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1. 发明专利

JP2007101552A Method for evaluating tissue morphogenesis and activity 审中-公开
标题翻译：评估组织形态和活性的方法
公开(公告)号：JP2007101552A
公开(公告)日：2007-04-19
申请号：JP2006303389
申请日：2006-11-08
申请人： Creative Biomolecules Inc , クリエイティブバイオモレキュールズ, インコーポレイテッド
发明人： SAMPATH KUBER T , COHEN CHARLES M
IPC分类号： G01N33/50 , A61K38/00 , A61K38/18 , A61K38/22 , A61P1/02 , A61P1/16 , A61P1/18 , A61P3/04 , A61P3/10 , A61P5/00 , A61P9/00 , A61P11/00 , A61P13/12 , A61P15/00 , A61P19/10 , A61P25/00 , A61P43/00 , C07K14/47 , C07K14/475 , C12N15/09 , G01N33/15 , G01N33/48 , G01N33/68
CPC分类号： G01N33/5088 , A61K38/1875
摘要： PROBLEM TO BE SOLVED: To provide a formula and its usage for quickly evaluating in vivo activity of morphogens and/or their analogs. SOLUTION: This method for evaluating efficacy and pharmacokinetics of morphogenetic protein and its analog capable of inducing functional tissue morphogenesis in a topical deficient site after at least 6 hours from damage of tissue includes a process for producing a topical tolerable deficient site in a nonhuman mammal, a process for administering a candidate morphogen protein after at least 6 hours from production of the topical tolerable deficient site, and a process for measuring ability of inducing new tissue morphogenesis matching the peripheral tissue in the deficient site. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种配方及其用于快速评估形态发生体和/或其类似物的体内活性的用途。解决方案：用于评估在组织损伤至少6小时后局部缺陷部位能够诱导功能组织形态发生的形态发生蛋白及其类似物的功效和药代动力学的方法包括在非人类哺乳动物，从产生局部可耐受缺陷部位至少6小时后施用候选形态发生蛋白的方法，以及测定诱导与缺陷部位中的外周组织匹配的新组织形态发生能力的方法。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JPH10504458A 失效
公开(公告)号：JPH10504458A
公开(公告)日：1998-05-06
申请号：JP50757296
申请日：1995-08-14
申请人： CREATIVE BIOMOLECULES INC , US HEALTH
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P37/02 , C07K16/00 , C07K16/44 , C07K16/46 , C12P21/02 , C12R1/91

3. 发明专利

JPH08505623A 失效
公开(公告)号：JPH08505623A
公开(公告)日：1996-06-18
申请号：JP51623994
申请日：1994-01-07
申请人： CREATIVE BIOMOLECULES INC , US HEALTH
IPC分类号： C07H21/04 , A61K35/14 , A61K38/00 , A61K39/395 , A61K45/00 , A61K47/48 , A61K49/00 , A61K51/10 , A61P35/00 , C07K16/28 , C07K16/44

