专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2012245003A Human binding molecule capable or neutralizing influenza virus h5n1 and use thereof 有权
标题翻译：人类结合分子能够或中和流感病毒H5N1及其使用
公开(公告)号：JP2012245003A
公开(公告)日：2012-12-13
申请号：JP2012179593
申请日：2012-08-13
申请人： Crucell Holland Bv , クルセルホランドベーヴェー
发明人： VAN DEN BRINK EDWARD NORBERT , DE KRUIF CORNELIS ADRIAAN , THROSBY MARK
IPC分类号： C12N15/09 , A61K39/395 , A61P31/16 , C07K16/10
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2760/00011 , C12N2760/00061 , C12N2760/16011 , C12N2760/16061 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： PROBLEM TO BE SOLVED: To provide binding molecules binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1.SOLUTION: The disclosure provides nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods for identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H5N1 infection. In a preferred embodiment, the antibodies provide cross-subtype protection in vivo, such that infections with H5, H2, H6, H9 and H1-based influenza subtypes can be prevented and/or treated.
摘要翻译：要解决的问题：提供结合分子结合分子，例如结合流感病毒H5N1的人单克隆抗体并具有针对流感病毒H5N1的中和活性。解决方案：本公开提供编码抗体的核酸分子，其序列和包含抗体的组合物以及用于鉴定或产生抗体的方法。抗体可用于诊断，预防和/或治疗流感病毒H5N1感染。在优选的实施方案中，抗体在体内提供交叉亚型保护，从而可以预防和/或治疗以H5，H2，H6，H9和H1为基础的流感亚型的感染。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2014221060A ブドウ球菌に対する殺活性を有するヒトの結合分子及びその使用方法有权
标题翻译：具有杀伤生物活性的人结合分子及其用途
公开(公告)号：JP2014221060A
公开(公告)日：2014-11-27
申请号：JP2014136049
申请日：2014-07-01
申请人：クルセルホランドベーヴェー , Crucell Holland Bv , クルセルホランドベーヴェー
发明人： THROSBY MARK , CECILIA A W GEUIJEN , DE KRUIF CORNELIS ADRIAAN
IPC分类号： C12N15/09 , A61K39/395 , A61K45/00 , A61P31/04 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12P21/08
CPC分类号： C07K16/1271 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77
摘要：【課題】少なくとも異なる2種のStaphylococcus種に対して、及びStaphylococcus aureusの少なくとも異なる3つの菌株に対して食作用食細胞殺活性を有するモノクローナル抗体の提供。【解決手段】ブドウ球菌に対し特異的に結合し、ブドウ球菌に対する殺活性を有するヒトのモノクローナル抗体、かかる結合分子をコードする核酸、結合分を含む組成物、及びヒトの結合分を同定又は生成する方法。前記結合分子は、ブドウ球菌に起因した診断、予防及び/又は処置に使用。【選択図】図1
摘要翻译：要解决的问题：提供对至少两种不同葡萄球菌物种和至少三种不同的金黄色葡萄球菌菌株具有调理性吞噬杀伤活性的单克隆抗体。解决方案：描述与葡萄球菌特异性结合并具有针对葡萄球菌的杀伤活性的人单克隆抗体，编码结合分子的核酸，包含结合分子的组合物以及鉴定或产生人结合分子的方法。结合分子可用于由葡萄球菌产生的诊断，预防和/或治疗。

3. 发明专利

JP2011224014A Adenovirus-derived gene delivery vehicle comprising at least one element of adenovirus type 35 有权
标题翻译： ADENOVIRUS衍生的基因交付车辆包含ADENOVIRUS TYPE 35的至少一个元件
公开(公告)号：JP2011224014A
公开(公告)日：2011-11-10
申请号：JP2011156125
申请日：2011-07-14
申请人： Crucell Holland Bv , クルセルホランドベーヴェー
发明人： BOUT ABRAHAM , HAVENGA MENZO JANS EMKO , VOGELS RONALD
IPC分类号： C12N15/09 , A61K35/76 , A61K48/00 , A61P43/00 , C07K14/075 , C12N5/10 , C12N7/04 , C12N15/34 , C12N15/86 , C12N15/861
CPC分类号： C07K14/005 , A61K48/00 , A61K2039/5154 , C07K2319/00 , C07K2319/74 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/6018
摘要： PROBLEM TO BE SOLVED: To redirect adenovirus tropism by altering capsid proteins.SOLUTION: Serotypes differ in their natural tropism. Adenovirus serotypes (2, 4, 5 and 9) all have a natural affiliation towards lung epithelia and other respiratory tissues. In contrast, serotypes (40 and 41) have a natural affiliation towards the gastrointestinal tract. The serotypes differ in at least capsid proteins (penton-base, hexon proteins), proteins responsible for cell binding (fiber proteins), and proteins involved in adenovirus replication. The difference in the tropism and the capsid proteins among serotypes has led to many research efforts aimed at redirecting the adenovirus tropism by modifying the capsid proteins.
摘要翻译：要解决的问题：通过改变衣壳蛋白来重定向腺病毒向性。
解决方案：血清型的自然向性不同。腺病毒血清型（2,4,5和9）都与肺上皮细胞和其他呼吸道组织具有天然的亲缘关系。相比之下，血清型（40和41）与胃肠道具有天然的联系。血清型至少在衣壳蛋白（penton-base，hexon proteins），负责细胞结合的蛋白质（纤维蛋白）和参与腺病毒复制的蛋白质上有所不同。血清型中对向性和衣壳蛋白的差异导致了许多研究工作，旨在通过修饰衣壳蛋白来重新定向腺病毒向性。版权所有（C）2012，JPO＆INPIT

