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1. 发明申请

US20080166724A1 VEGF-Modulated Genes and Methods Employing Them 审中-公开
标题翻译： VEGF调控基因和方法
公开(公告)号：US20080166724A1
公开(公告)日：2008-07-10
申请号：US11932133
申请日：2007-10-31
申请人： Hans-Peter Gerber , Luca Rastelli
发明人： Hans-Peter Gerber , Luca Rastelli
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/574
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides methods for modulating angiogenesis and/or apoptosis comprising modulating the activity of at least one VEGF-modulated gene polypeptide. The invention also provides pharmaceutical compositions for modulating angiogenesis and apoptosis for the prevention or treatment of diseases associated with VEGF-modulated genes expression. The invention also provides diagnostic assays that use VEGF-modulated gene polynucleotides that hybridize with naturally occurring sequences encoding VEGF-modulated genes and antibodies that specifically bind to the protein.The invention also provides novel human and mouse arginine-rich proteins (ARPs) and nucleotide sequences. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding ARPs and for a method for producing the protein.
摘要翻译：本发明提供调节血管生成和/或凋亡的方法，包括调节至少一种VEGF调节的基因多肽的活性。本发明还提供用于调节血管发生和凋亡以用于预防或治疗与VEGF调节的基因表达相关的疾病的药物组合物。本发明还提供使用VEGF调节的基因多核苷酸的诊断测定法，其与编码VEGF调节的基因的天然存在的序列和与蛋白质特异性结合的抗体杂交。本发明还提供新的人和小鼠富含精氨酸的蛋白质（ARP）和核苷酸序列。本发明提供了基因工程表达载体和宿主细胞，其包含编码ARP的核酸序列和用于产生蛋白质的方法。

2. 发明授权

US07056885B1 Fibroblast growth factor and nucleic acids encoding same 失效
标题翻译：成纤维细胞生长因子和核酸编码相同
公开(公告)号：US07056885B1
公开(公告)日：2006-06-06
申请号：US09609543
申请日：2000-07-03
申请人： Michael Jeffers , Richard A. Shimkets , Sudhirdas K. Prayaga , Ferenc L. Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John L. Herrmann , William J. LaRochelle , Henri Lichenstein
发明人： Michael Jeffers , Richard A. Shimkets , Sudhirdas K. Prayaga , Ferenc L. Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John L. Herrmann , William J. LaRochelle , Henri Lichenstein
IPC分类号： A61K38/18 , C07K14/50
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , A61K2039/505
摘要： The present invention provides FGF-CX polypeptides and polynucleotides, and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods of use for the FGF-CX polypeptide, polynucleotide and antibody.
摘要翻译：本发明提供FGF-CX多肽和多核苷酸，以及免疫特异性结合FGF-CX或FGF-CX多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。本发明另外提供了用于FGF-CX多肽，多核苷酸和抗体的方法。

3. 发明授权

US06987212B2 Amino polyol amine oxidase polynucleotides and related polypeptides and methods of use 失效
标题翻译：氨基多胺胺氧化酶多核苷酸及相关多肽及其使用方法
公开(公告)号：US06987212B2
公开(公告)日：2006-01-17
申请号：US10624619
申请日：2003-07-22
申请人： Jonathan P. Duvick , Jacob T. Gilliam , Joyce R. Maddox , Oswald R. Crasta , Otto Folkerts
发明人： Jonathan P. Duvick , Jacob T. Gilliam , Joyce R. Maddox , Oswald R. Crasta , Otto Folkerts
IPC分类号： C12N15/09 , C12N15/31 , C12N15/82 , A01H5/00 , A01H5/10
CPC分类号： C12N9/0022 , A23K10/14 , A23K10/18 , A23K30/18 , C07K2319/00 , C12N9/16 , C12N15/8209 , C12N15/8242 , C12N15/8282 , G01N2333/906
摘要： The present invention provides transformed plants comprising a polynucleotide enconding amino polyol amine oxidase (APAO ) from Exophiala spinifera and a method of expressing APAO transgenic plants and seeds. In this way, transgenic plant can be produced having fumonisin degrading capability, as well as with the capability of producing the degrading enzymes.
摘要翻译：本发明提供了转化植物，其包含包含来自外来叶柄菌的氨基多元胺胺氧化酶（APAO）的多核苷酸和表达APAO转基因植物和种子的方法。以这种方式，可以生产具有伏马菌素降解能力的转基因植物以及产生降解酶的能力。