4. 发明申请

WO9928341A2 MAINTENANCE OF SMOOTH MUSCLE INTEGRITY BY MORPHOGENIC PROTEINS 审中-公开
标题翻译：维生素C对肌肉蛋白质均匀的维持
公开(公告)号：WO9928341A2
公开(公告)日：1999-06-10
申请号：PCT/US9825398
申请日：1998-11-30
申请人： CREATIVE BIOMOLECULES INC , NAKAOKA TAKASHI , MIYAZONO KOHEI , SAMPATH KUBER T
发明人： NAKAOKA TAKASHI , MIYAZONO KOHEI , SAMPATH KUBER T
IPC分类号： A61K38/00 , A61K38/18 , A61K48/00 , C07K14/47 , C07K14/51 , C07K14/00
CPC分类号： C07K14/51 , A61K38/1875 , A61K48/00 , C07K14/4702
摘要： Disclosed are compositions and methods for maintaining the integrity of smooth muscle, particularly vascular smooth muscle. Vascular diseases are characterized by an excessive build-up of vascular smooth muscle cells, resulting in an occlusion of a blood vessel, and/or by loss of elasticity in the blood vessels. Causes of blood vessel occlusion include smooth muscle cell proliferation and inflammatory responses. Inhibition of the proliferation of smooth muscle cells or inflammatory responses represents an effective treatment for vascular disorders, such as atherosclerosis and restenosis. Treatment may include administration of a morphogenic protein. The protein itself may be delivered to the site of vascular occlusion or the protein may be delivered by a vector, such as an adenoviral vector containing a DNA insert encoding a morphogenic protein. Such compositions and methods may also inhibit the responses of smooth muscle cells to various traumas, such as exposure to toxic agents. All of these treatmetns operate to preserve the cell phenotype by inhibiting an increase in extracellular matrix proteins, such as collagen, or by maintaining the normal balance of extracellular matrix proteins, such as Types I and III collagen.
摘要翻译：公开了用于维持平滑肌，特别是血管平滑肌的完整性的组合物和方法。血管疾病的特征在于血管平滑肌细胞积聚过多，导致血管闭塞和/或血管丧失弹性。血管阻塞的原因包括平滑肌细胞增殖和炎症反应。抑制平滑肌细胞或炎症反应的增殖代表血管疾病如动脉粥样硬化和再狭窄的有效治疗方法。治疗可包括施用形态发生蛋白。蛋白质本身可以被递送到血管闭塞部位，或者蛋白质可以通过载体递送，例如含有编码形态发生蛋白的DNA插入物的腺病毒载体。这样的组合物和方法也可以抑制平滑肌细胞对各种创伤的反应，例如暴露于有毒物质。所有这些治疗方法通过抑制细胞外基质蛋白如胶原蛋白的增加或通过维持细胞外基质蛋白如I型和III型胶原的正常平衡来操作来保持细胞表型。

5. 发明申请

WO1998020890A1 MORPHOGEN PEPTIDE-INDUCED REGENERATION OF SENSE PERCEPTORY TISSUES 审中-公开
标题翻译：多发性神经元诱导的感染组织再生
公开(公告)号：WO1998020890A1
公开(公告)日：1998-05-22
申请号：PCT/US1997020743
申请日：1997-11-14
申请人： CREATIVE BIOMOLECULES, INC.
发明人： CREATIVE BIOMOLECULES, INC. , SAMPATH, Kuber , RUEGER, David, C. , COHEN, Charles, M. , CHARETTE, Marc, F. , JIN, Donald, F.
IPC分类号： A61K38/18
CPC分类号： A61K38/1875
摘要： Disclosed are methods and compositions for the treatment and prophylaxis of sensory perception deficits. Methods involve the administration of certain morphogenic compositions.
摘要翻译：公开了用于治疗和预防感觉知觉缺陷的方法和组合物。方法涉及给予某些形态发生组合物。