4. 发明申请

WO2008028946A3 HUMAN BINDING MOLECULES CAPABLE OF NEUTRALIZING INFLUENZA VIRUS H5N1 AND USES THEREOF 审中-公开
标题翻译：能够中和流感病毒H5N1的人结合分子及其用途
公开(公告)号：WO2008028946A3
公开(公告)日：2008-10-16
申请号：PCT/EP2007059356
申请日：2007-09-06
申请人： CRUCELL HOLLAND BV , VAN DEN BRINK EDWARD NORBERT , DE KRUIF CORNELIS ADRIAAN , THROSBY MARK
发明人： VAN DEN BRINK EDWARD NORBERT , DE KRUIF CORNELIS ADRIAAN , THROSBY MARK
IPC分类号： C07K16/10 , A61K39/145 , C12N5/10 , C12N15/09
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2760/00011 , C12N2760/00061 , C12N2760/16011 , C12N2760/16061 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： The present invention relates to binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. The disclosure provides nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the ant ibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H5N1 infection. In a preferred embodiment, the antibodies provide cross- subt ype protection in vivo, such that infections with H5, H2, H6, H9 and H1-based influenza subtypes can be prevented and/or treated.
摘要翻译：本发明涉及结合分子，例如结合流感病毒H5N1并具有针对流感病毒H5N1的中和活性的人单克隆抗体。本公开提供编码抗体的核酸分子，其序列和包含抗体的组合物以及鉴定或产生抗体的方法。该抗体可用于流感病毒H5N1感染的诊断，预防和/或治疗。在优选的实施方案中，抗体在体内提供交叉亚型保护，从而可以预防和/或治疗基于H5，H2，H6，H9和H1的流感亚型的感染。

5. 发明申请

WO2006120230A2 HOST CELL SPECIFIC BINDING MOLECULES CAPABLE OF NEUTRALIZING VIRUSES AND USES THEREOF 审中-公开
标题翻译：主要细胞特异性结合分子，可以中和病毒及其用途
公开(公告)号：WO2006120230A2
公开(公告)日：2006-11-16
申请号：PCT/EP2006062250
申请日：2006-05-11
申请人： CRUCELL HOLLAND BV , THROSBY MARK , DE KRUIF CORNELIS ADRIAAN
发明人： THROSBY MARK , DE KRUIF CORNELIS ADRIAAN
CPC分类号： C07K16/1081
摘要： The present invention provides human binding molecules specifically binding to a host cell protein and having virus neutralizing activity, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and/or treatment of viral infections.
摘要翻译：本发明提供与宿主细胞蛋白特异性结合并具有病毒中和活性的人结合分子，编码人结合分子的核酸分子，包含人结合分子的组合物以及鉴定或产生人结合分子的方法。人结合分子可用于病毒感染的诊断，预防和/或治疗。

