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1. 发明申请

US20070154538A1 Removal of fat cells by PDT 审中-公开
标题翻译：通过PDT去除脂肪细胞
公开(公告)号：US20070154538A1
公开(公告)日：2007-07-05
申请号：US11321105
申请日：2005-12-29
申请人： Wolfgang Neuberger , Volker Albrecht
发明人： Wolfgang Neuberger , Volker Albrecht
IPC分类号： A61K31/409 , A61K31/555 , A61K9/127
CPC分类号： A61K9/0019 , A61K9/127 , A61K31/409 , A61K31/555
摘要： A non-surgical, minimally invasive PhotoDynamic Therapy (PDT) method for destruction of undesirable fat cells in the body, which cause obesity, obesity related health problems, and undesirable body contours. In this method photosensitizing agents are formulated into a liposomal formulation or into other delivery means for administering the drug systemically, directly by injection and/or topical application. The photosensitizing formulation is selectively targeted at adipose tissue in the subcutaneous layer. Photosensitized adipose cells are illuminated with a predetermined wavelength of light energy known to initiate a photo cytotoxic effect. The light energy for photoactivation of the photosensitizing agent may be applied interstitially through optical fibers with or without a diffuser tip. Alternatively, a photosensitizing agent is selected to have an activating wavelength which permits external irradiation through the skin. The method ensures safe and permanent fat reduction, minimizes trauma to the area of treatment and also hastens the healing process. A lasting and permanent effect is provided in regions of fat accumulation as the adipose cells are permanently destroyed. This approach is also effective for fat deposits which do not respond to other treatments.
摘要翻译：用于破坏身体中不需要的脂肪细胞的非手术，微创光动力治疗（PDT）方法，其导致肥胖，肥胖相关的健康问题和不期望的身体轮廓。在该方法中，将光敏剂配制成脂质体制剂或其它递送装置，以直接通过注射和/或局部施用全身施用药物。光敏制剂选择性地靶向皮下层中的脂肪组织。用已知的预定波长的光能照射光敏脂肪细胞以引发光细胞毒作用。用于光敏剂的光活化的光能可以通过具有或不具有扩散器尖端的光纤在空隙中施加。或者，选择光敏剂以具有允许通过皮肤的外部照射的激活波长。该方法可确保安全和永久的脂肪减少，减少对治疗领域的创伤，并加快愈合过程。由于脂肪细胞被永久破坏，脂肪堆积区域的持久和永久效应。这种方法对于不响应其他处理的脂肪沉积物也是有效的。

2. 发明授权

US06959022B2 Multi-clad optical fiber lasers and their manufacture 有权
标题翻译：多层光纤激光器及其制造
公开(公告)号：US06959022B2
公开(公告)日：2005-10-25
申请号：US10733987
申请日：2003-12-11
申请人： Thomas Sandrock , Sonja Unger , Alexander Harschack , Volker Reichel
发明人： Thomas Sandrock , Sonja Unger , Alexander Harschack , Volker Reichel
IPC分类号： C03B37/014 , C03B37/018 , C03C13/04 , C03C25/10 , G02B20060101 , G02B1/00 , G02B6/02 , H01S3/067 , H01S3/30
CPC分类号： H01S3/06708 , C03B37/01426 , C03B37/01807 , C03B2203/12 , C03B2203/23 , C03C13/046 , C03C25/104 , H01S3/06729
摘要： An optical fiber is disclosed that can be used as an active medium in fiber lasers and/or fiber amplifiers, featuring a preferably rare-earth-doped silica active core surrounded by a pure or doped silica cladding layer (“pump core”). The pump core is surrounded by a doped or pure silica inner cladding for guiding pumping radiation within the pump core. Thus, the refractive index of the inner cladding is lower than that of the pump core. The fiber is surrounded by a protective coating made of polymeric material. One or more additional outer cladding layers, having refractive indexes lower than said inner cladding, may optionally be placed between the inner cladding and the protective coating to further protect the polymer coating from damage. Unlike the prior art, the protective coating does not serve as the only cladding, but is assisted by the inner cladding and optional outer cladding(s). The resultant fiber restricts radiation mainly to silica layers, thereby increasing the damage threshold and the applicable maximum pump power of the fiber.
摘要翻译：公开了一种光纤，其可以用作光纤激光器和/或光纤放大器中的有源介质，其特征在于由纯或掺杂的二氧化硅包层（“泵芯”）包围的优选稀土掺杂的二氧化硅活性核。泵芯由掺杂或纯二氧化硅内包层包围，用于引导泵芯内的泵浦辐射。因此，内包层的折射率低于泵芯的折射率。纤维被由聚合材料制成的保护涂层包围。具有低于所述内包层的折射率的一个或多个附加的外包层可以可选地被放置在内包层和保护涂层之间，以进一步保护聚合物涂层不被损坏。与现有技术不同，保护涂层不仅用作唯一的包层，而且由内包层和可选的外包层辅助。所得纤维将辐射主要限制为二氧化硅层，从而增加损伤阈值和适用的最大泵浦功率。