6. 发明申请

WO1995030003A2 MORPHOGENIC PROTEIN-SPECIFIC CELL SURFACE RECEPTORS AND USES THEREFOR 审中-公开
标题翻译：多形态蛋白特异性细胞表面受体及其用途
公开(公告)号：WO1995030003A2
公开(公告)日：1995-11-09
申请号：PCT/US1995005467
申请日：1995-04-28
申请人： CREATIVE BIOMOLECULES, INC. , THE LUDWIG INSTITUTE FOR CANCER RESEARCH , DIJKE, Peter, T. , MIYAZANO, Kohei , SAMPATH, Kuber, T. , HELDIN, Carl-Henrik
发明人： CREATIVE BIOMOLECULES, INC. , THE LUDWIG INSTITUTE FOR CANCER RESEARCH
IPC分类号： C12N15/12
CPC分类号： G01N33/6845 , A61K38/00 , C07K14/51 , C07K14/71 , G01N33/566 , G01N33/567 , G01N33/68 , G01N33/6887 , G01N33/74 , G01N2500/00 , G01N2500/04
摘要： Disclosed are: (1) nucleic acid sequences, amino acid sequences, homologies, structural features and various other data characterizing a morphogen cell surface receptors particularly OP-1-binding cell surface receptors; (2) methods for producing receptor proteins, including fragments thereof, using recombinant DNA technology; (3) methods for identifying novel morphogen receptors and their encoding DNAs; (4) methods and compositions for identifying compounds capable of modulating endogenous morphogen receptor levels; and (5) methods and compositions for identifying morphogen receptor binding analogs useful in the design of morphogen agonists and antagonists for therapeutic, diagnostic and experimental uses.
摘要翻译：公开的是：（1）核酸序列，氨基酸序列，同源性，结构特征以及表征形态发生细胞表面受体，特别是OP-1结合细胞表面受体的各种其它数据; （2）使用重组DNA技术生产受体蛋白，包括其片段的方法; （3）鉴定新型形态发生受体及其编码DNA的方法; （4）鉴定能够调节内源性形态发生物受体水平的化合物的方法和组合物; 和（5）用于鉴定形态发生受体结合类似物的方法和组合物，其可用于设计用于治疗，诊断和实验用途的形态发生激动剂和拮抗剂。

7. 发明申请

WO1994006449A2 MORPHOGEN-INDUCED LIVER REGENERATION 审中-公开
标题翻译：多形态诱导肝脏再生
公开(公告)号：WO1994006449A2
公开(公告)日：1994-03-31
申请号：PCT/US1993008808
申请日：1993-09-16
申请人： CREATIVE BIOMOLECULES, INC.
发明人： CREATIVE BIOMOLECULES, INC. , KUBERASAMPATH, Thangavel , RUEGER, David, C. , OPPERMANN, Hermann , PANG, Roy, H., L. , COHEN, Charles, M. , OZKAYNAK, Engin , SMART, John, E.
IPC分类号： A61K37/00
CPC分类号： A61K38/1875 , A61F2310/00365 , A61K48/00 , A61L27/227 , A61L27/24 , C07K14/51 , C07K16/22
摘要： Disclosed are therapeutic treatment methods, compositions and devices for maintaining liver function in a mammal, including means for regenerating lost or damaged hepatic tissue, means for enhancing viability and integration of hepatic tissue and organ transplants, and means for correcting liver function deficiencies, including means for enhancing diminished liver function due to tissue injury or disease. The methods, compositions and devices on this invention all provide a therapeutically effective morphogen concentration to the hepatic cells to be treated. Also disclosed are methods and compositions useful in a gene therapy or drug delivery protocol for correcting a protein deficiency in a mammal.
摘要翻译：公开了用于维持哺乳动物肝功能的治疗方法，组合物和装置，包括用于再生损伤或损伤的肝组织的手段，用于增强肝组织和器官移植的活力和整合的手段，以及用于矫正肝功能缺陷的手段，包括手段用于增强由于组织损伤或疾病引起的肝功能减退。本发明的方法，组合物和装置都提供对待治疗的肝细胞的治疗有效的形态发生浓度。还公开了可用于校正哺乳动物蛋白质缺乏症的基因治疗或药物递送方案中的方法和组合物。