6. 发明申请

WO2005080556A9 VIRUS PURIFICATION METHODS 审中-公开
标题翻译：病毒净化方法
公开(公告)号：WO2005080556A9
公开(公告)日：2006-10-26
申请号：PCT/EP2005050739
申请日：2005-02-21
申请人： CRUCELL HOLLAND BV , WEGGEMAN MIRANDA , VAN CORVEN EMILE JOANNES JOSEP
发明人： WEGGEMAN MIRANDA , VAN CORVEN EMILE JOANNES JOSEP
IPC分类号： C12N7/02
CPC分类号： C12N7/00 , C12N2501/70 , C12N2710/10051
摘要： The invention provides a method for the purification of a virus from a host cell, said method comprising the steps of: a) culturing host cells, b) infecting said host cells with a virus, c) treating the cell culture with nuclease, d) lysing said host cells to provide a lysate comprising the virus. The virus is preferably a recombinant adenovirus. The invention further provides a method for the purification of a recombinant virus expressing a heterologous protein that is capable of binding nucleic acid, comprising the steps of: a) culturing host cells, b) infecting said host cells with said recombinant virus, c) lysing said host cells to provide a lysate comprising said recombinant virus, d) subjecting the recombinant virus to anion exchange chromatography and size exclusion chromatography, characterized in that the virus containing mixture is buffer exchanged at least once with a solution comprising at least 2 M NaCl, or another salt providing an equivalent ionic strength.
摘要翻译：本发明提供了从宿主细胞纯化病毒的方法，所述方法包括以下步骤：a）培养宿主细胞，b）用病毒感染所述宿主细胞，c）用核酸酶处理细胞培养物，d）裂解所述宿主细胞以提供包含病毒的裂解物。该病毒优选是重组腺病毒。本发明进一步提供了纯化表达能够结合核酸的异源蛋白质的重组病毒的方法，包括以下步骤：a）培养宿主细胞，b）用所述重组病毒感染所述宿主细胞，c）裂解所述宿主细胞提供包含所述重组病毒的裂解物，d）使所述重组病毒经历阴离子交换层析和尺寸排阻层析，其特征在于，所述含病毒混合物用包含至少2M NaCl的溶液缓冲液交换至少一次，或提供相等离子强度的另一种盐。

7. 发明申请

WO2006037038A9 OPTIMIZED VACCINES TO PROVIDE PROTECTION AGAINST EBOLA AND OTHER VIRUSES 审中-公开
标题翻译：优化疫苗提供针对EBOLA和其他病毒的保护
公开(公告)号：WO2006037038A9
公开(公告)日：2006-05-26
申请号：PCT/US2005034798
申请日：2005-09-27
申请人： US GOV HEALTH & HUMAN SERV , CRUCELL HOLLAND BV , SULLIVAN NANCY , CHAKRABARTI BIMAL , YANG ZHI-YONG , PAU MARIA GRAZIA , GOUDSMIT JAAP , NABEL GARY J
发明人： SULLIVAN NANCY , CHAKRABARTI BIMAL , YANG ZHI-YONG , PAU MARIA GRAZIA , GOUDSMIT JAAP , NABEL GARY J
IPC分类号： C07K14/08 , A61K39/12 , C07K16/10 , C12N15/861
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5156 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/10343 , C12N2740/17022 , C12N2760/14022 , C12N2760/14134 , C12N2840/44
摘要： The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitro cytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine compositions, antibodies that are specifically reactive with the modified filovirus GPs, and related methods of making and using the same.
摘要翻译：本发明涉及包含编码经修饰的病毒糖蛋白（GP）的多核苷酸的核酸分子，其具有位于所述GP的相对保守区域中的至少一个氨基酸改变，其降低体外细胞毒性并且与体外细胞毒性相比保留免疫原性野生型病毒GP和相关修饰的流感病毒GP，质粒DNA，重组病毒，腺病毒，药物组合物，疫苗组合物，与修饰的病毒GP特异性反应的抗体的免疫原性及其制备和使用相关方法。

8. 发明申请

WO2005000894A3 BINDING MOLECULES FOR THE TREATMENT OF MYELOID CELL MALIGNANCIES 审中-公开
标题翻译：结合分子治疗髓系细胞恶性肿瘤
公开(公告)号：WO2005000894A3
公开(公告)日：2005-07-07
申请号：PCT/EP2004051243
申请日：2004-06-25
申请人： CRUCELL HOLLAND BV , VAN DEN OUDENRIJN SONJA , VAN MEIJER MARJA , BAKKER ADRIANUS QUIRINUS , BAKKER ALEXANDER BERTHOLD HENR
发明人： VAN DEN OUDENRIJN SONJA , VAN MEIJER MARJA , BAKKER ADRIANUS QUIRINUS , BAKKER ALEXANDER BERTHOLD HENR
IPC分类号： C07K14/705 , C07K16/28 , C07K16/30 , C07K16/18
CPC分类号： C07K14/705 , A61K2039/505 , C07K14/7056 , C07K16/2851 , C07K16/3061 , C07K16/3076 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/622 , C07K2317/77 , C07K2319/00
摘要： The present invention provides a human C-type lectin, binding molecules that specifically bind to the human C-type lectin, nucleic acid molecules encoding the binding molecules or the human C-type lectin, compositions comprising the binding molecules or the human C-type lectin and methods of identifying or producing the binding molecules. The human C-type lectin is specifically expressed on myeloid cells and binding molecules capable of specifically binding to the human C-type lectin can be used in the diagnosis, prevention and/or treatment of neoplastic disorders and diseases.
摘要翻译：本发明提供了人C型凝集素，与人C型凝集素特异性结合的结合分子，编码该结合分子或人C型凝集素的核酸分子，包含该结合分子或人C型的组合物凝集素以及鉴定或产生结合分子的方法。人C型凝集素特异性地表达于骨髓细胞上，并且能够特异性结合人C型凝集素的结合分子可用于肿瘤疾病和疾病的诊断，预防和/或治疗。

