of the defined area. The candidate pixel enclosing the largest area is selected from the group or set of candidate pixels, and the coordinates of that pixel are considered to be the coordinates of the corner of the fiducial mark. The methods can be performed using different gray values that define dark or fiducial pixels and light or empty pixels. Differences between the results at different gray values can be used as focus scores for automatic focusing on the fiducial mark.
摘要翻译：公开了用于定位和聚焦在标本滑块上的基准标记的方法。多个像素被识别为候选像素。基于从像素延伸的边界线定义的区域中的空白像素的数量以及限定区域的一个或多个维度（例如周长），将像素识别为候选像素。包含最大区域的候选像素从候选像素的组或一组中选择，并且该像素的坐标被认为是基准标记的角的坐标。可以使用定义暗或基准像素和光或空像素的不同灰度值来执行这些方法。不同灰度值下的结果差异可用作自动对焦基准标记的焦点分数。

7. 发明申请

WO2008077073A2 ASYMMETRIC RADIATION DOSING DEVICES AND METHODS FOR BRACHYTHERAPY 审中-公开
标题翻译：非对称辐射剂量装置和用于短程治疗的方法
公开(公告)号：WO2008077073A2
公开(公告)日：2008-06-26
申请号：PCT/US2007/087993
申请日：2007-12-18
申请人： CYTYC CORPORATION , ALLAN, Donna , AMANTE, Greg , ANAV, Risa , BENSON, Maria , CROCKER, Michael , EDMUNDSON, Gregory, K. , HO, Friedrick , KOTMEL, Robert , MAGNUSON, Glenn , MARTIN, Gregory, T. , OCAMPO, Walter , PATEL, Mukund , PAYNE, Mark , SAMPSON, Russel, M. , SCHENCK, Jessica , STUBBS, James , ZILVERSMIT, Moshe
发明人： ALLAN, Donna , AMANTE, Greg , ANAV, Risa , BENSON, Maria , CROCKER, Michael , EDMUNDSON, Gregory, K. , HO, Friedrick , KOTMEL, Robert , MAGNUSON, Glenn , MARTIN, Gregory, T. , OCAMPO, Walter , PATEL, Mukund , PAYNE, Mark , SAMPSON, Russel, M. , SCHENCK, Jessica , STUBBS, James , ZILVERSMIT, Moshe
IPC分类号： A61N5/10
CPC分类号： A61N5/1015 , A61M25/1002 , A61M25/1011 , A61M2025/1013 , A61N2005/1005
摘要： A brachytherapy treatment device includes at least one tubular insertion member, an expandable member, and means for deflecting the at least one tubular insertion member. The tubular insertion member has a longitudinal axis and proximal and distal ends. The expandable member is disposed on and surrounding the distal end of the tubular insertion member. The distal end of the at least one deflected tubular insertion member within the first expandable member is offset from the longitudinal axis when deflected. The at least one deflected tubular insertion member is configured to receive a radiation source to position a radiation source offset with regard to the longitudinal axis to form an asymmetric radiation dosing profile. Additional brachytherapy treatment devices and methods for forming an asymmetric radiation dosing profile are disclosed.
摘要翻译：近距离放射治疗装置包括至少一个管状插入构件，可膨胀构件以及用于偏转所述至少一个管状插入构件的装置。管状插入构件具有纵向轴线以及近端和远端。可膨胀构件设置在并围绕管状插入构件的远端。第一可扩张构件内的至少一个偏转的管状插入构件的远端在偏转时偏离纵向轴线。所述至少一个偏转的管状插入构件被配置成接收辐射源以将辐射源相对于纵向轴线偏移定位以形成不对称的辐射剂量轮廓。公开了额外的近距离放射治疗装置和用于形成不对称放射剂量配置文件的方法。

8. 发明申请

WO2008073902A3 METHOD FOR IMPROVING THE SHELF-LIFE OF HEMATOXYLIN STAINING SOLUTIONS 审中-公开
公开(公告)号：WO2008073902A3
公开(公告)日：2008-06-19
申请号：PCT/US2007/087000
申请日：2007-12-10
申请人： CYTYC CORPORATION , FOSTER, Patrick
发明人： FOSTER, Patrick
IPC分类号： C07D311/94 , C09D11/00 , G01N1/30
摘要： A method is provided for improving the shelf-life of a nuclear staining solution. In particular, the present invention provides a method of adding an antioxidant to a hematoxylin staining solution which maintains the performance of the stain over its shelf- life.

9. 发明申请

WO2008064280A1 DELIVERY CATHETER WITH IMPLANT EJECTION MECHANISM 审中-公开
标题翻译：带进出口机构的输送管
公开(公告)号：WO2008064280A1
公开(公告)日：2008-05-29
申请号：PCT/US2007/085328
申请日：2007-11-21
申请人： CYTYC CORPORATION , HARRINGTON, Douglas, C. , ROGY, Daniel, P. , VIRAY, Victor, E.
发明人： HARRINGTON, Douglas, C. , ROGY, Daniel, P. , VIRAY, Victor, E.
IPC分类号： A61F6/18 , A61F6/22
CPC分类号： A61F6/225 , A61F6/18
摘要： A delivery catheter (1) with a plug (20) ejection mechanism with a fluid filled actuator incorporated in the catheter's handle (2) is disclosed. After delivery of RF energy, the clinician deploys the plug within the region of the lesion by activating the plug ejection mechanism.
摘要翻译：公开了一种具有塞子（20）排出机构的输送导管（1），其具有结合在导管手柄（2）中的流体填充致动器。在输送RF能量之后，临床医生通过启动插头排出机构将插塞部署在病变区域内。

10. 发明申请

WO2007102895A2 FILTER CONTAMINATION CONTROL DEVICE 审中-公开
标题翻译：过滤器污染控制装置
公开(公告)号：WO2007102895A2
公开(公告)日：2007-09-13
申请号：PCT/US2006/061007
申请日：2006-11-16
申请人： CYTYC CORPORATION , TENNEY, Douglas, A.
发明人： TENNEY, Douglas, A.
CPC分类号： G01N1/24 , C12M33/02 , C12M33/14 , G01N2015/0088
摘要： A biological specimen filter for use in a biological specimen collection and transfer system having a vacuum source, the filter comprising a tubular body having an exterior surface, an interior chamber, a first end configured to couple to the vacuum source, and a second end having an opening in communication with the chamber, and a fluid trap extending around at least a portion of a circumference of the exterior surface of the tubular body and sized and shaped to catch fluid flowing along the exterior surface as the tubular body is inverted from a first position, in which the opening is submerged in a fluid source, to a second position, in which the opening is removed from the fluid source.
摘要翻译：一种用于具有真空源的生物样本收集和转移系统的生物标本过滤器，所述过滤器包括具有外表面的管状体，内部室，被配置为联接到所述真空源的第一端，以及具有与腔室连通的开口，以及围绕管状体的外表面的圆周的至少一部分延伸的流体阱，其尺寸和形状被设计成当管状体从第一将开口浸没在流体源中的位置移动到其中将开口从流体源移除的第二位置。

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