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2. 发明专利

JP2009539430A Expandable brachytherapy device 有权
公开(公告)号：JP2009539430A
公开(公告)日：2009-11-19
申请号：JP2009513474
申请日：2007-06-01
申请人：シアンナ・メディカル・インコーポレイテッドCianna Medical, Inc.
发明人：エドゥアルド・チ・シン , ジョージ・ディ・ハーマン , スティーブン・エル・ジェックス , ダグ・エス・サットン , トミー・ジー・ヌグイェン , マーク・エイ・リットチャート
IPC分类号： A61N5/10 , A61M36/04
CPC分类号： A61N5/1015 , A61N2005/1018
摘要：標的組織領域に小線源療法を施すための装置は、近位端および遠位端を含み、組織管に導入できる大きさで、放射線源を受けるための経路を含む複数の細長部材を持った細長体を備える。この細長部材は折畳み形状と拡張形状との間で移動することができる。使用時には、組織を通って管道を形成し、細長部材を持った細長体をこの管道を通って標的箇所まで進める。このとき、細長部材は折畳み形状とする。細長部材を標的箇所において拡張形状にし、１つ以上の放射線源を前記経路に沿って導入するなどし、標的箇所の組織を治療するため放射線を照射する。

4. 发明专利

JP2013063289A Expandable proximate irradiation device 有权
标题翻译：可扩展的近红外辐射装置
公开(公告)号：JP2013063289A
公开(公告)日：2013-04-11
申请号：JP2012264004
申请日：2012-12-03
申请人： Cianna Medical Inc , シアナメディカル,インク.
发明人： HERMANN GEORGE D , NGUYEN TOMMY G , NGUYEN THAN , SUTTON DOUG S , URQUIDI LUIS R
IPC分类号： A61N5/10
CPC分类号： A61N5/1014 , A61N5/1015 , A61N2005/1018
摘要： PROBLEM TO BE SOLVED: To provide an expandable device for proximately irradiating an internal tissue.SOLUTION: This invention relates to a device 10 for delivering a proximate irradiation to a target tissue region, having a proximal end 32 and a distal end 34 each sized to enter between tissues and an elongated body supporting two or more elongated members having pathways for receiving a radiation source. The elongated members can move between a folded structure and an expanded structure. During use, a tube passing the tissue is formed, and the elongated body supporting the elongated members is brought through the tube forward to a target position with the folded structure of the elongated members. The elongated members are directed to the expanded structure at the target position so as to, for instance, introduce one or more radiation sources along the pathways, thereby delivering the radiation and treating the tissue in the target position. This device is characterized by preventing an excess expansion and/or facilitating a prompt folding of the elongated members.
摘要翻译：要解决的问题：提供用于近似照射内部组织的可扩张装置。解决方案：本发明涉及一种用于将近距离辐射传送到目标组织区域的装置10，其具有各自尺寸适于进入组织之间的近端32和远端34，以及支撑两个或多个细长构件的细长体，接收辐射源的途径。细长构件可以在折叠结构和膨胀结构之间移动。在使用期间，形成通过组织的管，并且支撑细长构件的细长体通过管子向前延伸到具有细长构件的折叠结构的目标位置。细长构件在目标位置处被引导到膨胀结构，以便例如沿着路径引入一个或多个辐射源，从而传递辐射并将组织处理到目标位置。该装置的特征在于防止多余的膨胀和/或促进细长构件的迅速折叠。版权所有（C）2013，JPO＆INPIT

5. 发明申请

WO2018222777A1 RFID MARKERS AND SYSTEMS AND METHODS FOR IDENTIFIFYING AND LOCATING THEM 审中-公开
公开(公告)号：WO2018222777A1
公开(公告)日：2018-12-06
申请号：PCT/US2018/035219
申请日：2018-05-30
申请人： CIANNA MEDICAL, INC.
发明人： GREENE, John E. , RULKOV, Nikolai
IPC分类号： A61B90/00 , A61B90/98 , G06K7/10 , A61B5/06
摘要： Systems and methods are provided for identifying or locating a tag within a patient's body that include a probe that transmits synchronized electromagnetic signals, e.g., RF energy, and optical signals, e.g., infrared light pulses into the patient's body, whereupon the tag converts the optical signals into electrical energy to open and close a switch in the tag to modulate signals, e.g., backscatter signals, transmitted by the tag in response to the electromagnetic signals. For example, the tag may include photodiodes coupled to the switch that transforms the optical signals to alternately short the antenna to modulate the backscatter signals. Alternatively, the tag may include a smart circuit that harvests electrical energy from the optical signals to power the smart circuit and/or modulate the backscatter signals, e.g., to include data related to the tag and/or alternate the tag between an information mode and a distance mode.