9. 发明申请

WO2004045641A3 ANTIGEN-COMPLEXES 审中-公开
标题翻译：抗原复合物
公开(公告)号：WO2004045641A3
公开(公告)日：2005-02-03
申请号：PCT/EP0313084
申请日：2003-11-20
申请人： CRUCELL HOLLAND BV , STEGMANN ANTONIUS JOHANNES HEN
发明人： STEGMANN ANTONIUS JOHANNES HEN
IPC分类号： A61K9/00 , A61K9/107 , A61K9/127 , A61K9/51 , A61K39/145 , A61K39/39 , A61K47/48
CPC分类号： A61K9/1275 , A61K9/0043 , A61K9/1075 , A61K39/39 , A61K47/6901 , A61K2039/542 , A61K2039/543 , A61K2039/55555
摘要： The present invention provides novel methods and means for the preparation of vaccines that are capable of eliciting strong immune responses, especially through intranasal delivery. The invention discloses particles, referred to as 'co-micelles' in which antigens are present that interact through hydrophobic interactions with certain specific types of amphiphilic compounds, wherein said amphiphilic compounds have adjuvant activity and wherein said antigens are preferably antigenic surface proteins, such as integral membrane proteins from infectious agents like viruses.
摘要翻译：本发明提供了用于制备能够引发强的免疫反应的疫苗的新方法和手段，特别是通过鼻内递送。本发明公开了称为“共胶束”的颗粒，其中存在抗原，其通过与某些特定类型的两亲性化合物的疏水相互作用而相互作用，其中所述两亲化合物具有佐剂活性，并且其中所述抗原优选为抗原性表面蛋白，例如来自感染因子如病毒的整合膜蛋白。

10. 发明申请

WO2004001032A3 STABLE ADENOVIRAL VECTORS AND METHODS FOR PROPAGATION THEREOF 审中-公开
标题翻译：稳定的腺病毒载体及其传播方法
公开(公告)号：WO2004001032A3
公开(公告)日：2004-04-01
申请号：PCT/EP0350126
申请日：2003-04-24
申请人： CRUCELL HOLLAND BV , VOGELS RONALD , HAVENGA MENZO JANS EMCO , ZUIJDGEEST DAVID ADRIANUS THEO
发明人： VOGELS RONALD , HAVENGA MENZO JANS EMCO , ZUIJDGEEST DAVID ADRIANUS THEO
IPC分类号： C12N15/09 , A61K35/76 , A61K48/00 , C12N5/10 , C12N7/00 , C12N15/861
CPC分类号： C12N15/86 , A61K2039/5256 , C12N2710/10343 , C12N2840/20 , C12N2840/44
摘要： The present invention provides methods and means to increase the stability and/or the packaging capacity of recombinant adenoviruses, by overexpression of pIX in an adenoviral packaging cell, by retaining at least a part of the E1B 55K region in the recombinant adenoviral vector or by regulating pIX with a heterologous promoter. The invention further relates to methods and means for the production of such adenoviruses on complementing cell lines, wherein the early region 4 open reading frame 6 (E4-orf6) encoding nucleic acid is present in the adenovirus and wherein the E4-orf6 gene product is compatible with one or more products of the E1 gene products in the complementing cell, such that the adenoviral vector can be efficiently produced by the complementing cell.
摘要翻译：本发明提供了通过在腺病毒包装细胞中过表达pIX，通过在重组腺病毒载体中保留至少一部分E1B55K区域或通过调节重组腺病毒载体中的E1B55K区域的至少一部分来提高重组腺病毒的稳定性和/或包装能力的方法和手段 pIX与异源启动子。本发明还涉及在补体细胞系上产生这种腺病毒的方法和手段，其中编码核酸的早期区域4开放阅读框6（E4-orf6）存在于腺病毒中，其中E4-orf6基因产物是与补体细胞中E1基因产物的一种或多种产物相容，使得腺病毒载体可以通过补体细胞有效产生。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式