4. 发明授权

US06982250B2 Methods of prevention and treatment of inflammatory bowel disease 失效
标题翻译：预防和治疗炎症性肠病的方法
公开(公告)号：US06982250B2
公开(公告)日：2006-01-03
申请号：US10011364
申请日：2001-11-16
申请人： Henry Lichenstein , Michael Jeffers
发明人： Henry Lichenstein , Michael Jeffers
IPC分类号： A61K38/00 , C07K17/00
CPC分类号： C07K14/50 , A61K38/00 , C07K14/49 , C07K14/51 , C07K14/52
摘要： The present invention is based upon methods of treating inflammatory conditions in the intestinal tract of mammals using growth factor related polypeptides. The invention includes methods of reducing the morality rate or delaying mortality in a subject suffering from an inflammatory pathology. Methods of using fibroblast growth factor-CX (FGF-CX) polynucleotide sequences and the FGF-CX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, are claimed in the invention. Similarly, methods of using FCTRX polynucleotide sequences and the FCTRX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, alone or in combination, are also claimed in the invention. FCTRX collectively refers to any of six variant FCTRX sequences, variously designated FCTR1, FCTR2, FCTR3, FCTR4, FCTR5 and FCTR6.
摘要翻译：本发明是基于使用生长因子相关多肽治疗哺乳动物肠道炎症状况的方法。本发明包括降低患有炎性病理学的受试者的道德率或延缓死亡率的方法。在本发明中要求使用成纤维细胞生长因子CX（FGF-CX）多核苷酸序列和由这种核酸序列编码的FGF-CX多肽或其变体，片段和同系物的方法。类似地，在本发明中还要求保护使用FCTRX多核苷酸序列和由此类核酸序列编码的FCTRX多肽，或其变体，片段和同源物单独或组合使用的方法。 FCTRX统称为六种变体FCTRX序列中的任何一种，分别为FCTR1，FCTR2，FCTR3，FCTR4，FCTR5和FCTR6。

5. 发明申请

US20050227267A1 Method of identifying genetic regions associated with disease and predicting responsiveness to therapeutic agents 审中-公开
标题翻译：识别与疾病相关的遗传区域并预测对治疗剂的反应性的方法
公开(公告)号：US20050227267A1
公开(公告)日：2005-10-13
申请号：US11051167
申请日：2005-02-04
申请人： Joel Bader
发明人： Joel Bader
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/18 , G06F19/24 , G06F19/00
CPC分类号： G16B20/00 , G16B40/00
摘要： The invention relates to a method of identifying genetic regions related to disease and to predicting the response to therapeutic agents. The invention provides a method of identifying a genetic region associated with a disease and/or associated with responsiveness to a therapeutic agent.
摘要翻译：本发明涉及鉴定与疾病相关的遗传区域并预测对治疗剂的反应的方法。本发明提供了鉴定与疾病相关和/或与对治疗剂的反应性有关的遗传区域的方法。

6. 发明申请

US20050159373A1 Novel polypeptides, and nucleic acids encoding the same 审中-公开
标题翻译：新型多肽和编码其的核酸
公开(公告)号：US20050159373A1
公开(公告)日：2005-07-21
申请号：US10422335
申请日：2003-04-24
申请人： Diane Pennica , Luca Rastelli
发明人： Diane Pennica , Luca Rastelli
IPC分类号： A01K67/027 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/10 , A61P35/00 , A61P43/00 , C07K14/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/02 , C12Q1/68
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075 , A61K48/00
摘要： An isolated polypeptide comprising an amino acid sequence having at least 80% sequence identity to the sequence SEQ ID NOS:2, 4, 6 or 8, polynucleotides encoding these peptides, and antibodies to the polypeptides are useful in treating cancers.
摘要翻译：包含与序列SEQ ID NO：2,4,6或8具有至少80％序列同一性的氨基酸序列的分离的多肽，编码这些肽的多核苷酸和针对该多肽的抗体可用于治疗癌症。