3. 发明申请

WO2012012809A2 APPLICATION OF β-FUNCTIONALIZED DIHYDROXY-CHLORINS FOR PDT 审中-公开
标题翻译：用于PDT的功能性二羟基氯化物的应用
公开(公告)号：WO2012012809A2
公开(公告)日：2012-01-26
申请号：PCT/US2011/047576
申请日：2011-08-12
申请人： CERAMOPTEC GMBH , CERAMOPTEC INDUSTRIES, INC. , AICHER, Daniel , WIEHE, Arno , STARK, Christian, B., W. , ALBRECHT, Volker , GRAFE, Susanna
发明人： AICHER, Daniel , WIEHE, Arno , STARK, Christian, B., W. , ALBRECHT, Volker , GRAFE, Susanna
IPC分类号： C07D487/22 , A61K31/409 , A61P35/00 , A61P17/00
CPC分类号： A61K31/409 , C07D487/22
摘要： The present invention provides methods to obtain biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders. An embodiment of the present invention consists of a method to synthesize diketo-chlorins as precursors. In yet another embodiment these precursors are converted to β -unctionalized hydroxy- and dihydroxy-chlorins. Another embodiment is to provide amphiphilic compounds with a higher membrane affinity and increased PDT-efficacy. Another embodiment consists of the formulation of the desired isomer into a liposomal formulation to be injected avoiding undesirable effects like precipitation at the injection site or delayed pharmacokinetics of the tetrapyrrole systems.
摘要翻译：本发明提供了获得可用作诊断和治疗应用的光敏剂的生物活性化合物的方法，特别是用于癌症，感染和其它过度增殖性疾病的PDT，荧光诊断和PDT治疗非肿瘤适应症如关节炎，炎症疾病，病毒或细菌感染，皮肤病学，眼科学或泌尿系统疾病。本发明的一个实施方案由合成二酮二氢卟酚作为前体的方法组成。在另一个实施方案中，这些前体转化为β-无功羟基 - 和二羟基 - 二氢卟酚。另一个实施方案是提供具有更高膜亲和力和增加的PDT功效的两亲化合物。另一个实施方案包括将所需异构体配制成待注射的脂质体制剂，以避免不期望的作用，如注射部位的沉淀或四吡咯体系的延迟药代动力学。

4. 发明专利

DE202009018508U1 Endoluminale Laserablationsvorrichtung zur Behandlung von Venen 未知
公开(公告)号：DE202009018508U1
公开(公告)日：2011-12-09
申请号：DE202009018508
申请日：2009-03-02
申请人： CERAMOPTEC GMBH
IPC分类号： A61B18/22
摘要： Vorrichtung für die endoluminale Behandlung eines Blutgefäßes mit: einem biegsamen Wellenleiter (100, 200, 500, 600, 700, 800, 900), der eine Längsachse bestimmt, einem optisch mit einer Strahlungsquelle (424) verbindbaren, proximalen Ende und einem von dem Blutgefäß aufnehmbaren, distalen Ende, das eine Strahlung emittierende Oberfläche (110, 210, 510, 610) aufweist, die Strahlung von der Strahlungsquelle (424) bezüglich der Längsachse des Wellenleiters (100, 200, 500, 600, 700, 800, 900) in seitliche Richtung auf einen sich über einen Winkelbereich erstreckenden Abschnitt der umgebenden Gefäßwand emittiert, wobei der sich über einen Winkelbereich erstreckende Abschnitt ringförmig ausgebildet ist.