8. 发明申请

WO1994003200A1 MORPHOGEN-INDUCED NERVE REGENERATION AND REPAIR 审中-公开
标题翻译：多形态诱导的神经再生和修复
公开(公告)号：WO1994003200A1
公开(公告)日：1994-02-17
申请号：PCT/US1993007231
申请日：1993-07-29
申请人： CREATIVE BIOMOLECULES, INC.
发明人： CREATIVE BIOMOLECULES, INC. , RUEGER, David, C. , KUBERASAMPATH, Thangavel , OPPERMANN, Hermann , OZKAYNAK, Engin , PANG, Roy, H., L. , COHEN, Charles, M.
IPC分类号： A61K37/02
CPC分类号： C07K16/22 , A61F2310/00365 , A61K38/1875 , A61K48/00 , A61L27/227 , A61L27/24 , A61L2430/32 , C07K14/51
摘要： Disclosed are therapeutic treatment methods, compositions and devices for maintaining neural pathways in a mammal, including enhancing survival of neurons at risk of dying, inducing cellular repair of damaged neurons and neural pathways, and stimulating neurons to maintain their differentiated phenotype. In one embodiment, the invention provides means for stimulating CAM expression in neurons. The invention also provides means for evaluating the status of nerve tissue, including means for detecting and monitoring neuropathies in a mammal. The methods, devices and compositions include a morphogen-stimulating agent provided to the mammal in a therapeutically effective concentration.
摘要翻译：公开了用于在哺乳动物中维持神经通路的治疗治疗方法，组合物和装置，包括增加有死亡风险的神经元的存活，诱导受损神经元和神经通路的细胞修复，以及刺激神经元维持其分化表型。在一个实施方案中，本发明提供用于刺激神经元中的CAM表达的装置。本发明还提供了用于评估神经组织状态的手段，包括用于检测和监测哺乳动物神经病变的手段。方法，装置和组合物包括以治疗有效浓度提供给哺乳动物的形态发生剂刺激剂。

9. 发明申请

WO9305751A3 TREATMENT TO PREVENT LOSS OF AND/OR INCREASE BONE MASS IN METABOLIC BONE DISEASES 审中-公开
标题翻译：治疗骨髓损伤和/或增加骨质疏松的骨质疏松
公开(公告)号：WO9305751A3
公开(公告)日：1993-05-13
申请号：PCT/US9207432
申请日：1992-08-28
申请人： CREATIVE BIOMOLECULES INC
发明人： KUBERASAMPATH THANGAVEL , COHEN CHARLES M , OPPERMANN HERMANN , OZKAYNAK ENGIN , RUEGER DAVID C , PANG ROY H L , SMART JOHN E
IPC分类号： A61K38/00 , A01N1/02 , A61F2/00 , A61K6/00 , A61K38/17 , A61K38/18 , A61L27/22 , A61L27/24 , A61P3/00 , A61P43/00 , C07K14/51 , C07K14/575 , C07K14/585 , C07K14/625 , C07K14/65 , C07K16/00 , C07K16/22 , C07K19/00 , C12Q1/68 , G01N33/74 , A61K
CPC分类号： G01N33/74 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61K38/23 , A61K38/29 , A61K38/30 , A61L27/227 , A61L27/24 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/6881 , C12Q2600/158 , G01N2500/10 , A61K2300/00
摘要： The invention is a treatment for increasing the bone mass or preventing bone loss in an individual afflicted with a bone disease which includes administering to the individual a morphogen in a therapeutically effective amount so as to maintain or stimulate bone formation.

10. 发明申请

WO1992010567A1 SYNTHETIC BIOADHESIVE POLYPEPTIDE 审中-公开
标题翻译：合成生物聚合物
公开(公告)号：WO1992010567A1
公开(公告)日：1992-06-25
申请号：PCT/US1991009275
申请日：1991-12-10
申请人： CREATIVE BIOMOLECULES, INC.
发明人： CREATIVE BIOMOLECULES, INC. , PANG, Roy, H., L. , COHEN, Charles, M. , KECK, Peter, C.
IPC分类号： C12N15/11
CPC分类号： C07K14/001 , A61L24/106 , A61L27/227
摘要： This invention pertains to a synthetic adhesive composition for use in aqueous environments. The composition comprises polypeptide chains having an α-helical structure in aqueous environments and capable of cohesive and adhesive interactions. The polypeptide chains comprise polar and apolar amino acids, the apolar and polar amino acids being arranged to define apolar and polar vertical spiraling stripes on the helix surface. The apolar strips allow the polypeptide chains to aggregate into superhelical structures and the polar stripes allow interchain crosslinking within and between the superhelical structures.

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