6. 发明申请

WO2017151808A1 IMPLANTABLE MARKERS, AND SYSTEMS AND METHODS FOR USING THEM 审中-公开
标题翻译：可植入标记以及使用它们的系统和方法
公开(公告)号：WO2017151808A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/020260
申请日：2017-03-01
申请人： CIANNA MEDICAL, INC.
发明人： GREENE, John, E. , RULKOV, Nikolai
IPC分类号： A61B90/00
CPC分类号： A61B90/39 , A61B90/06 , A61B90/08 , A61B2017/00115 , A61B2017/00199 , A61B2017/00411 , A61B2034/2051 , A61B2090/061 , A61B2090/0807 , A61B2090/306 , A61B2090/3908 , A61B2090/3925 , A61B2090/3945 , A61B2090/3966 , A61B2090/3975 , A61B2090/3987
摘要： Markers, probes, and related systems and methods are provided for localizing locations within a patient's body, e.g., a lesion within a breast. The marker includes an energy converter e.g., one or more photodiodes, for transforming light energy striking the marker into electrical energy, a storage device coupled to the energy converter for storing the electrical energy, a threshold element that closes a switch when the electrical energy reaches a predetermined threshold to discharge the electrical energy and cause the antenna to transmit a radio frequency (RF) signal. The system includes a probe that transmits light into the patient's body and a processor that correlate the frequency of the RF signals to a distance from the probe to the marker.
摘要翻译：标记物，探针以及相关的系统和方法被提供用于定位患者体内的位置，例如乳房内的病变。该标记包括能量转换器，例如一个或多个光电二极管，用于将撞击标记的光能转换成电能，耦合到能量转换器以存储电能的存储设备，当电能到达时关闭开关的阈值元件预定阈值以释放电能并使天线发射射频（RF）信号。该系统包括一个将光线传输到患者体内的探头和一个处理器，该处理器将RF信号的频率与从探头到标记器的距离相关联。

7. 发明申请

WO2023049801A1 LOCALIZATION DEVICE, DELIVERY DEVICES, SYSTEMS, AND METHODS 审中-公开
公开(公告)号：WO2023049801A1
公开(公告)日：2023-03-30
申请号：PCT/US2022/076860
申请日：2022-09-22
申请人： CIANNA MEDICAL, INC.
发明人： GILSTRAP, David , VELASCO, Amber , MCARTHUR, Gregory R. , BAINSMITH, Matthew
IPC分类号： A61B10/02 , A61B17/34
摘要： Devices, systems, and methods used to deploy a localization device into a target lesion are disclosed. The system includes a delivery device configurable in a ready-to-deploy state and a deployed state. When the delivery device is in the ready-to-deploy state, biased engagement members are engaged with proximal detents of a handle of the delivery device. When the delivery device is in the deployed state, the biased engagement members are engaged with distal detents. The delivery device is transitioned from the ready-to-deploy state to the deployed state by distal displacement of a plunger relative to the handle. The localization device is deployed from a cannula of the delivery device into the target lesion when the delivery device transitions from the ready-to-deploy state to the deployed state.

8. 发明申请

WO2009079170A2 EXPANDABLE BRACHYTHERAPY APPARATUS AND METHODS FOR USING THEM 审中-公开
标题翻译：可扩展的宽带设备及其使用方法
公开(公告)号：WO2009079170A2
公开(公告)日：2009-06-25
申请号：PCT/US2008084587
申请日：2008-11-24
申请人： CIANNA MEDICAL INC , CHI SING EDUARDO , NGUYEN TOMMY G , HERMANN GEORGE D , NGUYEN THAN , SUTTON DOUG S
发明人： CHI SING EDUARDO , NGUYEN TOMMY G , HERMANN GEORGE D , NGUYEN THAN , SUTTON DOUG S
IPC分类号： A61N5/10
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.
摘要翻译：用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。细长构件可在折叠和膨胀构型之间移动。在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。

9. 发明申请

WO2008045812A1 EXPANDABLE BRACHYTHERAPY APPARATUS 审中-公开
标题翻译：可扩展的BRACHYTHERAPY设备
公开(公告)号：WO2008045812A1
公开(公告)日：2008-04-17
申请号：PCT/US2007/080652
申请日：2007-10-06
申请人： CIANNA MEDICAL, INC. , HERMANN, George, D. , NGUYEN, Tommy, G. , NGUYEN, Than , SUTTON, Doug, S. , URQUIDI, Luis, R.
发明人： HERMANN, George, D. , NGUYEN, Tommy, G. , NGUYEN, Than , SUTTON, Doug, S. , URQUIDI, Luis, R.
IPC分类号： A61N5/10
CPC分类号： A61N5/1014 , A61N5/1015 , A61N2005/1018
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways. The apparatus may include features to prevent overexpansion of the elongate members and/or to facilitate rapid collapse of the elongate members.
摘要翻译：用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。细长构件可在折叠和膨胀构型之间移动。在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。该装置可以包括防止细长构件的过度膨胀和/或促进细长构件的快速塌缩的特征。

10. 发明专利

AU2016270372B2 Passive tags, and systems and methods for using them 未知
公开(公告)号：AU2016270372B2
公开(公告)日：2021-04-01
申请号：AU2016270372
申请日：2016-06-03
申请人： CIANNA MEDICAL INC
发明人： RULKOV NIKOLAI , LOPEZ MICHAEL JOHN , GREENE JOHN E
IPC分类号： A61B90/00 , A61B5/05 , A61B90/98 , H01L23/60
摘要： Markers, microwave probes, and related systems and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The marker includes an energy converter e.g., one or more photodiodes, for transforming energy pulses striking the marker into electrical energy, a switch, e.g., FET, coupled to the photodiodes such that light from a probe cause the switch to open and close. A pair of antenna wires are coupled to the switch to provide an antenna, the switch configured to open and close when light strikes the photodiodes to modulate signals from the probe reflected by the antenna back to the probe to identify the location of the marker. The marker also includes an electro static discharge (ESD) protection device coupled to the switch to provide protection against an electrostatic discharge event.

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