5. 发明专利

DE60032637D1 未知
公开(公告)号：DE60032637D1
公开(公告)日：2007-02-08
申请号：DE60032637
申请日：2000-07-27
申请人： CERAMOPTEC GMBH
发明人： NEUBERGER WOLFGANG
IPC分类号： A61B18/18 , A61B18/20 , A61B18/22

6. 发明专利

DE69525392D1 未知
公开(公告)号：DE69525392D1
公开(公告)日：2002-03-21
申请号：DE69525392
申请日：1995-06-23
申请人： CERAMOPTEC GMBH
发明人： CECCHETTI WALTER , GUAZZIERI STEFANO
IPC分类号： A61B17/00 , A61B18/22 , A61B18/24 , A61B18/00 , B01F3/04
摘要： A medical laser delivery device having lensed caps at the fiber's distal end and capable for sideways directed radiation can produce high power densities at a distance further away from the fiber, and thus enable non-contact ablating procedures to be carried out with lower laser input power levels. An innovative manufacturing method to accomplish this goal is described as well as a novel design and method to affix caps to the optical fibers in a permanent manner unaffected by thermal heating of the device in operation. Also Fresnel reflections can be reduced by some embodiments of the lensed caps. The improvements can be achieved in several ways: including shaping part of a transparent quartz glass cap into a lens in the main exit direction of the beam; using highly refractive optical materials, such as transparent sapphire, as the cap, and shaping a portion thereof into a lens in the main exit direction; or, more generally, using caps made of any medically suitable material and inserting a microlens in the exit path of the beam. The glass cap can be fused with the fiber at the point of the main beam exit thus effectively reducing Fresnel losses. The glass cap can be further fused with the fiber around the entire circumference to permanently seal it onto the fiber tip. This fusion is possible by utilizing a new innovative laser heating and fusing mechanism. When this fusion is performed, before the lens is formed, in the region of the beam path (sideways directed), the formation of a focusing lens is greatly simplified.

7. 发明专利

DE69330522D1 未知
公开(公告)号：DE69330522D1
公开(公告)日：2001-09-06
申请号：DE69330522
申请日：1993-11-23
申请人： CERAMOPTEC GMBH
发明人： NABATOV ALEXEY , KUZIN EUGENY , ARTJUSHENKO DR , NEUBERGER DR
IPC分类号： C03B37/023 , C03C3/32 , C03C13/04 , C30B33/00 , G02B6/10 , C03C13/00

8. 发明专利

DE69514867D1 未知
公开(公告)号：DE69514867D1
公开(公告)日：2000-03-09
申请号：DE69514867
申请日：1995-06-08
申请人： CERAMOPTEC GMBH
发明人： CASTRO JOSE , DIVITA SAM , VULLESTERO NEIL
IPC分类号： C03B37/016 , C03C13/04 , G02B6/02 , G02B6/16

9. 发明专利

DE202007008378U1 未知
公开(公告)号：DE202007008378U1
公开(公告)日：2007-08-23
申请号：DE202007008378
申请日：2007-06-15
申请人： CERAMOPTEC GMBH
IPC分类号： A61N5/067

10. 发明专利

GB2408110B Microstructuring of optical waveguides to produce optical functional elements 未知
公开(公告)号：GB2408110B
公开(公告)日：2007-01-31
申请号：GB0502059
申请日：2003-07-04
申请人： LASER & MED TECH GMBH , CERAMOPTEC GMBH
发明人： ASHKENASI DAVID , ROSENFELD ARKADI , KNAPPE VERENA , ING GERHARD MUELLER PROF DR
IPC分类号： G02B6/02 , A61B18/22 , F21V8/00 , G02B6/00
摘要： The invention relates to a method for microstructuring an optical waveguide having a first cross-sectional region with a first refractive index, a second cross-sectional region with a second refractive index, and a boundary region in the transition from the first to the second cross-sectional region, in which the optical waveguide is exposed to laser radiation in the form of at least one ultra-short single pulse or a sequence of pulses with a defined energy input, whereby the radiant exposure takes place in such a manner that a modification of at least one optical property of the optical waveguide takes place at at least one defined portion of the boundary region.

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