7. 发明授权

US06875570B2 Proteins and nucleic acids encoding same 失效
标题翻译：蛋白质和编码相同的核酸
公开(公告)号：US06875570B2
公开(公告)日：2005-04-05
申请号：US09964956
申请日：2001-09-26
申请人： Valerie L. Gerlach , John R. MacDougall , Glennda Smithson , Isabelle Millet , David Stone , Erik Gunther , Karen Ellerman , William M. Grosse , John P. Alsobrook, II , Denise M. Lepley , Catherine E. Burgess , Muralidhara Padigaru , Ramesh Kekuda , Kimberly A. Spytek , Martin D. Leach , Richard A. Shimkets
发明人： Valerie L. Gerlach , John R. MacDougall , Glennda Smithson , Isabelle Millet , David Stone , Erik Gunther , Karen Ellerman , William M. Grosse , John P. Alsobrook, II , Denise M. Lepley , Catherine E. Burgess , Muralidhara Padigaru , Ramesh Kekuda , Kimberly A. Spytek , Martin D. Leach , Richard A. Shimkets
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/00 , A61P3/04 , A61P3/10 , A61P3/14 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/32 , A61P27/02 , A61P35/00 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/63 , C12Q1/68 , G01N33/566 , G01N33/574
CPC分类号： C07K14/47 , A61K38/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新型多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

8. 发明申请

US20030199103A1 Novel amino acid sequences for human epidermal growth factor-like polypeptides 审中-公开
标题翻译：人类表皮生长因子样多肽的新型氨基酸序列
公开(公告)号：US20030199103A1
公开(公告)日：2003-10-23
申请号：US09977639
申请日：2001-10-15
申请人： CuraGen Corporation
发明人： Richard A. Shimkets , Elma Fernandes , John Herrman , Corine Vernet
IPC分类号： C07K014/485 , C07H021/04 , C12P021/02 , C12N005/06 , G01N033/543
CPC分类号： C07K14/4756 , A61K38/00 , A61K48/00 , C07K14/47
摘要： This application is drawn to novel amino acid sequences for mammalian polypeptides that have sequence similarity to a protein fragment of human epidermal growth factor. The polypeptides are novel secreted proteins of approximately 708 amino acids.
摘要翻译：本申请被描述为与人表皮生长因子的蛋白质片段具有序列相似性的哺乳动物多肽的新型氨基酸序列。多肽是约708个氨基酸的新型分泌蛋白。

9. 发明申请

US20030104419A1 Method of classifying a thyroid carcinoma using differential gene expression 审中-公开
公开(公告)号：US20030104419A1
公开(公告)日：2003-06-05
申请号：US10137473
申请日：2002-04-30
申请人： CuraGen Corporation
发明人： Bonnie E. Gould-Rothberg , Luca Rastelli
IPC分类号： C12Q001/68 , G01N033/574
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Disclosed are methods of diagnosing and treating carcinomas, including metastatic thyroid carcinomas using differential gene expression. Also disclosed are novel nucleic acid sequences whose expression is differentially regulated in metastatic and non-metastatic thyroid carcinomas.

10. 发明申请

US20030032095A1 Novel nucleic acid sequences encoding human semaphorin-like polypeptides 审中-公开
标题翻译：编码人类信号素样多肽的新型核酸序列
公开(公告)号：US20030032095A1
公开(公告)日：2003-02-13
申请号：US10002050
申请日：2001-11-02
申请人： CuraGen Corporation
发明人： Richard A. Shimkets , Elma Fernandes , Corine Vernet , Meijia Yang , Ferenc L. Boldog , John L. Herrmann
IPC分类号： C12P021/02 , C12N005/06 , C07H021/04 , C07K014/435
CPC分类号： C07K14/4703 , A61K38/00 , C07K14/47 , C07K14/515 , C07K14/575 , C07K14/705
摘要： This application is drawn to novel nucleic acid sequences encoding mammalian polypeptides that have sequence similarity to human and Mus musculus Semaphorin. The nucleic acid sequence is 2284 nucleotides long and contains an open reading frame from nucleotides 166 to 1956. The encoded novel polypeptides comprise about 596 amino acids.
摘要翻译：本申请被描述为编码与人和Mus musculus semaphorin具有序列相似性的哺乳动物多肽的新型核酸序列。核酸序列长2284个核苷酸，含有166至1956个核苷酸的开放阅读框。编码的新型多肽包含约596个氨基酸。

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